Dietary dicarboxylic acids provide a nonstorable alternative fat source that protects mice against obesity

Dicarboxylic fatty acids are generated in the liver and kidney in a minor pathway called fatty acid ω-oxidation. The effects of consuming dicarboxylic fatty acids as an alternative source of dietary fat have not been explored. Here, we fed dodecanedioic acid, a 12-carbon dicarboxylic (DC12), to mice...

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Vydáno v:	The Journal of clinical investigation Ročník 134; číslo 12
Hlavní autoři:	Goetzman, Eric S., Zhang, Bob B., Zhang, Yuxun, Bharathi, Sivakama S., Bons, Joanna, Rose, Jacob, Shah, Samah, Solo, Keaton J., Schmidt, Alexandra V., Richert, Adam C., Mullett, Steven J., Gelhaus, Stacy L., Rao, Krithika S., Shiva, Sruti S., Pfister, Katherine E., Silva Barbosa, Anne, Sims-Lucas, Sunder, Dobrowolski, Steven F., Schilling, Birgit
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States American Society for Clinical Investigation 15.06.2024
Témata:	Acyl-CoA Oxidase - genetics Acyl-CoA Oxidase - metabolism Adipose Tissue - metabolism Amino acids Animals Carboxylic acids Care and treatment Dextrose Dicarboxylic Acids - administration & dosage Dicarboxylic Acids - metabolism Dicarboxylic Acids - pharmacology Dietary fat Dietary Fats - administration & dosage Dietary Fats - metabolism Dietary Fats - pharmacology Fatty acids Fatty Acids - metabolism Glucose Health aspects Liver Liver - metabolism Male Metabolism Mice Mice, Inbred C57BL Obesity Obesity - metabolism Obesity - prevention & control Oxidases Oxidation-Reduction Peroxisomes - metabolism Physiological aspects Testing Type 2 diabetes United States Pennsylvania Fatty acid oxidation Obesity Mitochondria Metabolism
ISSN:	1558-8238, 0021-9738, 1558-8238
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Abstract	Dicarboxylic fatty acids are generated in the liver and kidney in a minor pathway called fatty acid ω-oxidation. The effects of consuming dicarboxylic fatty acids as an alternative source of dietary fat have not been explored. Here, we fed dodecanedioic acid, a 12-carbon dicarboxylic (DC12), to mice at 20% of daily caloric intake for 9 weeks. DC12 increased metabolic rate, reduced body fat, reduced liver fat, and improved glucose tolerance. We observed DC12-specific breakdown products in liver, kidney, muscle, heart, and brain, indicating that oral DC12 escaped first-pass liver metabolism and was utilized by many tissues. In tissues expressing the "a" isoform of acyl-CoA oxidase-1 (ACOX1), a key peroxisomal fatty acid oxidation enzyme, DC12 was chain shortened to the TCA cycle intermediate succinyl-CoA. In tissues with low peroxisomal fatty acid oxidation capacity, DC12 was oxidized by mitochondria. In vitro, DC12 was catabolized even by adipose tissue and was not stored intracellularly. We conclude that DC12 and other dicarboxylic acids may be useful for combatting obesity and for treating metabolic disorders.
