Nanomaterial-based blood-brain-barrier (BBB) crossing strategies

Increasing attention has been paid to the diseases of central nervous system (CNS). The penetration efficiency of most CNS drugs into the brain parenchyma is rather limited due to the existence of blood-brain barrier (BBB). Thus, BBB crossing for drug delivery to CNS remains a significant challenge...

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Bibliographic Details
Published in:Biomaterials Vol. 224; p. 119491
Main Authors: Xie, Jinbing, Shen, Zheyu, Anraku, Yasutaka, Kataoka, Kazunori, Chen, Xiaoyuan
Format: Journal Article
Language:English
Published: Netherlands Elsevier Ltd 01.12.2019
Subjects:
Animals
biocompatibility
biodegradability
blood-brain barrier
Blood-brain barrier (BBB)
Blood-Brain Barrier - metabolism
brain
Central nervous system (CNS)
Central Nervous System Diseases - pathology
Clinical Trials as Topic
Disease Models, Animal
drug carriers
Drug Delivery Systems
drugs
Humans
Nanomaterials
Nanostructures - chemistry
parenchyma (animal tissue)
peptides
toxicity
Nanomaterials
Drug delivery systems
Central nervous system (CNS)
Blood-brain barrier (BBB)
ISSN:0142-9612, 1878-5905, 1878-5905
Online Access:Get full text
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Summary:Increasing attention has been paid to the diseases of central nervous system (CNS). The penetration efficiency of most CNS drugs into the brain parenchyma is rather limited due to the existence of blood-brain barrier (BBB). Thus, BBB crossing for drug delivery to CNS remains a significant challenge in the development of neurological therapeutics. Because of the advantageous properties (e.g., relatively high drug loading content, controllable drug release, excellent passive and active targeting, good stability, biodegradability, biocompatibility, and low toxicity), nanomaterials with BBB-crossability have been widely developed for the treatment of CNS diseases. This review summarizes the current understanding of the physiological structure of BBB, and provides various nanomaterial-based BBB-crossing strategies for brain delivery of theranostic agents, including intranasal delivery, temporary disruption of BBB, local delivery, cell penetrating peptide (CPP) mediated BBB-crossing, receptor mediated BBB-crossing, shuttle peptide mediated BBB-crossing, and cells mediated BBB-crossing. Clinicians, biologists, material scientists and chemists are expected to be interested in this review.
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ISSN:0142-9612
1878-5905
1878-5905
DOI:10.1016/j.biomaterials.2019.119491