Effect of Folic Acid Fortification on Plasma Folate and Total Homocysteine Concentrations
Background In 1996, the Food and Drug Administration issued a regulation requiring all enriched grain products to be fortified with folic acid to reduce the risk of neural-tube defects in newborns. Fortification (140 μg per 100 g) began in 1996, and the process was essentially complete by mid-1997....
Gespeichert in:
| Veröffentlicht in: | The New England journal of medicine Jg. 340; H. 19; S. 1449 - 1454 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Boston, MA
Massachusetts Medical Society
13.05.1999
|
| Schlagworte: | |
| ISSN: | 0028-4793, 1533-4406 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Background In 1996, the Food and Drug Administration issued a regulation requiring all enriched grain products to be fortified with folic acid to reduce the risk of neural-tube defects in newborns. Fortification (140 μg per 100 g) began in 1996, and the process was essentially complete by mid-1997. Methods To assess the effect of folic acid fortification on folate status, we measured plasma folate and total homocysteine concentrations (a sensitive marker of folate status) using blood samples from the fifth examination (January 1991 to December 1994) of the Framingham Offspring Study cohort for base-line values and the sixth examination (January 1995 to August 1998) for follow-up values. We divided the cohort into two groups on the basis of the date of their follow-up examination: the study group consisted of 350 subjects who were seen after fortification (September 1997 to March 1998), and the control group consisted of 756 subjects who were seen before fortification (January 1995 to September 1996). Results Among the subjects in the study group who did not use vitamin supplements, the mean folate concentrations increased from 4.6 to 10.0 ng per milliliter (11 to 23 nmol per liter) (P<0.001) from the base-line visit to the follow-up visit, and the prevalence of low folate concentrations (<3 ng per milliliter [7 nmol per liter]) decreased from 22.0 to 1.7 percent (P< 0.001). The mean total homocysteine concentration decreased from 10.1 to 9.4 μmol per liter during this period (P<0.001), and the prevalence of high homocysteine concentrations (>13 μmol per liter) decreased from 18.7 to 9.8 percent (P<0.001). In the control group, there were no statistically significant changes in concentrations of folate or homocysteine. Conclusions The fortification of enriched grain products with folic acid was associated with a substantial improvement in folate status in a population of middle-aged and older adults. |
|---|---|
| AbstractList | Background In 1996, the Food and Drug Administration issued a regulation requiring all enriched grain products to be fortified with folic acid to reduce the risk of neural-tube defects in newborns. Fortification (140 μg per 100 g) began in 1996, and the process was essentially complete by mid-1997. Methods To assess the effect of folic acid fortification on folate status, we measured plasma folate and total homocysteine concentrations (a sensitive marker of folate status) using blood samples from the fifth examination (January 1991 to December 1994) of the Framingham Offspring Study cohort for base-line values and the sixth examination (January 1995 to August 1998) for follow-up values. We divided the cohort into two groups on the basis of the date of their follow-up examination: the study group consisted of 350 subjects who were seen after fortification (September 1997 to March 1998), and the control group consisted of 756 subjects who were seen before fortification (January 1995 to September 1996). Results Among the subjects in the study group who did not use vitamin supplements, the mean folate concentrations increased from 4.6 to 10.0 ng per milliliter (11 to 23 nmol per liter) (P<0.001) from the base-line visit to the follow-up visit, and the prevalence of low folate concentrations (<3 ng per milliliter [7 nmol per liter]) decreased from 22.0 to 1.7 percent (P< 0.001). The mean total homocysteine concentration decreased from 10.1 to 9.4 μmol per liter during this period (P<0.001), and the prevalence of high homocysteine concentrations (>13 μmol per liter) decreased from 18.7 to 9.8 percent (P<0.001). In the control group, there were no statistically significant changes in concentrations of folate or homocysteine. Conclusions The fortification of enriched grain products with folic acid was associated with a substantial improvement in folate status in a population of middle-aged and older adults. In 1996, the Food and Drug Administration (FDA) issued a regulation, to be effective by January 1998, requiring that all enriched flour, rice, pasta, cornmeal, and other grain products contain 140 μg of folic acid per 100 g in addition to the thiamine, riboflavin, niacin, and iron already present in such products. 1 The goal of this folic acid fortification was to increase the intake of folate by women of childbearing age in response to the recommendation of the Public Health Service that “all women of childbearing age in the United States who are capable of becoming pregnant should consume 0.4 . . . In 1996, the Food and Drug Administration issued a regulation requiring all enriched grain products to be fortified with folic acid to reduce the risk of neural-tube defects in newborns. Fortification (140 microg per 100 g) began in 1996, and the process was essentially complete by mid-1997. To assess the effect of folic acid fortification on folate status, we measured plasma folate and total homocysteine concentrations (a sensitive marker of folate status) using blood samples from the fifth examination (January 1991 to December 1994) of the Framingham Offspring Study cohort for baseline values and the sixth examination (January 1995 to August 1998) for follow-up values. We divided the cohort into two groups on the basis of the date of their follow-up examination: the study group consisted of 350 subjects who were seen after fortification (September 1997 to March 1998), and the control group consisted of 756 subjects who were seen before fortification (January 1995 to September 1996). Among the subjects in the study group who did not use vitamin supplements, the mean folate concentrations increased from 4.6 to 10.0 ng per milliliter (11 to 23 nmol per liter) (P<0.001) from the baseline visit to the follow-up visit, and the prevalence of low folate concentrations (<3 ng per milliliter [7 nmol per liter]) decreased from 22.0 to 1.7 percent (P< 0.001). The mean total homocysteine concentration decreased from 10.1 to 9.4 micromol per liter during this period (P<0.001), and the prevalence of high homocysteine concentrations (>13 micromol per liter) decreased from 18.7 to 9.8 percent (P<0.001). In the control group, there were no statistically significant changes in concentrations of folate or homocysteine. The fortification of enriched grain products with folic acid was associated with a substantial improvement in folate status in a population of middle-aged and older adults. In 1996, the Food and Drug Administration issued a regulation requiring all enriched grain products to be fortified with folic acid to reduce the risk of neural-tube defects in newborns. Fortification (140 microg per 100 g) began in 1996, and the process was essentially complete by mid-1997.BACKGROUNDIn 1996, the Food and Drug Administration issued a regulation requiring all enriched grain products to be fortified with folic acid to reduce the risk of neural-tube defects in newborns. Fortification (140 microg per 100 g) began in 1996, and the process was essentially complete by mid-1997.To assess the effect of folic acid fortification on folate status, we measured plasma folate and total homocysteine concentrations (a sensitive marker of folate status) using blood samples from the fifth examination (January 1991 to December 1994) of the Framingham Offspring Study cohort for baseline values and the sixth examination (January 1995 to August 1998) for follow-up values. We divided the cohort into two groups on the basis of the date of their follow-up examination: the study group consisted of 350 subjects who were seen after fortification (September 1997 to March 1998), and the control group consisted of 756 subjects who were seen before fortification (January 1995 to September 1996).METHODSTo assess the effect of folic acid fortification on folate status, we measured plasma folate and total homocysteine concentrations (a sensitive marker of folate status) using blood samples from the fifth examination (January 1991 to December 1994) of the Framingham Offspring Study cohort for baseline values and the sixth examination (January 1995 to August 1998) for follow-up values. We divided the cohort into two groups on the