The role of inflammatory gene polymorphisms in severe COVID-19: a review

The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has profoundly impacted global healthcare systems and spurred extensive research efforts over the past three years. One critical aspect of the disease is the intricate interplay between the virus and the host immune response, particu...

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Vydáno v:Virology journal Ročník 21; číslo 1; s. 327
Hlavní autoři: Yip, Jia Qi, Oo, Adrian, Ng, Yan Ling, Chin, Kim Ling, Tan, Kim-Kee, Chu, Justin Jang Hann, AbuBakar, Sazaly, Zainal, Nurhafiza
Médium: Journal Article
Jazyk:angličtina
Vydáno: London BioMed Central 20.12.2024
BioMed Central Ltd
BMC
Témata:
Biomedical and Life Sciences
Biomedicine
Complications and side effects
COVID-19
COVID-19 - genetics
COVID-19 - immunology
COVID-19 - virology
COVID-19 infection
cytokines
Cytokines - genetics
Development and progression
disease severity
Gene expression
genes
Genetic aspects
Genetic polymorphisms
Genetic Predisposition to Disease
Health aspects
health services
Humans
Immune response
Immunological research
Inflammation
Inflammation - genetics
Inflammatory gene expression
pathogenesis
Polymorphism, Genetic
Review
SARS-CoV-2
SARS-CoV-2 - genetics
SARS-CoV-2 - immunology
Severe acute respiratory syndrome coronavirus 2
Severe COVID-19
Severity of Illness Index
Signal Transduction
therapeutics
Virology
viruses
Malaysia
COVID-19
Inflammatory gene expression
SARS-CoV-2
Severe COVID-19
Genetic polymorphisms
ISSN:1743-422X, 1743-422X
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Shrnutí:The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has profoundly impacted global healthcare systems and spurred extensive research efforts over the past three years. One critical aspect of the disease is the intricate interplay between the virus and the host immune response, particularly the role of inflammatory gene expression in severe COVID-19. While numerous previous studies have explored the role of genetic polymorphisms in COVID-19, research specifically focusing on inflammatory genes and their associations with disease severity remains limited. This review explores the relationship between severe COVID-19 outcomes and genetic polymorphisms within key inflammatory genes. By investigating the impact of genetic variations on immune responses, which include cytokine production and downstream signalling pathways, we aim to provide a comprehensive overview of how genetic polymorphisms contribute to the variability in disease presentation. Through an in-depth analysis of existing literature, we shed light on potential therapeutic targets and personalized approaches that may enhance our understanding of disease pathogenesis and treatment strategies.
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ISSN:1743-422X
1743-422X
DOI:10.1186/s12985-024-02597-3