Complement pathway activation mediates pancreatic cancer–induced muscle wasting and pathological remodeling

Cancer cachexia is a multifactorial condition characterized by skeletal muscle wasting that impairs quality of life and longevity for many cancer patients. A greater understanding of the molecular etiology of this condition is needed for effective therapies to be developed. We performed a quantitati...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 135; no. 12
Main Authors:	D’Lugos, Andrew C., Ducharme, Jeremy B., Callaway, Chandler S., Trevino, Jose G., Atkinson, Carl, Judge, Sarah M., Judge, Andrew R.
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 30.06.2025
Subjects:	Animals Cachexia - etiology Cachexia - genetics Cachexia - immunology Cachexia - metabolism Cachexia - pathology Carcinoma, Pancreatic Ductal - complications Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - immunology Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Causes of Cell Line, Tumor Complement Activation Complement C3 - deficiency Complement C3 - genetics Complement C3 - immunology Complement C3 - metabolism Female Health aspects Humans Male Mice Mice, Knockout Muscle biology Muscle diseases Muscle, Skeletal - immunology Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscles Muscular Atrophy - etiology Muscular Atrophy - genetics Muscular Atrophy - immunology Muscular Atrophy - pathology Oncology Pancreatic cancer Pancreatic Neoplasms - complications Pancreatic Neoplasms - genetics Pancreatic Neoplasms - immunology Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Physiological aspects United States Oncology Muscle Muscle biology Proteomics Cancer
ISSN:	1558-8238, 0021-9738, 1558-8238
Online Access:	Get full text
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