basis of the date of their follow-up examination: the study group consisted of 350 subjects who were seen after fortification (September 1997 to March 1998), and the control group consisted of 756 subjects who were seen before fortification (January 1995 to September 1996).Among the subjects in the study group who did not use vitamin supplements, the mean folate concentrations increased from 4.6 to 10.0 ng per milliliter (11 to 23 nmol per liter) (P<0.001) from the baseline visit to the follow-up visit, and the prevalence of low folate concentrations (<3 ng per milliliter [7 nmol per liter]) decreased from 22.0 to 1.7 percent (P< 0.001). The mean total homocysteine concentration decreased from 10.1 to 9.4 micromol per liter during this period (P<0.001), and the prevalence of high homocysteine concentrations (>13 micromol per liter) decreased from 18.7 to 9.8 percent (P<0.001). In the control group, there were no statistically significant changes in concentrations of folate or homocysteine.RESULTSAmong the subjects in the study group who did not use vitamin supplements, the mean folate concentrations increased from 4.6 to 10.0 ng per milliliter (11 to 23 nmol per liter) (P<0.001) from the baseline visit to the follow-up visit, and the prevalence of low folate concentrations (<3 ng per milliliter [7 nmol per liter]) decreased from 22.0 to 1.7 percent (P< 0.001). The mean total homocysteine concentration decreased from 10.1 to 9.4 micromol per liter during this period (P<0.001), and the prevalence of high homocysteine concentrations (>13 micromol per liter) decreased from 18.7 to 9.8 percent (P<0.001). In the control group, there were no statistically significant changes in concentrations of folate or homocysteine.The fortification of enriched grain products with folic acid was associated with a substantial improvement in folate status in a population of middle-aged and older adults.CONCLUSIONSThe fortification of enriched grain products with folic acid was associated with a substantial improvement in folate status in a population of middle-aged and older adults. |
| Author | Wilson, P.W.F Bostom, A.G Jacques, P.F Selhub, J Rosenberg, I.H |
| Author_xml | – sequence: 1 fullname: Jacques, P.F – sequence: 2 fullname: Selhub, J – sequence: 3 fullname: Bostom, A.G – sequence: 4 fullname: Wilson, P.W.F – sequence: 5 fullname: Rosenberg, I.H |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1789949$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/10320382$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkV9rFDEUxYNU7Hb1Ewg6iPgioze5mZnNY1m2Vql_wPbBpyGbuZEsM0lNsg_99ma7K0oRNgQSyO-cm3vuGTvxwRNjzzm849C077-sPn3mSiloOKIEroA_YjPeINZSQnvCZgBiUctO4Sk7S2kDZXGpnrBTDigAF2LGfqysJZOrYKuLMDpTnRs3lGvMzjqjswu-KvvbqNOkd4jOVGk_VNch67G6DFMwdymT81Qtgzfkc7xXpafssdVjomeHc85uLlbXy8v66uuHj8vzq9q0DeS6lbjmSsB60I0iyTsclIXWakQzoBULbFqwBMZYbFAR14pERy0SDo3s1jhnb_a-tzH82lLK_eSSoXHUnsI29a3qhMIS0TFQdrsC5QNz9uoBuAnb6EsTvRCoJIhGFejFAdquJxr62-gmHe_6P9EW4PUB0Mno0UbtjUt_uW6hlNz54B4zMaQUyf7j1O_m3P9nzkWlHqiMy_e5l_jdeET7dq-dptR72kxH6Jd72urQ65-xtHDzXZQHgE6C5C3-Bm_Yvt4 |
| CODEN | NEJMAG |
| CitedBy_id | crossref_primary_10_1111_j_1440_1754_2004_00289_x crossref_primary_10_1093_jn_136_1_153 crossref_primary_10_3389_fgene_2019_01013 crossref_primary_10_1002_bdr2_1564 crossref_primary_10_1093_jn_131_1_132 crossref_primary_10_1080_07315724_2001_10719039 crossref_primary_10_1373_clinchem_2003_026955 crossref_primary_10_1159_000057701 crossref_primary_10_1186_1475_2891_11_45 crossref_primary_10_1002_ana_10134 crossref_primary_10_1074_jbc_M110_147439 crossref_primary_10_1111_j_1753_4887_2011_00372_x crossref_primary_10_1016_j_rcsop_2023_100277 crossref_primary_10_1093_jn_136_12_3079 crossref_primary_10_1146_annurev_nutr_043020_091647 crossref_primary_10_3390_nu16111550 crossref_primary_10_1007_BF02982675 crossref_primary_10_3389_fnut_2022_1069911 crossref_primary_10_3945_ajcn_2010_29413 crossref_primary_10_1093_ajcn_82_2_442 crossref_primary_10_5694_j_1326_5377_2004_tb06296_x crossref_primary_10_3390_nu14204321 crossref_primary_10_1080_1028415X_2017_1331524 crossref_primary_10_14218_ERHM_2017_00027 crossref_primary_10_1016_j_nut_2004_01_003 crossref_primary_10_1054_chec_2001_0143 crossref_primary_10_1093_ajcn_86_3_718 crossref_primary_10_1002_pdi3_2517 crossref_primary_10_1034_j_1600_6143_2002_20404_x crossref_primary_10_1111_j_1753_4887_2004_tb00065_x crossref_primary_10_1192_bjp_bp_114_148361 crossref_primary_10_1586_17512433_2015_1010516 crossref_primary_10_1212_01_wnl_0000183063_99107_5c crossref_primary_10_1016_j_bbagen_2016_06_018 crossref_primary_10_1079_BJN20061812 crossref_primary_10_1161_01_RES_0000129182_46440_4a crossref_primary_10_1016_S0002_9343_02_01269_X crossref_primary_10_1093_ajcn_73_3_613 crossref_primary_10_1038_sj_ejcn_1602065 crossref_primary_10_3390_antiox10111645 crossref_primary_10_1177_1076029608322548 crossref_primary_10_1007_s11940_002_0009_1 crossref_primary_10_1373_clinchem_2005_061382 crossref_primary_10_1002_j_2040_4603_2016_tb00682_x crossref_primary_10_1056_NEJM199911113412006 crossref_primary_10_3390_nu16142199 crossref_primary_10_1002_tera_90005 crossref_primary_10_1016_j_atherosclerosis_2003_09_011 crossref_primary_10_1093_ajcn_73_4_673 crossref_primary_10_1002_tera_90006 crossref_primary_10_1111_j_1753_4887_2004_tb00076_x crossref_primary_10_1007_s11883_007_0048_x crossref_primary_10_1016_j_brainresbull_2005_09_020 crossref_primary_10_1161_01_ATV_19_12_2918 crossref_primary_10_1093_ajcn_83_5_993 crossref_primary_10_1016_j_jclinepi_2004_12_010 crossref_primary_10_1097_01_ede_0000239727_59575_da crossref_primary_10_1067_mob_2002_121105 crossref_primary_10_1016_j_appet_2011_05_314 crossref_primary_10_1093_ajcn_nqx019 crossref_primary_10_1093_ajcn_73_3_628 crossref_primary_10_1093_ajcn_nqz314 crossref_primary_10_1093_jn_133_11_3731S crossref_primary_10_1067_mva_2001_117144 crossref_primary_10_1093_ajcn_77_6_1474 crossref_primary_10_1146_annurev_med_60_041807_123308 crossref_primary_10_3389_fmolb_2016_00027 crossref_primary_10_1016_j_cca_2005_11_016 crossref_primary_10_1093_jn_133_6_1961S crossref_primary_10_2165_00003495_200262050_00004 crossref_primary_10_3945_ajcn_113_059683 crossref_primary_10_1016_j_jns_2010_07_013 crossref_primary_10_1093_ajcn_85_1_117 crossref_primary_10_1002_dmrr_902 crossref_primary_10_1212_01_WNL_0000137886_74175_5A crossref_primary_10_1007_s00394_024_03344_8 crossref_primary_10_1111_anu_12275 crossref_primary_10_3390_nu15040937 crossref_primary_10_2337_db09_0087 crossref_primary_10_1080_07315724_2001_10719024 crossref_primary_10_1097_01_wnr_0000215777_99473_52 crossref_primary_10_1017_S0007114521004220 crossref_primary_10_3390_nu17010040 crossref_primary_10_1016_S0140_6736_99_00437_7 crossref_primary_10_1016_S0398_7620_05_84617_6 crossref_primary_10_1016_j_euroneuro_2007_06_005 crossref_primary_10_1176_ajp_162_7_1387_a crossref_primary_10_1159_000365794 crossref_primary_10_1136_archdischild_2024_328115 crossref_primary_10_1016_j_eplepsyres_2005_03_005 crossref_primary_10_1093_ajcn_79_5_805 crossref_primary_10_1016_j_numecd_2004_04_002 crossref_primary_10_1093_ajcn_83_6_1380 crossref_primary_10_1093_ajcn_70_2_177 crossref_primary_10_1161_hs0302_103657 crossref_primary_10_4162_nrp_2007_1_3_163 crossref_primary_10_1016_S0749_0690_02_00048_4 crossref_primary_10_1515_CCLM_2007_349 crossref_primary_10_1007_s11745_001_0678_8 crossref_primary_10_3390_biom10020219 crossref_primary_10_4161_epi_27323 crossref_primary_10_1017_S1368980008004321 crossref_primary_10_1093_jn_nxab039 crossref_primary_10_1080_07315724_2007_10719635 crossref_primary_10_1161_ATVBAHA_121_316397 crossref_primary_10_1093_ajcn_79_3_473 crossref_primary_10_1080_10673220701551136 crossref_primary_10_1177_153473460200100102 crossref_primary_10_1016_j_tifs_2005_03_010 crossref_primary_10_1111_j_1753_4887_2008_00070_x crossref_primary_10_1038_sj_ejcn_1602497 crossref_primary_10_1080_01635581_2016_1152388 crossref_primary_10_1053_jada_2003_50062 crossref_primary_10_1159_000480447 crossref_primary_10_1111_j_1753_4887_2004_tb00067_x crossref_primary_10_1093_jn_132_8_2466S crossref_primary_10_1093_jn_132_9_2792 crossref_primary_10_1097_ALN_0b013e31829761e3 crossref_primary_10_1111_j_1753_4887_2009_00190_x crossref_primary_10_1007_s11883_007_0068_6 crossref_primary_10_1093_jn_136_6_1731S crossref_primary_10_1097_FPC_0b013e32834741ff crossref_primary_10_1191_1358863x02vm428ra crossref_primary_10_1111_j_1469_8749_2002_tb00838_x crossref_primary_10_3945_jn_108_096511 crossref_primary_10_1111_j_1572_0241_2000_03365_x crossref_primary_10_1093_ajcn_76_2_301 crossref_primary_10_2188_jea_JE20210031 crossref_primary_10_3390_nu11122843 crossref_primary_10_1016_S0301_2115_02_00305_6 crossref_primary_10_1016_S0899_9007_02_00808_0 crossref_primary_10_1093_jn_135_5_1040 crossref_primary_10_1161_01_STR_0000135228_20619_ad