Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans

Upstream ORFs (uORFs) are mRNA elements defined by a start codon in the 5' UTR that is out-of-frame with the main coding sequence. Although uORFs are present in approximately half of human and mouse transcripts, no study has investigated their global impact on protein expression. Here, we repor...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 106; H. 18; S. 7507 - 7512
Hauptverfasser:	Calvo, Sarah E, Pagliarini, David J, Mootha, Vamsi K
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 05.05.2009
Schlagworte:	5' Untranslated Regions - genetics Base Sequence Disease - genetics Humans Molecular Sequence Data Mutation Open Reading Frames Polymorphism, Genetic Protein Biosynthesis - genetics
ISSN:	1091-6490
Online-Zugang:	Weitere Angaben
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