Monte Carlo dosimetric analyses on the use of 90 Y-IsoPet intratumoral therapy in canine subjects
To investigate different dosimetric aspects of Y-IsoPet™ intratumoral therapy in canine soft tissue sarcomas, model the spatial spread of the gel post-injection, evaluate absorbed dose to clinical target volumes, and assess dose distributions and treatment efficacy. Six canine cases treated with Y-I...
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| Veröffentlicht in: | Physics in medicine & biology Jg. 69; H. 16 |
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| Sprache: | Englisch |
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21.08.2024
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| ISSN: | 1361-6560 |
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| Abstract | To investigate different dosimetric aspects of
Y-IsoPet™ intratumoral therapy in canine soft tissue sarcomas, model the spatial spread of the gel post-injection, evaluate absorbed dose to clinical target volumes, and assess dose distributions and treatment efficacy.
Six canine cases treated with
Y-IsoPet™ for soft tissue sarcoma at the Veterinary Health Center, University of Missouri are analyzed in this retrospective study. The dogs received intratumoral IsoPet™ injections, following a grid pattern to achieve a near-uniform dose distribution in the clinical target volume. Two dosimetry methods were performed retrospectively using the Monte Carlo toolkit OpenTOPAS: imaging-based dosimetry obtained from post-injection PET/CT scans, and stylized phantom-based dosimetry modeled from the planned injection points to the gross tumor volume. For the latter, a Gaussian parameter with variable sigma was introduced to reflect the spatial spread of IsoPet™. The two methods were compared using dose-volume histograms (DVHs) and dose homogeneity, allowing an approximation of the closest sigma for the spatial spread of the gel post-injection. In addition, we compared Monte Carlo-based dosimetry with voxel S-value (VSV)-based dosimetry to investigate the dosimetric differences.
Imaging-based dosimetry showed differences between Monte Carlo and VSV calculations in tumor high-density areas with higher self-absorption. Stylized phantom-based dosimetry indicated a more homogeneous target dose with increasing sigma. The sigma approximation of the
Y-IsoPet™ post-injection gel spread resulted in a median sigma of approximately 0.44 mm across all cases to reproduce the dose heterogeneity observed in Monte Carlo calculations.
The results indicate that dose modeling based on planned injection points can serve as a first-order approximation for the delivered dose in
Y-IsoPet™ therapy for canine soft tissue sarcomas. The dosimetry evaluation highlights the non-uniformity of absorbed doses despite the gel spread, emphasizing the importance of considering tumor dose heterogeneity in treatment evaluation. Our findings suggest that using Monte Carlo for dose calculation seems more suitable for this type of tumor where high-density areas might play an important role in dosimetry. |
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| AbstractList | To investigate different dosimetric aspects of
Y-IsoPet™ intratumoral therapy in canine soft tissue sarcomas, model the spatial spread of the gel post-injection, evaluate absorbed dose to clinical target volumes, and assess dose distributions and treatment efficacy.
Six canine cases treated with
Y-IsoPet™ for soft tissue sarcoma at the Veterinary Health Center, University of Missouri are analyzed in this retrospective study. The dogs received intratumoral IsoPet™ injections, following a grid pattern to achieve a near-uniform dose distribution in the clinical target volume. Two dosimetry methods were performed retrospectively using the Monte Carlo toolkit OpenTOPAS: imaging-based dosimetry obtained from post-injection PET/CT scans, and stylized phantom-based dosimetry modeled from the planned injection points to the gross tumor volume. For the latter, a Gaussian parameter with variable sigma was introduced to reflect the spatial spread of IsoPet™. The two methods were compared using dose-volume histograms (DVHs) and dose homogeneity, allowing an approximation of the closest sigma for the spatial spread of the gel post-injection. In addition, we compared Monte Carlo-based dosimetry with voxel S-value (VSV)-based dosimetry to investigate the dosimetric differences.
Imaging-based dosimetry showed differences between Monte Carlo and VSV calculations in tumor high-density areas with higher self-absorption. Stylized phantom-based dosimetry indicated a more homogeneous target dose with increasing sigma. The sigma approximation of the
Y-IsoPet™ post-injection gel spread resulted in a median sigma of approximately 0.44 mm across all cases to reproduce the dose heterogeneity observed in Monte Carlo calculations.
The results indicate that dose modeling based on planned injection points can serve as a first-order approximation for the delivered dose in
Y-IsoPet™ therapy for canine soft tissue sarcomas. The dosimetry evaluation highlights the non-uniformity of absorbed doses despite the gel spread, emphasizing the importance of considering tumor dose heterogeneity in treatment evaluation. Our findings suggest that using Monte Carlo for dose calculation seems more suitable for this type of tumor where high-density areas might play an important role in dosimetry. |
| Author | Terry, Jack F Bertolet, Alejandro Schuemann, Jan Bobić, Mislav Kunz, Louis Fisher, Darrell R Huesa-Berral, Carlos Maitz, Charles A |
| Author_xml | – sequence: 1 givenname: Mislav orcidid: 0000-0002-9409-8680 surname: Bobić fullname: Bobić, Mislav organization: Department of Physics, ETH Zurich, Zurich, Switzerland – sequence: 2 givenname: Carlos orcidid: 0000-0003-2290-0176 surname: Huesa-Berral fullname: Huesa-Berral, Carlos organization: Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America – sequence: 3 givenname: Jack F surname: Terry fullname: Terry, Jack F organization: Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America – sequence: 4 givenname: Louis orcidid: 0009-0008-6526-6025 surname: Kunz fullname: Kunz, Louis organization: Department of Physics, ETH Zurich, Zurich, Switzerland – sequence: 5 givenname: Jan orcidid: 0000-0002-7554-8818 surname: Schuemann fullname: Schuemann, Jan organization: Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America – sequence: 6 givenname: Darrell R surname: Fisher fullname: Fisher, Darrell R organization: Versant Medical Physics and Radiation Safety, Richland, Washington, and University of Washington, Seattle, United States of America – sequence: 7 givenname: Charles A orcidid: 0000-0003-2075-3926 surname: Maitz fullname: Maitz, Charles A organization: Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, MO, United States of America – sequence: 8 givenname: Alejandro orcidid: 0000-0002-9890-693X surname: Bertolet fullname: Bertolet, Alejandro organization: Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39053508$$D View this record in MEDLINE/PubMed |
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| Issue | 16 |
| Keywords | IsoPet soft tissue sarcomas dosimetry dog cancer models Y-90 therapy RadioGel comparative oncology |
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| Snippet | To investigate different dosimetric aspects of
Y-IsoPet™ intratumoral therapy in canine soft tissue sarcomas, model the spatial spread of the gel... |
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| SubjectTerms | Animals Dogs Monte Carlo Method Phantoms, Imaging Positron Emission Tomography Computed Tomography Radiometry Radiotherapy Dosage Sarcoma - radiotherapy Sarcoma - veterinary Yttrium Radioisotopes - therapeutic use |
| Title | Monte Carlo dosimetric analyses on the use of 90 Y-IsoPet intratumoral therapy in canine subjects |
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