Evaluating Nephrocheck ® as a Predictive Tool for Acute Kidney Injury

Acute kidney injury (AKI) is a common complication in critically ill patients in the intensive settings with increased risks of short- and long-term complications and mortality. AKI is also associated with an increased length of stay in intensive care units (ICU) and worse kidney function recovery a...

Full description

Saved in:

Bibliographic Details
Published in:	International journal of nephrology and renovascular disease Vol. 13; pp. 85 - 96
Main Authors:	Nalesso, Federico, Cattarin, Leda, Gobbi, Laura, Fragasso, Antonio, Garzotto, Francesco, Calò, Lorenzo Arcangelo
Format:	Journal Article
Language:	English
Published:	New Zealand Dove Medical Press Limited 01.01.2020 Dove Dove Medical Press
Subjects:	acute kidney injury (aki) Biological markers creatinine critical care medicine Health aspects Hospital admission and discharge Insulin insulin-like growth factor binding protein 7 (igfbp-7) intensive care unit interleukin 18 (il-18) Interleukins kidney injury molecule 1 (kim-1) liver-type fatty acid binding protein (l-fabp) Medical research Mortality neutrophil gelatinase-associated lipocalin (ngal) Protein binding Review Setting (Literature) tissue inhibitor of metalloproteinase 2 (timp-2) urine output KIM-1 NGAL IGFBP-7 interleukin-18 L-FABP TIMP-2
ISSN:	1178-7058, 1178-7058
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Acute kidney injury (AKI) is a common complication in critically ill patients in the intensive settings with increased risks of short- and long-term complications and mortality. AKI is also associated with an increased length of stay in intensive care units (ICU) and worse kidney function recovery at hospital discharge. The management of AKI is one of the major challenges for nephrologists and intensivists overall for its early diagnosis. The current KDIGO criteria used to define AKI include the serum creatinine and urinary output that are neither sensitive nor specific markers of kidney function, since they can be altered only after hours from the kidney injury. In order to allow an early AKI detection, in the last years, several studies focused on the identification of new biomarkers. Among all these markers, urinary insulin-like growth factor-binding protein (IGFBP-7) and tissue inhibitor of metalloproteinase (TIMP-2) have been proven as the best-performing and have been proposed as a predictive tool for the AKI detection in the critical settings in order to perform an early diagnosis. Patients undergoing major surgery, cardiac surgery, those with hemodynamic instability or those with sepsis are believed to be the top priority patient populations for the biomarker test. In this view, the urinary [TIMP-2] x [IGFBP-7] becomes an important tool for the early detection of patients at high risk for AKI and its integration with the local ICU experience has to provide a multidisciplinary management of AKI with the institution of a rapid response team in order to assess patients and customize AKI management.
AbstractList	Acute kidney injury (AKI) is a common complication in critically ill patients in the intensive settings with increased risks of short- and long-term complications and mortality. AKI is also associated with an increased length of stay in intensive care units (ICU) and worse kidney function recovery at hospital discharge. The management of AKI is one of the major challenges for nephrologists and intensivists overall for its early diagnosis. The current KDIGO criteria used to define AKI include the serum creatinine and urinary output that are neither sensitive nor specific markers of kidney function, since they can be altered only after hours from the kidney injury. In order to allow an early AKI detection, in the last years, several studies focused on the identification of new biomarkers. Among all these markers, urinary insulin-like growth factor-binding protein (IGFBP-7) and tissue inhibitor of metalloproteinase (TIMP-2) have been proven as the best-performing and have been proposed as a predictive tool for the AKI detection in the critical settings in order to perform an early diagnosis. Patients undergoing major surgery, cardiac surgery, those with hemodynamic instability or those with sepsis are believed to be the top priority patient populations for the biomarker test. In this view, the urinary [TIMP-2] x [IGFBP-7] becomes an important tool for the early detection of patients at high risk for AKI and its integration with the local ICU experience has to provide a multidisciplinary management of AKI with the institution of a rapid response team in order to assess patients and customize AKI management. Acute kidney injury (AKI) is a common complication in critically ill patients in the intensive settings with increased risks of short- and long-term complications and mortality. AKI is also associated with an increased length of stay in intensive care units (ICU) and worse kidney function recovery at hospital discharge. The management of AKI is one of the major challenges for nephrologists and intensivists overall for its early diagnosis. The current KDIGO criteria used to define AKI include the serum creatinine and urinary output that are neither sensitive nor specific markers of kidney function, since they can be altered only after hours from the kidney injury. In order to allow an early AKI detection, in the last years, several studies focused on the identification of new biomarkers. Among all these markers, urinary insulin-like growth factor-binding protein (IGFBP-7) and tissue inhibitor of metalloproteinase (TIMP-2) have been proven as the best-performing and have been proposed as a predictive tool for the AKI detection in the critical settings in order to perform an early diagnosis. Patients undergoing major surgery, cardiac surgery, those with hemodynamic instability or those with sepsis are believed to be the top priority patient populations for the biomarker test. In this view, the urinary [TIMP-2] x [IGFBP-7] becomes an important tool for the early detection of patients at high risk for AKI and its integration with the local ICU experience has to provide a multidisciplinary management of AKI with the institution of a rapid response team in order to assess patients and customize AKI management.Acute kidney injury (AKI) is a common complication in critically ill patients in the intensive settings with increased risks of short- and long-term complications and mortality. AKI is also associated with an increased length of stay in intensive care units (ICU) and worse kidney function recovery at hospital discharge. The management of AKI is one of the major challenges for nephrologists and intensivists overall for its early diagnosis. The current KDIGO criteria used to define AKI include the serum creatinine and urinary output that are neither sensitive nor specific markers of kidney function, since they can be altered only after hours from the kidney injury. In order to allow an early AKI detection, in the last years, several studies focused on the identification of new biomarkers. Among all these markers, urinary insulin-like growth factor-binding protein (IGFBP-7) and tissue inhibitor of metalloproteinase (TIMP-2) have been proven as the best-performing and have been proposed as a predictive tool for the AKI detection in the critical settings in order to perform an early diagnosis. Patients undergoing major surgery, cardiac surgery, those with hemodynamic instability or those with sepsis are believed to be the top priority patient populations for the biomarker test. In this view, the urinary [TIMP-2] x [IGFBP-7] becomes an important tool for the early detection of patients at high risk for AKI and its integration with the local ICU experience has to provide a multidisciplinary management of AKI with the institution of a rapid response team in order to assess patients and customize AKI management. Acute kidney injury (AKI) is a common complication in critically ill patients in the intensive settings with increased risks of short- and long-term complications and mortality. AKI is also associated with an increased length of stay in intensive care units (ICU) and worse kidney function recovery at hospital discharge. The management of AKI is one of the major challenges for nephrologists and intensivists overall for its early diagnosis. The current KDIGO criteria used to define AKI include the serum creatinine and urinary output that are neither sensitive nor specific markers of kidney function, since they can be altered only after hours from the kidney injury. In order to allow an early AKI detection, in the last years, several studies focused on the identification of new biomarkers. Among all these markers, urinary