Rapid outer-surface protein C DNA tattoo vaccination protects against Borrelia afzelii infection

Borrelia afzelii is the predominant Borrelia species causing Lyme borreliosis in Europe. Currently there is no human vaccine against Lyme borreliosis, and most research focuses on recombinant protein vaccines against Borrelia burgdorferi sensu stricto. DNA tattooing is a novel vaccination method tha...

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Bibliographic Details
Published in:	Gene therapy Vol. 21; no. 12; pp. 1051 - 1057
Main Authors:	Wagemakers, A, Mason, L M K, Oei, A, de Wever, B, van der Poll, T, Bins, A D, Hovius, J W R
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.12.2014 Nature Publishing Group
Subjects:	13/109 38/1 38/77 42/44 631/250/2152 631/250/255 631/250/590 64/60 Animals Antibodies, Bacterial - blood Antibodies, Bacterial - immunology Antigens, Bacterial - genetics Antigens, Bacterial - immunology Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - immunology Bacterial Vaccines - genetics Bacterial Vaccines - immunology Biomedical and Life Sciences Biomedicine Borrelia Borrelia afzelii Borrelia burgdorferi Borrelia burgdorferi Group Borreliosis Cell Biology Deoxyribonucleic acid DNA DNA vaccines DNA, Bacterial - genetics Gene Expression Gene Therapy Human Genetics Humoral immunity Immunization Immunoglobulin G Innovations Lyme disease Lyme Disease - immunology Lyme Disease - prevention & control Mice Mice, Inbred C3H Nanotechnology original-article Protein C Proteins Rodents Spirochetes Tattoos Testing Vaccination Vaccination - methods Vaccines Vaccines, DNA - genetics Vaccines, DNA - immunology
ISSN:	0969-7128, 1476-5462, 1476-5462
Online Access:	Get full text
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