crossref_primary_10_1093_clinchem_45_9_1517 crossref_primary_10_1111_pai_13128 crossref_primary_10_1016_j_nut_2006_12_006 crossref_primary_10_1111_j_1538_7836_2005_01427_x crossref_primary_10_1124_pr_54_4_599 crossref_primary_10_1002_mnfr_200600191 crossref_primary_10_1038_s41598_020_74268_6 crossref_primary_10_1016_S0009_9120_00_00083_7 crossref_primary_10_1093_ajcn_77_1_196 crossref_primary_10_1161_CIRCULATIONAHA_105_580332 crossref_primary_10_1016_S0899_9007_00_00307_5 crossref_primary_10_1016_j_biochi_2016_04_010 crossref_primary_10_1177_0379572117739063 crossref_primary_10_1161_hq0102_102190 crossref_primary_10_1093_ajcn_78_3_441 crossref_primary_10_1097_EDE_0b013e3182227887 crossref_primary_10_1146_annurev_nutr_24_012003_132306 crossref_primary_10_1186_s12918_018_0621_7 crossref_primary_10_4065_80_2_219 crossref_primary_10_1007_s11745_001_0677_9 crossref_primary_10_1016_j_tifs_2005_03_009 crossref_primary_10_1016_S0140_6736_01_07104_5 crossref_primary_10_1093_ajcn_86_5_1563S crossref_primary_10_1016_S0002_8223_01_00283_8 crossref_primary_10_1046_j_1365_3016_2003_00511_x crossref_primary_10_1186_s12974_020_01938_7 crossref_primary_10_1177_03795721241229503 crossref_primary_10_1007_s11940_000_0013_2 crossref_primary_10_1093_advances_nmab106 crossref_primary_10_1046_j_1532_5415_2001_49294_x crossref_primary_10_1079_PNS2004390 crossref_primary_10_1371_journal_pone_0000083 crossref_primary_10_1096_fj_201601214RR crossref_primary_10_3945_ajcn_2009_27514 crossref_primary_10_1186_1471_2393_4_20 crossref_primary_10_1016_S0899_9007_01_00645_1 crossref_primary_10_1093_jn_133_11_3758S crossref_primary_10_1038_s42255_025_01272_3 crossref_primary_10_1097_00007691_200210000_00008 crossref_primary_10_1016_j_nut_2021_111231 crossref_primary_10_1097_MAJ_0b013e31823782a5 crossref_primary_10_1093_jn_nxaa395 crossref_primary_10_1002_ijc_21978 crossref_primary_10_1093_jn_132_7_1872 crossref_primary_10_1079_PNS2003271 crossref_primary_10_1016_j_cjca_2012_10_024 crossref_primary_10_1093_ajcn_77_5_1318 crossref_primary_10_1016_j_jash_2015_08_007 crossref_primary_10_1017_S1368980012002984 crossref_primary_10_1186_s40199_014_0062_9 crossref_primary_10_1016_S0021_9150_02_00303_9 crossref_primary_10_1111_j_1365_2621_2004_tb17888_x crossref_primary_10_3945_jn_110_124313 crossref_primary_10_1016_S0025_7125_05_70215_7 crossref_primary_10_1186_1475_2867_12_10 crossref_primary_10_1079_PHN2001159 crossref_primary_10_1111_j_1447_0756_2010_01317_x crossref_primary_10_1177_109980040100300105 crossref_primary_10_1016_S0014_2565_00_70568_6 crossref_primary_10_2215_CJN_05310610 crossref_primary_10_3389_fneur_2023_1184141 crossref_primary_10_1158_1078_0432_CCR_05_0355 crossref_primary_10_1079_PHN2001173 crossref_primary_10_3389_fphar_2020_01062 crossref_primary_10_1067_mob_2001_113845 crossref_primary_10_1111_j_1747_4949_2008_00169_x crossref_primary_10_1152_ajpcell_00268_2010 crossref_primary_10_1038_sj_ejcn_1601365 crossref_primary_10_1161_CIR_0b013e3181daa7c9 crossref_primary_10_1146_annurev_pharmtox_45_120403_100018 crossref_primary_10_1161_01_STR_0000225929_96190_b3 crossref_primary_10_1079_NRR200126 crossref_primary_10_1161_01_STR_0000199845_27512_84 crossref_primary_10_1517_14656566_2_9_1449 crossref_primary_10_1159_000074794 crossref_primary_10_3390_nu17071122 crossref_primary_10_1007_s11936_004_0031_6 crossref_primary_10_1016_S0002_9149_02_02466_9 crossref_primary_10_1016_S0378_4347_01_00412_1 crossref_primary_10_1046_j_1523_5408_2002_00514_x crossref_primary_10_3148_68_3_2007_143 crossref_primary_10_1016_j_cll_2006_06_008 crossref_primary_10_1159_000064633 crossref_primary_10_1542_peds_2005_2143 crossref_primary_10_1186_s12884_023_05510_y crossref_primary_10_1016_j_bios_2016_05_005 crossref_primary_10_1080_07315724_2003_10719323 crossref_primary_10_1016_j_archger_2004_07_005 crossref_primary_10_1111_j_1742_1241_2009_02207_x crossref_primary_10_1371_journal_pone_0017706 crossref_primary_10_1371_journal_pone_0115295 crossref_primary_10_3945_ajcn_110_002659 crossref_primary_10_1111_j_1365_2621_2004_tb17889_x crossref_primary_10_1023_A_1022130217463 crossref_primary_10_1038_sj_ejcn_1602490 crossref_primary_10_1038_sj_ejcn_1601283 crossref_primary_10_1038_sj_ejcn_1602254 crossref_primary_10_1186_s12937_024_00977_7 crossref_primary_10_1373_clinchem_2008_103218 crossref_primary_10_1186_1471_2458_6_29 crossref_primary_10_1016_S0021_9150_00_00739_5 crossref_primary_10_1016_j_arcmed_2009_06_004 crossref_primary_10_1017_S0007114507721499 crossref_primary_10_1038_sj_ejcn_1601388 crossref_primary_10_1097_00004836_200108000_00008 crossref_primary_10_1093_clinchem_48_3_436 crossref_primary_10_1161_01_STR_32_5_1116 crossref_primary_10_1371_journal_pone_0193352 crossref_primary_10_1080_10641955_2016_1183673 crossref_primary_10_1177_09691413221102321 crossref_primary_10_1002_clc_4960251105 crossref_primary_10_1542_peds_106_4_825 crossref_primary_10_1079_PHN2001144 crossref_primary_10_1097_00041433_200112000_00007 crossref_primary_10_1093_ajcn_78_1_7 crossref_primary_10_1111_j_1753_4887_2007_tb00276_x crossref_primary_10_1016_j_neurobiolaging_2007_07_020 crossref_primary_10_1016_S0899_9007_00_00327_0 crossref_primary_10_1212_WNL_56_9_1188 crossref_primary_10_1016_j_jns_2019_07_015 crossref_primary_10_1016_S0828_282X_06_70238_0 crossref_primary_10_1111_j_1532_5415_2012_04076_x crossref_primary_10_1016_j_jff_2016_09_014 crossref_primary_10_1159_000074247 crossref_primary_10_1177_147827150003000203 crossref_primary_10_1002_ajh_10093 crossref_primary_10_1016_j_ahj_2005_04_025 crossref_primary_10_1016_j_envres_2020_109679 crossref_primary_10_1371_journal_pone_0155801 crossref_primary_10_1093_jn_134_6_1389 crossref_primary_10_1073_pnas_0703875104 crossref_primary_10_1017_S0029665100000252 crossref_primary_10_1016_j_metabol_2005_08_025 crossref_primary_10_3945_ajcn_2009_28456 crossref_primary_10_1134_S0006297909060017 crossref_primary_10_1016_j_clinbiochem_2007_07_014 crossref_primary_10_1002_pros_24776 crossref_primary_10_1161_JAHA_116_003768 crossref_primary_10_2105_AJPH_2005_067371 crossref_primary_10_3390_foods9101431 crossref_primary_10_4065_81_2_177 crossref_primary_10_1016_S0892_0362_03_00010_2 crossref_primary_10_1186_s12872_018_0774_8 crossref_primary_10_1093_jn_135_9_2253 crossref_primary_10_1096_fj_14_259283 crossref_primary_10_1007_s00280_007_0576_7 crossref_primary_10_1016_j_ccm_2010_07_004 crossref_primary_10_2165_00023210_200519070_00003 crossref_primary_10_1093_ajcn_77_1_211 crossref_primary_10_1093_jn_134_3_580 crossref_primary_10_1111_j_1365_2257_2004_00649_x crossref_primary_10_1016_j_fct_2016_07_014 crossref_primary_10_1093_ajcn_77_5_1241 crossref_primary_10_1212_WNL_0000000000001343 crossref_primary_10_1093_ajcn_73_5_927 crossref_primary_10_1007_s11883_006_0046_4 crossref_primary_10_1097_00017285_200407000_00007 crossref_primary_10_1373_49_8_1416 crossref_primary_10_1038_ijo_2017_109 crossref_primary_10_3945_ajcn_111_029595 crossref_primary_10_1111_j_1467_3010_2004_00429_x crossref_primary_10_1046_j_1365_2257_2000_00301_x crossref_primary_10_1016_j_nut_2009_05_015 crossref_primary_10_1016_j_atherosclerosis_2007_12_035 crossref_primary_10_1089_acm_2007_0663 crossref_primary_10_1016_j_jns_2006_05_040 crossref_primary_10_1016_j_ajog_2011_07_033 crossref_primary_10_1079_NRR200478 crossref_primary_10_1017_S0029665108007076 crossref_primary_10_1093_ajcn_80_4_1024 crossref_primary_10_1161_hq0302_105369 crossref_primary_10_1016_j_amjmed_2003_10_024 crossref_primary_10_1203_PDR_0b013e31815b8ec5 crossref_primary_10_1111_j_1520_037X_2000_80364_x crossref_primary_10_1097_00041433_200502000_00002 crossref_primary_10_1016_j_biopha_2003_11_005 crossref_primary_10_3390_nu13061790 crossref_primary_10_1093_ajcn_77_1_221 crossref_primary_10_1080_07315724_2017_1330162 crossref_primary_10_1056_NEJMe048096 crossref_primary_10_1080_08860220500461260 crossref_primary_10_1111_j_1742_1241_2012_02929_x crossref_primary_10_1007_BF03344557 crossref_primary_10_1097_00041327_200303000_00011 crossref_primary_10_1016_j_reprotox_2008_04_010 crossref_primary_10_1016_S0140_6736_12_62001_7 crossref_primary_10_1017_S0007114515001439 crossref_primary_10_3390_ijerph10094352 crossref_primary_10_1161_CIRCULATIONAHA_106_641688 crossref_primary_10_1002_1096_9926_200102_63_2_79__AID_TERA1013_3_0_CO_2_3 crossref_primary_10_1093_ajcn_77_1_8 crossref_primary_10_1016_j_nutres_2011_10_003 crossref_primary_10_1067_mai_2000_108502 crossref_primary_10_1038_sj_ejcn_1601228 crossref_primary_10_3945_ajcn_2008_26287 crossref_primary_10_1038_sj_ejcn_1602315 crossref_primary_10_1016_j_clinbiochem_2014_01_023 crossref_primary_10_1038_35101056 crossref_primary_10_1016_S0002_9149_01_01637_X crossref_primary_10_1161_01_ATV_21_5_849 crossref_primary_10_1155_2022_1486157 crossref_primary_10_3810_psm_1999_07_929 crossref_primary_10_1093_ajcn_82_2_279 crossref_primary_10_3390_nu16050755 