The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice

Polygenic risk score analyses on embryos (PGT-P) are being marketed by some private testing companies to parents using in vitro fertilisation as being useful in selecting the embryos that carry the least risk of disease in later life. It appears that at least one child has been born after such a pro...

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Vydáno v:European journal of human genetics : EJHG Ročník 30; číslo 5; s. 493 - 495
Hlavní autoři: Forzano, Francesca, Antonova, Olga, Clarke, Angus, de Wert, Guido, Hentze, Sabine, Jamshidi, Yalda, Moreau, Yves, Perola, Markus, Prokopenko, Inga, Read, Andrew, Reymond, Alexandre, Stefansdottir, Vigdis, van El, Carla, Genuardi, Maurizio
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Nature Publishing Group 01.05.2022
Témata:
Alzheimer's disease
Embryos
Estimates
Fertilization
Genetic Predisposition to Disease
Genetic screening
Genetic Testing
Genetics
Genome-Wide Association Study
Humans
In vitro fertilization
Medicine
Minority & ethnic groups
Multifactorial Inheritance
Parents & parenting
Polygenic inheritance
Population
Prenatal development
Risk assessment
Risk Factors
ISSN:1018-4813, 1476-5438, 1476-5438
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Shrnutí:Polygenic risk score analyses on embryos (PGT-P) are being marketed by some private testing companies to parents using in vitro fertilisation as being useful in selecting the embryos that carry the least risk of disease in later life. It appears that at least one child has been born after such a procedure. But the utility of a PRS in this respect is severely limited, and to date, no clinical research has been performed to assess its diagnostic effectiveness in embryos. Patients need to be properly informed on the limitations of this use of PRSs, and a societal debate, focused on what would be considered acceptable with regard to the selection of individual traits, should take place before any further implementation of the technique in this population.
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ISSN:1018-4813
1476-5438
1476-5438
DOI:10.1038/s41431-021-01000-x