Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes
Patients with severe asthma have increased granulocytes in their sputum compared with patients with mild to moderate asthma. We hypothesized that inflammatory granulocytes in sputum may identify specific asthma severity phenotypes and are associated with different patterns of inflammatory proteins i...
Uloženo v:
| Vydáno v: | Journal of allergy and clinical immunology Ročník 125; číslo 5; s. 1028 - 1036.e13 |
|---|---|
| Hlavní autoři: | , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
New York, NY
Mosby, Inc
01.05.2010
Elsevier Elsevier Limited |
| Témata: | |
| ISSN: | 0091-6749, 1097-6825, 1097-6825 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Patients with severe asthma have increased granulocytes in their sputum compared with patients with mild to moderate asthma.
We hypothesized that inflammatory granulocytes in sputum may identify specific asthma severity phenotypes and are associated with different patterns of inflammatory proteins in sputum supernatants.
This hypothesis was tested in 242 patients with asthma enrolled in the Severe Asthma Research Program who provided sputum samples for cell count, differential cell determinations, cell lysates for Western blot, and supernatant analyses by inflammatory protein microarrays and ELISAs. ANOVA and multiple linear regression models tested mediator associations.
Stratified by sputum granulocytes, <2% or ≥2% eosinophils and <40% or ≥40% neutrophils, subjects with both increased eosinophils and neutrophils had the lowest lung function and increased symptoms and health care use. Subjects with elevated eosinophils with or without increased neutrophils had significantly increased fraction exhaled nitric oxide (FeNO) and serum eosinophils and greater frequency of daily β-agonist use. Microarray data stratified by granulocytes revealed 25 to 28 inflammatory proteins increased >2-fold in sputa with ≥40% neutrophils. Microarray analyses stratified by severity of asthma identified 6 to 9 proteins increased >2-fold in sputa in subjects with severe asthma compared with nonsevere asthma. ELISA data stratified by sputum granulocytes showed significant increases in brain-derived neurotrophic factor, IL-1β, and macrophage inflammatory protein 3α/CCL20 for those with ≥40% neutrophils; these mediators demonstrated positive associations with neutrophil counts.
Combined increased sputum eosinophils and neutrophils identified patients with asthma with the lowest lung function, worse asthma control, and increased symptoms and health care requirements. Inflammatory protein analyses of sputum supernatants found novel mediators increased in patients with asthma, predominantly associated with increased sputum neutrophils. |
|---|---|
| AbstractList | Patients with severe asthma have increased granulocytes in their sputum compared with patients with mild to moderate asthma.
We hypothesized that inflammatory granulocytes in sputum may identify specific asthma severity phenotypes and are associated with different patterns of inflammatory proteins in sputum supernatants.
This hypothesis was tested in 242 patients with asthma enrolled in the Severe Asthma Research Program who provided sputum samples for cell count, differential cell determinations, cell lysates for Western blot, and supernatant analyses by inflammatory protein microarrays and ELISAs. ANOVA and multiple linear regression models tested mediator associations.
Stratified by sputum granulocytes, <2% or > or = 2% eosinophils and <40% or > or = 40% neutrophils, subjects with both increased eosinophils and neutrophils had the lowest lung function and increased symptoms and health care use. Subjects with elevated eosinophils with or without increased neutrophils had significantly increased fraction exhaled nitric oxide (FeNO) and serum eosinophils and greater frequency of daily beta-agonist use. Microarray data stratified by granulocytes revealed 25 to 28 inflammatory proteins increased >2-fold in sputa with > or = 40% neutrophils. Microarray analyses stratified by severity of asthma identified 6 to 9 proteins increased >2-fold in sputa in subjects with severe asthma compared with nonsevere asthma. ELISA data stratified by sputum granulocytes showed significant increases in brain-derived neurotrophic factor, IL-1beta, and macrophage inflammatory protein 3alpha/CCL20 for those with > or = 40% neutrophils; these mediators demonstrated positive associations with neutrophil counts.
Combined increased sputum eosinophils and neutrophils identified patients with asthma with the lowest lung function, worse asthma control, and increased symptoms and health care requirements. Inflammatory protein analyses of sputum supernatants found novel mediators increased in patients with asthma, predominantly associated with increased sputum neutrophils. Patients with severe asthma have increased granulocytes in their sputum compared with patients with mild to moderate asthma. Objective - We hypothesized that inflammatory granulocytes in sputum may identify specific asthma severity phenotypes and are associated with different patterns of inflammatory proteins in sputum supernatants. Methods - This hypothesis was tested in 242 patients with asthma enrolled in the Severe Asthma Research Program who provided sputum samples for cell count, differential cell determinations, cell lysates for Western blot, and supernatant analyses by inflammatory protein microarrays and ELISAs. ANOVA and multiple linear regression models tested mediator associations. Results - Stratified by sputum granulocytes, <2% or >=2% eosinophils and <40% or >=40% neutrophils, subjects with both increased eosinophils and neutrophils had the lowest lung function and increased symptoms and health care use. Subjects with elevated eosinophils with or without increased neutrophils had significantly increased fraction exhaled nitric oxide (FeNO) and serum eosinophils and greater frequency of daily beta -agonist use. Microarray data stratified by granulocytes revealed 25 to 28 inflammatory proteins increased >2-fold in sputa with >=40% neutrophils. Microarray analyses stratified by severity of asthma identified 6 to 9 proteins increased >2-fold in sputa in subjects with severe asthma compared with nonsevere asthma. ELISA data stratified by sputum granulocytes showed significant increases in brain-derived neurotrophic factor, IL-1 beta , and macrophage inflammatory protein 3 alpha /CCL20 for those with >=40% neutrophils; these mediators demonstrated positive associations with neutrophil counts. Conclusion - Combined increased sputum eosinophils and neutrophils identified patients with asthma with the lowest lung function, worse asthma control, and increased symptoms and health care requirements. Inflammatory protein analyses of sputum supernatants found novel mediators increased in patients with asthma, predominantly associated with increased sputum neutrophils. Patients with severe asthma have increased granulocytes in their sputum compared with patients with mild to moderate asthma.BACKGROUNDPatients with severe asthma have increased granulocytes in their sputum compared with patients with mild to moderate asthma.We hypothesized that inflammatory granulocytes in sputum may identify specific asthma severity phenotypes and are associated with different patterns of inflammatory proteins in sputum supernatants.OBJECTIVEWe hypothesized that inflammatory granulocytes in sputum may identify specific asthma severity phenotypes and are associated with different patterns of inflammatory proteins in sputum supernatants.This hypothesis was tested in 242 patients with asthma enrolled in the Severe Asthma Research Program who provided sputum samples for cell count, differential cell determinations, cell lysates for Western blot, and supernatant analyses by inflammatory protein microarrays and ELISAs. ANOVA and multiple linear regression models tested mediator associations.METHODSThis hypothesis was tested in 242 patients with asthma enrolled in the Severe Asthma Research Program who provided sputum samples for cell count, differential cell determinations, cell lysates for Western blot, and supernatant analyses by inflammatory protein microarrays and ELISAs. ANOVA and multiple linear regression models tested mediator associations.Stratified by sputum granulocytes, <2% or > or = 2% eosinophils and <40% or > or = 40% neutrophils, subjects with both increased eosinophils and neutrophils had the lowest lung function and increased symptoms and health care use. Subjects with elevated eosinophils with or without increased neutrophils had significantly increased fraction exhaled nitric oxide (FeNO) and serum eosinophils and greater frequency of daily beta-agonist use. Microarray data stratified by granulocytes revealed 25 to 28 inflammatory proteins increased >2-fold in sputa with > or = 40% neutrophils. Microarray analyses stratified by severity of asthma identified 6 to 9 proteins increased >2-fold in sputa in subjects with severe asthma compared with nonsevere asthma. ELISA data stratified by sputum granulocytes showed significant increases in brain-derived neurotrophic factor, IL-1beta, and macrophage inflammatory protein 3alpha/CCL20 for those with > or = 40% neutrophils; these mediators demonstrated positive associations with neutrophil counts.RESULTSStratified by sputum granulocytes, <2% or > or = 2% eosinophils and <40% or > or = 40% neutrophils, subjects with both increased eosinophils and neutrophils had the lowest lung function and increased symptoms and health care use. Subjects with elevated eosinophils with or without increased neutrophils had significantly increased fraction exhaled nitric oxide (FeNO) and serum eosinophils and greater frequency of daily beta-agonist use. Microarray data stratified by granulocytes revealed 25 to 28 inflammatory proteins increased >2-fold in sputa with > or = 40% neutrophils. Microarray analyses stratified by severity of asthma identified 6 to 9 proteins