miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels

Gene expression is potently regulated through the action of RNA-binding proteins (RBPs) and microRNAs (miRNAs). Here, we present evidence of a miRNA regulating an RBP. The RBP HuR can stabilize and modulate the translation of numerous target mRNAs involved in cell proliferation, but little is known...

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Bibliographic Details

Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 105; no. 51; p. 20297
Main Authors:	Abdelmohsen, Kotb, Srikantan, Subramanya, Kuwano, Yuki, Gorospe, Myriam
Format:	Journal Article
Language:	English
Published:	United States 23.12.2008
Subjects:	3' Untranslated Regions Antigens, Surface - biosynthesis Antigens, Surface - genetics Cell Line, Tumor Cell Proliferation Down-Regulation ELAV Proteins ELAV-Like Protein 1 Gene Expression Regulation Humans MicroRNAs - metabolism MicroRNAs - physiology RNA, Messenger - metabolism RNA-Binding Proteins - biosynthesis RNA-Binding Proteins - genetics
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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