Neural correlates of consciousness in patients who have emerged from a minimally conscious state: a cross-sectional multimodal imaging study
Between pathologically impaired consciousness and normal consciousness exists a scarcely researched transition zone, referred to as emergence from minimally conscious state, in which patients regain the capacity for functional communication, object use, or both. We investigated neural correlates of...
Gespeichert in:
| Veröffentlicht in: | Lancet neurology Jg. 15; H. 8; S. 830 - 842 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
England
Elsevier Ltd
01.07.2016
Elsevier Limited Elsevier |
| Schlagworte: | |
| ISSN: | 1474-4422, 1474-4465, 1474-4465 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Between pathologically impaired consciousness and normal consciousness exists a scarcely researched transition zone, referred to as emergence from minimally conscious state, in which patients regain the capacity for functional communication, object use, or both. We investigated neural correlates of consciousness in these patients compared with patients with disorders of consciousness and healthy controls, by multimodal imaging.
In this cross-sectional, multimodal imaging study, patients with unresponsive wakefulness syndrome, patients in a minimally conscious state, and patients who had emerged from a minimally conscious state, diagnosed with the Coma Recovery Scale–Revised, were recruited from the neurology department of the Centre Hospitalier Universitaire de Liège, Belgium. Key exclusion criteria were neuroimaging examination in an acute state, sedation or anaesthesia during scanning, large focal brain damage, motion parameters of more than 3 mm in translation and 3° in rotation, and suboptimal segmentation and normalisation. We acquired resting state functional and structural MRI data and 18F-fluorodeoxyglucose (FDG) PET data; we used seed-based functional MRI (fMRI) analysis to investigate positive default mode network connectivity (within-network correlations) and negative default mode network connectivity (between-network anticorrelations). We correlated FDG-PET brain metabolism with fMRI connectivity. We used voxel-based morphometry to test the effect of anatomical deformations on functional connectivity.
We recruited a convenience sample of 58 patients (21 [36%] with unresponsive wakefulness syndrome, 24 [41%] in a minimally conscious state, and 13 [22%] who had emerged from a minimally conscious state) and 35 healthy controls between Oct 1, 2009, and Oct 31, 2014. We detected consciousness-level-dependent increases (from unresponsive wakefulness syndrome, minimally conscious state, emergence from minimally conscious state, to healthy controls) for positive and negative default mode network connectivity, brain metabolism, and grey matter volume (p<0·05 false discovery rate corrected for multiple comparisons). Positive default mode network connectivity differed between patients and controls but not among patient groups (F test p<0·0001). Negative default mode network connectivity was only detected in healthy controls and in those who had emerged from a minimally conscious state; patients with unresponsive wakefulness syndrome or in a minimally conscious state showed pathological between-network positive connectivity (hyperconnectivity; F test p<0·0001). Brain metabolism correlated with positive default mode network connectivity (Spearman's r=0·50 [95% CI 0·26 to 0·61]; p<0·0001) and negative default mode network connectivity (Spearman's r=–0·52 [–0·35 to −0·67); p<0·0001). Grey matter volume did not differ between the studied groups (F test p=0·06).
Partial preservation of between-network anticorrelations, which are seemingly of neuronal origin and cannot be solely explained by morphological deformations, characterise patients who have emerged from a minimally conscious state. Conversely, patients with disorders of consciousness show pathological between-network correlations. Apart from a deeper understanding of the neural correlates of consciousness, these findings have clinical implications and might be particularly relevant for outcome prediction and could inspire new therapeutic options.
