In vivo biodistribution analysis of transmission competent and defective RNA virus-based episomal vector

RNA virus-based episomal vector (REVec) is an emerging viral vector system that mediates long-term stable gene expression in variety of cell types in vitro . However, little is known about its tissue tropism and persistence of gene expression in vivo . Here, to evaluate the feasibility of REVec for...

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Bibliographic Details
Published in:	Scientific reports Vol. 10; no. 1; pp. 5890 - 12
Main Authors:	Komatsu, Yumiko, Tanaka, Chiaki, Komorizono, Ryo, Tomonaga, Keizo
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 03.04.2020 Nature Publishing Group Nature Portfolio
Subjects:	631/1647/2300 631/326/596/2561 Animals Animals, Genetically Modified Antibodies, Neutralizing - blood Antibodies, Viral - blood Astrocytes Astrocytes - metabolism Body weight Brain - metabolism CD8 antigen Feasibility Studies Feces - virology Female Gene Expression Gene transfer Genetic Vectors - administration & dosage Genetic Vectors - genetics Genetic Vectors - isolation & purification Genetic Vectors - pharmacokinetics Humanities and Social Sciences Lymphocytes T Microglia Microglia - metabolism multidisciplinary Neurons - metabolism Pathogenicity Pathogens Plasmids - genetics Rats Rats, Inbred Lew RNA viruses RNA Viruses - genetics RNA Viruses - immunology RNA Viruses - isolation & purification Science Science (multidisciplinary) Tissue Distribution Transduction, Genetic Transgenes - genetics Tropism Virus Replication Virus Shedding
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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