insulin-like growth factor-binding protein (IGFBP-7) and tissue inhibitor of metalloproteinase (TIMP-2) have been proven as the best-performing and have been proposed as a predictive tool for the AKI detection in the critical settings in order to perform an early diagnosis. Patients undergoing major surgery, cardiac surgery, those with hemodynamic instability or those with sepsis are believed to be the top priority patient populations for the biomarker test. In this view, the urinary [TIMP-2] * [IGFBP-7] becomes an important tool for the early detection of patients at high risk for AKI and its integration with the local ICU experience has to provide a multidisciplinary management of AKI with the institution of a rapid response team in order to assess patients and customize AKI management. Keywords: TIMP-2, IGFBP-7, NGAL, KIM-1, interleukin-18, L-FABP Acute kidney injury (AKI) is a common complication in critically ill patients in the intensive settings with increased risks of short- and long-term complications and mortality. AKI is also associated with an increased length of stay in intensive care units (ICU) and worse kidney function recovery at hospital discharge. The management of AKI is one of the major challenges for nephrologists and intensivists overall for its early diagnosis. The current KDIGO criteria used to define AKI include the serum creatinine and urinary output that are neither sensitive nor specific markers of kidney function, since they can be altered only after hours from the kidney injury. In order to allow an early AKI detection, in the last years, several studies focused on the identification of new biomarkers. Among all these markers, urinary insulin-like growth factor-binding protein (IGFBP-7) and tissue inhibitor of metalloproteinase (TIMP-2) have been proven as the best-performing and have been proposed as a predictive tool for the AKI detection in the critical settings in order to perform an early diagnosis. Patients undergoing major surgery, cardiac surgery, those with hemodynamic instability or those with sepsis are believed to be the top priority patient populations for the biomarker test. In this view, the urinary [TIMP-2] * [IGFBP-7] becomes an important tool for the early detection of patients at high risk for AKI and its integration with the local ICU experience has to provide a multidisciplinary management of AKI with the institution of a rapid response team in order to assess patients and customize AKI management. Federico Nalesso,1 Leda Cattarin,1 Laura Gobbi,1 Antonio Fragasso,1 Francesco Garzotto,2 Lorenzo Arcangelo Calò1 1Department of Medicine, Nephrology, Dialysis and Transplantation Unit, University of Padova, Padova, Italy; 2Healthcare Directorate Unit, Veneto Institute of Oncology IOV-IRCCS, Padova, ItalyCorrespondence: Federico NalessoDepartment of Medicine, Nephrology, Dialysis and Transplantation Unit, University of Padova, Via Giustiniani, 2, Padova 35128, ItalyTel +39 049 8213128Email federico.nalesso@aopd.veneto.itAbstract: Acute kidney injury (AKI) is a common complication in critically ill patients in the intensive settings with increased risks of short- and long-term complications and mortality. AKI is also associated with an increased length of stay in intensive care units (ICU) and worse kidney function recovery at hospital discharge. The management of AKI is one of the major challenges for nephrologists and intensivists overall for its early diagnosis. The current KDIGO criteria used to define AKI include the serum creatinine and urinary output that are neither sensitive nor specific markers of kidney function, since they can be altered only after hours from the kidney injury. In order to allow an early AKI detection, in the last years, several studies focused on the identification of new biomarkers. Among all these markers, urinary insulin-like growth factor-binding protein (IGFBP-7) and tissue inhibitor of metalloproteinase (TIMP-2) have been proven as the best-performing and have been proposed as a predictive tool for the AKI detection in the critical settings in order to perform an early diagnosis. Patients undergoing major surgery, cardiac surgery, those with hemodynamic instability or those with sepsis are believed to be the top priority patient populations for the biomarker test. In this view, the urinary [TIMP-2] x [IGFBP-7] becomes an important tool for the early detection of patients at high risk for AKI and its integration with the local ICU experience has to provide a multidisciplinary management of AKI with the institution of a rapid response team in order to assess patients and customize AKI management.Keywords: TIMP-2, IGFBP-7, NGAL, KIM-1, interleukin-18, L-FABP
