Chromosomal translocations induced at specified loci in human stem cells

The precise genetic manipulation of stem and precursor cells offers extraordinary potential for the analysis, prevention, and treatment of human malignancies. Chromosomal translocations are hallmarks of several tumor types where they are thought to have arisen in stem or precursor cells. Although ap...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 106; no. 26; p. 10620
Main Authors:	Brunet, Erika, Simsek, Deniz, Tomishima, Mark, DeKelver, Russell, Choi, Vivian M, Gregory, Philip, Urnov, Fyodor, Weinstock, David M, Jasin, Maria
Format:	Journal Article
Language:	English
Published:	United States 30.06.2009
Subjects:	Base Sequence Cell Line Chromosome Breakage Chromosomes, Human, Pair 19 - genetics Chromosomes, Human, Pair 6 - genetics Chromosomes, Human, X - genetics DNA Breaks, Double-Stranded DNA Breaks, Single-Stranded DNA Damage DNA Repair Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Gene Rearrangement Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Humans In Situ Hybridization, Fluorescence Interleukin Receptor Common gamma Subunit - genetics Polymerase Chain Reaction Stem Cells - cytology Stem Cells - metabolism Translocation, Genetic
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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