Differential involvement of cortical and cerebellar areas using dominant and nondominant hands: An FMRI study

Motor fMRI studies, comparing dominant (DH) and nondominant (NDH) hand activations have reported mixed findings, especially for the extent of ipsilateral (IL) activations and their relationship with task complexity. To date, no study has directly compared DH and NDH activations using an event‐relate...

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Vydáno v:Human brain mapping Ročník 36; číslo 12; s. 5079 - 5100
Hlavní autoři: Alahmadi, Adnan A.S., Pardini, Matteo, Samson, Rebecca S., D'Angelo, Egidio, Friston, Karl J., Toosy, Ahmed T., Gandini Wheeler-Kingshott, Claudia A.M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Blackwell Publishing Ltd 01.12.2015
John Wiley & Sons, Inc
John Wiley and Sons Inc
Témata:
Adult
Brain Mapping
Cerebellum - blood supply
Cerebellum - physiology
Cerebral Cortex - blood supply
Cerebral Cortex - physiology
contra-lateral
dominant
Female
FMRI
force
Functional Laterality - physiology
Hand
Hand Strength - physiology
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Movement - physiology
Oxygen - blood
squeeze-ball
contra-lateral
force
squeeze-ball
dominant
FMRI
ISSN:1065-9471, 1097-0193, 1097-0193
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Popis
Shrnutí:Motor fMRI studies, comparing dominant (DH) and nondominant (NDH) hand activations have reported mixed findings, especially for the extent of ipsilateral (IL) activations and their relationship with task complexity. To date, no study has directly compared DH and NDH activations using an event‐related visually guided dynamic power‐grip paradigm with parametric (three) forces (GF) in healthy right‐handed subjects. We implemented a hierarchical statistical approach aimed to: (i) identify the main effect networks engaged when using either hand; (ii) characterise DH/NDH responses at different GFs; (iii) assess contralateral (CL)/IL‐specific and hemisphere‐specific activations. Beyond confirming previously reported results, this study demonstrated that increasing GF has an effect on motor response that is contextualised also by the use of DH or NDH. Linear analysis revealed increased activations in sensorimotor areas, with additional increased recruitments of subcortical and cerebellar areas when using the NDH. When looking at CL/IL‐specific activations, CL sensorimotor areas and IL cerebellum were activated with both hands. When performing the task with the NDH, several areas were also recruited including the CL cerebellum. Finally, there were hand‐side‐independent activations of nonmotor‐specific areas in the right and left hemispheres, with the right hemisphere being involved more extensively in sensori‐motor integration through associative areas while the left hemisphere showing greater activation at higher GF. This study shows that the functional networks subtending DH/NDH power‐grip visuomotor functions are qualitatively and quantitatively distinct and this should be taken into consideration when performing fMRI studies, particularly when planning interventions in patients with specific impairments. Hum Brain Mapp 36:5079–5100, 2015. © 2015 Wiley Periodicals, Inc.
Bibliografie:UKSACB
istex:39957DB2CC7D1527F47B2C7FEAC2E633E744EA17
MOE
ArticleID:HBM22997
KJF is funded by a Wellcome Trust Principal Research Fellowship (Ref: 088130/Z/09/Z)
National Institute for Health Research
AA is supported by KAU
MP thanks AKWO Association, Lavagna (Italy)
University College London
MS society of the UK
ark:/67375/WNG-VKZQXKW5-N
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ISSN:1065-9471
1097-0193
1097-0193
DOI:10.1002/hbm.22997