Chromosomal translocations induced at specified loci in human stem cells

The precise genetic manipulation of stem and precursor cells offers extraordinary potential for the analysis, prevention, and treatment of human malignancies. Chromosomal translocations are hallmarks of several tumor types where they are thought to have arisen in stem or precursor cells. Although ap...

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Vydáno v:	Proceedings of the National Academy of Sciences - PNAS Ročník 106; číslo 26; s. 10620
Hlavní autoři:	Brunet, Erika, Simsek, Deniz, Tomishima, Mark, DeKelver, Russell, Choi, Vivian M, Gregory, Philip, Urnov, Fyodor, Weinstock, David M, Jasin, Maria
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 30.06.2009
Témata:	Base Sequence Cell Line Chromosome Breakage Chromosomes, Human, Pair 19 - genetics Chromosomes, Human, Pair 6 - genetics Chromosomes, Human, X - genetics DNA Breaks, Double-Stranded DNA Breaks, Single-Stranded DNA Damage DNA Repair Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Gene Rearrangement Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Humans In Situ Hybridization, Fluorescence Interleukin Receptor Common gamma Subunit - genetics Polymerase Chain Reaction Stem Cells - cytology Stem Cells - metabolism Translocation, Genetic
ISSN:	1091-6490, 1091-6490
On-line přístup:	Zjistit podrobnosti o přístupu
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