Cells, scaffolds, and bioactive factors: Engineering strategies for improving regeneration following volumetric muscle loss

Severe traumatic skeletal muscle injuries, such as volumetric muscle loss (VML), result in the obliteration of large amounts of skeletal muscle and lead to permanent functional impairment. Current clinical treatments are limited in their capacity to regenerate damaged muscle and restore tissue funct...

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Bibliographic Details
Published in:Biomaterials Vol. 278; p. 121173
Main Authors: Eugenis, Ioannis, Wu, Di, Rando, Thomas A.
Format: Journal Article
Language:English
Published: Netherlands Elsevier Ltd 01.11.2021
Subjects:
biocompatible materials
Biomaterials
Immunomodulation
Innervation
muscle development
Muscle, Skeletal
muscles
nerve tissue
Recovery of Function
skeletal muscle
Skeletal muscle regeneration
therapeutics
Tissue Engineering
Tissue Scaffolds
Vascularization
Volumetric muscle loss
Tissue engineering
Immunomodulation
Innervation
Skeletal muscle regeneration
Volumetric muscle loss
Biomaterials
Vascularization
ISSN:0142-9612, 1878-5905, 1878-5905
Online Access:Get full text
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Description
Summary:Severe traumatic skeletal muscle injuries, such as volumetric muscle loss (VML), result in the obliteration of large amounts of skeletal muscle and lead to permanent functional impairment. Current clinical treatments are limited in their capacity to regenerate damaged muscle and restore tissue function, promoting the need for novel muscle regeneration strategies. Advances in tissue engineering, including cell therapy, scaffold design, and bioactive factor delivery, are promising solutions for VML therapy. Herein, we review tissue engineering strategies for regeneration of skeletal muscle, development of vasculature and nerve within the damaged muscle, and achievements in immunomodulation following VML. In addition, we discuss the limitations of current state of the art technologies and perspectives of tissue-engineered bioconstructs for muscle regeneration and functional recovery following VML.
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Authors contribute equally to this work.
ISSN:0142-9612
1878-5905
1878-5905
DOI:10.1016/j.biomaterials.2021.121173