increased >2-fold in sputa in subjects with severe asthma compared with nonsevere asthma. ELISA data stratified by sputum granulocytes showed significant increases in brain-derived neurotrophic factor, IL-1beta, and macrophage inflammatory protein 3alpha/CCL20 for those with > or = 40% neutrophils; these mediators demonstrated positive associations with neutrophil counts.Combined increased sputum eosinophils and neutrophils identified patients with asthma with the lowest lung function, worse asthma control, and increased symptoms and health care requirements. Inflammatory protein analyses of sputum supernatants found novel mediators increased in patients with asthma, predominantly associated with increased sputum neutrophils.CONCLUSIONCombined increased sputum eosinophils and neutrophils identified patients with asthma with the lowest lung function, worse asthma control, and increased symptoms and health care requirements. Inflammatory protein analyses of sputum supernatants found novel mediators increased in patients with asthma, predominantly associated with increased sputum neutrophils. Patients with severe asthma have increased granulocytes in their sputum compared with patients with mild to moderate asthma. We hypothesized that inflammatory granulocytes in sputum may identify specific asthma severity phenotypes and are associated with different patterns of inflammatory proteins in sputum supernatants. This hypothesis was tested in 242 patients with asthma enrolled in the Severe Asthma Research Program who provided sputum samples for cell count, differential cell determinations, cell lysates for Western blot, and supernatant analyses by inflammatory protein microarrays and ELISAs. ANOVA and multiple linear regression models tested mediator associations. Stratified by sputum granulocytes, <2% or ≥2% eosinophils and <40% or ≥40% neutrophils, subjects with both increased eosinophils and neutrophils had the lowest lung function and increased symptoms and health care use. Subjects with elevated eosinophils with or without increased neutrophils had significantly increased fraction exhaled nitric oxide (FeNO) and serum eosinophils and greater frequency of daily β-agonist use. Microarray data stratified by granulocytes revealed 25 to 28 inflammatory proteins increased >2-fold in sputa with ≥40% neutrophils. Microarray analyses stratified by severity of asthma identified 6 to 9 proteins increased >2-fold in sputa in subjects with severe asthma compared with nonsevere asthma. ELISA data stratified by sputum granulocytes showed significant increases in brain-derived neurotrophic factor, IL-1β, and macrophage inflammatory protein 3α/CCL20 for those with ≥40% neutrophils; these mediators demonstrated positive associations with neutrophil counts. Combined increased sputum eosinophils and neutrophils identified patients with asthma with the lowest lung function, worse asthma control, and increased symptoms and health care requirements. Inflammatory protein analyses of sputum supernatants found novel mediators increased in patients with asthma, predominantly associated with increased sputum neutrophils. Background Patients with severe asthma have increased granulocytes in their sputum compared with patients with mild to moderate asthma. Objective We hypothesized that inflammatory granulocytes in sputum may identify specific asthma severity phenotypes and are associated with different patterns of inflammatory proteins in sputum supernatants. Methods This hypothesis was tested in 242 patients with asthma enrolled in the Severe Asthma Research Program who provided sputum samples for cell count, differential cell determinations, cell lysates for Western blot, and supernatant analyses by inflammatory protein microarrays and ELISAs. ANOVA and multiple linear regression models tested mediator associations. Results Stratified by sputum granulocytes, <2% or >=2% eosinophils and <40% or >=40% neutrophils, subjects with both increased eosinophils and neutrophils had the lowest lung function and increased symptoms and health care use. Subjects with elevated eosinophils with or without increased neutrophils had significantly increased fraction exhaled nitric oxide (FeNO) and serum eosinophils and greater frequency of daily β-agonist use. Microarray data stratified by granulocytes revealed 25 to 28 inflammatory proteins increased >2-fold in sputa with >=40% neutrophils. Microarray analyses stratified by severity of asthma identified 6 to 9 proteins increased >2-fold in sputa in subjects with severe asthma compared with nonsevere asthma. ELISA data stratified by sputum granulocytes showed significant increases in brain-derived neurotrophic factor, IL-1β, and macrophage inflammatory protein 3α/CCL20 for those with >=40% neutrophils; these mediators demonstrated positive associations with neutrophil counts. Conclusion Combined increased sputum eosinophils and neutrophils identified patients with asthma with the lowest lung function, worse asthma control, and increased symptoms and health care requirements. Inflammatory protein analyses of sputum supernatants found novel mediators increased in patients with asthma, predominantly associated with increased sputum neutrophils. Background Patients with severe asthma have increased granulocytes in their sputum compared with patients with mild to moderate asthma. Objective We hypothesized that inflammatory granulocytes in sputum may identify specific asthma severity phenotypes and are associated with different patterns of inflammatory proteins in sputum supernatants. Methods This hypothesis was tested in 242 patients with asthma enrolled in the Severe Asthma Research Program who provided sputum samples for cell count, differential cell determinations, cell lysates for Western blot, and supernatant analyses by inflammatory protein microarrays and ELISAs. ANOVA and multiple linear regression models tested mediator associations. Results Stratified by sputum granulocytes, <2% or ≥2% eosinophils and <40% or ≥40% neutrophils, subjects with both increased eosinophils and neutrophils had the lowest lung function and increased symptoms and health care use. Subjects with elevated eosinophils with or without increased neutrophils had significantly increased fraction exhaled nitric oxide (FeNO) and serum eosinophils and greater frequency of daily β-agonist use. Microarray data stratified by granulocytes revealed 25 to 28 inflammatory proteins increased >2-fold in sputa with ≥40% neutrophils. Microarray analyses stratified by severity of asthma identified 6 to 9 proteins increased >2-fold in sputa in subjects with severe asthma compared with nonsevere asthma. ELISA data stratified by sputum granulocytes showed significant increases in brain-derived neurotrophic factor, IL-1β, and macrophage inflammatory protein 3α/CCL20 for those with ≥40% neutrophils; these mediators demonstrated positive associations with neutrophil counts. Conclusion Combined increased sputum eosinophils and neutrophils identified patients with asthma with the lowest lung function, worse asthma control, and increased symptoms and health care requirements. Inflammatory protein analyses of sputum supernatants found novel mediators increased in patients with asthma, predominantly associated with increased sputum neutrophils. |
| Author | Bleecker, Eugene R. Li, Huashi Hastie, Annette T. Meyers, Deborah A. Vestal, Penny L. Peters, Stephen P. Moore, Wendy C. |
| Author_xml | – sequence: 1 givenname: Annette T. surname: Hastie fullname: Hastie, Annette T. email: ahastie@wfubmc.edu – sequence: 2 givenname: Wendy C. surname: Moore fullname: Moore, Wendy C. – sequence: 3 givenname: Deborah A. surname: Meyers fullname: Meyers, Deborah A. – sequence: 4 givenname: Penny L. surname: Vestal fullname: Vestal, Penny L. – sequence: 5 givenname: Huashi surname: Li fullname: Li, Huashi – sequence: 6 givenname: Stephen P. surname: Peters fullname: Peters, Stephen P. – sequence: 7 givenname: Eugene R. surname: Bleecker fullname: Bleecker, Eugene R. |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22823929$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/20398920$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFUl1r3DAQNCWluaT9A30ohlL6dNeVfLKlEgIh9AsCfWj7LGRZzsm1patWPvC_r8xdmvagyZOQdma0uzNn2YnzzmTZSwIrAqR81606pe2KQnoAugLgT7IFAVEtS07ZSbYAEGRZVmtxmp0hdpDuBRfPslMKheCCwiJzV071ExrMfZsrjJtB5Wh2Jtg45duNcT5O21RVrsmta3s1DCr6kGrBR2Mdptccx7ozOmKOMahoW2uavJ5y3I5xHPLboNzYez1Fg8-zp63q0bw4nOfZj48fvl9_Xt58_fTl-upmqUsGcSmqBnRZ10YoQ-tSqYY3REND1w20AAVjirSsTNO0FeNrUrBa14xzVuqCtGVVnGeXe93tWA-m0calznq5DXZQYZJeWflvxdmNvPU7SXnFaTULvD0IBP9rNBjlYFGbvlfO-BFlxda8ArqGx5FFQUhFCUvI10fIzo8h7R8lYQyIIAJIQr36u_U_Pd95lgBvDgCFWvVtWq-2eI-jnBaCioTje5wOHjGYVmobkz1-ntj2koCcYyQ7OcdIzjGSQGWKUaLSI-qd-oOkiz3JJGN31gSJ2hqnTWNDSodsvH2YfnlE1711Nk3400wG71clMRHktzncc7ZJijXlYrbs_f8FHvv9NzN2Cx8 |
| CODEN | JACIBY |
