Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial

Potassium depletion by thiazide diuretics is associated with a rise in blood glucose. We assessed whether addition or substitution of a potassium-sparing diuretic, amiloride, to treatment with a thiazide can prevent glucose intolerance and improve blood pressure control. We did a parallel-group, ran...

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Bibliographic Details

Published in:	The lancet. Diabetes & endocrinology Vol. 4; no. 2; p. 136
Main Authors:	Brown, Morris J, Williams, Bryan, Morant, Steve V, Webb, David J, Caulfield, Mark J, Cruickshank, J Kennedy, Ford, Ian, McInnes, Gordon, Sever, Peter, Salsbury, Jackie, Mackenzie, Isla S, Padmanabhan, Sandosh, MacDonald, Thomas M
Format:	Journal Article
Language:	English
Published:	England 01.02.2016
Subjects:	Aged Amiloride - therapeutic use Diuretics - therapeutic use Double-Blind Method Female Glucose Intolerance - chemically induced Glucose Intolerance - prevention & control Humans Hydrochlorothiazide - adverse effects Hypertension - drug therapy Male Middle Aged
ISSN:	2213-8595, 2213-8595
Online Access:	Get more information
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