Belgian National Funds for Scientific Research (FNRS), European Commission, Natural Sciences and Engineering Research Council of Canada, James McDonnell Foundation, European Space Agency, Mind Science Foundation, French Speaking Community Concerted Research Action, Fondazione Europea di Ricerca Biomedica, University and University Hospital of Liège (Liège, Belgium), and University of Western Ontario (London, ON, Canada). |
|---|---|
| AbstractList | Summary Background Between pathologically impaired consciousness and normal consciousness exists a scarcely researched transition zone, referred to as emergence from minimally conscious state, in which patients regain the capacity for functional communication, object use, or both. We investigated neural correlates of consciousness in these patients compared with patients with disorders of consciousness and healthy controls, by multimodal imaging. Methods In this cross-sectional, multimodal imaging study, patients with unresponsive wakefulness syndrome, patients in a minimally conscious state, and patients who had emerged from a minimally conscious state, diagnosed with the Coma Recovery Scale–Revised, were recruited from the neurology department of the Centre Hospitalier Universitaire de Liège, Belgium. Key exclusion criteria were neuroimaging examination in an acute state, sedation or anaesthesia during scanning, large focal brain damage, motion parameters of more than 3 mm in translation and 3° in rotation, and suboptimal segmentation and normalisation. We acquired resting state functional and structural MRI data and18 F-fluorodeoxyglucose (FDG) PET data; we used seed-based functional MRI (fMRI) analysis to investigate positive default mode network connectivity (within-network correlations) and negative default mode network connectivity (between-network anticorrelations). We correlated FDG-PET brain metabolism with fMRI connectivity. We used voxel-based morphometry to test the effect of anatomical deformations on functional connectivity. Findings We recruited a convenience sample of 58 patients (21 [36%] with unresponsive wakefulness syndrome, 24 [41%] in a minimally conscious state, and 13 [22%] who had emerged from a minimally conscious state) and 35 healthy controls between Oct 1, 2009, and Oct 31, 2014. We detected consciousness-level-dependent increases (from unresponsive wakefulness syndrome, minimally conscious state, emergence from minimally conscious state, to healthy controls) for positive and negative default mode network connectivity, brain metabolism, and grey matter volume (p<0·05 false discovery rate corrected for multiple comparisons). Positive default mode network connectivity differed between patients and controls but not among patient groups ( F test p<0·0001). Negative default mode network connectivity was only detected in healthy controls and in those who had emerged from a minimally conscious state; patients with unresponsive wakefulness syndrome or in a minimally conscious state showed pathological between-network positive connectivity (hyperconnectivity; F test p<0·0001). Brain metabolism correlated with positive default mode network connectivity (Spearman's r =0·50 [95% CI 0·26 to 0·61]; p<0·0001) and negative default mode network connectivity (Spearman's r =–0·52 [–0·35 to −0·67); p<0·0001). Grey matter volume did not differ between the studied groups ( F test p=0·06). Interpretation Partial preservation of between-network anticorrelations, which are seemingly of neuronal origin and cannot be solely explained by morphological deformations, characterise patients who have emerged from a minimally conscious state. Conversely, patients with disorders of consciousness show pathological between-network correlations. Apart from a deeper understanding of the neural correlates of consciousness, these findings have clinical implications and might be particularly relevant for outcome prediction and could inspire new therapeutic options. Funding Belgian National Funds for Scientific Research (FNRS), European Commission, Natural Sciences and Engineering Research Council of Canada, James McDonnell Foundation, European Space Agency, Mind Science Foundation, French Speaking Community Concerted Research Action, Fondazione Europea di Ricerca Biomedica, University and University Hospital of Liège (Liège, Belgium), and University of Western Ontario (London, ON, Canada). Between pathologically impaired consciousness and normal consciousness exists a scarcely researched transition zone, referred to as emergence from minimally conscious state, in which patients regain the capacity for functional communication, object use, or both. We investigated neural correlates of consciousness in these patients compared with patients with disorders of consciousness and healthy controls, by multimodal imaging. Methods In this cross-sectional, multimodal imaging study, patients with unresponsive wakefulness syndrome, patients in a minimally conscious state, and patients who had emerged from a minimally conscious state, diagnosed with the Coma Recovery Scale-Revised, were recruited from the neurology department of the Centre