Routes, destinations and delays: recent advances in AMPA receptor trafficking

Postsynaptic AMPA-type glutamate receptors (AMPARs) mediate most fast excitatory synaptic transmission and are crucial for many aspects of brain function, including learning, memory and cognition. The number, synaptic localization and subunit composition of synaptic AMPARs are tightly regulated by n...

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Vydáno v:Trends in neurosciences (Regular ed.) Ročník 34; číslo 5; s. 258 - 268
Hlavní autoři: Henley, Jeremy M., Barker, Ellen A., Glebov, Oleg O.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Amsterdam Elsevier Ltd 01.05.2011
Elsevier
Elsevier Sequoia S.A
Témata:
Aminoacid receptors (glycine, glutamate, gaba)
Animals
Biological and medical sciences
Brain
Brain - physiology
Cell receptors
Cell structures and functions
Fundamental and applied biological sciences. Psychology
General aspects. Models. Methods
Humans
Models, Neurological
Molecular and cellular biology
Neurodegeneration
Neurology
Neurons - physiology
Neurosciences
Protein Transport - physiology
Receptors, AMPA - metabolism
Synapses - physiology
Synaptic Transmission - physiology
T cell receptors
Vertebrates: nervous system and sense organs
Composition
Memory
Central nervous system
Cognition
Glutamate receptor
Subunit
Encephalon
Learning
Postsynaptic
AMPA receptor
Synapse
Acquisition process
Synaptic transmission
Localization
ISSN:0166-2236, 1878-108X, 1878-108X
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Shrnutí:Postsynaptic AMPA-type glutamate receptors (AMPARs) mediate most fast excitatory synaptic transmission and are crucial for many aspects of brain function, including learning, memory and cognition. The number, synaptic localization and subunit composition of synaptic AMPARs are tightly regulated by network activity and by the history of activity at individual synapses. Furthermore, aberrant AMPAR trafficking is implicated in neurodegenerative diseases. AMPARs therefore represent a prime target for drug development and the mechanisms that control their synaptic delivery, retention and removal are the subject of extensive research. Here, we review recent findings that have provided new insights into AMPAR trafficking and that might lead to the development of novel therapeutic strategies.
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ISSN:0166-2236
1878-108X
1878-108X
DOI:10.1016/j.tins.2011.02.004