Endocervical adenocarcinomas and HPV genotyping in an HIV endemic milieu – a retrospective study

Background Cervical cancer is the most prevalent cancer in Mozambique, with endocervical adenocarcinoma accounting for approximately 5.5% of cases. Knowledge regarding the most prevalent HPV genotypes in endocervical adenocarcinoma is limited, within this setting. This study aimed to investigate hum...

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Veröffentlicht in:BMC women's health Jg. 25; H. 1; S. 20 - 8
Hauptverfasser: Lovane, Lucília, Larsson, Gabriella Lillsunde, Tulsidás, Satish, Carrilho, Carla, Andersson, Sören, Karlsson, Christina
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BioMed Central 15.01.2025
BioMed Central Ltd
Springer Nature B.V
BMC
Schlagworte:
Adenocarcinoma - epidemiology
Adenocarcinoma - virology
Adult
Automation
Cancer
Care and treatment
Cervical cancer
Complications and side effects
Endemic Diseases
Endocervical adenocarcinomas
Endometrial cancer
Female
Females
Genotype
Genotypes
Genotyping
Gynecology
HIV
HIV infection
HIV Infections - epidemiology
HPV
HPV vaccine
Human immunodeficiency virus
Human papillomavirus
Humans
Immunization
Immunohistochemistry
In situ hybridisation
Infections
Maternal and Child Health
Medicine
Medicine & Public Health
Middle Aged
Morphology
Mozambique - epidemiology
Papillomaviridae - genetics
Papillomaviridae - isolation & purification
Papillomavirus Infections - epidemiology
Papillomavirus Infections - virology
Pathology
Prevalence
Prevention
Reproductive Medicine
Retrospective Studies
Risk factors
Serology
Tumors
Uterine Cervical Neoplasms - epidemiology
Uterine Cervical Neoplasms - virology
Vaccines
Mozambique
Sub-Saharan Africa
Hungary
Endocervical adenocarcinomas
HIV
HPV vaccine
In situ hybridisation
HPV
ISSN:1472-6874, 1472-6874
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Zusammenfassung:Background Cervical cancer is the most prevalent cancer in Mozambique, with endocervical adenocarcinoma accounting for approximately 5.5% of cases. Knowledge regarding the most prevalent HPV genotypes in endocervical adenocarcinoma is limited, within this setting. This study aimed to investigate human papillomavirus (HPV) prevalence and genotypes within a cohort of endocervical adenocarcinoma patients in the context of Mozambique’s recently introduced vaccination programme, considering the country's HIV-endemic setting. Methods Forty consecutive cases of endocervical adenocarcinoma diagnosed at Maputo Central Hospital between 2017 and 2018, with limited clinical data available, were included. Human immunodeficiency virus (HIV) status was determined through serological data or in situ hybridisation on histopathological slides. HPV detection was performed using a multi-methodological approach, including Anyplex II, in-house polymerase chain reaction (PCR), and chromogenic and fluorescent in situ hybridisation techniques. Results All 40 cases exhibited HPV-dependent morphology. Fourteen of the 40 patients were HIV-positive. No significant differences were observed between the two groups regarding age, stage, or histopathological type. hrHPV16, 18, or 45 were detected in all cases. Notably, multiple hrHPV infections were identified exclusively in HIV-negative cases (10/26, p  = 0.0075), with hrHPV18/45 co-infection being the most common ( n  = 8). Conclusions These findings suggest that the newly implemented quadrivalent vaccination programme has the potential to prevent morbidity and mortality from endocervical adenocarcinoma, irrespective of HIV infection status, in Mozambique's HIV-endemic environment.
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ISSN:1472-6874
1472-6874
DOI:10.1186/s12905-025-03555-z