| CitedBy_id | crossref_primary_10_1016_j_ccm_2012_06_008 crossref_primary_10_1183_09031936_00117013 crossref_primary_10_3390_genes14091824 crossref_primary_10_1155_2022_9656278 crossref_primary_10_1016_j_jaci_2015_11_035 crossref_primary_10_1111_all_12580 crossref_primary_10_1016_j_ccm_2012_06_007 crossref_primary_10_1016_j_chest_2015_12_018 crossref_primary_10_1164_rccm_201405_0859PP crossref_primary_10_1016_j_jaci_2011_03_034 crossref_primary_10_1186_s12931_023_02603_2 crossref_primary_10_1186_s40413_017_0153_4 crossref_primary_10_3904_kjim_2023_299 crossref_primary_10_1016_j_rmed_2012_10_003 crossref_primary_10_1016_j_arbr_2015_03_010 crossref_primary_10_1172_JCI90890 crossref_primary_10_1111_cea_12762 crossref_primary_10_1186_s12890_018_0763_9 crossref_primary_10_4103_lungindia_lungindia_271_22 crossref_primary_10_1186_s12890_022_01824_3 crossref_primary_10_2217_imt_11_88 crossref_primary_10_1016_S2213_2600_24_00250_9 crossref_primary_10_1183_13993003_02446_2021 crossref_primary_10_1016_j_jaip_2024_11_005 crossref_primary_10_1155_2023_3732315 crossref_primary_10_1007_s40265_014_0213_9 crossref_primary_10_1164_rccm_202211_2074ED crossref_primary_10_3904_kjim_2019_083 crossref_primary_10_1016_j_chest_2025_05_013 crossref_primary_10_1016_j_celrep_2025_116054 crossref_primary_10_1016_j_phrs_2015_12_018 crossref_primary_10_3109_02770903_2014_971967 crossref_primary_10_1111_cea_13841 crossref_primary_10_1016_j_jaip_2019_11_006 crossref_primary_10_1164_rccm_201609_1830OC crossref_primary_10_1186_s13223_023_00868_2 crossref_primary_10_3390_biomedicines10112946 crossref_primary_10_1097_ACI_0b013e32834ecb4f crossref_primary_10_1016_j_jaci_2012_01_047 crossref_primary_10_1007_s11882_019_0881_3 crossref_primary_10_1016_j_jacig_2023_100194 crossref_primary_10_1016_j_drudis_2011_05_014 crossref_primary_10_1165_rcmb_2010_0450OC crossref_primary_10_1016_j_jaip_2022_04_044 crossref_primary_10_1002_iid3_397 crossref_primary_10_1183_09031936_00105013 crossref_primary_10_1097_MCP_0b013e32835b10ec crossref_primary_10_1016_j_anai_2010_09_007 crossref_primary_10_1016_j_jaci_2016_10_041 crossref_primary_10_1186_s12890_016_0232_2 crossref_primary_10_1016_j_lpm_2016_04_021 crossref_primary_10_1183_13993003_01129_2016 crossref_primary_10_20538_1682_0363_2023_1_143_152 crossref_primary_10_1007_s11882_013_0361_0 crossref_primary_10_1097_ACI_0000000000000165 crossref_primary_10_1016_j_molimm_2017_01_014 crossref_primary_10_1055_s_0042_1750130 crossref_primary_10_1038_ncomms13696 crossref_primary_10_1016_j_jaci_2023_01_028 crossref_primary_10_3390_cells11172764 crossref_primary_10_1016_j_intimp_2023_110892 crossref_primary_10_1016_j_jaci_2013_03_044 crossref_primary_10_1183_09031936_00202013 crossref_primary_10_1038_mi_2014_56 crossref_primary_10_1513_AnnalsATS_201304_087AW crossref_primary_10_1016_j_pupt_2013_07_003 crossref_primary_10_1164_rccm_202009_3713OC crossref_primary_10_1111_cei_12958 crossref_primary_10_3390_ijerph17249318 crossref_primary_10_1186_1465_9921_14_17 crossref_primary_10_1016_j_jaip_2018_08_008 crossref_primary_10_1073_pnas_1204151109 crossref_primary_10_3390_ijms21176372 crossref_primary_10_3390_jcm12175447 crossref_primary_10_1111_cea_12179 crossref_primary_10_1007_s00210_017_1459_z crossref_primary_10_1096_fj_202301428RR crossref_primary_10_1016_j_medcle_2015_05_044 crossref_primary_10_1038_s41385_019_0172_2 crossref_primary_10_3390_jcm8101615 crossref_primary_10_1016_j_jaci_2010_10_024 crossref_primary_10_1038_emm_2016_135 crossref_primary_10_1016_j_ccm_2012_05_003 crossref_primary_10_1371_journal_pone_0181425 crossref_primary_10_1016_j_chest_2018_07_028 crossref_primary_10_1016_j_jaci_2014_12_1936 crossref_primary_10_1016_j_jaci_2022_11_016 crossref_primary_10_1073_pnas_1015476108 crossref_primary_10_1164_rccm_201108_1503OC crossref_primary_10_1016_j_waojou_2019_100078 crossref_primary_10_1007_s10753_020_01362_2 crossref_primary_10_1016_j_jaci_2016_10_024 crossref_primary_10_1097_CM9_0000000000002456 crossref_primary_10_1097_MCP_0b013e32834d09a5 crossref_primary_10_1111_all_12828 crossref_primary_10_1111_imr_12543 crossref_primary_10_1111_cea_12200 crossref_primary_10_1513_AnnalsATS_201303_047AW crossref_primary_10_1164_rccm_202402_0403OC crossref_primary_10_3390_cells12182208 crossref_primary_10_1007_s11882_020_00935_3 crossref_primary_10_4049_jimmunol_1800293 crossref_primary_10_1177_1753465816632638 crossref_primary_10_1111_imr_70011 crossref_primary_10_1016_S2213_2600_13_70128_0 crossref_primary_10_1016_j_jaci_2013_12_1091 crossref_primary_10_1016_j_rmed_2015_03_002 crossref_primary_10_1016_j_jbi_2011_09_006 crossref_primary_10_1371_journal_pone_0114791 crossref_primary_10_1016_j_jaip_2023_02_001 crossref_primary_10_1089_respcare_12352 crossref_primary_10_1155_2013_609395 crossref_primary_10_1007_s10875_012_9807_8 crossref_primary_10_1016_j_jaci_2016_09_015 crossref_primary_10_1016_j_jaip_2018_08_024 crossref_primary_10_1097_MCP_0b013e3283418f95 crossref_primary_10_1016_j_jaci_2013_10_011 crossref_primary_10_1007_s11882_017_0751_9 crossref_primary_10_1016_j_jaci_2015_02_032 crossref_primary_10_1016_j_jaci_2012_06_034 crossref_primary_10_1155_2014_136463 crossref_primary_10_2147_COPD_S364982 crossref_primary_10_1177_1479972314562210 crossref_primary_10_1016_j_it_2011_10_004 crossref_primary_10_1016_j_pharmthera_2013_07_001 crossref_primary_10_1007_s12026_012_8296_4 crossref_primary_10_1089_ped_2018_0886 crossref_primary_10_2478_fzm_2022_0031 crossref_primary_10_1186_s12890_016_0208_2 crossref_primary_10_1371_journal_pone_0177538 crossref_primary_10_1016_j_jaip_2014_09_007 crossref_primary_10_1016_j_jaip_2021_10_065 crossref_primary_10_3389_fmed_2022_969243 crossref_primary_10_3892_etm_2017_4776 crossref_primary_10_1016_j_jaci_2011_12_979 crossref_primary_10_1016_j_scib_2021_01_026 crossref_primary_10_1016_j_jaci_2017_02_045 crossref_primary_10_1038_s41598_024_70880_y crossref_primary_10_1016_j_jaci_2025_05_006 crossref_primary_10_1164_rccm_202002_0454OC crossref_primary_10_1164_rccm_201107_1317PP crossref_primary_10_1371_journal_pone_0074730 crossref_primary_10_3109_08820139_2015_1041606 crossref_primary_10_1172_JCI153397 crossref_primary_10_1111_resp_13014 crossref_primary_10_1111_j_1365_2796_2012_02558_x crossref_primary_10_1183_13993003_01585_2021 crossref_primary_10_3390_ijms20174216 crossref_primary_10_1016_j_jaci_2021_03_024 crossref_primary_10_1055_s_0041_1727233 crossref_primary_10_4168_aair_2017_9_6_466 crossref_primary_10_1111_all_12730 crossref_primary_10_3389_fimmu_2022_943554 crossref_primary_10_3389_fped_2019_00256 crossref_primary_10_1016_j_jaip_2016_08_001 crossref_primary_10_1183_13993003_00844_2019 crossref_primary_10_1186_1710_1492_9_23 crossref_primary_10_3390_ijms242216042 crossref_primary_10_1111_j_1365_2222_2012_04004_x crossref_primary_10_1089_ped_2015_0560 crossref_primary_10_1016_j_ddmec_2012_09_001 crossref_primary_10_1016_j_intimp_2023_110225 crossref_primary_10_1016_j_jaci_2018_06_008 crossref_primary_10_1183_09031936_00209513 crossref_primary_10_3390_ijms20030713 crossref_primary_10_1007_s12016_020_08787_5 crossref_primary_10_1016_j_jaci_2012_03_030 crossref_primary_10_1007_s13670_015_0124_y crossref_primary_10_1111_all_13833 crossref_primary_10_1186_s12931_018_0922_9 crossref_primary_10_1177_0300985817741729 crossref_primary_10_1097_ACI_0000000000000426 crossref_primary_10_1016_j_resinv_2021_05_011 crossref_primary_10_1164_rccm_201109_1712OC crossref_primary_10_1165_rcmb_2011_0267OC crossref_primary_10_2500_aap_2021_42_200102 crossref_primary_10_1016_j_gene_2013_05_031 crossref_primary_10_1016_j_gene_2016_03_026 crossref_primary_10_1111_j_1365_2222_2012_04014_x crossref_primary_10_1016_j_intimp_2023_109920 crossref_primary_10_1093_jimmun_vkaf002 crossref_primary_10_1016_j_rmed_2018_07_006 crossref_primary_10_1016_j_cbi_2019_03_001 crossref_primary_10_3390_ijms25031933 crossref_primary_10_1111_j_1600_065X_2011_01032_x crossref_primary_10_1183_16000617_0010_2016 crossref_primary_10_3389_fimmu_2025_1552394 crossref_primary_10_1378_chest_11_0627 crossref_primary_10_1016_j_anai_2014_01_021 crossref_primary_10_1016_j_jaci_2024_04_027 crossref_primary_10_4168_aair_2017_9_1_3 crossref_primary_10_1165_rcmb_2024_0133OC crossref_primary_10_4168_aair_2021_13_3_375 crossref_primary_10_1016_j_anai_2014_08_024 crossref_primary_10_1007_s11882_017_0678_1 crossref_primary_10_1111_sji_70032 crossref_primary_10_1007_s12016_018_8712_1 crossref_primary_10_1016_j_anai_2020_06_017 crossref_primary_10_1016_j_jaip_2018_12_027 crossref_primary_10_1165_rcmb_2013_0522OC crossref_primary_10_1183_13993003_00336_2016 crossref_primary_10_1080_02770903_2021_1962908 crossref_primary_10_1155_2016_7596531 crossref_primary_10_1016_j_jaip_2017_05_015 crossref_primary_10_1016_j_jaci_2020_01_039 crossref_primary_10_1097_MCP_0000000000000231 crossref_primary_10_1080_02770903_2022_2155186 crossref_primary_10_1097_MCP_0b013e3283410ae4 crossref_primary_10_1186_s40413_016_0131_2 crossref_primary_10_1016_j_anai_2013_06_028 crossref_primary_10_1016_j_jaci_2011_02_042 crossref_primary_10_1016_j_jaci_2019_08_031 crossref_primary_10_1016_j_anai_2021_01_023 crossref_primary_10_1165_rcmb_2015_0015OC crossref_primary_10_1186_s12931_021_01808_7 crossref_primary_10_1111_cea_12223 crossref_primary_10_1165_rcmb_2018_0175OC crossref_primary_10_1111_j_1365_2222_2012_03959_x crossref_primary_10_1038_mi_2011_60 crossref_primary_10_1186_s12931_019_1111_1 crossref_primary_10_1016_j_arbres_2014_12_007 crossref_primary_10_1111_crj_13365 crossref_primary_10_1038_nm_2356 crossref_primary_10_1016_j_bbadis_2024_167040 crossref_primary_10_1016_j_rmed_2024_107881 crossref_primary_10_1113_EP092502 crossref_primary_10_1186_s12931_024_03077_6 crossref_primary_10_1155_2013_619614 crossref_primary_10_1371_journal_pone_0067560 crossref_primary_10_1016_S2213_2600_17_30190_X crossref_primary_10_1093_immhor_vlaf042 crossref_primary_10_1016_j_ccm_2021_04_009 crossref_primary_10_1007_s00417_014_2785_1 crossref_primary_10_3390_jpm11121299 crossref_primary_10_1016_j_jaci_2020_05_039 crossref_primary_10_4049_jimmunol_1100500 crossref_primary_10_1186_s12950_018_0191_x crossref_primary_10_1186_1471_2466_13_11 crossref_primary_10_1183_20734735_042912 crossref_primary_10_3389_fmed_2017_00158 crossref_primary_10_1016_j_jaci_2010_06_043 crossref_primary_10_1371_journal_pone_0297616 crossref_primary_10_1586_ers_12_38 crossref_primary_10_1016_j_jaci_2013_06_048 crossref_primary_10_1084_jem_20220236 crossref_primary_10_1111_all_15375 crossref_primary_10_1111_resp_12315 crossref_primary_10_1186_s40733_016_0021_y crossref_primary_10_1016_j_jaci_2017_07_014 crossref_primary_10_1016_j_lfs_2022_121119 crossref_primary_10_1016_j_jaip_2015_04_002 crossref_primary_10_1183_13993003_00780_2015 crossref_primary_10_1016_j_jaci_2021_09_031 crossref_primary_10_1016_S0001_4079_19_32230_7 crossref_primary_10_1165_rcmb_2021_0535OC crossref_primary_10_1586_17512433_2016_1172208 crossref_primary_10_1016_j_jaci_2013_05_007 crossref_primary_10_1007_s11033_016_4007_x crossref_primary_10_1002_puh2_15 crossref_primary_10_1016_j_intimp_2022_109037 crossref_primary_10_1016_j_jaci_2024_05_013 crossref_primary_10_1513_AnnalsATS_201303_070AW crossref_primary_10_1165_rcmb_2012_0423OC