Hospitalier Universitaire de Liège, Belgium. Key exclusion criteria were neuroimaging examination in an acute state, sedation or anaesthesia during scanning, large focal brain damage, motion parameters of more than 3 mm in translation and 3° in rotation, and suboptimal segmentation and normalisation. We acquired resting state functional and structural MRI data and18F-fluorodeoxyglucose (FDG) PET data; we used seed-based functional MRI (fMRI) analysis to investigate positive default mode network connectivity (within-network correlations) and negative default mode network connectivity (between-network anticorrelations). We correlated FDG-PET brain metabolism with fMRI connectivity. We used voxel-based morphometry to test the effect of anatomical deformations on functional connectivity. Findings We recruited a convenience sample of 58 patients (21 [36%] with unresponsive wakefulness syndrome, 24 [41%] in a minimally conscious state, and 13 [22%] who had emerged from a minimally conscious state) and 35 healthy controls between Oct 1, 2009, and Oct 31, 2014. We detected consciousness-level-dependent increases (from unresponsive wakefulness syndrome, minimally conscious state, emergence from minimally conscious state, to healthy controls) for positive and negative default mode network connectivity, brain metabolism, and grey matter volume (p<0·05 false discovery rate corrected for multiple comparisons). Positive default mode network connectivity differed between patients and controls but not among patient groups (Ftest p<0·0001). Negative default mode network connectivity was only detected in healthy controls and in those who had emerged from a minimally conscious state; patients with unresponsive wakefulness syndrome or in a minimally conscious state showed pathological between-network positive connectivity (hyperconnectivity;Ftest p<0·0001). Brain metabolism correlated with positive default mode network connectivity (Spearman'sr=0·50 [95% CI 0·26 to 0·61]; p<0·0001) and negative default mode network connectivity (Spearman'sr=-0·52 [-0·35 to -0·67); p<0·0001). Grey matter volume did not differ between the studied groups (Ftest p=0·06). Interpretation Partial preservation of between-network anticorrelations, which are seemingly of neuronal origin and cannot be solely explained by morphological deformations, characterise patients who have emerged from a minimally conscious state. Conversely, patients with disorders of consciousness show pathological between-network correlations. Apart from a deeper understanding of the neural correlates of consciousness, these findings have clinical implications and might be particularly relevant for outcome prediction and could inspire new therapeutic options. Funding Belgian National Funds for Scientific Research (FNRS), European Commission, Natural Sciences and Engineering Research Council of Canada, James McDonnell Foundation, European Space Agency, Mind Science Foundation, French Speaking Community Concerted Research Action, Fondazione Europea di Ricerca Biomedica, University and University Hospital of Liège (Liège, Belgium), and University of Western Ontario (London, ON, Canada). BACKGROUNDBetween pathologically impaired consciousness and normal consciousness exists a scarcely researched transition zone, referred to as emergence from minimally conscious state, in which patients regain the capacity for functional communication, object use, or both. We investigated neural correlates of consciousness in these patients compared with patients with disorders of consciousness and healthy controls, by multimodal imaging.METHODSIn this cross-sectional, multimodal imaging study, patients with unresponsive wakefulness syndrome, patients in a minimally conscious state, and patients who had emerged from a minimally conscious state, diagnosed with the Coma Recovery Scale-Revised, were recruited from the neurology department of the Centre Hospitalier Universitaire de Liège, Belgium. Key exclusion criteria were neuroimaging examination in an acute state, sedation or anaesthesia during scanning, large focal brain damage, motion parameters of more than 3 mm in translation and 3° in rotation, and suboptimal segmentation and normalisation. We acquired resting state functional and structural MRI data and (18)F-fluorodeoxyglucose (FDG) PET data; we used seed-based functional MRI (fMRI) analysis to investigate positive default mode network connectivity (within-network correlations) and negative default mode network connectivity (between-network anticorrelations). We correlated FDG-PET brain metabolism with fMRI connectivity. We used voxel-based morphometry to test the effect of anatomical deformations on functional connectivity.FINDINGSWe recruited a convenience sample of 58 patients (21 [36%] with unresponsive wakefulness syndrome, 24 [41%] in a minimally conscious state, and 13 [22%] who had emerged from a minimally conscious state) and 35 healthy controls between Oct 1, 2009, and Oct 31, 2014. We detected consciousness-level-dependent increases (from unresponsive wakefulness syndrome, minimally conscious state, emergence from minimally conscious