Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation

Caveolin-1 is the principal protein component of caveolae membrane domains, which are located at the cell surface in most cell types. Evidence has accumulated suggesting that caveolin-1 may function as a suppressor of cell transformation in cultured cells. The human CAV-1 gene is located at a putati...

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Bibliographic Details
Published in:	The American journal of pathology Vol. 162; no. 6; p. 2029
Main Authors:	Capozza, Franco, Williams, Terence M, Schubert, William, McClain, Steve, Bouzahzah, Boumediene, Sotgia, Federica, Lisanti, Michael P
Format:	Journal Article
Language:	English
Published:	United States 01.06.2003
Subjects:	9,10-Dimethyl-1,2-benzanthracene - toxicity Animals Carcinogens - toxicity Caveolin 1 Caveolins - genetics Caveolins - metabolism Cell Division - drug effects Cyclin D1 - metabolism Epidermis - drug effects Epidermis - pathology Hyperplasia Immunohistochemistry Keratinocytes - drug effects Keratinocytes - metabolism Keratinocytes - ultrastructure Mice Mice, Inbred C57BL Mice, Knockout Microscopy, Electron Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - metabolism Neoplasms, Experimental - chemically induced Neoplasms, Experimental - pathology Phosphorylation Skin - drug effects Skin - pathology Skin - ultrastructure Time Factors Up-Regulation
ISSN:	0002-9440
Online Access:	Get more information
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