Combination of growth factor treatment and scaffold deposition following traumatic brain injury has only a temporary effect on regeneration

The recovery after traumatic brain injury (TBI) is hampered by the poor regenerative capacity of the brain. Today there is no treatment available that effectively restores lost brain tissue, but much research is focused on the stimulation of endogenous neural stem cells to viably and functionally re...

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Bibliographic Details
Published in:	Brain research Vol. 1588; pp. 37 - 46
Main Authors:	Clausen, Fredrik, Lindh, Tone, Salimi, Shabnam, Erlandsson, Anna
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 07.11.2014 Elsevier
Subjects:	Adult and adolescent clinical studies Animals Astrocytes - drug effects Astrocytes - physiology Biological and medical sciences Brain - drug effects Brain - pathology Brain - physiopathology Brain - surgery Brain Injuries - drug therapy Brain Injuries - pathology Brain Injuries - physiopathology Brain Injuries - surgery Disease Models, Animal Drug Implants - therapeutic use Drug Therapy, Combination Epidermal growth factor Epidermal Growth Factor - administration & dosage Extracellular Matrix Injuries of the nervous system and the skull. Diseases due to physical agents Male Maze Learning - drug effects Medical sciences Nerve Regeneration - drug effects Nerve Regeneration - physiology Neural stem cells Neural Stem Cells - drug effects Neural Stem Cells - physiology Neurogenesis - drug effects Neurogenesis - physiology Neurology Neurons - drug effects Neurons - physiology Neuroprotective Agents - administration & dosage Organic mental disorders. Neuropsychology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Rats, Sprague-Dawley Regeneration Scaffold Time Factors Traumas. Diseases due to physical agents Traumatic brain injury Treatment Outcome Vascular endothelial factor Vascular Endothelial Growth Factor A - administration & dosage Regeneration Vascular endothelial factor Neural stem cells Traumatic brain injury Epidermal growth factor Scaffold Nervous system diseases Stem cell Endothelium Treatment Blood vessel Circulatory system Head trauma Growth factor
ISSN:	0006-8993, 1872-6240, 1872-6240
Online Access:	Get full text
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