crossref_primary_10_1016_S0963_9969_01_00157_0 crossref_primary_10_1007_s11883_000_0020_5 crossref_primary_10_1093_ajcn_86_6_1581 crossref_primary_10_1016_S0027_5107_99_00194_3 crossref_primary_10_1016_j_jneb_2008_04_360 crossref_primary_10_1016_S0021_9150_99_00023_4 crossref_primary_10_1002_sim_3841 crossref_primary_10_1093_jn_130_11_2850 crossref_primary_10_1017_BJN20061862 crossref_primary_10_1016_S0749_3797_03_00097_7 crossref_primary_10_1634_theoncologist_12_7_808 crossref_primary_10_1111_j_1601_183X_2011_00749_x crossref_primary_10_2478_v10039_008_0050_8 crossref_primary_10_1007_BF03405255 crossref_primary_10_1093_ajcn_82_6_1346 crossref_primary_10_1177_15648265080292S110 crossref_primary_10_1017_S0029665108008872 crossref_primary_10_1093_ajcn_77_3_658 crossref_primary_10_1111_j_1469_8749_2001_tb00193_x crossref_primary_10_1161_CIRCULATIONAHA_106_652842 crossref_primary_10_1182_blood_V101_7_2483 crossref_primary_10_1016_S0271_5317_02_00547_X crossref_primary_10_1177_15648265080292S116 crossref_primary_10_1093_ajh_hps015 crossref_primary_10_1373_clinchem_2007_097469 crossref_primary_10_1007_s00772_006_0482_z crossref_primary_10_1080_07315724_2003_10719297 crossref_primary_10_1007_BF03405009 crossref_primary_10_1096_fj_03_0382fje crossref_primary_10_1002_em_20025 crossref_primary_10_1056_NEJMoa032739 crossref_primary_10_1016_j_clnu_2024_05_034 crossref_primary_10_1093_jn_132_2_283 crossref_primary_10_1093_ajcn_82_4_717 crossref_primary_10_1093_jn_132_2_289 crossref_primary_10_1097_00005082_200001000_00010 crossref_primary_10_1210_jc_2008_1777 crossref_primary_10_1016_j_jada_2007_10_050 crossref_primary_10_1136_bmjopen_2018_026564 crossref_primary_10_1002_path_2101 crossref_primary_10_1016_S0002_9394_03_00571_3 crossref_primary_10_1161_01_CIR_0000149077_87074_DE crossref_primary_10_1177_15648265080292S103 crossref_primary_10_1007_BF03405010 crossref_primary_10_1046_j_1532_5415_2002_50155_x crossref_primary_10_1097_00006250_200006000_00021 crossref_primary_10_1542_peds_2005_2784 crossref_primary_10_1177_15648265080292S109 crossref_primary_10_1038_ncpneuro0093 crossref_primary_10_1016_j_exger_2022_112066 crossref_primary_10_1093_ajcn_84_1_156 crossref_primary_10_1046_j_1523_5408_2002_t01_1_00006_x crossref_primary_10_1093_ajcn_72_5_1095 crossref_primary_10_1177_088307380001500505 crossref_primary_10_1016_j_yebeh_2005_05_020 crossref_primary_10_1177_088307380001500506 crossref_primary_10_3945_jn_108_092726 crossref_primary_10_1038_sj_jhh_1002052 crossref_primary_10_1002_jcp_25693 crossref_primary_10_3945_ajcn_111_013433 crossref_primary_10_1038_sj_ejcn_1601554 crossref_primary_10_1038_sj_ejcn_1601674 crossref_primary_10_1161_01_STR_0000018602_09015_C1 crossref_primary_10_1007_s12603_009_0018_9 crossref_primary_10_1093_ajcn_73_2_151 crossref_primary_10_1016_j_jacc_2005_05_031 crossref_primary_10_1161_01_STR_0000153048_87248_3b crossref_primary_10_1097_01_hjh_0000222754_75196_5c crossref_primary_10_1093_ajcn_82_6_1320 crossref_primary_10_1017_S1462399409000969 crossref_primary_10_1079_BJN2002653 crossref_primary_10_1016_j_jare_2025_09_026 crossref_primary_10_1093_ije_dyv156 crossref_primary_10_1079_BJN2002776 crossref_primary_10_1136_jamia_2001_0080585 crossref_primary_10_1056_NEJM200005113421911 crossref_primary_10_1002_bdra_20319 crossref_primary_10_1093_ajcn_76_1_180 crossref_primary_10_1517_14728220802560281 crossref_primary_10_1161_CIRCULATIONAHA_110_989145 crossref_primary_10_1200_JCO_2008_16_1943 crossref_primary_10_1053_sper_2002_34773 crossref_primary_10_1161_STROKEAHA_117_013369 crossref_primary_10_1111_jfbc_12635 crossref_primary_10_1002_bdra_20683 crossref_primary_10_1016_j_tjnut_2024_04_008 crossref_primary_10_1038_sj_ejcn_1601540 crossref_primary_10_3389_fnut_2023_1279207 crossref_primary_10_1038_sj_ejcn_1601545 crossref_primary_10_1161_HYPERTENSIONAHA_119_14621 crossref_primary_10_1093_clinchem_47_6_1001 crossref_primary_10_1080_07315724_2003_10719270 crossref_primary_10_1177_15648265080292S122 crossref_primary_10_1017_S1368980019004841 crossref_primary_10_1111_j_1365_277X_2011_01158_x crossref_primary_10_1177_15648265080292S120 crossref_primary_10_3390_nu9060539 crossref_primary_10_1007_s00394_014_0704_1 crossref_primary_10_1111_j_1467_3010_2005_00523_x crossref_primary_10_3390_ijerph10083263 crossref_primary_10_1056_NEJMoa032845 crossref_primary_10_1093_jn_133_10_3166 crossref_primary_10_3945_ajcn_110_004671 crossref_primary_10_1007_BF03327348 crossref_primary_10_1093_jn_131_12_3277 crossref_primary_10_1111_ane_12106 crossref_primary_10_2165_00128072_200002060_00003 crossref_primary_10_1016_j_jchromb_2009_07_024 crossref_primary_10_1002_clc_4960241108 crossref_primary_10_1634_theoncologist_2014_0221 crossref_primary_10_1093_ajcn_82_4_806 crossref_primary_10_1016_S0022_510X_02_00210_1 crossref_primary_10_3945_ajcn_112_051052 crossref_primary_10_1093_ajcn_84_5_989 crossref_primary_10_1002_tera_10079 crossref_primary_10_1093_jnci_djx119 crossref_primary_10_2188_jea_15_29 crossref_primary_10_1093_ajcn_87_3_734 crossref_primary_10_1161_STROKEAHA_114_006927 crossref_primary_10_1300_J052v22n02_03 crossref_primary_10_1161_01_CIR_102_18_2284 crossref_primary_10_1080_20014091084209 crossref_primary_10_1161_circ_106_25_3373 crossref_primary_10_1007_s13142_013_0195_2 crossref_primary_10_1097_00042307_200003000_00007 crossref_primary_10_1007_s11033_012_1629_5 crossref_primary_10_1016_j_annepidem_2009_01_016 crossref_primary_10_1002_bdra_20020 crossref_primary_10_1016_j_ab_2003_10_009 crossref_primary_10_1016_j_nutres_2013_01_002 crossref_primary_10_1073_pnas_96_22_12216 crossref_primary_10_1016_j_mrgentox_2018_10_002 crossref_primary_10_1016_j_numecd_2005_02_003 crossref_primary_10_2165_00002512_200623060_00004 crossref_primary_10_1007_s10549_018_05118_3 crossref_primary_10_1056_NEJMcp010710 crossref_primary_10_3390_nu15143237 crossref_primary_10_1016_j_nut_2007_10_007 crossref_primary_10_1007_s10900_006_9029_1 crossref_primary_10_1046_j_1444_1586_2002_00034_x crossref_primary_10_1161_01_STR_0000135296_93614_94 crossref_primary_10_2165_11310860_000000000_00000 crossref_primary_10_1016_j_nut_2010_10_017 crossref_primary_10_3109_09637486_2011_631522 crossref_primary_10_1373_clinchem_2011_181099 crossref_primary_10_1111_j_1341_8076_2005_00265_x crossref_primary_10_1056_NEJM199909163411215 crossref_primary_10_4236_health_2024_161003 crossref_primary_10_1161_01_HYP_0000101690_58391_13 crossref_primary_10_1111_j_1532_5415_1999_tb01576_x crossref_primary_10_1016_j_jnutbio_2003_08_010 crossref_primary_10_3390_nu15081891 crossref_primary_10_1093_clinchem_46_8_1277 crossref_primary_10_1016_j_ajog_2005_08_027 crossref_primary_10_1016_S1053_2498_02_01153_1 crossref_primary_10_1097_01_AOG_0000154886_40318_5e crossref_primary_10_1186_s12883_020_01701_8 crossref_primary_10_1038_ajh_2011_133 crossref_primary_10_1080_01635581_2013_741754 crossref_primary_10_1093_ajcn_88_3_763 crossref_primary_10_1136_bmjopen_2017_016154 crossref_primary_10_1002_mnfr_201200108 crossref_primary_10_1016_j_thromres_2013_06_005 crossref_primary_10_1038_sj_ejcn_1601507 crossref_primary_10_1097_00008486_200404000_00005 crossref_primary_10_1186_s13041_014_0067_9 crossref_primary_10_1096_fj_201801533R crossref_primary_10_1212_WNL_59_9_1475 crossref_primary_10_1016_j_amjcard_2004_02_009 crossref_primary_10_1016_j_bone_2007_08_021 crossref_primary_10_1016_j_clnu_2008_08_006 crossref_primary_10_1016_S1474_4422_07_70219_3 crossref_primary_10_1080_10641960802251958 crossref_primary_10_1186_1471_2296_2_5 crossref_primary_10_1007_BF03195624 crossref_primary_10_1016_j_ahj_2004_01_023 crossref_primary_10_1097_00001648_200203000_00026 crossref_primary_10_1056_NEJMoa055227 crossref_primary_10_1002_bdra_20059 crossref_primary_10_1016_j_jfoodeng_2011_07_032 crossref_primary_10_1017_S0007114507691788 crossref_primary_10_1016_j_clinbiochem_2009_04_014 crossref_primary_10_1185_030079906X96344 crossref_primary_10_1016_j_psc_2007_07_006 crossref_primary_10_1042_BCJ20190275 crossref_primary_10_1016_S0895_7967_03_00027_9 crossref_primary_10_1097_01_EDE_0000040253_12446_B2 crossref_primary_10_1515_dx_2022_0042 crossref_primary_10_1016_S1567_5688_03_00028_X crossref_primary_10_1053_jada_2003_50030 crossref_primary_10_1038_ejcn_2010_20 crossref_primary_10_1093_ajcn_81_3_669 crossref_primary_10_1093_jn_nxaa382 crossref_primary_10_1097_00008486_200203000_00008 crossref_primary_10_1038_s41598_018_34205_0 crossref_primary_10_1097_00006205_200210000_00019 crossref_primary_10_1161_01_STR_0000185929_38534_f3 crossref_primary_10_1016_j_ypmed_2003_09_001 crossref_primary_10_1053_j_jrn_2010_04_005 crossref_primary_10_1080_1028415X_2023_2218533 crossref_primary_10_1016_j_clinbiochem_2007_04_007 crossref_primary_10_1007_s10038_005_0247_7 crossref_primary_10_1159_000069885 crossref_primary_10_1002_art_20516 crossref_primary_10_1016_j_ahj_2006_03_004 crossref_primary_10_3390_nu8110725 