Subclinical atherosclerosis and its progression are modulated by PLIN2 through a feed‐forward loop between LXR and autophagy

Background Hyperlipidaemia is a major risk factor for cardiovascular disease, and atherosclerosis is the underlying cause of both myocardial infarction and stroke. We have previously shown that the Pro251 variant of perilipin‐2 reduces plasma triglycerides and may therefore be beneficial to reduce a...

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Published in:	Journal of internal medicine Vol. 286; no. 6; pp. 660 - 675
Main Authors:	Saliba‐Gustafsson, P., Pedrelli, M., Gertow, K., Werngren, O., Janas, V., Pourteymour, S., Baldassarre, D., Tremoli, E., Veglia, F., Rauramaa, R., Smit, A.J., Giral, P., Kurl, S., Pirro, M., Faire, U., Humphries, S.E., Hamsten, A., Gonçalves, I., Orho‐Melander, M., Franco‐Cereceda, A., Borén, J., Eriksson, P., Magné, J., Parini, P., Ehrenborg, E., Sirtori, C. R., Castelnuovo, S., Amato, M., Frigerio, B., Ravani, A., Sansaro, D., Tedesco, C., Bovis, F., Discacciati, A., Ahl, M., Blomgren, G., Eriksson, M. J., Fahlstadius, P., Heinonen, M., Nilson, L., Cooper, J., Acharya, J., Huttunen, K., Rauramaa, E., Pekkarinen, H., Penttila, I. M., Torronen, J., Gessel, A. I., van Roon, A. M., Teune, G. C., Kuipers, W. D., Bruin, M., Nicolai, A., Haarsma‐Jorritsma, P., Mulder, D. J., Bilo, H. J. G., Smeets, G. H., Beaudeux, J. L., Kahn, J. F., Carreau, V., Kontush, A., Karppi, J., Nurmi, T., Nyyssonen, K., Salonen, R., Tuomainen, T. P., Tuomainen, J., Kauhanen, J., Vaudo, G., Alaeddin, A., Siepi, D., Lupattelli, G., Schillaci, G.
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01.12.2019 Wiley John Wiley and Sons Inc
Subjects:	27OH-cholesterol accumulation Aged Arteriosclerosis Atherosclerosis Atherosclerosis - metabolism Autophagy Blood Buffy coat Cardiology and Cardiovascular Disease Cardiovascular diseases Carotid Intima-Media Thickness Cerebral infarction Cholesterol Clinical Medicine Disease Progression Efflux Europe Female Foam Cells - metabolism General & Internal Medicine Genotypes Health risks Humans Hyperlipidemia identification Inflammation Inflammatory response Kardiologi och kardiovaskulära sjukdomar Klinisk medicin Life Sciences Lipoproteins - metabolism Liver X Receptors - metabolism liver-X-receptor Longitudinal Studies macrophage foam cells Macrophages Macrophages - metabolism Male Medical and Health Sciences Medicin och hälsovetenskap metabolism Middle Aged Monocytes Myocardial infarction Original Perilipin-2 - metabolism Phagocytosis PLIN2 protects receptors reverse cholesterol transport Risk analysis Risk factors ser251pro stimulation Thickness Triglycerides Europe atherosclerosis liver-X-receptor 27OH-cholesterol PLIN2 autophagy
ISSN:	0954-6820, 1365-2796, 1365-2796
Online Access:	Get full text
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