miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels

Gene expression is potently regulated through the action of RNA-binding proteins (RBPs) and microRNAs (miRNAs). Here, we present evidence of a miRNA regulating an RBP. The RBP HuR can stabilize and modulate the translation of numerous target mRNAs involved in cell proliferation, but little is known...

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Podrobná bibliografie

Vydáno v:	Proceedings of the National Academy of Sciences - PNAS Ročník 105; číslo 51; s. 20297
Hlavní autoři:	Abdelmohsen, Kotb, Srikantan, Subramanya, Kuwano, Yuki, Gorospe, Myriam
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 23.12.2008
Témata:	3' Untranslated Regions Antigens, Surface - biosynthesis Antigens, Surface - genetics Cell Line, Tumor Cell Proliferation Down-Regulation ELAV Proteins ELAV-Like Protein 1 Gene Expression Regulation Humans MicroRNAs - metabolism MicroRNAs - physiology RNA, Messenger - metabolism RNA-Binding Proteins - biosynthesis RNA-Binding Proteins - genetics
ISSN:	1091-6490, 1091-6490
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