crossref_primary_10_1016_j_pupt_2011_01_011 crossref_primary_10_1016_j_jaci_2019_02_027 crossref_primary_10_1164_rccm_201611_2232PP crossref_primary_10_1097_PCC_0000000000001695 crossref_primary_10_1159_000371849 crossref_primary_10_1016_j_jaci_2013_11_005 crossref_primary_10_1016_j_jaci_2017_09_035 crossref_primary_10_1016_j_jaip_2022_02_020 crossref_primary_10_1111_cea_13129 crossref_primary_10_3109_08830185_2015_1096936 crossref_primary_10_1016_j_bbrc_2012_10_097 crossref_primary_10_1371_journal_pone_0171721 crossref_primary_10_1111_cea_12156 crossref_primary_10_1164_rccm_202206_1183OC crossref_primary_10_1007_s10735_022_10101_w crossref_primary_10_1016_j_coi_2021_03_004 crossref_primary_10_1038_s41385_021_00462_y crossref_primary_10_4168_aair_2021_13_4_646 crossref_primary_10_1016_j_jaci_2025_03_008 crossref_primary_10_1016_j_ccm_2018_10_016 crossref_primary_10_1016_j_smim_2019_101294 crossref_primary_10_1183_16000617_0201_2022 crossref_primary_10_1080_02770903_2021_1989696 crossref_primary_10_1007_s10753_014_0038_4 crossref_primary_10_1111_crj_12747 crossref_primary_10_1155_2023_9943584 crossref_primary_10_4168_aair_2023_15_3_406 crossref_primary_10_1016_j_jaip_2018_11_013 crossref_primary_10_1111_all_12445 crossref_primary_10_2147_JIR_S295038 crossref_primary_10_1016_j_jaip_2015_10_008 crossref_primary_10_1186_1465_9921_13_72 crossref_primary_10_1016_j_jaci_2015_09_033 crossref_primary_10_1111_all_13415 crossref_primary_10_1111_cea_12269 crossref_primary_10_1111_cea_14447 crossref_primary_10_1016_j_jaci_2014_12_1871 crossref_primary_10_1016_j_biopsycho_2021_108226 crossref_primary_10_1016_j_clim_2015_04_006 crossref_primary_10_1038_nm_2678 crossref_primary_10_2217_epi_2016_0149 crossref_primary_10_1371_journal_pone_0079565 crossref_primary_10_1183_13993003_00528_2020 crossref_primary_10_1016_j_cyto_2022_155878 crossref_primary_10_1038_mi_2017_84 crossref_primary_10_1111_j_1365_2222_2012_03983_x crossref_primary_10_1097_MCP_0b013e32835b118e crossref_primary_10_1164_rccm_201607_1453OC crossref_primary_10_1007_s11882_011_0210_y crossref_primary_10_1016_j_jaip_2025_04_055 crossref_primary_10_1155_2015_630637 crossref_primary_10_1016_j_jaip_2020_10_032 crossref_primary_10_3109_02770903_2014_991971 crossref_primary_10_1038_mi_2014_8 crossref_primary_10_1371_journal_pone_0180778 crossref_primary_10_1164_rccm_201703_0483ED crossref_primary_10_3389_fimmu_2020_614781 crossref_primary_10_1016_j_iac_2016_03_004 |
| Cites_doi | 10.1067/mai.2002.127797 10.1164/rccm.200702-333OC 10.1016/j.jaci.2004.01.757 10.1046/j.1365-2222.2003.01593.x 10.1073/pnas.091062498 10.1164/ajrccm.163.6.9901105 10.1067/mai.2002.120274 10.1016/S0014-2999(01)01138-4 10.1067/mai.2001.119411 10.1164/ajrccm.157.6.9609040 10.1006/cyto.1996.0097 10.1016/j.jneuroim.2004.10.026 10.1164/rccm.200404-440OC 10.1111/j.1440-1843.2006.00784.x 10.1016/j.jaci.2005.08.029 10.1183/09031936.03.00261903 10.1016/S0012-3692(15)31427-6 10.1111/j.1600-065X.2008.00624.x 10.1183/09031936.04.00043104a 10.1165/ajrcmb.21.4.3670 10.1183/09031936.96.09122448 10.1111/j.1365-2222.2005.02314.x 10.1164/ajrccm.160.5.9806170 10.1136/thorax.57.10.875 10.1016/S1081-1206(10)60795-8 10.1136/thx.2006.073429 10.1165/rcmb.2002-0095OC 10.1165/rcmb.2005-0303OC 10.1016/j.jaci.2006.11.639 10.1378/chest.119.5.1329 10.1590/S0100-879X2005000900010 10.1164/ajrccm.158.6.9803023 10.1016/j.jaci.2004.11.043 10.1016/j.rmed.2003.09.012 10.1164/rccm.200906-0896OC 10.1378/chest.08-0962 10.1164/ajrccm.154.2.8756799 10.1002/path.1321 10.1136/thx.2006.061358 10.1164/rccm.200603-311OC 10.1164/ajrccm.158.6.9803014 10.1016/S0012-3692(15)52584-1 10.1183/09031936.98.11061240 10.1016/j.jaci.2007.02.042 10.1016/j.jaci.2006.08.003 10.1111/j.1365-2222.2004.01885.x 10.1164/ajrccm.161.1.9802048 10.1164/ajrccm.162.6.ats9-00 10.1164/rccm.200711-1754OC 10.1016/j.jaci.2005.12.1339 10.1164/rccm.200503-369OC 10.1016/S1081-1206(10)61017-4 10.1038/nm1660 10.1152/ajplung.00072.2008 10.4049/jimmunol.173.12.7565 10.1182/blood-2004-02-0701 10.1016/S1567-5769(01)00063-7 10.1016/j.jaci.2004.08.032 |
| ContentType | Journal Article |
| Copyright | 2010 American Academy of Allergy, Asthma & Immunology American Academy of Allergy, Asthma & Immunology 2015 INIST-CNRS Copyright 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved. Copyright Elsevier Limited May 2010 |
| Copyright_xml | – notice: 2010 American Academy of Allergy, Asthma & Immunology – notice: American Academy of Allergy, Asthma & Immunology – notice: 2015 INIST-CNRS – notice: Copyright 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved. – notice: Copyright Elsevier Limited May 2010 |
| CorporateAuthor | National Heart, Lung, and Blood Institute Severe Asthma Research Program |
| CorporateAuthor_xml | – name: National Heart, Lung, and Blood Institute Severe Asthma Research Program |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7SS 7T5 H94 K9. NAPCQ 7X8 5PM |
| DOI | 10.1016/j.jaci.2010.02.008 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Entomology Abstracts (Full archive) Immunology Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Entomology Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium Immunology Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE AIDS and Cancer Research Abstracts MEDLINE - Academic Entomology Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1097-6825 |
| EndPage | 1036.e13 |
| ExternalDocumentID | PMC2878277 3389957041 20398920 22823929 10_1016_j_jaci_2010_02_008 S0091674910002897 1_s2_0_S0091674910002897 |
| Genre | Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NHLBI Severe Asthma Research Program Awards grantid: HL69167 – fundername: National Institutes of Health/National Heart, Lung, and Blood Institute – fundername: Wake Forest University General Clinical Research Center grantid: MO1 RR07122 – fundername: NCRR NIH HHS grantid: MO1 RR07122 – fundername: NHLBI NIH HHS grantid: R01 HL069167 – fundername: NHLBI NIH HHS grantid: U10 HL109164 – fundername: NCRR NIH HHS grantid: M01 RR007122 – fundername: NHLBI NIH HHS grantid: HL69167 |
| GroupedDBID | --- --K --M -~X .1- .55 .FO .GJ .XZ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 354 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8F7 8FE 8FH 8P~ 9JM AAAJQ AABNK AAEDT AAEDW AAFWJ AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AARKO AATTM AAXKI AAXUO AAYWO ABBQC ABFNM ABJNI ABLJU ABMAC ABMZM ABOCM ABWVN ABXDB ACDAQ ACGFO ACGFS ACIEU ACLOT ACPRK ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADFRT ADMUD ADNMO ADVLN ADXHL AEBSH AEIPS AEKER AENEX AEUPX AFFNX AFJKZ AFPUW AFRAH AFRHN AFTJW AFXIZ AGEKW AGHFR AGQPQ AGUBO AGYEJ AHHHB AHMBA AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV BPHCQ BVXVI C45 CAG CJTIS COF CS3 DU5 EBS EFJIC EFKBS EFLBG EJD EO8 EO9 EP2 EP3 EX3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HDU HMK HMO HVGLF HZ~ IHE J1W J5H K-O KOM L7B LK8 LUGTX M27 M41 MO0 N4W N9A O-L O9- O9~ OAUVE OBH ODZKP OHH OHT OK0 OK1 OVD OZT P-8 P-9 P2P PC. PQQKQ PROAC Q38 R2- ROL RPZ SAE SCC SDF SDG SDP SEL SES SEW SJN SPCBC SSH SSI SSZ T5K TEORI TWZ UGJ UNMZH UV1 WH7 WOW WUQ X7M XFW YOC YQI YQJ Z5R ZGI ZXP ZY1 ~02 ~G- ~HD ~KM AACTN RIG 9DU AAYXX CITATION AGCQF AGRNS IQODW CGR CUY CVF ECM EIF NPM 7SS 7T5 H94 K9. NAPCQ 7X8 5PM |
| ID | FETCH-LOGICAL-c650t-97d0c6bbe9ae2b6aad8d1c0d24d0f00355a1f56938f7584135bcb58856c31f673 |
| ISICitedReferencesCount | 378 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000277686700011&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0091-6749 1097-6825 |
| IngestDate | Tue Sep 30 16:53:41 EDT 2025 Sun Sep 28 10:29:49 EDT 2025 Sun Sep 28 12:10:38 EDT 2025 Sun Nov 02 22:32:00 EST 2025 Sat May 31 02:12:33 EDT 2025 Mon Jul 21 09:15:11 EDT 2025 Tue Nov 18 20:49:32 EST 2025 Sat Nov 29 07:25:47 EST 2025 Sun Apr 06 06:54:17 EDT 2025 Wed Apr 02 07:27:49 EDT 2025 Tue Oct 14 19:30:21 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Keywords | Asthma phenotypes TNFSF14 BDNF CCL20 EGF PARC SARP CXCL13 FVC BLC ICS MIP-3α MCP protein microarrays CCL18 SAM Forced vital capacity Epidermal growth factor B-lymphocyte chemoattractant/CXCL13 Severe Asthma Research Program of the National Heart, Lung, and Blood Institute Inhaled corticosteroid Macrophage inflammatory protein 3α/CCL20 TNF superfamily factor 14/LIGHT, Lymphotoxin homologous, Inducible expression, competes with HSV Glycoprotein D for HVEM receptor on T lymphocytes Pulmonary and regulated chemokine/CCL18 Brain-derived neurotrophic factor Monocyte chemoattractant protein Significance Analysis of Microarrays Human Lung disease Immunopathology Chemokine CC Exodus Respiratory disease Granulocyte LIGHT ligand CXCLl3 Inflammation Protein microarray CC chemokine Protein Asthma Phenotype Immunology Sputum Bronchus disease Obstructive pulmonary disease |
| Language | English |
| License | CC BY 4.0 Copyright 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c650t-97d0c6bbe9ae2b6aad8d1c0d24d0f00355a1f56938f7584135bcb58856c31f673 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
| OpenAccessLink | http://www.jacionline.org/article/S0091674910002897/pdf |
| PMID | 20398920 |
| PQID | 1550191901 |
| PQPubID | 105664 |
| PageCount | 9 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_2878277 proquest_miscellaneous_754870240 proquest_miscellaneous_733117215 proquest_journals_1550191901 pubmed_primary_20398920 pascalfrancis_primary_22823929 crossref_citationtrail_10_1016_j_jaci_2010_02_008 crossref_primary_10_1016_j_jaci_2010_02_008 elsevier_sciencedirect_doi_10_1016_j_jaci_2010_02_008 elsevier_clinicalkeyesjournals_1_s2_0_S0091674910002897 elsevier_clinicalkey_doi_10_1016_j_jaci_2010_02_008 |
| PublicationCentury | 2000 |
| PublicationDate | 2010-05-01 |
| PublicationDateYYYYMMDD | 2010-05-01 |
| PublicationDate_xml | – month: 05 year: 2010 text: 2010-05-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | New York, NY |
| PublicationPlace_xml | – name: New York, NY – name: United States – name: St. Louis |
| PublicationTitle | Journal of allergy and clinical immunology |
