Prominent Reduction in Pyramidal Neurons Density in the Orbitofrontal Cortex of Elderly Depressed Patients

Elderly depressed patients have more vascular hyperintensities in frontal white matter and basal ganglia than elderly control subjects. Cell pathology that might be related to increased vascular hyperintensities has not been examined. Postmortem samples from the orbitofrontal cortex (ORB) were colle...

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Bibliographic Details
Published in:	Biological psychiatry (1969) Vol. 58; no. 4; pp. 297 - 306
Main Authors:	Rajkowska, Grazyna, Miguel-Hidalgo, Jose Javier, Dubey, Priti, Stockmeier, Craig A., Krishnan, K. Ranga Rama
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 15.08.2005 Elsevier Science
Subjects:	Adult and adolescent clinical studies Age Factors Age of Onset Aged Aged, 80 and over aging Biological and medical sciences Cell Count - methods Demography Depression Depressive Disorder - pathology Female Frontal Lobe - pathology Geriatric Psychiatry glial cells Humans late-life depression major depression Male Medical sciences Mood disorders morphometry Neuroglia - metabolism Neuroglia - pathology Postmortem Postmortem Changes Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Pyramidal Cells - metabolism Pyramidal Cells - pathology glial cells morphometry late-life depression aging major depression Postmortem Human Mood disorder Glial cell Orbitofrontal cortex Senescence Neuroglia Central nervous system Depression Density Encephalon Morphometry Pyramidal neuron Elderly
ISSN:	0006-3223, 1873-2402
Online Access:	Get full text
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