AbstractList	Dicarboxylic fatty acids are generated in the liver and kidney in a minor pathway called fatty acid ω-oxidation. The effects of consuming dicarboxylic fatty acids as an alternative source of dietary fat have not been explored. Here, we fed dodecanedioic acid, a 12-carbon dicarboxylic (DC12), to mice at 20% of daily caloric intake for 9 weeks. DC12 increased metabolic rate, reduced body fat, reduced liver fat, and improved glucose tolerance. We observed DC12-specific breakdown products in liver, kidney, muscle, heart, and brain, indicating that oral DC12 escaped first-pass liver metabolism and was utilized by many tissues. In tissues expressing the “a” isoform of acyl-CoA oxidase-1 (ACOX1), a key peroxisomal fatty acid oxidation enzyme, DC12 was chain shortened to the TCA cycle intermediate succinyl-CoA. In tissues with low peroxisomal fatty acid oxidation capacity, DC12 was oxidized by mitochondria. In vitro, DC12 was catabolized even by adipose tissue and was not stored intracellularly. We conclude that DC12 and other dicarboxylic acids may be useful for combatting obesity and for treating metabolic disorders. Dicarboxylic acids serve as an alternative energy source that dramatically remodels metabolism in mice. Dicarboxylic fatty acids are generated in the liver and kidney in a minor pathway called fatty acid m-oxidation. The effects of consuming dicarboxylic fatty acids as an alternative source of dietary fat have not been explored. Here, we fed dodecanedioic acid, a 12-carbon dicarboxylic ([DC.sub.12]), to mice at 20% of daily caloric intake for 9 weeks. [DC.sub.12] increased metabolic rate, reduced body fat, reduced liver fat, and improved glucose tolerance. We observed [DC.sub.12]-specific breakdown products in liver, kidney, muscle, heart, and brain, indicating that oral [DC.sub.12] escaped first-pass liver metabolism and was utilized by many tissues. In tissues expressing the "a" isoform of acyl-CoA oxidase-1 (ACOX1), a key peroxisomal fatty acid oxidation enzyme, [DC.sub.12] was chain shortened to the TCA cycle intermediate succinyl-CoA. In tissues with low peroxisomal fatty acid oxidation capacity, [DC.sub.12] was oxidized by mitochondria. In vitro, [DC.sub.12] was catabolized even by adipose tissue and was not stored intracellularly. We conclude that [DC.sub.12] and other dicarboxylic acids may be useful for combatting obesity and for treating metabolic disorders. Dicarboxylic fatty acids are generated in the liver and kidney in a minor pathway called fatty acid ω-oxidation. The effects of consuming dicarboxylic fatty acids as an alternative source of dietary fat have not been explored. Here, we fed dodecanedioic acid, a 12-carbon dicarboxylic (DC12), to mice at 20% of daily caloric intake for 9 weeks. DC12 increased metabolic rate, reduced body fat, reduced liver fat, and improved glucose tolerance. We observed DC12-specific breakdown products in liver, kidney, muscle, heart, and brain, indicating that oral DC12 escaped first-pass liver metabolism and was utilized by many tissues. In tissues expressing the "a" isoform of acyl-CoA oxidase-1 (ACOX1), a key peroxisomal fatty acid oxidation enzyme, DC12 was chain shortened to the TCA cycle intermediate succinyl-CoA. In tissues with low peroxisomal fatty acid oxidation capacity, DC12 was oxidized by mitochondria. In vitro, DC12 was catabolized even by adipose tissue and was not stored intracellularly. We conclude that DC12 and other dicarboxylic acids may be useful for combatting obesity and for treating metabolic disorders.Dicarboxylic fatty acids are generated in the liver and kidney in a minor pathway called fatty acid ω-oxidation. The effects of consuming dicarboxylic fatty acids as an alternative source of dietary fat have not been explored. Here, we fed dodecanedioic acid, a 12-carbon dicarboxylic (DC12), to mice at 20% of daily caloric intake for 9 weeks. DC12 increased metabolic rate, reduced body fat, reduced liver fat, and improved glucose tolerance. We observed DC12-specific breakdown products in liver, kidney, muscle, heart, and brain, indicating that oral DC12 escaped first-pass liver metabolism and was utilized by many tissues. In tissues expressing the "a" isoform of acyl-CoA oxidase-1 (ACOX1), a key