miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels

Gene expression is potently regulated through the action of RNA-binding proteins (RBPs) and microRNAs (miRNAs). Here, we present evidence of a miRNA regulating an RBP. The RBP HuR can stabilize and modulate the translation of numerous target mRNAs involved in cell proliferation, but little is known...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 105; H. 51; S. 20297
Hauptverfasser:	Abdelmohsen, Kotb, Srikantan, Subramanya, Kuwano, Yuki, Gorospe, Myriam
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 23.12.2008
Schlagworte:	3' Untranslated Regions Antigens, Surface - biosynthesis Antigens, Surface - genetics Cell Line, Tumor Cell Proliferation Down-Regulation ELAV Proteins ELAV-Like Protein 1 Gene Expression Regulation Humans MicroRNAs - metabolism MicroRNAs - physiology RNA, Messenger - metabolism RNA-Binding Proteins - biosynthesis RNA-Binding Proteins - genetics
ISSN:	1091-6490, 1091-6490
Online-Zugang:	Weitere Angaben
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!