Audience	Academic
Author	Gobbi, Laura Nalesso, Federico Garzotto, Francesco Cattarin, Leda Calò, Lorenzo Arcangelo Fragasso, Antonio
Author_xml	– sequence: 1 givenname: Federico orcidid: 0000-0002-1167-2764 surname: Nalesso fullname: Nalesso, Federico – sequence: 2 givenname: Leda surname: Cattarin fullname: Cattarin, Leda – sequence: 3 givenname: Laura surname: Gobbi fullname: Gobbi, Laura – sequence: 4 givenname: Antonio orcidid: 0000-0002-6964-0183 surname: Fragasso fullname: Fragasso, Antonio – sequence: 5 givenname: Francesco surname: Garzotto fullname: Garzotto, Francesco – sequence: 6 givenname: Lorenzo Arcangelo surname: Calò fullname: Calò, Lorenzo Arcangelo
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/32425580$$D View this record in MEDLINE/PubMed
BookMark	eNqNkt9u0zAUhyM0xMbYJbcoEhLipsV2Ev-5QarGBoVpIBjX1ql90nqkcbGTSn0pHoInw13L1iLQSCI5sr_zncT-Pc4OWt9ilj2lZMhoKV6N319-fjP8QpVkjD3IjigVciBIJQ923g-zkxivSboKxTljj7LDgpWsqiQ5ys7PltD00Ll2ml_iYha8maH5lv_8kUPMIf8U0DrTuSXmV943ee1DPjJ9h_kHZ1tc5eP2ug-rJ9nDGpqIJ9vxOPt6fnZ1-m5w8fHt-HR0MTC8VN3AVkpOagGsMga4wCI9KCopa2UVR2mEKUlZALHcKFpQNLW1NRpbVQVnxBbH2XjjtR6u9SK4OYSV9uD0zYQPUw2hc6ZBzSsBgGgJEXVJEWHCKQA3RnGKE1Mm1-uNa9FP5mgNtl2AZk-6v9K6mZ76pRZUKirXgpdbQfDfe4ydnrtosGmgRd9HzUrCCyLLUib0-QadQvo019Y-Gc0a1yPOOBfpXPg9VMFVRdS67fAvVLotzp1JAaldmt_T_mfBXYcXOwUzhKabRd_0nfNt3DffA94Zn-3u9e0m_w5iAgYbwAQfY8D6FqFEr7Oub7Kut1lPfPEHb1wH677p31zzj6pfS1D-fw
CitedBy_id	crossref_primary_10_3166_afmu_2022_0438 crossref_primary_10_3389_fmed_2024_1386018 crossref_primary_10_1007_s12519_025_00965_9 crossref_primary_10_1111_jocs_16200 crossref_primary_10_3390_jcm11144027 crossref_primary_10_1080_0886022X_2024_2419523 crossref_primary_10_3233_NPM_230120 crossref_primary_10_1007_s00467_021_05403_2 crossref_primary_10_1016_j_jclinane_2023_111188 crossref_primary_10_3389_fmed_2022_847129 crossref_primary_10_3390_biomedicines11082111 crossref_primary_10_2215_CJN_16541221 crossref_primary_10_1016_j_trim_2023_101934 crossref_primary_10_1371_journal_pone_0307938 crossref_primary_10_3390_jcm10143113 crossref_primary_10_1053_j_jvca_2021_10_013 crossref_primary_10_3390_jcm11226752 crossref_primary_10_3390_jcm12124083 crossref_primary_10_1111_jvim_17143 crossref_primary_10_23938_ASSN_1081 crossref_primary_10_1016_j_cca_2025_120325 crossref_primary_10_1186_s13052_025_01899_8 crossref_primary_10_1002_ehf2_13955 crossref_primary_10_1016_j_jclinane_2024_111458 crossref_primary_10_3390_jcm12165201 crossref_primary_10_1016_j_jsams_2022_10_012 crossref_primary_10_3390_medicina57101076 crossref_primary_10_1038_s41598_023_38242_2 crossref_primary_10_1177_03913988211043203 crossref_primary_10_3390_diagnostics13010079
Cites_doi	10.1515/cclm-2018-0776 10.1159/000445462 10.1371/journal.pone.0093460 10.1186/s13054-014-0606-x 10.1007/s11255-017-1556-4 10.1093/ndt/gfy227 10.1016/j.jtcvs.2018.08.090 10.1097/CCM.0000000000001827 10.1186/s13054-017-1665-6 10.1159/000445460 10.1159/000452402 10.1001/jama.294.7.813 10.1111/tri.12636 10.1159/000485591 10.1053/j.jvca.2017.04.024 10.1177/0391398819852958 10.1186/s13054-019-2504-8 10.1016/j.transproceed.2017.09.023 10.1038/kisup.2011.32 10.26355/eurrev_201806_15180 10.1159/000445461 10.1159/000502837 10.1093/ndt/gfq136 10.1097/TP.0000000000002472 10.1001/jamainternmed.2019.6390 10.1186/s13054-016-1373-7 10.1038/nrneph.2012.197 10.1001/jama.2017.16326 10.1016/j.accpm.2018.05.001 10.1155/2019/3471215 10.1016/j.nefro.2017.11.013 10.1007/s00134-015-3934-7 10.1186/cc12503 10.1016/j.resuscitation.2019.06.008 10.1007/978-1-4939-0888-2_2 10.5301/ijao.5000661 10.1097/SHK.0000000000000052 10.1371/journal.pone.0120863 10.1186/cc2872 10.1186/s13054-019-2341-9 10.1016/j.athoracsur.2017.12.034 10.1186/s13054-019-2390-0 10.1159/000503443 10.1053/j.ajkd.2015.12.033 10.1111/tri.13148 10.1186/s13613-017-0317-y 10.2147/IJNRD.S135271 10.1515/cclm-2016-0973 10.1159/000479298 10.1186/s13054-014-0717-4 10.1186/s13054-018-2042-9 10.1002/clc.22683 10.1186/s12885-019-6233-9 10.3389/fphys.2016.00286 10.1038/nm.2144 10.1038/ki.2013.153 10.1016/j.semnephrol.2011.11.003 10.1053/j.jvca.2015.06.017 10.1007/s00134-016-4670-3 10.1161/JAHA.118.008834 10.1016/S0140-6736(05)74811-X 10.1186/cc11240 10.1186/s13054-016-1503-2