state, to healthy controls) for positive and negative default mode network connectivity, brain metabolism, and grey matter volume (p<0·05 false discovery rate corrected for multiple comparisons). Positive default mode network connectivity differed between patients and controls but not among patient groups (F test p<0·0001). Negative default mode network connectivity was only detected in healthy controls and in those who had emerged from a minimally conscious state; patients with unresponsive wakefulness syndrome or in a minimally conscious state showed pathological between-network positive connectivity (hyperconnectivity; F test p<0·0001). Brain metabolism correlated with positive default mode network connectivity (Spearman's r=0·50 [95% CI 0·26 to 0·61]; p<0·0001) and negative default mode network connectivity (Spearman's r=-0·52 [-0·35 to -0·67); p<0·0001). Grey matter volume did not differ between the studied groups (F test p=0·06).INTERPRETATIONPartial preservation of between-network anticorrelations, which are seemingly of neuronal origin and cannot be solely explained by morphological deformations, characterise patients who have emerged from a minimally conscious state. Conversely, patients with disorders of consciousness show pathological between-network correlations. Apart from a deeper understanding of the neural correlates of consciousness, these findings have clinical implications and might be particularly relevant for outcome prediction and could inspire new therapeutic options.FUNDINGBelgian National Funds for Scientific Research (FNRS), European Commission, Natural Sciences and Engineering Research Council of Canada, James McDonnell Foundation, European Space Agency, Mind Science Foundation, French Speaking Community Concerted Research Action, Fondazione Europea di Ricerca Biomedica, University and University Hospital of Liège (Liège, Belgium), and University of Western Ontario (London, ON, Canada). Background Between pathologically impaired consciousness and normal consciousness exists a scarcely researched transition zone, referred to as emergence from minimally conscious state, in which patients regain the capacity for functional communication, object use, or both. We investigated neural correlates of consciousness in these patients compared with patients with disorders of consciousness and healthy controls, by multimodal imaging. Methods In this cross-sectional, multimodal imaging study, patients with unresponsive wakefulness syndrome, patients in a minimally conscious state, and patients who had emerged from a minimally conscious state, diagnosed with the Coma Recovery Scale–Revised, were recruited from the neurology department of the Centre Hospitalier Universitaire de Liège, Belgium. Key exclusion criteria were neuroimaging examination in an acute state, sedation or anaesthesia during scanning, large focal brain damage, motion parameters of more than 3 mm in translation and 3° in rotation, and suboptimal segmentation and normalisation. We acquired resting state functional and structural MRI data and ¹⁸F-fl uorodeoxyglucose (FDG) PET data; we used seed-based functional MRI (fMRI) analysis to investigate positive default mode network connectivity (within-network correlations) and negative default mode network connectivity (between-network anticorrelations). We correlated FDG-PET brain metabolism with fMRI connectivity. We used voxel- based morphometry to test the eff ect of anatomical deformations on functional connectivity. Findings We recruited a convenience sample of 58 patients (21 [36%] with unresponsive wakefulness syndrome, 24 [41%] in a minimally conscious state, and 13 [22%] who had emerged from a minimally conscious state) and 35 healthy controls between Oct 1, 2009, and Oct 31, 2014. We detected consciousness-level-dependent increases (from unresponsive wakefulness syndrome, minimally conscious state, emergence from minimally conscious state, to healthy controls) for positive and negative default mode network connectivity, brain metabolism, and grey matter volume (p<0·05 false discovery rate corrected for multiple comparisons). Positive default mode network connectivity diff ered between patients and controls but not among patient groups (F test p<0·0001). Negative default mode network connectivity was only detected in healthy controls and in those who had emerged from a minimally conscious state; patients with unresponsive wakefulness syndrome or in a minimally conscious state showed pathological between-network positive connectivity (hyperconnectivity; F test p<0·0001). Brain metabolism correlated with positive default mode network connectivity (Spearman’s r=0·50 [95% CI 0·26 to 0·61]; p<0·0001) and negative default mode network connectivity (Spearman’s r=–0·52 [–0·35 to –0·67); p<0·0001). Grey matter volume did not diff er between the studied groups (F test p=0·06). Interpretation Partial preservation of between-network anticorrelations, which are seemingly of neuronal origin and cannot be solely explained by morphological deformations, characterise patients who have emerged from a minimally conscious state. Conversely, patients