Increased somatic mutation burdens in normal human cells due to defective DNA polymerases

Mutation accumulation in somatic cells contributes to cancer development and is proposed as a cause of aging. DNA polymerases Pol ε and Pol δ replicate DNA during cell division. However, in some cancers, defective proofreading due to acquired POLE / POLD1 exonuclease domain mutations causes markedly...

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Bibliographic Details
Published in:	Nature genetics Vol. 53; no. 10; pp. 1434 - 1442
Main Authors:	Robinson, Philip S., Coorens, Tim H. H., Palles, Claire, Mitchell, Emily, Abascal, Federico, Olafsson, Sigurgeir, Lee, Bernard C. H., Lawson, Andrew R. J., Lee-Six, Henry, Moore, Luiza, Sanders, Mathijs A., Hewinson, James, Martin, Lynn, Pinna, Claudia M. A., Galavotti, Sara, Rahbari, Raheleh, Campbell, Peter J., Martincorena, Iñigo, Tomlinson, Ian, Stratton, Michael R.
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.10.2021 Nature Publishing Group
Subjects:	631/208/212 631/443/7 631/67/1504 Adolescent Adult Aged Agriculture Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Cancer Research Cell division DNA Polymerase II - genetics DNA Polymerase III - genetics DNA polymerases Embryonic Development - genetics Gene Function Gene mutations Genetic aspects Genetic research Genome, Human - genetics Germ-Line Mutation - genetics Health aspects Human Genetics Humans Intestinal Neoplasms - pathology Intestines - pathology Middle Aged Mutagenesis - genetics Phylogeny Somatic cells Stem Cells - pathology Young Adult United Kingdom
ISSN:	1061-4036, 1546-1718, 1546-1718
Online Access:	Get full text
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