Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543/PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment

Background Periodontal ligament stem cells (PDLSCs) are the ideal seed cells for periodontal tissue regeneration. It is well established that persistent inflammation significantly impairs the osteogenic differentiation capability of PDLSCs. Therefore, maintaining PDLSC osteogenic potential under the...

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Bibliographic Details
Published in:	Stem cell research & therapy Vol. 13; no. 1; pp. 1 - 14
Main Authors:	Zhao, Xinyuan, Sun, Wenjuan, Guo, Bing, Cui, Li
Format:	Journal Article
Language:	English
Published:	London BioMed Central 13.08.2022 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	1-Phosphatidylinositol 3-kinase AKT protein Alkaline phosphatase Antibodies Biomedical and Life Sciences Biomedical Engineering and Bioengineering Bone loss Cell Biology Cell cycle Cell differentiation circBIRC6 Circular RNA Gene expression Immunofluorescence Inflammation Inflammatory microenvironment Life Sciences Ligaments Microenvironments MicroRNAs Mineralization miR-543 Osteogenic differentiation Periodontal ligament Periodontal ligament stem cells Periodontitis Phosphatases Proteins PTEN PTEN protein Regeneration Regenerative Medicine/Tissue Engineering Ribonucleic acid RNA Signal transduction Stem Cells TOR protein Western blotting United States > US China Periodontal ligament stem cells PTEN miR-543 Inflammatory microenvironment circBIRC6 Osteogenic differentiation
ISSN:	1757-6512, 1757-6512
Online Access:	Get full text
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