with disorders of consciousness show pathological between-network correlations. Apart from a deeper understanding of the neural correlates of consciousness, these fi ndings have clinical implications and might be particularly relevant for outcome prediction and could inspire new therapeutic options. Between pathologically impaired consciousness and normal consciousness exists a scarcely researched transition zone, referred to as emergence from minimally conscious state, in which patients regain the capacity for functional communication, object use, or both. We investigated neural correlates of consciousness in these patients compared with patients with disorders of consciousness and healthy controls, by multimodal imaging. In this cross-sectional, multimodal imaging study, patients with unresponsive wakefulness syndrome, patients in a minimally conscious state, and patients who had emerged from a minimally conscious state, diagnosed with the Coma Recovery Scale-Revised, were recruited from the neurology department of the Centre Hospitalier Universitaire de Liège, Belgium. Key exclusion criteria were neuroimaging examination in an acute state, sedation or anaesthesia during scanning, large focal brain damage, motion parameters of more than 3 mm in translation and 3° in rotation, and suboptimal segmentation and normalisation. We acquired resting state functional and structural MRI data and (18)F-fluorodeoxyglucose (FDG) PET data; we used seed-based functional MRI (fMRI) analysis to investigate positive default mode network connectivity (within-network correlations) and negative default mode network connectivity (between-network anticorrelations). We correlated FDG-PET brain metabolism with fMRI connectivity. We used voxel-based morphometry to test the effect of anatomical deformations on functional connectivity. We recruited a convenience sample of 58 patients (21 [36%] with unresponsive wakefulness syndrome, 24 [41%] in a minimally conscious state, and 13 [22%] who had emerged from a minimally conscious state) and 35 healthy controls between Oct 1, 2009, and Oct 31, 2014. We detected consciousness-level-dependent increases (from unresponsive wakefulness syndrome, minimally conscious state, emergence from minimally conscious state, to healthy controls) for positive and negative default mode network connectivity, brain metabolism, and grey matter volume (p<0·05 false discovery rate corrected for multiple comparisons). Positive default mode network connectivity differed between patients and controls but not among patient groups (F test p<0·0001). Negative default mode network connectivity was only detected in healthy controls and in those who had emerged from a minimally conscious state; patients with unresponsive wakefulness syndrome or in a minimally conscious state showed pathological between-network positive connectivity (hyperconnectivity; F test p<0·0001). Brain metabolism correlated with positive default mode network connectivity (Spearman's r=0·50 [95% CI 0·26 to 0·61]; p<0·0001) and negative default mode network connectivity (Spearman's r=-0·52 [-0·35 to -0·67); p<0·0001). Grey matter volume did not differ between the studied groups (F test p=0·06). Partial preservation of between-network anticorrelations, which are seemingly of neuronal origin and cannot be solely explained by morphological deformations, characterise patients who have emerged from a minimally conscious state. Conversely, patients with disorders of consciousness show pathological between-network correlations. Apart from a deeper understanding of the neural correlates of consciousness, these findings have clinical implications and might be particularly relevant for outcome prediction and could inspire new therapeutic options. Belgian National Funds for Scientific Research (FNRS), European Commission, Natural Sciences and Engineering Research Council of Canada, James McDonnell Foundation, European Space Agency, Mind Science Foundation, French Speaking Community Concerted Research Action, Fondazione Europea di Ricerca Biomedica, University and University Hospital of Liège (Liège, Belgium), and University of Western Ontario (London, ON, Canada). Between pathologically impaired consciousness and normal consciousness exists a scarcely researched transition zone, referred to as emergence from minimally conscious state, in which patients regain the capacity for functional communication, object use, or both. We investigated neural correlates of consciousness in these patients compared with patients with disorders of consciousness and healthy controls, by multimodal imaging. In this cross-sectional, multimodal imaging study, patients with unresponsive wakefulness syndrome, patients in a minimally conscious state, and patients who had emerged from a minimally conscious state, diagnosed with the Coma Recovery Scale–Revised, were recruited from the neurology department of the Centre Hospitalier Universitaire de Liège, Belgium. Key exclusion criteria were neuroimaging examination in an acute state, sedation or anaesthesia during scanning, large focal brain damage, motion parameters of more than 3 mm in