Pharmacogenomic profiling of variants affecting efficacy and toxicity of anti-infective medicines in a south Asian population from Sri Lanka

Background Anti-infective medicines are crucial for treating infections, but improper dosing can cause toxicity, resistance and treatment failure. Pharmacogenomics can address genetic variations affecting drug efficacy and safety. Despite the high burden of diseases like TB and HIV in Sri Lanka and...

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Bibliographic Details
Published in:	BMC infectious diseases Vol. 25; no. 1; pp. 153 - 12
Main Authors:	Ranasinghe, Priyanga, Jeyapragasam, Hajanthy, Sirisena, Nirmala, Bhagya Hendalage, D. P., Dissanayake, Vajira H. W.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 01.02.2025 BioMed Central Ltd BMC
Subjects:	Adult Anti-infective agents Anti-Infective Agents - adverse effects Anti-Infective Agents - pharmacology Anti-Infective Agents - therapeutic use Anti-infectives Arylamine N-Acetyltransferase - genetics Dosage and administration Female Genetic aspects Genetic Variation HIV Humans Infectious Diseases Internal Medicine Male Medical Microbiology Medicine Medicine & Public Health Middle Aged Parasitology Pharmacogenetics Pharmacogenomic Variants Pharmacogenomics Pharmacology, Experimental Physiological aspects Polymorphism, Single Nucleotide South Asia South Asian People - genetics Sri Lanka Tropical Medicine Tuberculosis Sri Lanka Anti-infectives Tuberculosis HIV Sri Lanka Voriconazole South Asia Pharmacogenomics
ISSN:	1471-2334, 1471-2334
Online Access:	Get full text
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