crossref_primary_10_1079_BJN20041145 crossref_primary_10_1002_bdra_10141 crossref_primary_10_1007_s00404_012_2501_5 crossref_primary_10_1053_j_ajkd_2016_11_014 crossref_primary_10_1093_ajcn_86_4_1187 crossref_primary_10_1161_01_CIR_103_7_1006 crossref_primary_10_3945_jn_109_113878 crossref_primary_10_1080_07315724_2005_10719474 crossref_primary_10_1007_BF03346589 crossref_primary_10_1373_clinchem_2007_100214 crossref_primary_10_1016_S0002_8223_02_90281_6 crossref_primary_10_3390_nu8120761 crossref_primary_10_1016_j_jff_2022_105317 crossref_primary_10_1007_s11936_002_0016_2 crossref_primary_10_1097_00019442_200303000_00016 crossref_primary_10_1111_jch_13246 crossref_primary_10_1007_s00115_003_1606_2 crossref_primary_10_1038_s41538_025_00396_w crossref_primary_10_1093_ajcn_76_4_897 crossref_primary_10_1373_clinchem_2007_102632 crossref_primary_10_1016_S0022_3999_00_00158_6 crossref_primary_10_1097_00001648_200211000_00015 crossref_primary_10_1586_17446651_2_5_559 crossref_primary_10_1097_00041433_200012000_00003 crossref_primary_10_1097_00045391_200107000_00009 crossref_primary_10_3390_ijms25126302 crossref_primary_10_7326_0003_4819_131_5_199909070_00002 crossref_primary_10_7326_0003_4819_131_5_199909070_00003 crossref_primary_10_1056_NEJM200105243442108 crossref_primary_10_1007_s13311_011_0054_0 crossref_primary_10_1093_jn_132_6_1361 crossref_primary_10_1016_S0006_2952_01_00532_9 crossref_primary_10_1186_1471_2458_11_46 crossref_primary_10_3390_nu8120777 crossref_primary_10_3945_ajcn_2008_26947E crossref_primary_10_3945_ajcn_2008_26947C crossref_primary_10_3945_ajcn_2008_26404 crossref_primary_10_1016_S0021_9150_02_00386_6 crossref_primary_10_2165_00023210_200115060_00002 crossref_primary_10_1016_S0021_9150_01_00531_7 crossref_primary_10_1517_14740338_5_4_511 crossref_primary_10_1093_ajcn_82_1_26 crossref_primary_10_1542_peds_2004_2189 crossref_primary_10_1159_000068693 crossref_primary_10_1080_07352680903436283 crossref_primary_10_1097_01_psy_0000221380_92521_51 crossref_primary_10_1161_HYPERTENSIONAHA_119_14102 crossref_primary_10_1046_j_1365_2141_2001_02822_x crossref_primary_10_1515_CCLM_2001_128 crossref_primary_10_1002_biof_174 crossref_primary_10_3945_jn_112_172858 crossref_primary_10_1002_bdra_10127 crossref_primary_10_4065_83_11_1203 crossref_primary_10_1002_tera_10048 crossref_primary_10_1002_ijc_70109 crossref_primary_10_1016_S0002_8223_01_00062_1 crossref_primary_10_1093_ajcn_81_6_1372 crossref_primary_10_1111_j_1753_4887_1999_tb06905_x crossref_primary_10_1016_j_cca_2011_04_038 crossref_primary_10_1111_j_1532_5415_2004_52526_x crossref_primary_10_1002_biof_173 crossref_primary_10_1093_jn_nxab444 crossref_primary_10_3109_07853890109002059 crossref_primary_10_1093_ajcn_86_5_1581 crossref_primary_10_3390_nu10020241 crossref_primary_10_1161_01_STR_0000071109_23410_AB crossref_primary_10_1002_bdra_20049 crossref_primary_10_1093_humrep_dew308 crossref_primary_10_1517_13543784_9_11_2637 crossref_primary_10_1111_j_1753_4887_2005_tb00108_x crossref_primary_10_1161_01_STR_0000169946_31639_af crossref_primary_10_1017_S1368980011000395 crossref_primary_10_1093_ajcn_86_5_1773 crossref_primary_10_1111_j_1365_277X_2008_00931_x crossref_primary_10_1080_14779072_2018_1497974 crossref_primary_10_5858_2007_131_477_DNFFMA crossref_primary_10_1016_j_ccc_2011_09_007 crossref_primary_10_1007_s10552_012_0022_y crossref_primary_10_1016_S1053_2498_03_00202_X crossref_primary_10_1056_NEJMoa011613 crossref_primary_10_1002_clc_4950250503 crossref_primary_10_1016_S0735_1097_00_00809_3 crossref_primary_10_2165_00019053_200220070_00001 crossref_primary_10_1079_BJN2001425 crossref_primary_10_1016_j_lfs_2015_07_031 crossref_primary_10_3945_jn_111_156919 crossref_primary_10_1186_1743_7075_9_2 crossref_primary_10_1097_00055735_199912000_00004 crossref_primary_10_1093_ajcn_86_5_1405 crossref_primary_10_1007_s10654_004_2253_z crossref_primary_10_1016_j_nutres_2011_09_019 crossref_primary_10_1016_S0140_6736_05_72063_8 crossref_primary_10_2105_AJPH_2014_302377 crossref_primary_10_1016_S0140_6736_06_68582_6 crossref_primary_10_1017_S0007114508995647 crossref_primary_10_1111_j_1442_2042_2008_02163_x crossref_primary_10_1080_07315724_2000_10718946 crossref_primary_10_1093_ajcn_80_5_1123 crossref_primary_10_1097_01_ede_0000172132_13513_e0 crossref_primary_10_1161_JAHA_117_008517 crossref_primary_10_1590_S0102_311X2010001100003 crossref_primary_10_1017_S0007114522002082 crossref_primary_10_1161_CIRCULATIONAHA_105_570846 crossref_primary_10_1161_01_CIR_0000133444_17867_56 crossref_primary_10_1093_aje_kwq197 crossref_primary_10_1359_JBMR_0301261 crossref_primary_10_1177_09691413221117464 crossref_primary_10_1016_j_jnim_2017_04_001 crossref_primary_10_1017_S0007114509274745 crossref_primary_10_1093_jn_130_12_3090 crossref_primary_10_1093_jn_131_10_2643 crossref_primary_10_1097_MCO_0b013e32831cec62 crossref_primary_10_1080_07315724_2001_10719179 crossref_primary_10_1016_S0140_6736_05_77074_4 crossref_primary_10_1016_j_nut_2009_09_022 crossref_primary_10_2165_00002512_200016040_00001 crossref_primary_10_1016_j_ymgme_2014_07_016 crossref_primary_10_3109_09286586_2015_1012272 crossref_primary_10_1111_j_1447_0756_2010_01358_x crossref_primary_10_1016_j_clnu_2021_05_034 crossref_primary_10_1161_01_STR_31_11_2751 crossref_primary_10_1007_s11239_009_0365_8 crossref_primary_10_1016_S0140_6736_02_09901_4 crossref_primary_10_1111_jnc_14319 crossref_primary_10_1093_ajcn_78_4_765 crossref_primary_10_3390_nu7010074 crossref_primary_10_1002_ijc_31934 crossref_primary_10_1016_j_jstrokecerebrovasdis_2019_104633 crossref_primary_10_1007_s43032_021_00467_9 crossref_primary_10_1016_j_metabol_2006_12_012 crossref_primary_10_1097_01_nrl_0000253066_85963_aa crossref_primary_10_3109_19390210903535019 crossref_primary_10_3945_jn_110_131425 crossref_primary_10_3389_fneur_2022_902474 crossref_primary_10_3945_ajcn_110_004473 crossref_primary_10_1007_s00198_005_1961_x |
| Cites_doi | 10.1093/clinchem/34.11.2357 10.1016/0026-0495(88)90093-5 10.1136/bmj.306.6893.1645 10.1056/NEJM199804093381501 10.1001/jama.262.20.2847 10.1001/jama.277.22.1775 10.3109/00365518809167487 10.5694/j.1326-5377.1989.tb136723.x 10.1038/sj.ejcn.1600576 10.1093/oxfordjournals.aje.a116211 10.1001/jama.274.13.1049 10.1001/jama.269.10.1257 10.2105/AJPH.47.4_Pt_2.4 10.1093/jn/124.10.1927 10.1002/pd.1970100303 10.1093/clinchem/36.11.1993 10.1016/0378-4347(87)80438-3 10.1056/NEJM199707243370403 10.1016/0140-6736(91)90133-A 10.1001/jama.270.22.2693 10.1161/01.ATV.15.9.1314 10.1016/0091-7435(75)90037-7 10.1016/S0140-6736(95)92407-8 10.1111/j.1365-2796.1995.tb01190.x 10.1136/bmj.282.6275.1509 10.1093/ije/24.4.704 10.1093/oxfordjournals.aje.a008828 10.1001/jama.275.24.1893 10.1056/NEJM199804093381509 10.1001/jama.268.7.877 10.1016/0009-8981(83)90077-3 10.1001/jama.260.21.3141 10.1001/jama.276.23.1879 10.1016/S0140-6736(83)92654-5 10.1001/jama.279.5.359 |
| ContentType | Journal Article |
| Copyright | Copyright © 1999 Massachusetts Medical Society. All rights reserved. 1999 INIST-CNRS |
| Copyright_xml | – notice: Copyright © 1999 Massachusetts Medical Society. All rights reserved. – notice: 1999 INIST-CNRS |
| DBID | FBQ AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7RV 7X7 7XB 8AO 8C1 8FE 8FH 8FI ABUWG AFKRA AN0 AZQEC BBNVY BEC BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH HCIFZ K0Y LK8 M0R M0T M1P M2M M2O M2P M7P MBDVC NAPCQ PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PSYQQ Q9U 7S9 L.6 7X8 |
| DOI | 10.1056/NEJM199905133401901 |
| DatabaseName | AGRIS CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Nursing & Allied Health Database Health & Medical Collection ProQuest Central (purchase pre-March 2016) ProQuest Pharma Collection ProQuest Public Health Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection ProQuest Central (Alumni) ProQuest Central UK/Ireland British Nursing Database ProQuest Central Essentials Biological Science Collection eLibrary ProQuest Central Natural Science Collection ProQuest One ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep SciTech Premium Collection New England Journal of Medicine Biological Sciences Consumer Health Database Healthcare Administration Database PML(ProQuest Medical Library) Psychology Database (ProQuest) Research Library Science Database Biological Science Database Research Library (Corporate) Nursing & Allied Health Premium ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic AGRICOLA AGRICOLA - Academic MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Psychology Research Library Prep ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials elibrary ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing New England Journal of Medicine ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Research Library ProQuest Central (New) ProQuest Public Health ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest Family Health ProQuest One Academic Eastern Edition British Nursing Index with Full Text ProQuest Health Management ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Medical Library ProQuest Psychology Journals ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) AGRICOLA AGRICOLA - Academic MEDLINE - Academic |