translation and 3° in rotation, and suboptimal segmentation and normalisation. We acquired resting state functional and structural MRI data and 18F-fluorodeoxyglucose (FDG) PET data; we used seed-based functional MRI (fMRI) analysis to investigate positive default mode network connectivity (within-network correlations) and negative default mode network connectivity (between-network anticorrelations). We correlated FDG-PET brain metabolism with fMRI connectivity. We used voxel-based morphometry to test the effect of anatomical deformations on functional connectivity. We recruited a convenience sample of 58 patients (21 [36%] with unresponsive wakefulness syndrome, 24 [41%] in a minimally conscious state, and 13 [22%] who had emerged from a minimally conscious state) and 35 healthy controls between Oct 1, 2009, and Oct 31, 2014. We detected consciousness-level-dependent increases (from unresponsive wakefulness syndrome, minimally conscious state, emergence from minimally conscious state, to healthy controls) for positive and negative default mode network connectivity, brain metabolism, and grey matter volume (p<0·05 false discovery rate corrected for multiple comparisons). Positive default mode network connectivity differed between patients and controls but not among patient groups (F test p<0·0001). Negative default mode network connectivity was only detected in healthy controls and in those who had emerged from a minimally conscious state; patients with unresponsive wakefulness syndrome or in a minimally conscious state showed pathological between-network positive connectivity (hyperconnectivity; F test p<0·0001). Brain metabolism correlated with positive default mode network connectivity (Spearman's r=0·50 [95% CI 0·26 to 0·61]; p<0·0001) and negative default mode network connectivity (Spearman's r=–0·52 [–0·35 to −0·67); p<0·0001). Grey matter volume did not differ between the studied groups (F test p=0·06). Partial preservation of between-network anticorrelations, which are seemingly of neuronal origin and cannot be solely explained by morphological deformations, characterise patients who have emerged from a minimally conscious state. Conversely, patients with disorders of consciousness show pathological between-network correlations. Apart from a deeper understanding of the neural correlates of consciousness, these findings have clinical implications and might be particularly relevant for outcome prediction and could inspire new therapeutic options. Belgian National Funds for Scientific Research (FNRS), European Commission, Natural Sciences and Engineering Research Council of Canada, James McDonnell Foundation, European Space Agency, Mind Science Foundation, French Speaking Community Concerted Research Action, Fondazione Europea di Ricerca Biomedica, University and University Hospital of Liège (Liège, Belgium), and University of Western Ontario (London, ON, Canada). Background Between pathologically impaired consciousness and normal consciousness exists a scarcely researched transition zone, referred to as emergence from minimally conscious state, in which patients regain the capacity for functional communication, object use, or both. We investigated neural correlates of consciousness in these patients compared with patients with disorders of consciousness and healthy controls, by multimodal imaging. Methods In this cross-sectional, multimodal imaging study, patients with unresponsive wakefulness syndrome, patients in a minimally conscious state, and patients who had emerged from a minimally conscious state, diagnosed with the Coma Recovery Scale-Revised, were recruited from the neurology department of the Centre Hospitalier Universitaire de Liege, Belgium. Key exclusion criteria were neuroimaging examination in an acute state, sedation or anaesthesia during scanning, large focal brain damage, motion parameters of more than 3 mm in translation and 3 degree in rotation, and suboptimal segmentation and normalisation. We acquired resting state functional and structural MRI data and 18F-fluorodeoxyglucose (FDG) PET data; we used seed-based functional MRI (fMRI) analysis to investigate positive default mode network connectivity (within-network correlations) and negative default mode network connectivity (between-network anticorrelations). We correlated FDG-PET brain metabolism with fMRI connectivity. We used voxel-based morphometry to test the effect of anatomical deformations on functional connectivity. Findings We recruited a convenience sample of 58 patients (21 [36%] with unresponsive wakefulness syndrome, 24 [41%] in a minimally conscious state, and 13 [22%] who had emerged from a minimally conscious state) and 35 healthy controls between Oct 1, 2009, and Oct 31, 2014. We detected consciousness-level-dependent increases (from unresponsive wakefulness syndrome, minimally conscious state, emergence from minimally conscious state, to healthy controls) for positive and negative default mode network connectivity, brain metabolism, and grey matter volume (p<0.05 false discovery rate corrected for multiple comparisons). Positive default mode network connectivity