Functional stoichiometry of the unitary calcium-release-activated calcium channel

Two proteins, STIM1 in the endoplasmic reticulum and Orai1 in the plasma membrane, are required for the activation of Ca(2+) release-activated Ca(2+) (CRAC) channels at the cell surface. How these proteins interact to assemble functional CRAC channels has remained uncertain. Here, we determine how m...

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Bibliographic Details

Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 105; no. 36; p. 13668
Main Authors:	Ji, Wei, Xu, Pingyong, Li, Zhengzheng, Lu, Jingze, Liu, Lin, Zhan, Yi, Chen, Yu, Hille, Bertil, Xu, Tao, Chen, Liangyi
Format:	Journal Article
Language:	English
Published:	United States 09.09.2008
Subjects:	Calcium - metabolism Calcium Channels - genetics Calcium Channels - metabolism Cell Line Cell Survival Fluorescence Resonance Energy Transfer Humans
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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