Spatial transcriptomic analysis of virtual prostate biopsy reveals confounding effect of tissue heterogeneity on genomic signatures

Genetic signatures have added a molecular dimension to prognostics and therapeutic decision-making. However, tumour heterogeneity in prostate cancer and current sampling methods could confound accurate assessment. Based on previously published spatial transcriptomic data from multifocal prostate can...

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Bibliographic Details
Published in:	Molecular cancer Vol. 22; no. 1; pp. 162 - 5
Main Authors:	Figiel, Sandy, Yin, Wencheng, Doultsinos, Dimitrios, Erickson, Andrew, Poulose, Ninu, Singh, Reema, Magnussen, Anette, Anbarasan, Thineskrishna, Teague, Renuka, He, Mengxiao, Lundeberg, Joakim, Loda, Massimo, Verrill, Clare, Colling, Richard, Gill, Pelvender S., Bryant, Richard J., Hamdy, Freddie C., Woodcock, Dan J., Mills, Ian G., Cussenot, Olivier, Lamb, Alastair D.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 03.10.2023 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Analysis Archives & records Biomedical and Life Sciences Biomedicine Biopsy Cancer Research Cell cycle Clinical decision making Cloning Correspondence Decision making Gene expression Genes Genetic research Genomes Genomics Health aspects Humans Male Oncology Prognostic genetic signatures Prostate - pathology Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Review boards Spatial transcriptomics Stroma Transcriptome Transcriptomics Tumors Virtual biopsy Virtual biopsy Spatial transcriptomics Prostate cancer Prognostic genetic signatures
ISSN:	1476-4598, 1476-4598
Online Access:	Get full text
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