differed between patients and controls but not among patient groups (F test p<0.0001). Negative default mode network connectivity was only detected in healthy controls and in those who had emerged from a minimally conscious state; patients with unresponsive wakefulness syndrome or in a minimally conscious state showed pathological between-network positive connectivity (hyperconnectivity; F test p<0.0001). Brain metabolism correlated with positive default mode network connectivity (Spearman's r=0.50 [95% CI 0.26 to 0.61]; p<0.0001) and negative default mode network connectivity (Spearman's r=-0.52 [-0.35 to -0.67); p<0.0001). Grey matter volume did not differ between the studied groups (F test p=0.06). Interpretation Partial preservation of between-network anticorrelations, which are seemingly of neuronal origin and cannot be solely explained by morphological deformations, characterise patients who have emerged from a minimally conscious state. Conversely, patients with disorders of consciousness show pathological between-network correlations. Apart from a deeper understanding of the neural correlates of consciousness, these findings have clinical implications and might be particularly relevant for outcome prediction and could inspire new therapeutic options. Funding Belgian National Funds for Scientific Research (FNRS), European Commission, Natural Sciences and Engineering Research Council of Canada, James McDonnell Foundation, European Space Agency, Mind Science Foundation, French Speaking Community Concerted Research Action, Fondazione Europea di Ricerca Biomedica, University and University Hospital of Liege (Liege, Belgium), and University of Western Ontario (London, ON, Canada). |
| Author | Gomez, Francisco Heine, Lizette Tshibanda, Luaba Amico, Enrico Bahri, Mohamed Ali Charland-Verville, Vanessa Hustinx, Roland Thibaut, Aurore Antonopoulos, Georgios Soddu, Andrea Laureys, Steven Demertzi, Athena Di Perri, Carol Wannez, Sarah |
| Author_xml | – sequence: 1 givenname: Carol surname: Di Perri fullname: Di Perri, Carol email: diperric@gmail.com organization: Coma Science Group, GIGA Research, Université et Centre Hospitalier Universitaire de Liège, Liège, Belgium – sequence: 2 givenname: Mohamed Ali surname: Bahri fullname: Bahri, Mohamed Ali organization: GIGA-Cyclotron Research Centre: In Vivo Imaging, Université de Liège, Liège, Belgium – sequence: 3 givenname: Enrico surname: Amico fullname: Amico, Enrico organization: Coma Science Group, GIGA Research, Université et Centre Hospitalier Universitaire de Liège, Liège, Belgium – sequence: 4 givenname: Aurore surname: Thibaut fullname: Thibaut, Aurore organization: Coma Science Group, GIGA Research, Université et Centre Hospitalier Universitaire de Liège, Liège, Belgium – sequence: 5 givenname: Lizette surname: Heine fullname: Heine, Lizette organization: Coma Science Group, GIGA Research, Université et Centre Hospitalier Universitaire de Liège, Liège, Belgium – sequence: 6 givenname: Georgios surname: Antonopoulos fullname: Antonopoulos, Georgios organization: Coma Science Group, GIGA Research, Université et Centre Hospitalier Universitaire de Liège, Liège, Belgium – sequence: 7 givenname: Vanessa surname: Charland-Verville fullname: Charland-Verville, Vanessa organization: Coma Science Group, GIGA Research, Université et Centre Hospitalier Universitaire de Liège, Liège, Belgium – sequence: 8 givenname: Sarah surname: Wannez fullname: Wannez, Sarah organization: Coma Science Group, GIGA Research, Université et Centre Hospitalier Universitaire de Liège, Liège, Belgium – sequence: 9 givenname: Francisco surname: Gomez fullname: Gomez, Francisco organization: Department of Mathematics, Universidad Nacional de Colombia sede Bogotá, Bogotá, Colombia – sequence: 10 givenname: Roland surname: Hustinx fullname: Hustinx, Roland organization: Nuclear Medicine Department, Centre Hospitalier Universitaire de Liège, Liège, Belgium – sequence: 11 givenname: Luaba surname: Tshibanda fullname: Tshibanda, Luaba organization: Department of Neuroradiology, Centre Hospitalier Universitaire de Liège, Liège, Belgium – sequence: 12 givenname: Athena surname: Demertzi fullname: Demertzi, Athena organization: Coma Science Group, GIGA Research, Université et Centre Hospitalier Universitaire de Liège, Liège, Belgium – sequence: 13 givenname: Andrea surname: Soddu fullname: Soddu, Andrea organization: Brain and Mind Institute, Department of Physics and Astronomy, University of Western Ontario, London, ON, Canada – sequence: 14 givenname: Steven surname: Laureys fullname: Laureys, Steven email: steven.laureys@ulg.ac.be organization: Coma Science Group, GIGA Research, Université et Centre Hospitalier Universitaire de Liège, Liège, Belgium |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27131917$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkt1u1DAQhS1URNuFRwBZ4qZcBGzH-aMChCr-pAougGvLcSZbF8de7GTRvgMPzexmaaWVULnKODnnc2bOnJIjHzwQ8piz55zx8sVXLiuZSSnEGS-fMcY5z_J75GT_uiyObmohjslpSteMCS5r_oAci4rnvOHVCfn9GaaoHTUhRnB6hERDjyefjA1T8pAStZ6u9GjBj4n-ugr0Sq-BwgBxCR3tYxiopoP1dtDObW69NI3Ie4kfTQwpZQnMaIPHy4bJjXYIHZZoWlq_RO3UbR6S-712CR7tnwvy_f27bxcfs8svHz5dvL3MTCmLMWt5V0nWFA00bS4B2rY3fSO1EHmNfem67houQOeSl1xqrqVsqtZUBbasC9PnC5LPXGdhCSrE1qq1UEHbuZ7cUmmjWlBClLUSTNYIXpCz2bWK4ecEaVSDTQac0x6wXcVrVpeiaXh9t7RqqkKyUkqUPj2QXocp4pT2KlbmO9WTvWpqB-jUKuLg4kb9DRIFxSzYzTpCfyPhTG0XRu0WRm23QeFptzAqR9_5gc9YjA1zGqO27k73m9kNmNbaQlQYPXgDnY2YtuqCvZPw-oBgHK6S0e4HbCDdzkIlodgM2TJ4uSNsAa_-DfiPH_gD47sB3w |
