AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells

A novel EGFR-tyrosine kinase inhibitor (TKI), osimertinib, has marked efficacy in patients with EGFR -mutated lung cancer. However, some patients show intrinsic resistance and an insufficient response to osimertinib. This study showed that osimertinib stimulated AXL by inhibiting a negative feedback...

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Bibliographic Details
Published in:	Nature communications Vol. 10; no. 1; pp. 259 - 14
Main Authors:	Taniguchi, Hirokazu, Yamada, Tadaaki, Wang, Rong, Tanimura, Keiko, Adachi, Yuta, Nishiyama, Akihiro, Tanimoto, Azusa, Takeuchi, Shinji, Araujo, Luiz H., Boroni, Mariana, Yoshimura, Akihiro, Shiotsu, Shinsuke, Matsumoto, Isao, Watanabe, Satoshi, Kikuchi, Toshiaki, Miura, Satoru, Tanaka, Hiroshi, Kitazaki, Takeshi, Yamaguchi, Hiroyuki, Mukae, Hiroshi, Uchino, Junji, Uehara, Hisanori, Takayama, Koichi, Yano, Seiji
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 16.01.2019 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/109 13/51 13/89 45/77 631/67/1612 631/67/1612/1350 64/60 82/80 Acrylamides Adenocarcinoma of Lung - drug therapy Adenocarcinoma of Lung - genetics Adenocarcinoma of Lung - pathology Adult Aniline Compounds Animals Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Axl protein Cancer Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Cell Line, Tumor Cell survival Cell Survival - drug effects Cell Survival - genetics Disease-Free Survival Drug Resistance, Neoplasm - genetics Emergence Enzyme inhibitors Epidermal growth factor receptors ErbB Receptors - antagonists & inhibitors ErbB Receptors - genetics ErbB Receptors - metabolism Feedback loops Female Gene Knockdown Techniques Heterocyclic Compounds, 2-Ring - pharmacology Heterocyclic Compounds, 2-Ring - therapeutic use Humanities and Social Sciences Humans Inhibitors Lung - pathology Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - pathology Male Mice Mice, Inbred NOD multidisciplinary Mutation Negative feedback Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - prevention & control Patients Piperazines - pharmacology Piperazines - therapeutic use Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Protein-tyrosine kinase Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Pyrazoles - pharmacology Pyrazoles - therapeutic use Receptor Protein-Tyrosine Kinases - antagonists & inhibitors Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Receptor, ErbB-3 - genetics Receptor, ErbB-3 - metabolism RNA, Small Interfering - metabolism Science Science (multidisciplinary) Targeted cancer therapy Treatment Outcome Tumors Tyrosine Viability Xenograft Model Antitumor Assays
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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