Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans

Upstream ORFs (uORFs) are mRNA elements defined by a start codon in the 5' UTR that is out-of-frame with the main coding sequence. Although uORFs are present in approximately half of human and mouse transcripts, no study has investigated their global impact on protein expression. Here, we repor...

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Bibliographic Details

Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 106; no. 18; pp. 7507 - 7512
Main Authors:	Calvo, Sarah E, Pagliarini, David J, Mootha, Vamsi K
Format:	Journal Article
Language:	English
Published:	United States 05.05.2009
Subjects:	5' Untranslated Regions - genetics Base Sequence Disease - genetics Humans Molecular Sequence Data Mutation Open Reading Frames Polymorphism, Genetic Protein Biosynthesis - genetics
ISSN:	1091-6490
Online Access:	Get more information
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