Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair

Canonical roles for macrophages in mediating the fibrotic response after a heart attack include extracellular matrix turnover and activation of cardiac fibroblasts to initiate collagen deposition. Here we reveal that macrophages directly contribute collagen to the forming post-injury scar. Unbiased...

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Bibliographic Details
Published in:	Nature communications Vol. 11; no. 1; pp. 600 - 17
Main Authors:	Simões, Filipa C., Cahill, Thomas J., Kenyon, Amy, Gavriouchkina, Daria, Vieira, Joaquim M., Sun, Xin, Pezzolla, Daniela, Ravaud, Christophe, Masmanian, Eva, Weinberger, Michael, Mayes, Sarah, Lemieux, Madeleine E., Barnette, Damien N., Gunadasa-Rohling, Mala, Williams, Ruth M., Greaves, David R., Trinh, Le A., Fraser, Scott E., Dallas, Sarah L., Choudhury, Robin P., Sauka-Spengler, Tatjana, Riley, Paul R.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 30.01.2020 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/106 13/31 13/51 38/32 38/39 38/91 631/250/2504 64/110 64/116 692/4019/592/2725 Adoptive Transfer Animals Cell activation Cicatrix - metabolism Cicatrix - pathology Collagen Collagen - metabolism Danio rerio Deposition Embryo, Mammalian - metabolism Extracellular matrix Extracellular Matrix Proteins - metabolism Fibroblasts Fibrosis Gene Expression Regulation Green Fluorescent Proteins - metabolism Heart Heart - physiopathology Heart attacks Humanities and Social Sciences Injuries Macrophages Macrophages - metabolism Macrophages - pathology Mice Monocytes - metabolism multidisciplinary Myocardial infarction Regeneration RNA, Messenger - genetics RNA, Messenger - metabolism Scars Science Science (multidisciplinary) Spleen - pathology Transcription, Genetic Transcriptome - genetics Wound Healing Zebrafish Zebrafish - embryology Zebrafish - physiology Zebrafish Proteins - metabolism
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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