| PublicationTitleAlternate | J Allergy Clin Immunol |
| PublicationYear | 2010 |
| Publisher | Mosby, Inc Elsevier Elsevier Limited |
| Publisher_xml | – name: Mosby, Inc – name: Elsevier – name: Elsevier Limited |
| References | Simpson, Scott, Boyle, Gibson (bib10) 2006; 11 Asai, Kanazawa, Otani, Shiraishi, Hirata, Yoshikawa (bib30) 2002; 110 Berry, Shaw, Green, Brightling, Wardlaw, Pavord (bib19) 2005; 35 Hamilton, Torres-Lozano, Puddicombe, Richter, Kimber, Dearman (bib48) 2003; 33 Park, Jangm, An, Min, Jang, Lee (bib32) 2005; 128 Hahn, Islamian, Renz, Nockher (bib35) 2006; 117 Braun, Lommatzsch, Mannsfeldt, Neuhaus-Steinmetz, Fischer, Schnoy (bib34) 1999; 21 Simpson, Scott, Boyle, Gibson (bib14) 2005; 172 Woodruff, Khashayar, Lazarus, Janson, Avila, Boushey (bib21) 2001; 108 Fahy, Boushey (bib20) 1998; 11 Sabnis, Reilly, Veranth, Yost (bib38) 2008; 295 Jatakanon, Uasuf, Maziak, Lim, Chung, Barnes (bib6) 1999; 160 Simpson, Grissell, Douwes, Scott, Boyle, Gibson (bib9) 2007; 62 Thomas, Green, Brightling, Birring, Parker, Wardlaw (bib22) 2004; 126 Vignola, Riccobono, Mirabella, Profita, Chanez, Bellia (bib31) 1998; 158 Kikuchi, Kikuchi, Kobayashi, Hagiwara, Sakamoto, Kanazawa (bib53) 2006; 34 Daldegan, Teixeira, Talvani (bib11) 2005; 38 Fox, Patel, Barnes, Belvisi (bib43) 2001; 424 Proceedings of the ATS Workshop on Refractory Asthma (bib16) 2000; 162 Haldar, Pavord, Shaw, Berry, Thomas, Brightling (bib24) 2008; 178 Dente, Carnevali, Bartoli, Cianchetti, Bacci, Di Franco (bib12) 2006; 97 Amishima, Munakata, Nasuhara, Sato, Kakahashi, Homma (bib51) 1998; 157 Lemiere, Ernst, Olivenstein, Yamauchi, Govindaraju, Ludwig (bib4) 2006; 118 Nockher, Renz (bib41) 2006; 117 Virchow, Julius, Lommatzsch, Luttmann, Renz, Braun (bib42) 1998; 158 Louis, Lau, Bron, Roldaan, Radermecker, Djukanovic (bib1) 2000; 161 Bartoli, Bacci, Carnevali, Cianchetti, Dente, DiFranco (bib3) 2004; 98 Fahy, Boushey, Lazarus, Mauger, Cherniack, Chinchilli (bib17) 2001; 163 Reibman, Hsu, Chen, Bleck, Gordon (bib39) 2003; 28 Carlsen, Baekkevold, Morton, Haraldsen, Brandtzaeg (bib46) 2004; 104 Gibson, Simpson, Saltos (bib26) 2001; 119 Kanazawa, Yoshikawa (bib29) 2005; 95 Goya, Matsuoka, Mori, Morishita, Kida, Kobashi (bib47) 2003; 200 Tusher, Tibshirani, Chu (bib18) 2001; 98 ten Brinke, Zwinderman, Sterk, Rabe, Bel (bib7) 2004; 170 Hastie, Everts, Cho, Zangrilli, Shaver, Pollice (bib37) 1996; 8 Schulte-Herbruggen, Nassenstein, Lommatzsch, Quarcoo, Renz, Braun (bib44) 2005; 160 Fulkerson, Zimmermann, Hassman, Finkelman, Rothenberg (bib45) 2004; 173 Subauste, Proud (bib49) 2001; 1 Gershman, Wong, Liu, Mahlmeister, Fahy (bib52) 1996; 9 Berry, Morgan, Shaw, Parker, Green, Brightling (bib8) 2007; 62 Pizzichini, Pizzichini, Efthimiadis, Evans, Morris, Squillace (bib13) 1996; 154 Arend, Palmer, Gabay (bib36) 2008; 223 Moore, Bleecker, Curran-Everett, Erzurum, Ameredes, Bacharier (bib15) 2007; 119 Polosa, Puddicombe, Krishna, Tuck, Howarth, Holgate (bib50) 2002; 109 Haldar, Pavord (bib25) 2007; 119 Simpson, Timmins, Fakes, Talbot, Gibson (bib27) 2004; 23 Moore, Meyers, Wenzel, Teague, Li, Li (bib23) 2010; 181 Weckmann, Collison, Simpson, Kopp, Wark, Smyth (bib33) 2007; 13 Kim, Kim, Iijima, Kobayashi, Kita (bib28) 2009; 135 Pichavant, Charbonnier, Taront, Brichet, Wallaert, Pestel (bib40) 2005; 115 Green, Brightling, Woltmann, Parker, Wardlaw, Pavord (bib5) 2002; 57 (bib2) 2003; 22 (10.1016/j.jaci.2010.02.008_bib2) 2003; 22 Bartoli (10.1016/j.jaci.2010.02.008_bib3) 2004; 98 Gershman (10.1016/j.jaci.2010.02.008_bib60) 1996; 9 Haldar (10.1016/j.jaci.2010.02.008_bib25) 2007; 119 Hamilton (10.1016/j.jaci.2010.02.008_bib48) 2003; 33 Simpson (10.1016/j.jaci.2010.02.008_bib10) 2006; 11 Sabnis (10.1016/j.jaci.2010.02.008_bib38) 2008; 295 Hadjicharalambous (10.1016/j.jaci.2010.02.008_bib63) 2004; 113 Tusher (10.1016/j.jaci.2010.02.008_bib18) 2001; 98 Jatakanon (10.1016/j.jaci.2010.02.008_bib6) 1999; 160 Green (10.1016/j.jaci.2010.02.008_bib5) 2002; 57 Amishima (10.1016/j.jaci.2010.02.008_bib51) 1998; 157 Kikuchi (10.1016/j.jaci.2010.02.008_bib53) 2006; 34 Green (10.1016/j.jaci.2010.02.008_bib56) 2002; 57 Simpson (10.1016/j.jaci.2010.02.008_bib27) 2004; 23 Moore (10.1016/j.jaci.2010.02.008_bib54) 2007; 119 Woodruff (10.1016/j.jaci.2010.02.008_bib21) 2001; 108 Erin (10.1016/j.jaci.2010.02.008_bib70) 2008; 177 Tusher (10.1016/j.jaci.2010.02.008_bib66) 2001; 98 Asai (10.1016/j.jaci.2010.02.008_bib30) 2002; 110 Nockher (10.1016/j.jaci.2010.02.008_bib41) 2006; 117 Schulte-Herbruggen (10.1016/j.jaci.2010.02.008_bib44) 2005; 160 Vignola (10.1016/j.jaci.2010.02.008_bib31) 1998; 158 Subauste (10.1016/j.jaci.2010.02.008_bib49) 2001; 1 Kanazawa (10.1016/j.jaci.2010.02.008_bib29) 2005; 95 Kim (10.1016/j.jaci.2010.02.008_bib28) 2009; 135 Berry (10.1016/j.jaci.2010.02.008_bib65) 2005; 35 Proceedings of the ATS Workshop on Refractory Asthma (10.1016/j.jaci.2010.02.008_bib16) 2000; 162 Hastie (10.1016/j.jaci.2010.02.008_bib37) 1996; 8 Arend (10.1016/j.jaci.2010.02.008_bib36) 2008; 223 Park (10.1016/j.jaci.2010.02.008_bib32) 2005; 128 Batra (10.1016/j.jaci.2010.02.008_bib68) 2004; 34 ten Brinke (10.1016/j.jaci.2010.02.008_bib7) 2004; 170 Fahy (10.1016/j.jaci.2010.02.008_bib17) 2001; 163 Gibson (10.1016/j.jaci.2010.02.008_bib26) 2001; 119 Haldar (10.1016/j.jaci.2010.02.008_bib24) 2008; 178 Bartoli (10.1016/j.jaci.2010.02.008_bib69) 2004; 98 Gibson (10.1016/j.jaci.2010.02.008_bib55) 2001; 119 Hahn (10.1016/j.jaci.2010.02.008_bib35) 2006; 117 Polosa (10.1016/j.jaci.2010.02.008_bib50) 2002; 109 Fahy (10.1016/j.jaci.2010.02.008_bib59) 2001; 163 Carlsen (10.1016/j.jaci.2010.02.008_bib46) 2004; 104 Lemiere (10.1016/j.jaci.2010.02.008_bib4) 2006; 118 Pichavant (10.1016/j.jaci.2010.02.008_bib40) 2005; 115 Goya (10.1016/j.jaci.2010.02.008_bib47) 2003; 200 Berry (10.1016/j.jaci.2010.02.008_bib64) 2004; 114 Fulkerson (10.1016/j.jaci.2010.02.008_bib45) 2004; 173 Fahy (10.1016/j.jaci.2010.02.008_bib20) 1998; 11 Weckmann (10.1016/j.jaci.2010.02.008_bib33) 2007; 13 Gershman (10.1016/j.jaci.2010.02.008_bib52) 1996; 9 Moore (10.1016/j.jaci.2010.02.008_bib15) 2007; 119 Lewis (10.1016/j.jaci.2010.02.008_bib67) 2008; 177 Simpson (10.1016/j.jaci.2010.02.008_bib9) 2007; 62 Simpson (10.1016/j.jaci.2010.02.008_bib58) 2006; 11 Virchow (10.1016/j.jaci.2010.02.008_bib42) 1998; 158 Dente (10.1016/j.jaci.2010.02.008_bib12) 2006; 97 Pizzichini (10.1016/j.jaci.2010.02.008_bib13) 1996; 154 Woodruff (10.1016/j.jaci.2010.02.008_bib61) 2001; 108 Thomas (10.1016/j.jaci.2010.02.008_bib22) 2004; 126 Louis (10.1016/j.jaci.2010.02.008_bib1) 2000; 161 Moore (10.1016/j.jaci.2010.02.008_bib23) 2010; 181 Braun (10.1016/j.jaci.2010.02.008_bib34) 1999; 21 Berry (10.1016/j.jaci.2010.02.008_bib8) 2007; 62 Fox (10.1016/j.jaci.2010.02.008_bib43) 2001; 424 Daldegan (10.1016/j.jaci.2010.02.008_bib11) 2005; 38 Simpson (10.1016/j.jaci.2010.02.008_bib14) 2005; 172 Reibman (10.1016/j.jaci.2010.02.008_bib39) 2003; 28 Lemiere (10.1016/j.jaci.2010.02.008_bib57) 2006; 118 Amishima (10.1016/j.jaci.2010.02.008_bib62) 1998; 157 Berry (10.1016/j.jaci.2010.02.008_bib19) 2005; 35 |
| References_xml | – volume: 21 start-page: 537 year: 1999 end-page: 546 ident: bib34 article-title: Cellular sources of enhanced brain-derived neurotrophic factor production in a mouse model of allergic inflammation publication-title: Am J Respir Cell Mol Biol – volume: 424 start-page: 159 year: 2001 end-page: 162 ident: bib43 article-title: Release of nerve growth factor by human pulmonary epithelial cells: role in airway inflammatory diseases publication-title: Eur J Pharmacol – volume: 178 start-page: 218 year: 2008 end-page: 224 ident: bib24 article-title: Cluster analysis and clinical asthma phenotypes publication-title: Am J Respir Crit Care Med – volume: 117 start-page: 787 year: 2006 end-page: 794 ident: bib35 article-title: Airway epithelial cells produce neurotrophins and promote the survival of eosinophils during allergic airway inflammation publication-title: J Allergy Clin Immunol – volume: 295 start-page: L194 year: 2008 end-page: L200 ident: bib38 article-title: Increased transcription of cytokine genes in human lung epithelial cells through activation of a TRPM8 variant by cold temperatures publication-title: Am J Physiol Lung Cell Mol Physiol – volume: 172 start-page: 559 year: 2005 end-page: 565 ident: bib14 article-title: Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma publication-title: Am J Respir Crit Care Med – volume: 35 start-page: 1175 year: 2005 end-page: 1179 ident: bib19 article-title: The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma publication-title: Clin Exp Allergy – volume: 163 start-page: 1470 year: 2001 end-page: 1475 ident: bib17 article-title: Safety and reproducibility of sputum induction in asthmatic subjects in a multicenter study publication-title: Am J Respir Crit Care Med – volume: 158 start-page: 2002 year: 1998 end-page: 2005 ident: bib42 article-title: Neurotrophins are increased in bronchoalveolar lavage fluid after segmental allergen provocation publication-title: Am J Respir Crit Care Med – volume: 62 start-page: 211 year: 2007 end-page: 218 ident: bib9 article-title: Innate immune activation in neutrophilic asthma and bronchiectasis publication-title: Thorax – volume: 95 start-page: 546 year: 2005 end-page: 550 ident: bib29 article-title: Effect of beclomethasone dipropionate on basic fibroblast growth factor levels in induced sputum samples from asthmatic patients publication-title: Ann Allergy Asthma Immunol – volume: 98 start-page: 5116 year: 2001 end-page: 5121 ident: bib18 article-title: Significance analysis of microarrays applied to ionizing radiation response publication-title: Proc Nat Acad Sci U S A – volume: 223 start-page: 20 year: 2008 end-page: 38 ident: bib36 article-title: IL-1, IL-18, and IL-33 families of cytokines publication-title: Immunol Rev – volume: 34 start-page: 760 year: 2006 end-page: 765 ident: bib53 article-title: Eosinophil trans-basement membrane migration induced by interleukin-8 and neutrophils publication-title: Am J Respir Cell Mol