| DatabaseTitleList | AGRICOLA ProQuest One Psychology MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7RV name: Nursing & Allied Health Database url: https://search.proquest.com/nahs sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1533-4406 |
| EndPage | 1454 |
| ExternalDocumentID | 41267596 10320382 1789949 10_1056_NEJM199905133401901 NJ199905133401901 US201300740416 |
| Genre | Original Article Research Support, U.S. Gov't, Non-P.H.S Research Support, U.S. Gov't, P.H.S Journal Article General Information |
| GrantInformation_xml | – fundername: NHLBI NIH HHS grantid: N01-HC-38038 |
| GroupedDBID | --- -DZ -ET -~X .-4 .55 .CO .GJ 0R~ 0WA 123 186 1CY 1KJ 1VV 29N 2KS 2WC 34G 36B 39C 3O- 4.4 41~ 53G 5RE 6TJ 7FN 7RV 7X7 85S 8AO 8C1 8FE 8FH 8FI 8WZ 9M8 A6W AACLI AAEJM AAIKC AAMNW AAQOH AAQQT AARDX AAUTI AAWTL AAYOK ABACO ABBLC ABCQX ABDPE ABDQB ABEFU ABEHJ ABIVO ABJNI ABOCM ABPPZ ABQIJ ABUWG ABWJO ACGFS ACGOD ACKOT ACNCT ACPFK ACPRK ACPVT ACRZS ACTDY ADBBV ADRHT ADUKH AENEX AERZD AETEA AFFDN AFFNX AFHKK AFKRA AFOSN AGFXO AGHSJ AGNAY AHMBA AJJEV AJUXI ALIPV ALMA_UNASSIGNED_HOLDINGS AN0 AQUVI AZQEC BBNVY BCU BENPR BHPHI BKEYQ BKNYI BNQBC BPHCQ BVXVI BYPQX C45 CCPQU CJ0 CS3 D0S DCD DU5 DWQXO EBS EJD EX3 F5P FA8 FBQ FD8 FM. FYUFA GNUQQ GUQSH H13 HCIFZ HF~ HMCUK HZ~ J5H K-O KOO L7B LK8 LPU M0R M0T M1P M2M M2O M2P M7P MQT MVM N4W NAPCQ NEJ NHB O9- OHT OK1 OMK OVD P-O P2P PCD PHGZT PQQKQ PROAC PSQYO PSYQQ QJJ QZG RHI RWL RXW S10 SJFOW SJN SKT TAE TAF TEORI TN5 TUQ TWZ UBX UCV UIG UKHRP UKR UMD UQL W2G WH7 WHG WOQ WOW X7M XJT XOL XYN XZL YCJ YFH YHZ YQI YQJ YR2 YR5 YRY YYP YYQ YZZ ZCA ZGI ZHY ZKB ZR0 ZVN ZXP ~KM - 08R 0R 1AW 3V. 4 55 5D0 8RP AALRV AAPBV AASXA ABFLS ABPTK ABQES ABUFD ACDCL ACJLH ACVYA ADCBC AFDAS AFMIJ AHVBC AIKQT AJYGW BBAFP CO DZ ET G8K GJ HZ IH2 K78 KM MBDVC N9A O0- OHM PADUT PQEST PQUKI PRINS S6N U1N UHB VQA X XFK YNT ZA5 ZKG AAYXX ADXHL AFFHD CITATION PHGZM PJZUB PPXIY PQGLB IQODW CGR CUY CVF ECM EIF NPM R.3 VXZ YIF YIN Z5M 7XB BEC K0Y PKEHL Q9U 7S9 L.6 PUEGO 7X8 |
| ID | FETCH-LOGICAL-c650t-643b1920bda59e4173d9f06fa33cd3f283560fe0ccf3539e1a9e27e63e3d547b3 |
| IEDL.DBID | 7RV |
| ISICitedReferencesCount | 890 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000080198700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0028-4793 |
| IngestDate | Fri Sep 05 11:17:37 EDT 2025 Thu Sep 04 16:00:20 EDT 2025 Thu Nov 06 14:17:30 EST 2025 Wed Feb 19 01:18:27 EST 2025 Mon Jul 21 09:11:16 EDT 2025 Sat Nov 29 04:49:43 EST 2025 Tue Nov 18 21:55:33 EST 2025 Wed Nov 11 00:32:58 EST 2020 Thu Apr 03 09:45:44 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 19 |
| Keywords | Human Plasma Middle age Hematology Vitamin Biological marker Marker Concentration Epidemiology Folic acid Folate Cohort study Total Biological effect Effectiveness factor Elderly |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c650t-643b1920bda59e4173d9f06fa33cd3f283560fe0ccf3539e1a9e27e63e3d547b3 |
| Notes | http://hdl.handle.net/10113/116 http://dx.doi.org/10.1056/NEJM199905133401901 SourceType-Scholarly Journals-1 ObjectType-General Information-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.nejm.org/doi/pdf/10.1056/NEJM199905133401901?articleTools=true |
| PMID | 10320382 |
| PQID | 223940259 |
| PQPubID | 40644 |
| PageCount | 6 |
| ParticipantIDs | proquest_miscellaneous_69729313 proquest_miscellaneous_47353917 proquest_journals_223940259 pubmed_primary_10320382 pascalfrancis_primary_1789949 crossref_primary_10_1056_NEJM199905133401901 crossref_citationtrail_10_1056_NEJM199905133401901 mms_nejm_10_1056_NEJM199905133401901 fao_agris_US201300740416 |
| ProviderPackageCode | DCD 7FN |
| PublicationCentury | 1900 |
| PublicationDate | 1999-05-13 |
| PublicationDateYYYYMMDD | 1999-05-13 |
| PublicationDate_xml | – month: 05 year: 1999 text: 1999-05-13 day: 13 |
| PublicationDecade | 1990 |
| PublicationPlace | Boston, MA |
| PublicationPlace_xml | – name: Boston, MA – name: United States – name: Boston |
| PublicationTitle | The New England journal of medicine |
| PublicationTitleAlternate | N Engl J Med |
| PublicationYear | 1999 |
| Publisher | Massachusetts Medical Society |
| Publisher_xml | – name: Massachusetts Medical Society |
| References | Vergel, RG, Sanchez, LR, Heredero, BL, Rodriguez, PL, Martinez, AJ (r006) 1990; 10 Dawber, TR, Moore, FE, Mann, GV (r015) 1957; 47 Oakley, GP (r013) 1998; 338 Selhub, J, Jacques, PF, Wilson, PWF, Rush, D, Rosenberg, IH (r014) 1993; 270 Tamura, T, Freeberg, LE, Cornwell, PE (r019) 1990; 36 Shin, YS, Rasshofer, R, Friedrich, B, Endres, W (r020) 1983; 127 Ubbink, JB, Vermaak, WJH, Becker, PJ, Delport, R, Potgieter, HC (r034) 1994; 124 Werler, MM, Shapiro, S, Mitchell, AA (r008) 1993; 269 Mulinare, J, Cordero, JF, Erickson, JD, Berry, RJ (r009) 1988; 260 Afman, L, Bagley, P, Selhub, J (r028) 1999; 13 Boushey, CJ, Beresford, SA, Omenn, GS, Motulsky, AG (r030) 1995; 274 Stampfer, MJ, Malinow, MR, Willett, WC (r035) 1992; 268 Arnesen, E, Refsum, H, Bonaa, KH, Ueland, PM, Forde, OH, Nordrehaug, JE (r036) 1995; 24 Laurence, KM, James, N, Miller, MH, Tennant, GB, Campbell, H (r005) 1981; 282 Landgren, F, Israelsson, B, Lindgren, A, Hultberg, B, Andersson, A, Brattstrom, L (r033) 1995; 237 Feinleib, M, Kannel, WB, Garrison, RJ, McNamara, PM, Castelli, WP (r016) 1975; 4 Malinow, MR, Duell, PB, Hess, DL (r024) 1998; 338 Smithells, RW, Nevin, NC, Seller, MJ (r007) 1983; 1 SAS user's guide, version 6. Cary, N.C.: SAS Institute, 1989. Verhoef, P, Stampfer, MJ, Buring, JE (r041) 1996; 143 Tucker, KL, Mahnken, B, Wilson, PWF, Jacques, P, Selhub, J (r029) 1996; 276 Rimm, ED, Giovannucci, EL, Stampfer, MJ, Colditz, GA, Litin, LB, Willett, WC (r021) 1992; 135 Herbert V, Das KC. Folic acid and vitamin B . In: Shils ME, Olson JA, Shike M, eds. Modern nutrition in health and disease. 8th ed. Vol. 1. Philadelphia: Lea & Febiger, 1994:402-25. Bower, C, Stanley, FJ (r011) 1989; 150 Wilcken, DEL, Dudman, NPB, Tyrrell, PA, Robertson, MR (r032) 1988; 37 (r002) 1992; 41 Czeizel, AE (r004) 1993; 306 Nygard, O, Nordrehaug, JE, Refsum, H, Ueland, PM, Farstad, M, Vollset, SE (r039) 1997; 337 Horne, DW, Patterson, D (r018) 1988; 34 Milunsky, A, Jick, H, Jick, SS (r010) 1989; 262 Hopkins, PN, Wu, LL, Wu, J (r026) 1995; 15 (r012) 1993; 58 Graham, IM, Daly, LE, Refsum, HM (r038) 1997; 277 Gregory, JF, Bailey, LB, Toth, JP, Williamson, J (r025) 1998; 12 Perry, IJ, Refsum, H, Morris, RW, Ebrahim, SB, Ueland, PM, Shaper, AG (r037) 1995; 346 Schorah, CJ, Devitt, H, Lucock, M, Dowell, AC (r027) 1988; 52 Rimm, EB, Willett, WC, Hu, FB (r040) 1998; 279 (r003) 1991; 338 (r001) 1996; 61 Araki, A, Sako, Y (r017) 1987; 422 Brattstrom, LE, Israelsson, B, Jeppsson, J-O, Hultberg, BL (r031) 1988; 48 Morrison, HI, Schaubel, D, Desmeules, M, Wigle, DT (r042) 1996; 275 Gregory JF (r025) 1998; 12 Horne DW (r018) 1988; 34 Afman L (r028) 1999; 13 r020 r042 r022 r023 r040 r017 r039 r013 r035 r014 r036 r015 r037 r016 r038 Verhoef P (r041) 1996; 143 Bower C (r011) 1989; 150 Rimm ED (r021) 1992; 135 r031 r010 r032 r033 Ubbink JB (r034) 1994; 124 r030 r006 r007 r029 r008 r009 Tamura T (r019) 1990; 36 r024 r003 r004 r026 r005 r027 10498471 - N Engl J Med. 1999 Sep 16;341(12):923; author reply 924 10498472 - N Engl J Med. 1999 Sep 16;341(12):923-4 10498470 - N Engl J Med. 1999 Sep 16;341(12):922-3; author reply 924 |