ContentType	Journal Article
Copyright	2020 Nalesso et al. COPYRIGHT 2020 Dove Medical Press Limited 2020 Nalesso et al. 2020 Nalesso et al.
Copyright_xml	– notice: 2020 Nalesso et al. – notice: COPYRIGHT 2020 Dove Medical Press Limited – notice: 2020 Nalesso et al. 2020 Nalesso et al.
DBID	AAYXX CITATION NPM 7X8 5PM DOA
DOI	10.2147/IJNRD.S198222
DatabaseName	CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef PubMed MEDLINE - Academic
DatabaseTitleList	PubMed MEDLINE - Academic
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
DocumentTitleAlternate	Nalesso et al
EISSN	1178-7058
EndPage	96
ExternalDocumentID	oai_doaj_org_article_657aaeed007f41eeab61aa6cc961ebc4 PMC7189184 A626676226 A623695094 32425580 10_2147_IJNRD_S198222
Genre	Journal Article Review
GroupedDBID	--- 0YH 29J 2WC 53G 5VS 7X7 8FE 8FH 8FI 8FJ 8G5 AAYXX ABUWG ADBBV ADRAZ AFFHD AFKRA ALMA_UNASSIGNED_HOLDINGS AOIJS AQTUD AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI CCPQU CITATION DIK DWQXO E3Z EBD FYUFA GNUQQ GROUPED_DOAJ GUQSH GX1 HCIFZ HMCUK HYE IAO IHR IHW IPNFZ ITC KQ8 LK8 M2O M48 M7P M~E O5R O5S OK1 P2P PGMZT PHGZM PHGZT PIMPY PQGLB PQQKQ PROAC RIG RPM TDBHL TR2 UKHRP VDV ALIPV NPM 7X8 PUEGO 5PM
ID	FETCH-LOGICAL-c649t-d598bf7a25cca67e37e3e7588f9d96e8c7c4043a0d6c9131ecfddfecd553620d3
IEDL.DBID	DOA
ISICitedReferencesCount	32
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000528699800001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1178-7058
IngestDate	Fri Oct 03 12:50:21 EDT 2025 Tue Nov 04 01:56:44 EST 2025 Thu Sep 04 17:34:53 EDT 2025 Tue Nov 11 10:22:29 EST 2025 Tue Nov 11 10:04:55 EST 2025 Tue Nov 04 18:08:56 EST 2025 Tue Nov 04 17:52:21 EST 2025 Thu May 22 21:24:06 EDT 2025 Thu May 22 21:22:32 EDT 2025 Thu Jan 02 22:58:24 EST 2025 Sat Nov 29 05:58:41 EST 2025 Tue Nov 18 21:54:02 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Keywords	KIM-1 NGAL IGFBP-7 interleukin-18 L-FABP TIMP-2
Language	English
License	http://creativecommons.org/licenses/by-nc/3.0 2020 Nalesso et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c649t-d598bf7a25cca67e37e3e7588f9d96e8c7c4043a0d6c9131ecfddfecd553620d3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ORCID	0000-0002-6964-0183 0000-0002-1167-2764
OpenAccessLink	https://doaj.org/article/657aaeed007f41eeab61aa6cc961ebc4
PMID	32425580
PQID	2406308448
PQPubID	23479
PageCount	12
ParticipantIDs	doaj_primary_oai_doaj_org_article_657aaeed007f41eeab61aa6cc961ebc4 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7189184 proquest_miscellaneous_2406308448 gale_infotracmisc_A626676226 gale_infotracmisc_A623695094 gale_infotracacademiconefile_A626676226 gale_infotracacademiconefile_A623695094 gale_healthsolutions_A626676226 gale_healthsolutions_A623695094 pubmed_primary_32425580 crossref_primary_10_2147_IJNRD_S198222 crossref_citationtrail_10_2147_IJNRD_S198222
PublicationCentury	2000
PublicationDate	2020-01-01
PublicationDateYYYYMMDD	2020-01-01
PublicationDate_xml	– month: 01 year: 2020 text: 2020-01-01 day: 01
PublicationDecade	2020
PublicationPlace	New Zealand
PublicationPlace_xml	– name: New Zealand
PublicationTitle	International journal of nephrology and renovascular disease
PublicationTitleAlternate	Int J Nephrol Renovasc Dis
PublicationYear	2020
Publisher	Dove Medical Press Limited Dove Dove Medical Press
Publisher_xml	– name: Dove Medical Press Limited – name: Dove – name: Dove Medical Press
References	Atici (ref35) 2018; 22 Meola (ref57) 2016; 188 Ismail (ref33) 2012; 32 Oezkur (ref21) 2017; 42 Cummings (ref19) 2019; 157 Schmitt (ref38) 2018; 31 Meersch (ref18) 2014; 9 Honore (ref42) 2016; 44 Di Leo (ref10) 2018; 45 Adler (ref30) 2018; 22 Ortega (ref11) 2018; 38 Schanz (ref48) 2017; 10 van der Vorst (ref46) 2019; 19 Toprak (ref49) 2017; 49 Nadim (ref17) 2018; 7 L’Acqua (ref51) 2019; 42 Mayer (ref20) 2017; 31 Grieshaber (ref23) 2019 Noto (ref50) 2019; 23 Husain-Syed (ref54) 2018; 105 Kashani (ref55) 2017; 55 Schanz (ref34) 2017; 40 Maizel (ref43) 2019; 2019 McCullough (ref62) 2019; 9 Bank (ref39) 2019; 103 Uchino (ref1) 2005; 294 Cuartero (ref41) 2017; 7 Bellomo (ref4) 2004; 8 Husain-Syed (ref6) 2019; 34 House (ref32) 2010; 25 Rundgren (ref28) 2019; 23 Cho (ref64) 2019 Meersch (ref26) 2017; 43 Yang (ref36) 2017; 49 Pianta (ref37) 2015; 