Dietary dicarboxylic acids provide a nonstorable alternative fat source that protects mice against obesity

Dicarboxylic fatty acids are generated in the liver and kidney in a minor pathway called fatty acid ω-oxidation. The effects of consuming dicarboxylic fatty acids as an alternative source of dietary fat have not been explored. Here, we fed dodecanedioic acid, a 12-carbon dicarboxylic (DC12), to mice...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 134; no. 12
Main Authors:	Goetzman, Eric S., Zhang, Bob B., Zhang, Yuxun, Bharathi, Sivakama S., Bons, Joanna, Rose, Jacob, Shah, Samah, Solo, Keaton J., Schmidt, Alexandra V., Richert, Adam C., Mullett, Steven J., Gelhaus, Stacy L., Rao, Krithika S., Shiva, Sruti S., Pfister, Katherine E., Silva Barbosa, Anne, Sims-Lucas, Sunder, Dobrowolski, Steven F., Schilling, Birgit
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 15.06.2024
Subjects:	Acyl-CoA Oxidase - genetics Acyl-CoA Oxidase - metabolism Adipose Tissue - metabolism Amino acids Animals Carboxylic acids Care and treatment Dextrose Dicarboxylic Acids - administration & dosage Dicarboxylic Acids - metabolism Dicarboxylic Acids - pharmacology Dietary fat Dietary Fats - administration & dosage Dietary Fats - metabolism Dietary Fats - pharmacology Fatty acids Fatty Acids - metabolism Glucose Health aspects Liver Liver - metabolism Male Metabolism Mice Mice, Inbred C57BL Obesity Obesity - metabolism Obesity - prevention & control Oxidases Oxidation-Reduction Peroxisomes - metabolism Physiological aspects Testing Type 2 diabetes United States Pennsylvania Fatty acid oxidation Obesity Mitochondria Metabolism
ISSN:	1558-8238, 0021-9738, 1558-8238
Online Access:	Get full text
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