High‐throughput sequencing for biology and medicine

Advances in genome sequencing have progressed at a rapid pace, with increased throughput accompanied by plunging costs. But these advances go far beyond faster and cheaper. High‐throughput sequencing technologies are now routinely being applied to a wide range of important topics in biology and medi...

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Bibliographic Details
Published in:Molecular systems biology Vol. 9; no. 1; pp. 640 - n/a
Main Authors: Soon, Wendy Weijia, Hariharan, Manoj, Snyder, Michael P
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 2013
John Wiley & Sons, Ltd
EMBO Press
Nature Publishing Group
Springer Nature
Subjects:
Biology
Biomedical Research - methods
Costs
Deoxyribonucleic acid
DNA
DNA methylation
EMBO09
EMBO24
Epigenomics
Gene expression
Gene Expression Profiling
Gene sequencing
Genetic Variation
Genome
Genomes
Genotyping
High-Throughput Nucleotide Sequencing - methods
high‐throughput
Histones - metabolism
Humans
Medical research
Medicine
Proteins
Researchers
Review
RNA polymerase
sequencing
Single-Cell Analysis
technologies
technologies
high‐throughput
medicine
biology
sequencing
ISSN:1744-4292, 1744-4292
Online Access:Get full text
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Summary:Advances in genome sequencing have progressed at a rapid pace, with increased throughput accompanied by plunging costs. But these advances go far beyond faster and cheaper. High‐throughput sequencing technologies are now routinely being applied to a wide range of important topics in biology and medicine, often allowing researchers to address important biological questions that were not possible before. In this review, we discuss these innovative new approaches—including ever finer analyses of transcriptome dynamics, genome structure and genomic variation—and provide an overview of the new insights into complex biological systems catalyzed by these technologies. We also assess the impact of genotyping, genome sequencing and personal omics profiling on medical applications, including diagnosis and disease monitoring. Finally, we review recent developments in single‐cell sequencing, and conclude with a discussion of possible future advances and obstacles for sequencing in biology and health. Genome sequencing technologies have advanced rapidly, dramatically decreasing cost and increasing throughput. But beyond faster and cheaper, these advances have also stimulated the development of innovative new experimental approaches, and are opening new doors in human medicine and health.
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ISSN:1744-4292
1744-4292
DOI:10.1038/msb.2012.61