28 Lewington (ref47) 2013; 84 Ronco (ref61) 2019; 9 Kellum (ref2) 2012; 2 Haase (ref5) 2012; 8 Birnie (ref24) 2014; 18 Titeca-Beauport (ref31) 2019; 141 Zaouter (ref22) 2018; 37 James (ref65) 2017; 318 Hu (ref16) 2016; 30 Guzzi (ref67) 2019; 23 Barnum (ref13) 2014; 1170 Gocze (ref45) 2015; 10 Kashani (ref15) 2013; 17 Clark (ref44) 2017; 21 Ronco (ref52) 2012; 16 Hsu (ref66) 2020; 180 Samoni (ref56) 2016; 7 Hoste (ref3) 2015; 41 Wetz (ref25) 2015; 19 Wang (ref40) 2018; 24 Yang (ref14) 2010; 16 Rizo-Topete (ref60) 2017; 43 Mishra (ref7) 2005; 365 Ronco (ref53) 2016; 20 Beitland (ref29) 2016; 20 Gomez (ref12) 2014; 41 Meola (ref59) 2016; 188 Meola (ref58) 2016; 188 Levante (ref27) 2017; 40 Vijayan (ref63) 2016; 68 Fan (ref9) 2019; 57 Murray (ref8) 2020; 180
References_xml	– volume: 57 start-page: 567 year: 2019 ident: ref9 publication-title: Clin Chem Lab Med doi: 10.1515/cclm-2018-0776 – volume: 188 start-page: 21 year: 2016 ident: ref59 publication-title: Contrib Nephrol doi: 10.1159/000445462 – volume: 9 start-page: e93460 year: 2014 ident: ref18 publication-title: PLoS One doi: 10.1371/journal.pone.0093460 – volume: 18 start-page: 606 year: 2014 ident: ref24 publication-title: Crit Care doi: 10.1186/s13054-014-0606-x – volume: 49 start-page: 1041 year: 2017 ident: ref49 publication-title: Int Urol Nephrol doi: 10.1007/s11255-017-1556-4 – year: 2019 ident: ref23 publication-title: Thorac Cardiovasc Surg – volume: 34 start-page: 308 year: 2019 ident: ref6 publication-title: Nephrol Dial Transplant doi: 10.1093/ndt/gfy227 – volume: 157 start-page: 1545 year: 2019 ident: ref19 publication-title: J Thorac Cardiovasc Surg doi: 10.1016/j.jtcvs.2018.08.090 – volume: 44 start-page: 1851 year: 2016 ident: ref42 publication-title: Crit Care Med doi: 10.1097/CCM.0000000000001827 – volume: 21 start-page: 92 year: 2017 ident: ref44 publication-title: Crit Care doi: 10.1186/s13054-017-1665-6 – volume: 188 start-page: 1 year: 2016 ident: ref58 publication-title: Contrib Nephrol doi: 10.1159/000445460 – volume: 43 start-page: 82 year: 2017 ident: ref60 publication-title: Blood Purif doi: 10.1159/000452402 – volume: 294 start-page: 813 year: 2005 ident: ref1 publication-title: JAMA. doi: 10.1001/jama.294.7.813 – volume: 28 start-page: 1392 year: 2015 ident: ref37 publication-title: Transpl Int doi: 10.1111/tri.12636 – volume: 45 start-page: 270 year: 2018 ident: ref10 publication-title: Blood Purif doi: 10.1159/000485591 – volume: 31 start-page: 2072 year: 2017 ident: ref20 publication-title: J Cardiothorac Vasc Anesth doi: 10.1053/j.jvca.2017.04.024 – volume: 42 start-page: 665 year: 2019 ident: ref51 publication-title: Int J Artif Organs doi: 10.1177/0391398819852958 – volume: 23 start-page: 225 year: 2019 ident: ref67 publication-title: Crit Care doi: 10.1186/s13054-019-2504-8 – volume: 49 start-page: 2050 year: 2017 ident: ref36 publication-title: Transplant Proc doi: 10.1016/j.transproceed.2017.09.023 – volume: 2 start-page: 19 year: 2012 ident: ref2 publication-title: Kidney Int Suppl doi: 10.1038/kisup.2011.32 – volume: 22 start-page: 3534 year: 2018 ident: ref35 publication-title: Eur Rev Med Pharmacol Sci doi: 10.26355/eurrev_201806_15180 – volume: 188 start-page: 11 year: 2016 ident: ref57 publication-title: Contrib Nephrol doi: 10.1159/000445461 – volume: 9 start-page: 358 year: 2019 ident: ref62 publication-title: Cardiorenal Med doi: 10.1159/000502837 – volume: 25 start-page: 1416 year: 2010 ident: ref32 publication-title: Nephrol Dial Transplant doi: 10.1093/ndt/gfq136 – volume: 103 start-page: 1014 year: 2019 ident: ref39 publication-title: Transplantation doi: 10.1097/TP.0000000000002472 – volume: 180 start-page: 402 year: 2020 ident: ref66 publication-title: JAMA Intern Med doi: 10.1001/jamainternmed.2019.6390 – volume: 20 start-page: 201 year: 2016 ident: ref53 publication-title: Crit Care doi: 10.1186/s13054-016-1373-7 – start-page: 23 year: 2019 ident: ref64 publication-title: Korean J Intern Med – volume: 8 start-page: 735 year: 2012 ident: ref5 publication-title: Nat Rev Nephrol doi: 10.1038/nrneph.2012.197 – volume: 318 start-page: 1787 year: 2017 ident: ref65 publication-title: JAMA doi: 10.1001/jama.2017.16326 – volume: 37 start-page: 335 year: 2018 ident: ref22 publication-title: Anaesth Crit Care Pain Med doi: 10.1016/j.accpm.2018.05.001 – volume: 2019 start-page: 3471215 year: 2019 ident: ref43 