| References_xml | – volume: 276 start-page: 1879 year: 1996 end-page: 1885 ident: r029 article-title: Folic acid fortification of the food supply: potential benefits and risks for the elderly population. publication-title: JAMA – volume: 135 start-page: 1114 year: 1992 end-page: 1126 ident: r021 article-title: Reproducibility and validity of an expanded self-administered semiquantitative food frequency questionnaire among male health professionals. publication-title: Am J Epidemiol – reference: SAS user's guide, version 6. Cary, N.C.: SAS Institute, 1989. – volume: 13 start-page: A891 year: 1999 end-page: A891 ident: r028 article-title: Determination of folic acid in fortified cereal products using the affinity/HPLC method. publication-title: FASEB J – volume: 279 start-page: 359 year: 1998 end-page: 364 ident: r040 article-title: Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. publication-title: JAMA – volume: 1 start-page: 1027 year: 1983 end-page: 1031 ident: r007 article-title: Further experience of vitamin supplementation for prevention of neural tube defect recurrences. publication-title: Lancet – volume: 269 start-page: 1257 year: 1993 end-page: 1261 ident: r008 article-title: Periconceptional folic acid exposure and risk of occurrent neural tube defects. publication-title: JAMA – volume: 237 start-page: 381 year: 1995 end-page: 388 ident: r033 article-title: Plasma homocysteine in acute myocardial infarction: homocysteine-lowering effect of folic acid. publication-title: J Intern Med – volume: 277 start-page: 1775 year: 1997 end-page: 1781 ident: r038 article-title: Plasma homocysteine as a risk factor for vascular disease: the European Concerted Action Project. publication-title: JAMA – reference: Herbert V, Das KC. Folic acid and vitamin B . In: Shils ME, Olson JA, Shike M, eds. Modern nutrition in health and disease. 8th ed. Vol. 1. Philadelphia: Lea & Febiger, 1994:402-25. – volume: 338 start-page: 1009 year: 1998 end-page: 1015 ident: r024 article-title: Reduction of plasma homocyst(e)ine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease. publication-title: N Engl J Med – volume: 52 start-page: 407 year: 1988 end-page: 411 ident: r027 article-title: The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study. publication-title: Eur J Clin Nutr – volume: 422 start-page: 43 year: 1987 end-page: 52 ident: r017 article-title: Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection. publication-title: J Chromatogr – volume: 274 start-page: 1049 year: 1995 end-page: 1057 ident: r030 article-title: A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes. publication-title: JAMA – volume: 338 start-page: 131 year: 1991 end-page: 137 ident: r003 article-title: Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. publication-title: Lancet – volume: 338 start-page: 1060 year: 1998 end-page: 1061 ident: r013 article-title: Eat right and take a multivitamin. publication-title: N Engl J Med – volume: 47 start-page: 4 year: 1957 end-page: 24 ident: r015 article-title: Coronary heart disease in the Framingham study. publication-title: Am J Public Health – volume: 143 start-page: 845 year: 1996 end-page: 859 ident: r041 article-title: Homocysteine metabolism and risk of myocardial infarction: relation with vitamins B6, B12, and folate. publication-title: Am J Epidemiol – volume: 4 start-page: 518 year: 1975 end-page: 525 ident: r016 article-title: The Framingham Offspring Study: design and preliminary data. publication-title: Prev Med – volume: 127 start-page: 77 year: 1983 end-page: 85 ident: r020 article-title: Pyridoxal-5'-phosphate determination by a sensitive micromethod in human blood, urine and tissues: its relation to cystathioninuria in neuroblastoma and biliary atresia. publication-title: Clin Chim Acta – volume: 268 start-page: 877 year: 1992 end-page: 881 ident: r035 article-title: A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians. publication-title: JAMA – volume: 346 start-page: 1395 year: 1995 end-page: 1398 ident: r037 article-title: Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men. publication-title: Lancet – volume: 58 start-page: 53305 year: 1993 end-page: 53312 ident: r012 article-title: Fed Regist publication-title: Fed Regist – volume: 306 start-page: 1645 year: 1993 end-page: 1648 ident: r004 article-title: Prevention of congenital abnormalities by periconceptional multivitamin supplementation. publication-title: BMJ – volume: 48 start-page: 215 year: 1988 end-page: 221 ident: r031 article-title: Folic acid -- an innocuous means to reduce plasma homocysteine. publication-title: Scand J Clin Lab Invest – volume: 270 start-page: 2693 year: 1993 end-page: 2698 ident: r014 article-title: Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. publication-title: JAMA – volume: 36 start-page: 1993 year: 1990 end-page: 1993 ident: r019 article-title: Inhibition by EDTA of growth of Lactobacillus casei in the folate microbiological assay and its reversal by added manganese or iron. publication-title: Clin Chem – volume: 41 start-page: 1 year: 1992 end-page: 7 ident: r002 article-title: MMWR Morb Mortal Wkly Rep publication-title: MMWR Morb Mortal Wkly Rep – volume: 262 start-page: 2847 year: 1989 end-page: 2852 ident: r010 article-title: Multivitamin/folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects. publication-title: JAMA – volume: 34 start-page: 2357 year: 1988 end-page: 2359 ident: r018 article-title: Lactobacillus casei microbiological assay of folic acid derivatives in 96-well microtiter plates. publication-title: Clin Chem – volume: 15 start-page: 1314 year: 1995 end-page: 1320 ident: r026 article-title: Higher plasma homocyst(e)ine and increased susceptibility to adverse effects of low folate in early familial coronary artery disease. publication-title: Arterioscler Thromb Vasc Biol – volume: 24 start-page: 704 year: 1995 end-page: 709 ident: r036 article-title: Serum total homocysteine and coronary heart disease. publication-title: Int J Epidemiol – volume: 337 start-page: 230 year: 1997 end-page: 236 ident: r039 article-title: Plasma homocysteine levels and mortality in patients with coronary artery disease. publication-title: N Engl J Med – volume: 150 start-page: 613 year: 1989 end-page: 619 ident: r011 article-title: Dietary folate as a risk factor for neural-tube defects: evidence from a case-control study in Western Australia. publication-title: Med J Aust – volume: 282 start-page: 1509 year: 1981 end-page: 1511 ident: r005 article-title: Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects. publication-title: BMJ – volume: 10 start-page: 149 year: 1990 end-page: 152 ident: r006 article-title: Primary prevention of neural tube defects with folic acid supplementation: Cuban experience. publication-title: Prenat Diagn – volume: 124 start-page: 1927 year: 1994 end-page: 1933 ident: r034 article-title: Vitamin requirements for the treatment of hyperhomocysteinemia in humans. publication-title: J Nutr – volume: 275 start-page: 1893 year: 1996 end-page: 1896 ident: r042 article-title: Serum folate and risk of fatal coronary heart disease. publication-title: JAMA – volume: 61 start-page: 8781 year: 1996 end-page: 8797 ident: r001 article-title: Fed Regist publication-title: Fed Regist – volume: 260 start-page: 3141 year: 1988 end-page: 3145 ident: r009 article-title: Periconceptional use of multivitamins and the occurrence of neural tube defects. publication-title: JAMA – volume: 12 start-page: A511 year: 1998 end-page: A511 ident: r025 article-title: Kinetic model of folate metabolism in nonpregnant women chronically given [ H ]folic acid with three levels of total folate intake. publication-title: FASEB J – volume: 37 start-page: 697 year: 1988 end-page: 701 ident: r032 article-title: Folic acid lowers elevated plasma homocysteine in chronic renal insufficiency: possible implications for prevention of vascular disease. publication-title: Metabolism – volume: 34 start-page: 2357 year: 1988 ident: r018 publication-title: Clin Chem doi: 10.1093/clinchem/34.11.2357 – ident: r032 doi: 10.1016/0026-0495(88)90093-5 – ident: r004 doi: 10.1136/bmj.306.6893.1645 – ident: r024 doi: 10.1056/NEJM199804093381501 – ident: r010 doi: 10.1001/jama.262.20.2847 – ident: r038 doi: 10.1001/jama.277.22.1775 – ident: r031 doi: 10.3109/00365518809167487 – volume: 150 start-page: 613 year: 1989 ident: r011 publication-title: Med J Aust doi: 10.5694/j.1326-5377.1989.tb136723.x – ident: r027 doi: 10.1038/sj.ejcn.1600576 – volume: 135 start-page: 1114 year: 1992 ident: r021 publication-title: Am J Epidemiol doi: 10.1093/oxfordjournals.aje.a116211 – ident: r022 – ident: r030 doi: 10.1001/jama.274.13.1049 – ident: r008 doi: 10.1001/jama.269.10.1257 – ident: r015 doi: 10.2105/AJPH.47.4_Pt_2.4 – volume: 124 start-page: 1927 year: 1994 ident: r034 publication-title: J Nutr doi: 10.1093/jn/124.10.1927 – ident: r006 doi: 10.1002/pd.1970100303 – volume: 36 start-page: 1993 year: 1990 ident: r019 publication-title: Clin Chem doi: 10.1093/clinchem/36.11.1993 – ident: r017 doi: 10.1016/0378-4347(87)80438-3 – ident: r039 doi: 10.1056/NEJM199707243370403 – ident: r003 doi: 10.1016/0140-6736(91)90133-A – ident: r014 doi: 10.1001/jama.270.22.2693 – volume: 41 start-page: 1 year: 1992 ident: r002 publication-title: MMWR Morb Mortal Wkly Rep – ident: r026 doi: 10.1161/01.ATV.15.9.1314 – ident: r016 doi: 10.1016/0091-7435(75)90037-7 – ident: r037 doi: 10.1016/S0140-6736(95)92407-8 – ident: r033 doi: 10.1111/j.1365-2796.1995.tb01190.x – ident: r005 doi: 10.1136/bmj.282.6275.1509 – ident: r036 doi: 10.1093/ije/24.4.704 – volume: 61 start-page: 8781 year: 1996 ident: r001 publication-title: Fed Regist – volume: 143 start-page: 845 year: 1996 ident: r041 publication-title: Am J Epidemiol doi: 10.1093/oxfordjournals.aje.a008828 – ident: r042 doi: 10.1001/jama.275.24.1893 – volume: 58 start-page: 53305 year: 1993 ident: r012 publication-title: Fed Regist – ident: r013 doi: 10.1056/NEJM199804093381509 – ident: r023 – ident: r035 doi: 10.1001/jama.268.7.877 – ident: r020 doi: 10.1016/0009-8981(83)90077-3 – ident: r009 doi: 10.1001/jama.260.21.3141 – ident: r029 doi: 10.1001/jama.276.23.1879 – ident: r007 doi: 10.1016/S0140-6736(83)92654-5 – volume: 13 start-page: A891 year: 1999 ident: r028 publication-title: FASEB J – ident: r040 doi: 10.1001/jama.279.5.359 – volume: 12 start-page: A511 year: 1998 ident: r025 publication-title: FASEB J – reference: 10498472 - N Engl J Med. 1999 Sep 16;341(12):923-4 – reference: 10498471 - N Engl J Med. 1999 Sep 16;341(12):923; author reply 924 – reference: 10498470 - N Engl J Med. 1999 Sep 16;341(12):922-3; author reply 924 |