Biol – volume: 62 start-page: 1043 year: 2007 end-page: 1049 ident: bib8 article-title: Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma publication-title: Thorax – volume: 9 start-page: 2448 year: 1996 end-page: 2453 ident: bib52 article-title: Comparison of two methods of collecting induced sputum in asthmatic subjects publication-title: Eur Respir J – volume: 98 start-page: 184 year: 2004 end-page: 193 ident: bib3 article-title: Clinical assessment of asthma severity partially corresponds to sputum eosinophilic airway inflammation publication-title: Respir Med – volume: 160 start-page: 204 year: 2005 end-page: 209 ident: bib44 article-title: Tumor necrosis factor-a and interleukin-6 regulate secretion of brain-derived neurotrophic factor in human monocytes publication-title: J Neuroimmunol – volume: 97 start-page: 312 year: 2006 end-page: 320 ident: bib12 article-title: Profiles of proinflammatory cytokines in sputum from different groups of severe asthmatic patients publication-title: Ann Allergy Asthma Immunol – volume: 108 start-page: 753 year: 2001 end-page: 758 ident: bib21 article-title: Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma publication-title: J Allergy Clin Immunol – volume: 162 start-page: 2341 year: 2000 end-page: 2351 ident: bib16 article-title: current understanding, recommendations, and unanswered questions publication-title: Am J Respir Crit Care Med – volume: 109 start-page: 75 year: 2002 end-page: 81 ident: bib50 article-title: Expression of c-erbB receptors and ligands in the bronchial epithelium of asthmatic subjects publication-title: J Allergy Clin Immunol – volume: 57 start-page: 875 year: 2002 end-page: 879 ident: bib5 article-title: Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids publication-title: Thorax – volume: 157 start-page: 1907 year: 1998 end-page: 1912 ident: bib51 article-title: Expression of epidermal growth factor and epidermal growth factor receptor immunoreactivity in the asthmatic human airway publication-title: Am J Respir Crit Care Med – volume: 154 start-page: 308 year: 1996 end-page: 317 ident: bib13 article-title: Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements publication-title: Am J Respir Crit Care Med – volume: 128 start-page: 1921 year: 2005 end-page: 1927 ident: bib32 article-title: Interleukin-13 and interleukin-5 in induced sputum of eosinophilic bronchitis: comparison with asthma publication-title: Chest – volume: 181 start-page: 315 year: 2010 end-page: 323 ident: bib23 article-title: Identification of asthma phenotypes using cluster analysis in the severe asthma research program publication-title: Am J Respir Crit Care Med – volume: 158 start-page: 1945 year: 1998 end-page: 1950 ident: bib31 article-title: Sputum metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio correlates with airflow obstruction in asthma and chronic bronchitis publication-title: Am J Respir Crit Care Med – volume: 22 start-page: 470 year: 2003 end-page: 477 ident: bib2 article-title: The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma publication-title: Eur Respir J – volume: 110 start-page: 571 year: 2002 end-page: 575 ident: bib30 article-title: Imbalance between vascular endothelial growth factor and endostatin levels in induced sputum from asthmatic subjects publication-title: J Allergy Clin Immunol – volume: 11 start-page: 54 year: 2006 end-page: 61 ident: bib10 article-title: Inflammatory subtypes in asthma: assessment and identification using induced sputum publication-title: Respirology – volume: 117 start-page: 67 year: 2006 end-page: 71 ident: bib41 article-title: Neurotrophins and asthma: novel insight into neuroimmune interaction publication-title: J Allergy Clin Immunol – volume: 200 start-page: 82 year: 2003 end-page: 87 ident: bib47 article-title: Sustained interleukin-6 signalling leads to the development of lymphoid organ-like structures in the lung publication-title: J Pathol – volume: 135 start-page: 295 year: 2009 end-page: 302 ident: bib28 article-title: Protein microarray analysis in patients with asthma: elevation of the chemokine PARC/CCL18 in sputum publication-title: Chest – volume: 11 start-page: 1240 year: 1998 end-page: 1247 ident: bib20 article-title: Effect of low-dose beclomethasone dipropionate on asthma control and airway inflammation publication-title: Eur Respir J – volume: 161 start-page: 9 year: 2000 end-page: 16 ident: bib1 article-title: The relationship between airways inflammation and asthma severity publication-title: Am J Respir Crit Care Med – volume: 28 start-page: 648 year: 2003 end-page: 654 ident: bib39 article-title: Airway epithelial cells release MIP3α/CCL20 in response to cytokines and ambient particulate matter publication-title: Am J Respir Cell Mol Biol – volume: 23 start-page: 759 year: 2004 end-page: 762 ident: bib27 article-title: Effect of saliva contamination on induced sputum cell counts, IL-8 and eosinophil cationic protein levels publication-title: Eur Respir J – volume: 115 start-page: 771 year: 2005 end-page: 778 ident: bib40 article-title: Asthmatic bronchial epithelium activated by the proteolytic allergen Der p 1 increases selective dendritic cell recruitment publication-title: J Allergy Clin Immunol – volume: 119 start-page: 1043 year: 2007 end-page: 1052 ident: bib25 article-title: Noneosinophilic asthma: a distinct clinical and pathologic phenotype publication-title: J Allergy Clin Immunol – volume: 118 start-page: 1033 year: 2006 end-page: 1039 ident: bib4 article-title: Airway inflammation assessed by invasive and noninvasive means in severe asthma: eosinophilic and noneosinophilic phenotypes publication-title: J Allergy Clin Immunol – volume: 13 start-page: 1308 year: 2007 end-page: 1315 ident: bib33 article-title: Critical link between TRAIL and CCL20 for the activation of T publication-title: Nat Med – volume: 126 start-page: 1811 year: 2004 end-page: 1814 ident: bib22 article-title: The influence of age on induced sputum differential cell counts in normal subjects publication-title: Chest – volume: 33 start-page: 233 year: 2003 end-page: 240 ident: bib48 article-title: The role of the epidermal growth factor receptor in sustaining neutrophil inflammation in severe asthma publication-title: Clin Exp Allergy – volume: 1 start-page: 1229 year: 2001 end-page: 1234 ident: bib49 article-title: Effects of tumor necrosis factor-alpha, epidermal growth factor and transforming growth factor-alpha on interleukin-8 production by, and human rhinovirus replication in, bronchial epithelial cells publication-title: Internat Immunopharcacol – volume: 119 start-page: 405 year: 2007 end-page: 413 ident: bib15 article-title: Characterization of the severe asthma phenotype by the NHLBI Severe Asthma Research Program publication-title: J Allergy Clin Immunol – volume: 104 start-page: 3021 year: 2004 end-page: 3027 ident: bib46 article-title: Monocyte-like and mature macrophages produce CXCL13 (B cell-attracting chemokine 1) in inflammatory lesions with lymphoid neogenesis publication-title: Blood – volume: 38 start-page: 1359 year: 2005 end-page: 1365 ident: bib11 article-title: Concentration of CCL11, CXCL8, and TNF-α in sputum and plasma of patients undergoing asthma or chronic obstructive pulmonary disease exacerbation publication-title: Braz J Med Bio Res – volume: 160 start-page: 1532 year: 1999 end-page: 1539 ident: bib6 article-title: Neutrophilic inflammation in severe persistent asthma publication-title: Am J Respir Crit Care Med – volume: 173 start-page: 7565 year: 2004 end-page: 7574 ident: bib45 article-title: Pulmonary chemokine expression is coordinately regulated by STAT1, STAT6, and IFN-γ publication-title: J Immunol – volume: 119 start-page: 1329 year: 2001 end-page: 1336 ident: bib26 article-title: Heterogeneity of airway inflammation in persistent asthma: Evidence of neutrophilic inflammation and increased sputum interleukin-8 publication-title: Chest – volume: 8 start-page: 730 year: 1996 end-page: 738 ident: bib37 article-title: IL-1b release from cultured bronchial epithelial cells and bronchoalveolar lavage cells from allergic and normal humans following segmental challenge with ragweed publication-title: Cytokine – volume: 170 start-page: 601 year: 2004 end-page: 605 ident: bib7 article-title: Refractory" eosinophilic airway inflammation in severe asthma: effect of parenteral corticosteroids publication-title: Am J Respir Crit Care Med – volume: 110 start-page: 571 year: 2002 ident: 10.1016/j.jaci.2010.02.008_bib30 article-title: Imbalance between vascular endothelial growth factor and endostatin levels in induced sputum from asthmatic subjects publication-title: J Allergy Clin Immunol doi: 10.1067/mai.2002.127797 – volume: 177 start-page: 376 year: 2008 ident: 10.1016/j.jaci.2010.02.008_bib67 article-title: Disease-specific gene expression profiling in multiple models of lung disease publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200702-333OC – volume: 113 start-page: 657 year: 2004 ident: 10.1016/j.jaci.2010.02.008_bib63 article-title: Measurement of eotaxin (CCL11) in induced sputum supernatants: validation and detection in asthma publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2004.01.757 – volume: 33 start-page: 233 year: 2003 ident: 10.1016/j.jaci.2010.02.008_bib48 article-title: The role of the epidermal growth factor receptor in sustaining neutrophil inflammation in severe asthma publication-title: Clin Exp Allergy doi: 10.1046/j.1365-2222.2003.01593.x – volume: 98 start-page: 5116 year: 2001 ident: 10.1016/j.jaci.2010.02.008_bib66 article-title: Significance analysis of microarrays applied to ionizing radiation response publication-title: Proc Nat Acad Sci U S A doi: 10.1073/pnas.091062498 – volume: 163 start-page: 1470 year: 2001 ident: 10.1016/j.jaci.2010.02.008_bib59 article-title: Safety and reproducibility of sputum induction in asthmatic subjects in a multicenter study publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.163.6.9901105 – volume: 109 start-page: 75 