publication-title: Dis Markers doi: 10.1155/2019/3471215 – volume: 38 start-page: 361 year: 2018 ident: ref11 publication-title: Nefrologia doi: 10.1016/j.nefro.2017.11.013 – volume: 41 start-page: 1411 year: 2015 ident: ref3 publication-title: Intensive Care Med doi: 10.1007/s00134-015-3934-7 – volume: 17 start-page: R25 year: 2013 ident: ref15 publication-title: Crit Care doi: 10.1186/cc12503 – volume: 141 start-page: 104 year: 2019 ident: ref31 publication-title: Resuscitation doi: 10.1016/j.resuscitation.2019.06.008 – volume: 1170 start-page: 29 year: 2014 ident: ref13 publication-title: Methods Mol Biol doi: 10.1007/978-1-4939-0888-2_2 – volume: 40 start-page: 714 year: 2017 ident: ref27 publication-title: Int J Artif Organs doi: 10.5301/ijao.5000661 – volume: 41 start-page: 3 year: 2014 ident: ref12 publication-title: Shock doi: 10.1097/SHK.0000000000000052 – volume: 10 start-page: e0120863 year: 2015 ident: ref45 publication-title: PLoS One doi: 10.1371/journal.pone.0120863 – volume: 8 start-page: R204 year: 2004 ident: ref4 publication-title: Crit Care doi: 10.1186/cc2872 – volume: 23 start-page: 1 year: 2019 ident: ref50 publication-title: Crit Care doi: 10.1186/s13054-019-2341-9 – volume: 105 start-page: 1094 year: 2018 ident: ref54 publication-title: Ann Thorac Surg doi: 10.1016/j.athoracsur.2017.12.034 – volume: 23 start-page: 1 year: 2019 ident: ref28 publication-title: Crit Care doi: 10.1186/s13054-019-2390-0 – volume: 9 start-page: 354 year: 2019 ident: ref61 publication-title: Cardiorenal Med doi: 10.1159/000503443 – volume: 68 start-page: 19 year: 2016 ident: ref63 publication-title: AJKD doi: 10.1053/j.ajkd.2015.12.033 – volume: 31 start-page: 751 year: 2018 ident: ref38 publication-title: Transpl Int doi: 10.1111/tri.13148 – volume: 7 start-page: 92 year: 2017 ident: ref41 publication-title: Ann Intensive Care doi: 10.1186/s13613-017-0317-y – volume: 180 start-page: 513 year: 2020 ident: ref8 publication-title: Kidney Int – volume: 10 start-page: 17581 year: 2017 ident: ref48 publication-title: Int J Nephrol Renovasc Dis doi: 10.2147/IJNRD.S135271 – volume: 55 start-page: 1074 year: 2017 ident: ref55 publication-title: Clin Chem Lab Med doi: 10.1515/cclm-2016-0973 – volume: 42 start-page: 456 year: 2017 ident: ref21 publication-title: Kidney Blood Press Res doi: 10.1159/000479298 – volume: 19 start-page: 3 year: 2015 ident: ref25 publication-title: Crit Care doi: 10.1186/s13054-014-0717-4 – volume: 22 start-page: 1 year: 2018 ident: ref30 publication-title: Crit Care doi: 10.1186/s13054-018-2042-9 – volume: 40 start-page: 485 year: 2017 ident: ref34 publication-title: Clin Cardiol doi: 10.1002/clc.22683 – volume: 19 start-page: 1066 year: 2019 ident: ref46 publication-title: BMC Cancer doi: 10.1186/s12885-019-6233-9 – volume: 7 start-page: 286 year: 2016 ident: ref56 publication-title: Front Physiol doi: 10.3389/fphys.2016.00286 – volume: 16 start-page: 535 year: 2010 ident: ref14 publication-title: Nat Med doi: 10.1038/nm.2144 – volume: 84 start-page: 457 year: 2013 ident: ref47 publication-title: Kidney Int doi: 10.1038/ki.2013.153 – volume: 32 start-page: 18 year: 2012 ident: ref33 publication-title: Semin Nephrol doi: 10.1016/j.semnephrol.2011.11.003 – volume: 30 start-page: 82 year: 2016 ident: ref16 publication-title: J Cardiothorac Vasc Anesth doi: 10.1053/j.jvca.2015.06.017 – volume: 43 start-page: 1551 year: 2017 ident: ref26 publication-title: Intensive Care Med doi: 10.1007/s00134-016-4670-3 – volume: 24 start-page: 6937947 year: 2018 ident: ref40 publication-title: Biomed Res Int – volume: 7 year: 2018 ident: ref17 publication-title: J Am Heart Assoc doi: 10.1161/JAHA.118.008834 – volume: 365 start-page: 1231 year: 2005 ident: ref7 publication-title: Lancet doi: 10.1016/S0140-6736(05)74811-X – volume: 16 start-page: 313 year: 2012 ident: ref52 publication-title: Crit Care doi: 10.1186/cc11240 – volume: 20 start-page: 1 year: 2016 ident: ref29 publication-title: Crit Care doi: 10.1186/s13054-016-1503-2
SSID	ssj0000396622
Score	2.3076477
SecondaryResourceType	review_article
Snippet	Acute kidney injury (AKI) is a common complication in critically ill patients in the intensive settings with increased risks of short- and long-term... Federico Nalesso,1 Leda Cattarin,1 Laura Gobbi,1 Antonio Fragasso,1 Francesco Garzotto,2 Lorenzo Arcangelo Calò1 1Department of Medicine, Nephrology, Dialysis...
