Structure and E3-ligase activity of the Ring-Ring complex of Polycomb proteins Bmi1 and Ring1b

Polycomb group proteins Ring1b and Bmi1 ( B ‐cell‐specific M oloney murine leukaemia virus i ntegration site 1) are critical components of the chromatin modulating PRC1 complex. Histone H2A ubiquitination by the PRC1 complex strongly depends on the Ring1b protein. Here we show that the E3‐ligase act...

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Vydáno v:	The EMBO journal Ročník 25; číslo 11; s. 2465 - 2474
Hlavní autoři:	Buchwald, Gretel, van der Stoop, Petra, Weichenrieder, Oliver, Perrakis, Anastassis, van Lohuizen, Maarten, Sixma, Titia K
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Chichester, UK John Wiley & Sons, Ltd 07.06.2006 Nature Publishing Group UK Springer Nature B.V
Témata:	Amino Acid Sequence Animals Biomedical research Bmi1 Breast cancer Chromatin Crystal structure Crystallography, X-Ray Dimerization E3 ligase EMBO09 EMBO40 Enzymatic activity Female Histones - metabolism Humans Leukemia Mice Models, Molecular Molecular biology Molecular Sequence Data Multiprotein Complexes Murine leukemia virus Mutation Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism polycomb Polycomb Repressive Complex 1 Protein Conformation Proteins Proto-Oncogene Proteins - chemistry Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Repressor Proteins - chemistry Repressor Proteins - genetics Repressor Proteins - metabolism Ring1b Sequence Alignment Stem cells Ubiquitin - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism crystal structure Ring1b E3 ligase Bmi1 polycomb
ISSN:	0261-4189, 1460-2075
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