Routes, destinations and delays: recent advances in AMPA receptor trafficking
Postsynaptic AMPA-type glutamate receptors (AMPARs) mediate most fast excitatory synaptic transmission and are crucial for many aspects of brain function, including learning, memory and cognition. The number, synaptic localization and subunit composition of synaptic AMPARs are tightly regulated by n...
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| Published in: | Trends in neurosciences (Regular ed.) Vol. 34; no. 5; pp. 258 - 268 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
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Amsterdam
Elsevier Ltd
01.05.2011
Elsevier Elsevier Sequoia S.A |
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| ISSN: | 0166-2236, 1878-108X, 1878-108X |
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| Abstract | Postsynaptic AMPA-type glutamate receptors (AMPARs) mediate most fast excitatory synaptic transmission and are crucial for many aspects of brain function, including learning, memory and cognition. The number, synaptic localization and subunit composition of synaptic AMPARs are tightly regulated by network activity and by the history of activity at individual synapses. Furthermore, aberrant AMPAR trafficking is implicated in neurodegenerative diseases. AMPARs therefore represent a prime target for drug development and the mechanisms that control their synaptic delivery, retention and removal are the subject of extensive research. Here, we review recent findings that have provided new insights into AMPAR trafficking and that might lead to the development of novel therapeutic strategies. |
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| AbstractList | Postsynaptic AMPA-type glutamate receptors (AMPARs) mediate most fast excitatory synaptic transmission and are crucial for many aspects of brain function, including learning, memory and cognition. The number, synaptic localization and subunit composition of synaptic AMPARs are tightly regulated by network activity and by the history of activity at individual synapses. Furthermore, aberrant AMPAR trafficking is implicated in neurodegenerative diseases. AMPARs therefore represent a prime target for drug development and the mechanisms that control their synaptic delivery, retention and removal are the subject of extensive research. Here, we review recent findings that have provided new insights into AMPAR trafficking and that might lead to the development of novel therapeutic strategies.Postsynaptic AMPA-type glutamate receptors (AMPARs) mediate most fast excitatory synaptic transmission and are crucial for many aspects of brain function, including learning, memory and cognition. The number, synaptic localization and subunit composition of synaptic AMPARs are tightly regulated by network activity and by the history of activity at individual synapses. Furthermore, aberrant AMPAR trafficking is implicated in neurodegenerative diseases. AMPARs therefore represent a prime target for drug development and the mechanisms that control their synaptic delivery, retention and removal are the subject of extensive research. Here, we review recent findings that have provided new insights into AMPAR trafficking and that might lead to the development of novel therapeutic strategies. Postsynaptic AMPA-type glutamate receptors (AMPARs) mediate most fast excitatory synaptic transmission and are crucial for many aspects of brain function, including learning, memory and cognition. The number, synaptic localization and subunit composition of synaptic AMPARs are tightly regulated by network activity and by the history of activity at individual synapses. Furthermore, aberrant AMPAR trafficking is implicated in neurodegenerative diseases. AMPARs therefore represent a prime target for drug development and the mechanisms that control their synaptic delivery, retention and removal are the subject of extensive research. Here, we review recent findings that have provided new insights into AMPAR trafficking and that might lead to the development of novel therapeutic strategies. Postsynaptic AMPA-type glutamate receptors (AMPARs) mediate most fast excitatory synaptic transmission and are crucial for many aspects of brain function, including learning, memory and cognition. The number, synaptic localization and subunit composition of synaptic AMPARs are tightly regulated by network activity and by the history of activity at individual synapses. Furthermore, aberrant AMPAR trafficking is implicated in neurodegenerative diseases. AMPARs therefore represent a prime target for drug development and the mechanisms that control their synaptic delivery, retention and removal are the subject of extensive research. Here, we review recent findings that have provided new insights into AMPAR trafficking and that might lead to the development of novel therapeutic strategies. [PUBLICATION ABSTRACT] |
| Author | Barker, Ellen A. Glebov, Oleg O. Henley, Jeremy M. |
| Author_xml | – sequence: 1 givenname: Jeremy M. surname: Henley fullname: Henley, Jeremy M. email: j.m.henley@bristol.ac.uk – sequence: 2 givenname: Ellen A. surname: Barker fullname: Barker, Ellen A. – sequence: 3 givenname: Oleg O. surname: Glebov fullname: Glebov, Oleg O. |
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| SubjectTerms | Aminoacid receptors (glycine, glutamate, gaba) Animals Biological and medical sciences Brain Brain - physiology Cell receptors Cell structures and functions Fundamental and applied biological sciences. Psychology General aspects. Models. Methods Humans Models, Neurological Molecular and cellular biology Neurodegeneration Neurology Neurons - physiology Neurosciences Protein Transport - physiology Receptors, AMPA - metabolism Synapses - physiology Synaptic Transmission - physiology T cell receptors Vertebrates: nervous system and sense organs |
| Title | Routes, destinations and delays: recent advances in AMPA receptor trafficking |
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