Cysteine proteases in protozoan parasites

Cysteine proteases (CPs) play key roles in the pathogenesis of protozoan parasites, including cell/tissue penetration, hydrolysis of host or parasite proteins, autophagy, and evasion or modulation of the host immune response, making them attractive chemotherapeutic and vaccine targets. This review h...

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Vydáno v:PLoS neglected tropical diseases Ročník 12; číslo 8; s. e0006512
Hlavní autoři: Siqueira-Neto, Jair L., Debnath, Anjan, McCall, Laura-Isobel, Bernatchez, Jean A., Ndao, Momar, Reed, Sharon L., Rosenthal, Philip J.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Public Library of Science 01.08.2018
Public Library of Science (PLoS)
Témata:
Animals
Autophagy
Biology and Life Sciences
Cell cycle
Chemotherapy
Cryptosporidium
Cysteine
Cysteine Proteases - metabolism
Defence mechanisms
Disease control
Enzymes
Eukaryota - enzymology
Extracellular matrix
Human diseases
Humans
Immune response
Immune system
Immunity
Immunomodulation
Medicine and Health Sciences
Organisms
Parasites
Parasites - metabolism
Parasitic diseases
Pathogenesis
Pathogens
Phagocytosis
Pharmaceutical sciences
Pharmacy
Plasmodium
Proteases
Protozoa
Protozoan Proteins - metabolism
Protozoans
Review
Target recognition
Tissue
Tissues
Tropical diseases
Vaccines
Canada
La Jolla California
Montreal Quebec Canada
San Francisco California
California
United States > US
ISSN:1935-2735, 1935-2727, 1935-2735
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Shrnutí:Cysteine proteases (CPs) play key roles in the pathogenesis of protozoan parasites, including cell/tissue penetration, hydrolysis of host or parasite proteins, autophagy, and evasion or modulation of the host immune response, making them attractive chemotherapeutic and vaccine targets. This review highlights current knowledge on clan CA cysteine proteases, the best-characterized group of cysteine proteases, from 7 protozoan organisms causing human diseases with significant impact: Entamoeba histolytica, Leishmania species (sp.), Trypanosoma brucei, T. cruzi, Cryptosporidium sp., Plasmodium sp., and Toxoplasma gondii. Clan CA proteases from three organisms (T. brucei, T. cruzi, and Plasmodium sp.) are well characterized as druggable targets based on in vitro and in vivo models. A number of candidate inhibitors are under development. CPs from these organisms and from other protozoan parasites should be further characterized to improve our understanding of their biological functions and identify novel targets for chemotherapy.
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Current address: Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, United States of America
The authors have declared that no competing interests exist.
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0006512