year: 2002 ident: 10.1016/j.jaci.2010.02.008_bib50 article-title: Expression of c-erbB receptors and ligands in the bronchial epithelium of asthmatic subjects publication-title: J Allergy Clin Immunol doi: 10.1067/mai.2002.120274 – volume: 424 start-page: 159 year: 2001 ident: 10.1016/j.jaci.2010.02.008_bib43 article-title: Release of nerve growth factor by human pulmonary epithelial cells: role in airway inflammatory diseases publication-title: Eur J Pharmacol doi: 10.1016/S0014-2999(01)01138-4 – volume: 108 start-page: 753 year: 2001 ident: 10.1016/j.jaci.2010.02.008_bib21 article-title: Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma publication-title: J Allergy Clin Immunol doi: 10.1067/mai.2001.119411 – volume: 157 start-page: 1907 year: 1998 ident: 10.1016/j.jaci.2010.02.008_bib62 article-title: Expression of epidermal growth factor and epidermal growth factor receptor immunoreactivity in the asthmatic human airway publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.157.6.9609040 – volume: 8 start-page: 730 year: 1996 ident: 10.1016/j.jaci.2010.02.008_bib37 article-title: IL-1b release from cultured bronchial epithelial cells and bronchoalveolar lavage cells from allergic and normal humans following segmental challenge with ragweed publication-title: Cytokine doi: 10.1006/cyto.1996.0097 – volume: 160 start-page: 204 year: 2005 ident: 10.1016/j.jaci.2010.02.008_bib44 article-title: Tumor necrosis factor-a and interleukin-6 regulate secretion of brain-derived neurotrophic factor in human monocytes publication-title: J Neuroimmunol doi: 10.1016/j.jneuroim.2004.10.026 – volume: 170 start-page: 601 year: 2004 ident: 10.1016/j.jaci.2010.02.008_bib7 article-title: Refractory" eosinophilic airway inflammation in severe asthma: effect of parenteral corticosteroids publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200404-440OC – volume: 11 start-page: 54 year: 2006 ident: 10.1016/j.jaci.2010.02.008_bib10 article-title: Inflammatory subtypes in asthma: assessment and identification using induced sputum publication-title: Respirology doi: 10.1111/j.1440-1843.2006.00784.x – volume: 117 start-page: 67 year: 2006 ident: 10.1016/j.jaci.2010.02.008_bib41 article-title: Neurotrophins and asthma: novel insight into neuroimmune interaction publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2005.08.029 – volume: 22 start-page: 470 year: 2003 ident: 10.1016/j.jaci.2010.02.008_bib2 article-title: The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma publication-title: Eur Respir J doi: 10.1183/09031936.03.00261903 – volume: 126 start-page: 1811 year: 2004 ident: 10.1016/j.jaci.2010.02.008_bib22 article-title: The influence of age on induced sputum differential cell counts in normal subjects publication-title: Chest doi: 10.1016/S0012-3692(15)31427-6 – volume: 223 start-page: 20 year: 2008 ident: 10.1016/j.jaci.2010.02.008_bib36 article-title: IL-1, IL-18, and IL-33 families of cytokines publication-title: Immunol Rev doi: 10.1111/j.1600-065X.2008.00624.x – volume: 23 start-page: 759 year: 2004 ident: 10.1016/j.jaci.2010.02.008_bib27 article-title: Effect of saliva contamination on induced sputum cell counts, IL-8 and eosinophil cationic protein levels publication-title: Eur Respir J doi: 10.1183/09031936.04.00043104a – volume: 21 start-page: 537 year: 1999 ident: 10.1016/j.jaci.2010.02.008_bib34 article-title: Cellular sources of enhanced brain-derived neurotrophic factor production in a mouse model of allergic inflammation publication-title: Am J Respir Cell Mol Biol doi: 10.1165/ajrcmb.21.4.3670 – volume: 9 start-page: 2448 year: 1996 ident: 10.1016/j.jaci.2010.02.008_bib52 article-title: Comparison of two methods of collecting induced sputum in asthmatic subjects publication-title: Eur Respir J doi: 10.1183/09031936.96.09122448 – volume: 35 start-page: 1175 year: 2005 ident: 10.1016/j.jaci.2010.02.008_bib19 article-title: The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma publication-title: Clin Exp Allergy doi: 10.1111/j.1365-2222.2005.02314.x – volume: 160 start-page: 1532 year: 1999 ident: 10.1016/j.jaci.2010.02.008_bib6 article-title: Neutrophilic inflammation in severe persistent asthma publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.160.5.9806170 – volume: 57 start-page: 875 year: 2002 ident: 10.1016/j.jaci.2010.02.008_bib5 article-title: Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids publication-title: Thorax doi: 10.1136/thorax.57.10.875 – volume: 97 start-page: 312 year: 2006 ident: 10.1016/j.jaci.2010.02.008_bib12 article-title: Profiles of proinflammatory cytokines in sputum from different groups of severe asthmatic patients publication-title: Ann Allergy Asthma Immunol doi: 10.1016/S1081-1206(10)60795-8 – volume: 62 start-page: 1043 year: 2007 ident: 10.1016/j.jaci.2010.02.008_bib8 article-title: Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma publication-title: Thorax doi: 10.1136/thx.2006.073429 – volume: 28 start-page: 648 year: 2003 ident: 10.1016/j.jaci.2010.02.008_bib39 article-title: Airway epithelial cells release MIP3α/CCL20 in response to cytokines and ambient particulate matter publication-title: Am J Respir Cell Mol Biol doi: 10.1165/rcmb.2002-0095OC – volume: 34 start-page: 760 year: 2006 ident: 10.1016/j.jaci.2010.02.008_bib53 article-title: Eosinophil trans-basement membrane migration induced by interleukin-8 and neutrophils publication-title: Am J Respir Cell Mol Biol doi: 10.1165/rcmb.2005-0303OC – volume: 119 start-page: 405 year: 2007 ident: 10.1016/j.jaci.2010.02.008_bib54 article-title: Characterization of the severe asthma phenotype by the NHLBI Severe Asthma Research Program publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2006.11.639 – volume: 157 start-page: 1907 year: 1998 ident: 10.1016/j.jaci.2010.02.008_bib51 article-title: Expression of epidermal growth factor and epidermal growth factor receptor immunoreactivity in the asthmatic human airway publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.157.6.9609040 – volume: 9 start-page: 2448 year: 1996 ident: 10.1016/j.jaci.2010.02.008_bib60 article-title: Comparison of two methods of collecting induced sputum in asthmatic subjects publication-title: Eur Respir J doi: 10.1183/09031936.96.09122448 – volume: 119 start-page: 1329 year: 2001 ident: 10.1016/j.jaci.2010.02.008_bib55 article-title: Heterogeneity of airway inflammation in persistent asthma: evidence of neutrophilic inflammation and increased sputum interleukin-8 publication-title: Chest doi: 10.1378/chest.119.5.1329 – volume: 38 start-page: 1359 year: 2005 ident: 10.1016/j.jaci.2010.02.008_bib11 article-title: Concentration of CCL11, CXCL8, and TNF-α in sputum and plasma of patients undergoing asthma or chronic obstructive pulmonary disease exacerbation publication-title: Braz J Med Bio Res doi: 10.1590/S0100-879X2005000900010 – volume: 158 start-page: 2002 year: 1998 ident: 10.1016/j.jaci.2010.02.008_bib42 article-title: Neurotrophins are increased in bronchoalveolar lavage fluid after segmental allergen provocation publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.158.6.9803023 – volume: 115 start-page: 771 year: 2005 ident: 10.1016/j.jaci.2010.02.008_bib40 article-title: Asthmatic bronchial epithelium activated by the proteolytic allergen Der p 1 increases selective dendritic cell recruitment publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2004.11.043 – volume: 98 start-page: 184 year: 2004 ident: 10.1016/j.jaci.2010.02.008_bib3 article-title: Clinical assessment of asthma severity partially corresponds to sputum eosinophilic airway inflammation publication-title: Respir Med doi: 10.1016/j.rmed.2003.09.012 – volume: 181 start-page: 315 year: 2010 ident: 10.1016/j.jaci.2010.02.008_bib23 article-title: Identification of asthma phenotypes using cluster analysis in the severe asthma research program publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200906-0896OC – volume: 135 start-page: 295 year: 2009 ident: 10.1016/j.jaci.2010.02.008_bib28 article-title: Protein microarray analysis in patients with asthma: elevation of the chemokine PARC/CCL18 in sputum publication-title: Chest doi: 10.1378/chest.08-0962 – volume: 35 start-page: 1175 year: 2005 ident: 10.1016/j.jaci.2010.02.008_bib65 article-title: The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma publication-title: Clin Exp Allergy doi: 10.1111/j.1365-2222.2005.02314.x – volume: 154 start-page: 308 year: 1996 ident: 10.1016/j.jaci.2010.02.008_bib13 article-title: Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.154.2.8756799 – volume: 200 start-page: 82 year: 2003 ident: 10.1016/j.jaci.2010.02.008_bib47 article-title: Sustained interleukin-6 signalling leads to the development of lymphoid organ-like structures in the lung publication-title: J Pathol doi: 10.1002/path.1321 – volume: 108 start-page: 753 year: 2001 ident: 10.1016/j.jaci.2010.02.008_bib61 article-title: Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma publication-title: J Allergy Clin Immunol doi: 10.1067/mai.2001.119411 – volume: 62 start-page: 211 year: 2007 ident: 10.1016/j.jaci.2010.02.008_bib9 article-title: Innate immune activation in neutrophilic asthma and bronchiectasis publication-title: Thorax doi: 10.1136/thx.2006.061358 – volume: 177 start-page: 132 year: 2008 ident: 10.1016/j.jaci.2010.02.008_bib70 article-title: Optimized dialysis and protease inhibition of sputum dithiothreitol supernatants publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200603-311OC – volume: 158 start-page: 1945 year: 1998 ident: 10.1016/j.jaci.2010.02.008_bib31 article-title: Sputum metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio correlates with airflow obstruction in asthma and chronic bronchitis publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.158.6.9803014 – volume: 57 start-page: 875 year: 2002 ident: 10.1016/j.jaci.2010.02.008_bib56 article-title: Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids publication-title: Thorax doi: 10.1136/thorax.57.10.875 – volume: 98 start-page: 