SourceID	doaj pubmedcentral proquest gale pubmed crossref
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	85
SubjectTerms	acute kidney injury (aki) Biological markers creatinine critical care medicine Health aspects Hospital admission and discharge Insulin insulin-like growth factor binding protein 7 (igfbp-7) intensive care unit interleukin 18 (il-18) Interleukins kidney injury molecule 1 (kim-1) liver-type fatty acid binding protein (l-fabp) Medical research Mortality neutrophil gelatinase-associated lipocalin (ngal) Protein binding Review Setting (Literature) tissue inhibitor of metalloproteinase 2 (timp-2) urine output
Title	Evaluating Nephrocheck ® as a Predictive Tool for Acute Kidney Injury
URI	https://www.ncbi.nlm.nih.gov/pubmed/32425580 https://www.proquest.com/docview/2406308448 https://pubmed.ncbi.nlm.nih.gov/PMC7189184 https://doaj.org/article/657aaeed007f41eeab61aa6cc961ebc4
Volume	13
WOSCitedRecordID	wos000528699800001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1178-7058 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000396622 issn: 1178-7058 databaseCode: DOA dateStart: 20080101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1178-7058 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000396622 issn: 1178-7058 databaseCode: M~E dateStart: 20080101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1178-7058 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000396622 issn: 1178-7058 databaseCode: M7P dateStart: 20080101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1178-7058 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000396622 issn: 1178-7058 databaseCode: 7X7 dateStart: 20080101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1178-7058 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000396622 issn: 1178-7058 databaseCode: BENPR dateStart: 20080101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1178-7058 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000396622 issn: 1178-7058 databaseCode: PIMPY dateStart: 20080101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVPQU databaseName: Research Library customDbUrl: eissn: 1178-7058 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000396622 issn: 1178-7058 databaseCode: M2O dateStart: 20080101 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest – providerCode: PRVAWR databaseName: Taylor & Francis Open Access customDbUrl: eissn: 1178-7058 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000396622 issn: 1178-7058 databaseCode: 0YH dateStart: 20081201 isFulltext: true titleUrlDefault: https://www.tandfonline.com providerName: Taylor & Francis
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lj9MwELZgQYgL4k1gKUZCcCFsnIcfxy50RYGGaFlQ9xS5tgOFVYr6QOJP8SP4Zcw42agRj70gRT7EEyv5ZuyZSZxvCHkUa2s0S3jIk8SGqU5ZqF0qQy650yqOhPK1CD68EXkup1NVbJX6wj1hDT1wA9wez4TWsJCDL6tS5pyecaY1N0Zx5mbGM4HCiFvJlF-DEwjj_ScExiBNElEmG4JNLMuzN36VH7549o4hd13cc0iet__31XnLPfW3Tm75ooOr5EobRNJhc_PXyDlXXyeXJu1n8htkNGo5vOuPNHegLiyLZb78_EH1impaLFES1zl6tFicUIhb6dBs1o6-ntvafafj-jNAfZO8PxgdPX8ZtvUSQsNTtQ5tpuSsEjrOQC1cuAQOB_mArJRV3EkjDHLp6Mhyo1jCnKmsrZyxWQZuLLLJLbJTL2p3h1BbydRUmYFsyKZGYIEhIzhDvEzk0iwgT09BK01LJo41LU5KSCoQ49JjXLYYB-RxJ_61YdH4m-A-aqATQvJrfwJMomxNojzLJALyAPVXNn-SdlO4HEKoxxUyBv5DAvf8QkgakCdeAqc5PJjR7d8KAA8SZvXGOlOyG3O3JwkT2fQG-nN3d_XDU3MssQs3x9VusVmVGJQlkYREOyC3G_PsAMR4OctkFBDRM9wewv2eev7J04xD1KIg_7_7P1Ryj1yO8UWFf3e1S3bWy427Ty6ab-v5ajkg58VU-FYOyIX9UV4cDvx8hnYSv8VWFNBTjCfF8S9yF089
linkProvider	Directory of Open Access Journals
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Evaluating+Nephrocheck%5BR%5D+as+a+Predictive+Tool+for+Acute+Kidney+Injury&rft.jtitle=International+journal+of+nephrology+and+renovascular+disease&rft.au=Nalesso%2C+Federico&rft.au=Fragasso%2C+Antonio&rft.au=Gobbi%2C+Laura&rft.au=Garzotto%2C+Francesco&rft.date=2020-01-01&rft.pub=Dove+Medical+Press+Limited&rft.issn=1178-7058&rft.eissn=1178-7058&rft.spage=85&rft_id=info:doi/10.2147%2FIJNRD.S198222&rft.externalDBID=n%2Fa&rft.externalDocID=A623695094
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1178-7058&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1178-7058&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1178-7058&client=summon