The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice

Polygenic risk score analyses on embryos (PGT-P) are being marketed by some private testing companies to parents using in vitro fertilisation as being useful in selecting the embryos that carry the least risk of disease in later life. It appears that at least one child has been born after such a pro...

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Published in:European journal of human genetics : EJHG Vol. 30; no. 5; pp. 493 - 495
Main Authors: Forzano, Francesca, Antonova, Olga, Clarke, Angus, de Wert, Guido, Hentze, Sabine, Jamshidi, Yalda, Moreau, Yves, Perola, Markus, Prokopenko, Inga, Read, Andrew, Reymond, Alexandre, Stefansdottir, Vigdis, van El, Carla, Genuardi, Maurizio
Format: Journal Article
Language:English
Published: England Nature Publishing Group 01.05.2022
Subjects:
Alzheimer's disease
Embryos
Estimates
Fertilization
Genetic Predisposition to Disease
Genetic screening
Genetic Testing
Genetics
Genome-Wide Association Study
Humans
In vitro fertilization
Medicine
Minority & ethnic groups
Multifactorial Inheritance
Parents & parenting
Polygenic inheritance
Population
Prenatal development
Risk assessment
Risk Factors
ISSN:1018-4813, 1476-5438, 1476-5438
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Abstract Polygenic risk score analyses on embryos (PGT-P) are being marketed by some private testing companies to parents using in vitro fertilisation as being useful in selecting the embryos that carry the least risk of disease in later life. It appears that at least one child has been born after such a procedure. But the utility of a PRS in this respect is severely limited, and to date, no clinical research has been performed to assess its diagnostic effectiveness in embryos. Patients need to be properly informed on the limitations of this use of PRSs, and a societal debate, focused on what would be considered acceptable with regard to the selection of individual traits, should take place before any further implementation of the technique in this population.
AbstractList Polygenic risk score analyses on embryos (PGT-P) are being marketed by some private testing companies to parents using in vitro fertilisation as being useful in selecting the embryos that carry the least risk of disease in later life. It appears that at least one child has been born after such a procedure. But the utility of a PRS in this respect is severely limited, and to date, no clinical research has been performed to assess its diagnostic effectiveness in embryos. Patients need to be properly informed on the limitations of this use of PRSs, and a societal debate, focused on what would be considered acceptable with regard to the selection of individual traits, should take place before any further implementation of the technique in this population.
Author Reymond, Alexandre
Read, Andrew
Hentze, Sabine
Prokopenko, Inga
Jamshidi, Yalda
de Wert, Guido
Forzano, Francesca
Clarke, Angus
Moreau, Yves
Genuardi, Maurizio
van El, Carla
Stefansdottir, Vigdis
Antonova, Olga
Perola, Markus
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ContentType Journal Article
Contributor Macek, Milan
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Jamshidi, Yalda
Houge, Gunnar Douzgos
Rial-Sebbag, Emmanuelle
Oliveira, Carla
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Snippet Polygenic risk score analyses on embryos (PGT-P) are being marketed by some private testing companies to parents using in vitro fertilisation as being useful...
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SubjectTerms Alzheimer's disease
Embryos
Estimates
Fertilization
Genetic Predisposition to Disease
Genetic screening
Genetic Testing
Genetics
Genome-Wide Association Study
Humans
In vitro fertilization
Medicine
Minority & ethnic groups
Multifactorial Inheritance
Parents & parenting
Polygenic inheritance
Population
Prenatal development
Risk assessment
Risk Factors
Title The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice
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