5116 year: 2001 ident: 10.1016/j.jaci.2010.02.008_bib18 article-title: Significance analysis of microarrays applied to ionizing radiation response publication-title: Proc Nat Acad Sci U S A doi: 10.1073/pnas.091062498 – volume: 128 start-page: 1921 year: 2005 ident: 10.1016/j.jaci.2010.02.008_bib32 article-title: Interleukin-13 and interleukin-5 in induced sputum of eosinophilic bronchitis: comparison with asthma publication-title: Chest doi: 10.1016/S0012-3692(15)52584-1 – volume: 11 start-page: 1240 year: 1998 ident: 10.1016/j.jaci.2010.02.008_bib20 article-title: Effect of low-dose beclomethasone dipropionate on asthma control and airway inflammation publication-title: Eur Respir J doi: 10.1183/09031936.98.11061240 – volume: 119 start-page: 405 year: 2007 ident: 10.1016/j.jaci.2010.02.008_bib15 article-title: Characterization of the severe asthma phenotype by the NHLBI Severe Asthma Research Program publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2006.11.639 – volume: 119 start-page: 1329 year: 2001 ident: 10.1016/j.jaci.2010.02.008_bib26 article-title: Heterogeneity of airway inflammation in persistent asthma: Evidence of neutrophilic inflammation and increased sputum interleukin-8 publication-title: Chest doi: 10.1378/chest.119.5.1329 – volume: 11 start-page: 54 year: 2006 ident: 10.1016/j.jaci.2010.02.008_bib58 article-title: Inflammatory subtypes in asthma: assessment and identification using induced sputum publication-title: Respirology doi: 10.1111/j.1440-1843.2006.00784.x – volume: 119 start-page: 1043 year: 2007 ident: 10.1016/j.jaci.2010.02.008_bib25 article-title: Noneosinophilic asthma: a distinct clinical and pathologic phenotype publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2007.02.042 – volume: 118 start-page: 1033 year: 2006 ident: 10.1016/j.jaci.2010.02.008_bib4 article-title: Airway inflammation assessed by invasive and noninvasive means in severe asthma: eosinophilic and noneosinophilic phenotypes publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2006.08.003 – volume: 34 start-page: 437 year: 2004 ident: 10.1016/j.jaci.2010.02.008_bib68 publication-title: Clin Exp Allergy doi: 10.1111/j.1365-2222.2004.01885.x – volume: 161 start-page: 9 year: 2000 ident: 10.1016/j.jaci.2010.02.008_bib1 article-title: The relationship between airways inflammation and asthma severity publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.161.1.9802048 – volume: 162 start-page: 2341 year: 2000 ident: 10.1016/j.jaci.2010.02.008_bib16 article-title: current understanding, recommendations, and unanswered questions publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.162.6.ats9-00 – volume: 178 start-page: 218 year: 2008 ident: 10.1016/j.jaci.2010.02.008_bib24 article-title: Cluster analysis and clinical asthma phenotypes publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200711-1754OC – volume: 117 start-page: 787 year: 2006 ident: 10.1016/j.jaci.2010.02.008_bib35 article-title: Airway epithelial cells produce neurotrophins and promote the survival of eosinophils during allergic airway inflammation publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2005.12.1339 – volume: 172 start-page: 559 year: 2005 ident: 10.1016/j.jaci.2010.02.008_bib14 article-title: Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200503-369OC – volume: 95 start-page: 546 year: 2005 ident: 10.1016/j.jaci.2010.02.008_bib29 article-title: Effect of beclomethasone dipropionate on basic fibroblast growth factor levels in induced sputum samples from asthmatic patients publication-title: Ann Allergy Asthma Immunol doi: 10.1016/S1081-1206(10)61017-4 – volume: 118 start-page: 1033 year: 2006 ident: 10.1016/j.jaci.2010.02.008_bib57 article-title: Airway inflammation assessed by invasive and noninvasive means in severe asthma: eosinophilic and noneosinophilic phenotypes publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2006.08.003 – volume: 13 start-page: 1308 year: 2007 ident: 10.1016/j.jaci.2010.02.008_bib33 article-title: Critical link between TRAIL and CCL20 for the activation of TH2 cells and the expression of allergic airway disease publication-title: Nat Med doi: 10.1038/nm1660 – volume: 295 start-page: L194 year: 2008 ident: 10.1016/j.jaci.2010.02.008_bib38 article-title: Increased transcription of cytokine genes in human lung epithelial cells through activation of a TRPM8 variant by cold temperatures publication-title: Am J Physiol Lung Cell Mol Physiol doi: 10.1152/ajplung.00072.2008 – volume: 173 start-page: 7565 year: 2004 ident: 10.1016/j.jaci.2010.02.008_bib45 article-title: Pulmonary chemokine expression is coordinately regulated by STAT1, STAT6, and IFN-γ publication-title: J Immunol doi: 10.4049/jimmunol.173.12.7565 – volume: 98 start-page: 184 year: 2004 ident: 10.1016/j.jaci.2010.02.008_bib69 article-title: Clinical assessment of asthma severity partially corresponds to sputum eosinophilic airway inflammation publication-title: Respir Med doi: 10.1016/j.rmed.2003.09.012 – volume: 104 start-page: 3021 year: 2004 ident: 10.1016/j.jaci.2010.02.008_bib46 article-title: Monocyte-like and mature macrophages produce CXCL13 (B cell-attracting chemokine 1) in inflammatory lesions with lymphoid neogenesis publication-title: Blood doi: 10.1182/blood-2004-02-0701 – volume: 1 start-page: 1229 year: 2001 ident: 10.1016/j.jaci.2010.02.008_bib49 article-title: Effects of tumor necrosis factor-alpha, epidermal growth factor and transforming growth factor-alpha on interleukin-8 production by, and human rhinovirus replication in, bronchial epithelial cells publication-title: Internat Immunopharcacol doi: 10.1016/S1567-5769(01)00063-7 – volume: 163 start-page: 1470 year: 2001 ident: 10.1016/j.jaci.2010.02.008_bib17 article-title: Safety and reproducibility of sputum induction in asthmatic subjects in a multicenter study publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.163.6.9901105 – volume: 114 start-page: 1106 year: 2004 ident: 10.1016/j.jaci.2010.02.008_bib64 article-title: Sputum and bronchial submucosal IL-13 expression in asthma and eosinophilic bronchitis publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2004.08.032 |
| SSID | ssj0009389 |
| Score | 2.509201 |
| Snippet | Patients with severe asthma have increased granulocytes in their sputum compared with patients with mild to moderate asthma.
We hypothesized that inflammatory... Background Patients with severe asthma have increased granulocytes in their sputum compared with patients with mild to moderate asthma. Objective We... Patients with severe asthma have increased granulocytes in their sputum compared with patients with mild to moderate asthma.BACKGROUNDPatients with severe... Patients with severe asthma have increased granulocytes in their sputum compared with patients with mild to moderate asthma. Objective - We hypothesized that... |
| SourceID | pubmedcentral proquest pubmed pascalfrancis crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1028 |
| SubjectTerms | Adolescent Adult Allergy and Immunology Asthma Asthma - physiopathology Asthma phenotypes BDNF Biological and medical sciences CCL18 CCL20 Child Child, Preschool Chronic obstructive pulmonary disease, asthma CXCL13 Enzyme-Linked Immunosorbent Assay Female Fundamental and applied biological sciences. Psychology Fundamental immunology Granulocytes - cytology Humans Immunopathology Inflammation - immunology Inflammation - physiopathology Inflammation Mediators - analysis Linear Models Male Medical sciences Meetings Methods Phenotype Pneumology Protein Array Analysis protein microarrays Proteins Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Severity of Illness Index Sputum - cytology TNFSF14 Young Adult |
| Title | Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0091674910002897 https://www.clinicalkey.es/playcontent/1-s2.0-S0091674910002897 https://dx.doi.org/10.1016/j.jaci.2010.02.008 https://www.ncbi.nlm.nih.gov/pubmed/20398920 https://www.proquest.com/docview/1550191901 https://www.proquest.com/docview/733117215 https://www.proquest.com/docview/754870240 https://pubmed.ncbi.nlm.nih.gov/PMC2878277 |
| Volume | 125 |
| WOSCitedRecordID | wos000277686700011&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1097-6825 dateEnd: 20200131 omitProxy: false ssIdentifier: ssj0009389 issn: 0091-6749 databaseCode: AIEXJ dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLa6DSEkhLgTGJMfeItS5W7nsUJDA20TEmX0zXISh7Vak6pJpvXH8d84rp1L11EuEi9RFTuJm_PF5xz7nO8g9M6TFRfTzLc46BLL9_3E4o5ILJtk1M9ESuN15bmLU3J-TieT6PNg8KPJhbm-InlOb26ixX8VNZwDYcvU2b8Qd3tTOAG_QehwBLHD8Y8Er2hGFJcsL6vLOTdB-wlZpM6UAV2FXHUtNetSBoCYq432NWPDVMWVl3U8W4d5KFbdTNup5aKu6rn5HfRbDUpwVekAxG3jVlZoWWpupzb5cipzUTaW8U9ggGqDZCTTgyphjoctBAodAvxN5ClMXF2DWDXlu9VkaY7atgtQclxVZQYNsjJPh_1lDbUj31vWOCs0s-hGOCgYhI4VEkVy2s7fKnNaAzXozcbSeOppdge09VCo1NctzaEWMWbDGU-mOuJPUrnSTk-20Ytf5DDkKBy1UUv20IFLgggm1YPRx-PJp4712aPK_9LD1llbKsDw9pN-ZRk9XPAShJSpQit3eUK3A3p7FtL4MXqkpY9HCpJP0EDkT9H9Mx288QzlDTJxkWGFTNwgE3fIxIAZ3EcmbpAJZ3GDTNwhE8crrJCJ-8h8jr5-OB6_P7F0uQ8rATehsiKS2kkYxyLiwo1DzlOaOomdun5qZ3LHO-BOFoTwTjNwcsH4CuIkDigNwsRzspB4L9B-XuTiFcKgtEQoqB3HkeP7hEc2Dx1qw82DGBSUayCnedUs0Vz4siTLFWuCHmdMiodJ8TDbZSAeA5ntNQvFBLOzt9dIkDWfGWhlBnDbeRW56ypR6vmlZA4roSfbgqCBgvZKbTsrm_i3TzzagFf711yXutJ3MtBhgzfWjSIIwDWUvoSBcNsMiknuNvJcFHXJZDFYub4U7Ogil0skyaKBXioAd4-3vYhGLrSQDWi3HSQt_mZLPr1c0-O7FLweQl7_4xt5gx5089Eh2q-WtXiL7iXX1bRcHqE9MqFH-jv_CcjAN7k |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Analyses+of+asthma+severity+phenotypes+and+inflammatory+proteins+in+subjects+stratified+by+sputum+granulocytes&rft.jtitle=Journal+of+allergy+and+clinical+immunology&rft.au=Hastie%2C+Annette+T.&rft.au=Moore%2C+Wendy+C.&rft.au=Meyers%2C+Deborah+A.&rft.au=Vestal%2C+Penny+L.&rft.date=2010-05-01&rft.pub=Mosby%2C+Inc&rft.issn=0091-6749&rft.volume=125&rft.issue=5&rft.spage=1028&rft.epage=1036.e13&rft_id=info:doi/10.1016%2Fj.jaci.2010.02.008&rft.externalDocID=S0091674910002897 |
| thumbnail_m | http://cvtisr.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F00916749%2FS0091674910X00070%2Fcov150h.gif |