| SSID | ssj0000149 |
| Score | 2.2492514 |
| Snippet | Background In 1996, the Food and Drug Administration issued a regulation requiring all enriched grain products to be fortified with folic acid to reduce the... In 1996, the Food and Drug Administration (FDA) issued a regulation, to be effective by January 1998, requiring that all enriched flour, rice, pasta, cornmeal,... In 1996, the Food and Drug Administration issued a regulation requiring all enriched grain products to be fortified with folic acid to reduce the risk of... |
| SourceID | proquest pubmed pascalfrancis crossref mms fao |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1449 |
| SubjectTerms | Acids Adult Age Aged Aged, 80 and over Biological and medical sciences Birth defects blood plasma Case-Control Studies Cohort Studies Dietary Supplements Federal regulation Female folic acid Folic Acid - administration & dosage Folic Acid - blood Folic Acid Deficiency - drug therapy food fortification Food, Fortified General and cellular metabolism. Vitamins hematologic tests homocysteine Homocysteine - blood human health human nutrition Humans Male Medical sciences Middle age Middle Aged Older people Pharmacology. Drug treatments Vitamin B Vitamin B Complex - administration & dosage Womens health |
| SummonAdditionalLinks | – databaseName: New England Journal of Medicine Current dbid: DCD link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3RT54wEL84XZa9TDe3ydStDz6OWDha6KP59IsP05hME1-WppR2cRmwfHzu798V-PTTqHEJISSUAr07-juu9zuAPVkZg4VQsbTcx5lMHNmczWNPaMKWxude9InC3_LT0-LyUp0tJavfi-ALuR9qwodceR4qkWQh9ZmcnTXSNBUqNRxODpfYoka0O_4wWpAMPdzJnYnohTct7eu6C4sjTUfj44fCFo8jz34Gmq7_57NvwJsRarKDQTfewopr3sGrkzGYvgk_SEXYwF7MWs-mgSGYHdirig5n_RKiXmqMtjPC2LUJTQiaMtNU7Lwl1M6O27q1gQuaOmSTkAHZjDS83Xu4mB6dT47jsdpCbAmlzWOCJiUJiJeVEcplSY6V8lx6g2gr9IGXTXLvuLUeBSqXGOXS3El0WIksL_EDrDZt47aAUSdYEPIqjOOZS7DMhCKkVUlZoixkEkG6GHptRyryUBHjt-5D4kLqBwYugq83F_0ZmDiebr5FMtXmJ30r9cX3NERoCS5xAqAR7JGgdeN-1U_3sHtHE27vmpOTmqkItheaoUfD73Tal5onnzKCLzdnyWJDGMY0rr3udCj2jOQlP95CKnJ5MMEIPg4Kt_TCmHIs0k_Pe4VteD3QTIg4wR1Ync-u3S68tH_nV93sc289_wBv0AZi priority: 102 providerName: Massachusetts Medical Society |
| Title | Effect of Folic Acid Fortification on Plasma Folate and Total Homocysteine Concentrations |
| URI | http://dx.doi.org/10.1056/NEJM199905133401901 https://www.ncbi.nlm.nih.gov/pubmed/10320382 https://www.proquest.com/docview/223940259 https://www.proquest.com/docview/47353917 https://www.proquest.com/docview/69729313 |
| Volume | 340 |
| WOSCitedRecordID | wos000080198700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVBGY databaseName: New England Journal of Medicine Current customDbUrl: eissn: 1533-4406 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: DCD dateStart: 19900101 isFulltext: true titleUrlDefault: https://www.nejm.org/medical-index providerName: Massachusetts Medical Society – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1533-4406 dateEnd: 20250907 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: M7P dateStart: 19800103 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Consumer Health Database customDbUrl: eissn: 1533-4406 dateEnd: 20250907 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: M0R dateStart: 19800103 isFulltext: true titleUrlDefault: https://search.proquest.com/familyhealth providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1533-4406 dateEnd: 20250907 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: 7X7 dateStart: 19800103 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Healthcare Administration Database customDbUrl: eissn: 1533-4406 dateEnd: 20250907 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: M0T dateStart: 19800103 isFulltext: true titleUrlDefault: https://search.proquest.com/healthmanagement providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1533-4406 dateEnd: 20250907 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: 7RV dateStart: 19800103 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1533-4406 dateEnd: 20250907 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: BENPR dateStart: 19800103 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Public Health Database customDbUrl: eissn: 1533-4406 dateEnd: 20250907 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: 8C1 dateStart: 19800103 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Psychology Database (ProQuest) customDbUrl: eissn: 1533-4406 dateEnd: 20250907 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: M2M dateStart: 19800103 isFulltext: true titleUrlDefault: https://www.proquest.com/psychology providerName: ProQuest – providerCode: PRVPQU databaseName: Research Library (Proquest) customDbUrl: eissn: 1533-4406 dateEnd: 20250907 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: M2O dateStart: 19800103 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest – providerCode: PRVPQU databaseName: Science Database customDbUrl: eissn: 1533-4406 dateEnd: 20250907 omitProxy: false ssIdentifier: ssj0000149 issn: 0028-4793 databaseCode: M2P dateStart: 19800103 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3Pb9MwFLbYhtAu_GYLY8OHHYlmx4mdnBB0mzjQUpUN9YIix7FhiCal6fj7ec9xyyaxXpCqT63qOkrfs_057_l7hBzLWmuRZ0UsDXNxKrmFMWdU7IBNmEo75TJ_UPijGo3y6bQYh9ycLqRVruZEP1HXrcFn5CeJr-ENZP3t_FeMRaMwuBoqaGyRHY5LN7izmny5oR4V2G94gLQSHcrkCRaaxwP4DMubpHiemt9amLacbgFnsw6TJXUH_5frC13czUT9inT-6D_v5TF5GKgofdf7zhNyzzZPyYNhCLY_I1_BhWif70FbRx0qCFNtrmp4u_ApRt6qFF5z4OAzjU2AulLd1HTZAqun39tZa1ArGjqkBk9INkGmt3tOLs_PLgYf4lCNITbA4pYxUJcKDMiqWmeFTbkSdeGYdFoIUwuHum2SOcuMcSITheW6sImyUlhRZ6mqxAuy3bSN3ScUOhE5MLNcW5ZaLqo0K4CJ1VJWQuaSRyRZmaI0QaocK2b8LH3IPJPlP-wXkTfrH817pY7NzffBxqX-BnNpefk5wQgu0CkGBDUix2D4srE_Zpt7OLzlGX-vqmATmxYROVhZvwwTQ1euTR-R1-tvYURjmEY3tr3uSiwGLWAXfXcLWcCWSHARkb3eAW_csEiYyJOXG699QHZ79Yks5uIV2V4uru0huW9-L6-6xZEfRIhT5TEHzAf8iOy8PxuNJ_DpdHAKOGQTjxeIydDjJ49jRDX-AyI5JjM |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Nb9QwEB21BVEufENDKfWh3IjqxIkdHxBCQNWq2xUSrbQXZBzHhlYkWTZbED-K_8g4H0sr0b31gLSKVlrHSdbP4zfxzBuAHV5ozbJUhtxQFyY8sjjnjAgdsgmTaydc2iYKj8R4nE0m8sMK_B5yYXxY5WATW0Nd1Ma_I9-N2xreSNZfT7-HvmiU31wdKmh0qDi0v36ix9a8OniHw_sijvfeH7_dD_uiAqFBMjIPcQXO8T5oXuhU2iQSrJCOcqcZMwVzXn6MU2epMY6lTNpISxsLy5llRZqInGG_q3ADzbjwEWRiIi6oVfVsu39hNYgcpXzXF7b3Cf_Ul1NJfP52dGkhXHW6xmNZNj44Uzc4Pq4rrHE1821XwL27_9l_dw_u9FSbvOnmxn1YsdUDuHXUBxM8hE84RUgXz0JqR5xXSCbanBb4ddaGULWoJfiZoo9Rat8EqTnRVUHmNXot5Gtd1sZrYWOHxPgM0KqXIW4ewcm1PNxjWKvqym4AwU5Yhswz05YmNmJ5kkpkmgXnOeMZjwKIh6FXppdi9xVBvqk2JCDl6h94CeDl4qRpp0SyvPkGYkrpL7hWqJOPsd-hRrpIkYAHsINAU5U9K5f3sHUJiX-vKtBJT2QAmwPaVG_4GrWAWgDbi1_RYvltKF3Z-rxRvtg1k5G4ugWX6PKxiAXwpAP8hQdmMWVZ_HTptbdhff_4aKRGB-PDTbjdKW2kYcSewdp8dm634Kb5MT9tZs_bCUzg83Wj_g8p2Xfo |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1db9MwFL3aBpp44XssjDE_jDeiOnHsxA8IIUbFtK2axCbtBRnHsWGIJKXpQPw0_h3X-SibxPq2B6SqqlTXSZpj-9z43nMAdkWhNcu4DIWhLkxEZHHMmTR0yCZMrl3qeFsofJhOJtnZmTxegd9DLYxPqxzmxHaiLmrjn5GP4tbDG8n6yPVZEcd749fT76E3kPIbrYObRoeQA_vrJ0Zvzav9PbzVL-J4_O7k7fuwNxgIDRKTeYircY7nRPNCc2mTKGWFdFQ4zZgpmPNSZII6S41xjDNpIy1tnFrBLCt4kuYM-12FW2nCY59NdkRPLilX9cy7f3g1CB5xMfIm9774n3prlcTXckdXFsVVp2t8L8vGJ2rqBu-V60w2rmfB7Wo4vvcf_4_34W5Pwcmbbsw8gBVbPYT1oz7J4BF8xKFDujwXUjvivHIy0ea8wI-zNrWqRTPB1xRjj1L7JkjZia4KMq8xmiFf6rI2XiMbOyTGV4ZWvTxx8xhOb-TiNmCtqiu7CQQ7YRky0kxbmtiI5QmXyEALIXImMhEFEA8wUKaXaPdOId9UmyrAhfoHdgJ4ufjRtFMoWd58E_Gl9GdcQ9Tph9jvXCONpEjMA9hF0KnKfi2X97B9BZV_j5pi8J7IALYG5Kl-QmzUAnYB7Cy-xZnMb0_pytYXjfIm2ExG6fUthMRQkEUsgCcd-C9dMIspy-KnS4-9A-sIdnW4PznYgjudAAcPI_YM1uazC7sNt82P-Xkze96OZQKfbhr0fwAOgYC4 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+effect+of+folic+acid+fortification+on+plasma+folate+and+total+homocysteine+concentrations&rft.jtitle=The+New+England+journal+of+medicine&rft.au=JACQUES%2C+P.+F&rft.au=SELHUB%2C+J&rft.au=BOSTOM%2C+A.+G&rft.au=WILSON%2C+P.+W.+F&rft.date=1999-05-13&rft.pub=Massachusetts+Medical+Society&rft.issn=0028-4793&rft.volume=340&rft.issue=19&rft.spage=1449&rft.epage=1454&rft_id=info:doi/10.1056%2FNEJM199905133401901&rft.externalDBID=n%2Fa&rft.externalDocID=1789949 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-4793&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-4793&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-4793&client=summon |