peroxisomal fatty acid oxidation enzyme, DC12 was chain shortened to the TCA cycle intermediate succinyl-CoA. In tissues with low peroxisomal fatty acid oxidation capacity, DC12 was oxidized by mitochondria. In vitro, DC12 was catabolized even by adipose tissue and was not stored intracellularly. We conclude that DC12 and other dicarboxylic acids may be useful for combatting obesity and for treating metabolic disorders. Dicarboxylic fatty acids are generated in the liver and kidney in a minor pathway called fatty acid ω-oxidation. The effects of consuming dicarboxylic fatty acids as an alternative source of dietary fat have not been explored. Here, we fed dodecanedioic acid, a 12-carbon dicarboxylic (DC12), to mice at 20% of daily caloric intake for 9 weeks. DC12 increased metabolic rate, reduced body fat, reduced liver fat, and improved glucose tolerance. We observed DC12-specific breakdown products in liver, kidney, muscle, heart, and brain, indicating that oral DC12 escaped first-pass liver metabolism and was utilized by many tissues. In tissues expressing the “a” isoform of acyl-CoA oxidase-1 (ACOX1), a key peroxisomal fatty acid oxidation enzyme, DC12 was chain shortened to the TCA cycle intermediate succinyl-CoA. In tissues with low peroxisomal fatty acid oxidation capacity, DC12 was oxidized by mitochondria. In vitro, DC12 was catabolized even by adipose tissue and was not stored intracellularly. We conclude that DC12 and other dicarboxylic acids may be useful for combatting obesity and for treating metabolic disorders.
Audience	Academic
Author	Goetzman, Eric S. Bons, Joanna Shah, Samah Rose, Jacob Schilling, Birgit Zhang, Bob B. Richert, Adam C. Rao, Krithika S. Zhang, Yuxun Silva Barbosa, Anne Pfister, Katherine E. Sims-Lucas, Sunder Dobrowolski, Steven F. Shiva, Sruti S. Schmidt, Alexandra V. Mullett, Steven J. Solo, Keaton J. Gelhaus, Stacy L. Bharathi, Sivakama S.
AuthorAffiliation	3 Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA 2 The Buck Institute for Research on Aging, Novato, California, USA 1 Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA 5 Vascular Medicine Institute and 4 Health Sciences Mass Spectrometry Core, University of Pittsburgh, Pittsburgh, Pennsylvania, USA 6 Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
AuthorAffiliation_xml	– name: 1 Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA – name: 5 Vascular Medicine Institute and – name: 4 Health Sciences Mass Spectrometry Core, University of Pittsburgh, Pittsburgh, Pennsylvania, USA – name: 2 The Buck Institute for Research on Aging, Novato, California, USA – name: 6 Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA – name: 3 Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
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BackLink	https://www.ncbi.nlm.nih.gov/pubmed/38687608$$D View this record in MEDLINE/PubMed
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Keywords	Fatty acid oxidation Obesity Mitochondria Metabolism
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Snippet	Dicarboxylic fatty acids are generated in the liver and kidney in a minor pathway called fatty acid ω-oxidation. The effects of consuming dicarboxylic fatty... Dicarboxylic fatty acids are generated in the liver and kidney in a minor pathway called fatty acid m-oxidation. The effects of consuming dicarboxylic fatty...
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SubjectTerms	Acyl-CoA Oxidase - genetics Acyl-CoA Oxidase - metabolism Adipose Tissue - metabolism Amino acids Animals Carboxylic acids Care and treatment Dextrose Dicarboxylic Acids - administration & dosage Dicarboxylic Acids - metabolism Dicarboxylic Acids - pharmacology Dietary fat Dietary Fats - administration & dosage Dietary Fats - metabolism Dietary Fats - pharmacology Fatty acids Fatty Acids - metabolism Glucose Health aspects Liver Liver - metabolism Male Metabolism Mice Mice, Inbred C57BL Obesity Obesity - metabolism Obesity - prevention & control Oxidases Oxidation-Reduction Peroxisomes - metabolism Physiological aspects Testing Type 2 diabetes
Title	Dietary dicarboxylic acids provide a nonstorable alternative fat source that protects mice against obesity
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