| CODEN | LANCAO |
| CitedBy_id | crossref_primary_10_1016_j_bica_2017_10_001 crossref_primary_10_3390_e22090917 crossref_primary_10_1097_RLU_0000000000002335 crossref_primary_10_1007_s12028_017_0445_0 crossref_primary_10_1097_RCT_0000000000001034 crossref_primary_10_1097_MD_0000000000030199 crossref_primary_10_3389_fneur_2020_00933 crossref_primary_10_1016_j_neuroimage_2022_119128 crossref_primary_10_1007_s11055_021_01173_4 crossref_primary_10_1016_j_nicl_2019_101841 crossref_primary_10_1523_JNEUROSCI_0647_21_2021 crossref_primary_10_18359_rlbi_5635 crossref_primary_10_1016_j_jocn_2018_09_020 crossref_primary_10_31083_j_jin2202037 crossref_primary_10_3389_fnhum_2022_972538 crossref_primary_10_1371_journal_pcbi_1010412 crossref_primary_10_1002_acn3_648 crossref_primary_10_7717_peerj_6575 crossref_primary_10_1016_j_lpm_2022_104163 crossref_primary_10_1016_j_clinph_2021_12_002 crossref_primary_10_1016_S1474_4422_16_30202_2 crossref_primary_10_3389_fnsys_2023_1112206 crossref_primary_10_1093_nc_niae027 crossref_primary_10_1093_nc_niae025 crossref_primary_10_1371_journal_pone_0298110 crossref_primary_10_3390_brainsci9050123 crossref_primary_10_3389_fneur_2018_00665 crossref_primary_10_3389_fnsys_2021_648860 crossref_primary_10_3389_fnhum_2016_00528 crossref_primary_10_1016_j_lpm_2023_104180 crossref_primary_10_3389_fnhum_2025_1533212 crossref_primary_10_1515_revneuro_2020_0012 crossref_primary_10_1016_j_nicl_2021_102797 crossref_primary_10_1097_CCM_0000000000004406 crossref_primary_10_1038_s41467_023_38972_x crossref_primary_10_1186_s13054_025_05429_0 crossref_primary_10_1186_s40708_020_00116_y crossref_primary_10_3390_healthcare11081148 crossref_primary_10_1038_s41598_020_61180_2 crossref_primary_10_1111_ner_12903 crossref_primary_10_1080_02643294_2024_2420406 crossref_primary_10_1186_s13054_025_05338_2 crossref_primary_10_3171_2019_9_FOCUS19652 crossref_primary_10_1097_ALN_0000000000002876 crossref_primary_10_1093_cercor_bhac222 crossref_primary_10_1186_s12910_022_00770_3 crossref_primary_10_1016_S1474_4422_16_30027_8 crossref_primary_10_1111_cns_14787 crossref_primary_10_3389_fnhum_2022_992649 crossref_primary_10_1016_j_nicl_2025_103864 crossref_primary_10_1007_s12264_022_00909_7 crossref_primary_10_3390_jcm13195704 crossref_primary_10_1016_j_neuron_2024_03_002 crossref_primary_10_1038_s42003_023_04474_1 crossref_primary_10_1016_j_socscimed_2023_116261 crossref_primary_10_1007_s00415_024_12591_y crossref_primary_10_1038_s41467_022_34410_6 crossref_primary_10_1097_01_NT_0000554416_75768_40 crossref_primary_10_3389_fnbeh_2022_1001519 crossref_primary_10_3389_fneur_2018_01012 crossref_primary_10_1093_brain_awac335 crossref_primary_10_1007_s12028_021_01281_6 crossref_primary_10_1016_j_clinph_2021_10_018 crossref_primary_10_1080_02699052_2021_1894482 crossref_primary_10_3390_brainsci9050103 crossref_primary_10_1016_j_neuroimage_2017_11_030 crossref_primary_10_3390_brainsci11060749 crossref_primary_10_1016_j_neuroimage_2019_03_012 crossref_primary_10_1016_j_tins_2018_01_003 crossref_primary_10_1038_s41467_019_12658_9 crossref_primary_10_3389_fneur_2023_1027160 crossref_primary_10_1016_j_cortex_2018_05_004 crossref_primary_10_1162_netn_a_00259 crossref_primary_10_1016_j_neuroscience_2021_06_031 crossref_primary_10_1016_j_nicl_2022_102951 crossref_primary_10_5698_1535_7597_18_3_147 crossref_primary_10_3389_fnins_2019_00731 crossref_primary_10_1371_journal_pone_0267194 crossref_primary_10_1038_s41598_020_57695_3 crossref_primary_10_3389_fnins_2023_1113695 crossref_primary_10_1515_revneuro_2023_0159 crossref_primary_10_1016_j_brainres_2022_148162 crossref_primary_10_1038_s41598_020_67234_9 crossref_primary_10_1016_j_neubiorev_2025_106333 crossref_primary_10_1016_j_neuroimage_2023_120018 crossref_primary_10_3389_fnins_2021_554194 crossref_primary_10_3389_fneur_2018_01024 crossref_primary_10_3389_fnins_2022_878203 crossref_primary_10_1016_j_bja_2024_12_036 crossref_primary_10_1007_s10548_024_01087_7 crossref_primary_10_1016_j_cobeha_2025_101545 crossref_primary_10_1007_s12264_018_0250_6 crossref_primary_10_1016_j_neuroimage_2019_116316 crossref_primary_10_1016_j_neurot_2024_e00374 crossref_primary_10_1038_s41593_020_0639_1 crossref_primary_10_1523_JNEUROSCI_1684_24_2025 crossref_primary_10_1002_brb3_1476 crossref_primary_10_1162_netn_a_00244 crossref_primary_10_1016_j_clinph_2022_09_017 crossref_primary_10_1038_s41598_017_03170_5 crossref_primary_10_3389_fneur_2023_1257886 crossref_primary_10_1016_j_nicl_2020_102471 crossref_primary_10_1038_s41598_024_52267_1 crossref_primary_10_1371_journal_pone_0205967 crossref_primary_10_1089_brain_2020_0744 crossref_primary_10_1055_a_1892_1894 crossref_primary_10_1007_s12028_022_01525_z crossref_primary_10_1007_s12264_018_0243_5 crossref_primary_10_1016_S1474_4422_16_30205_8 crossref_primary_10_3390_brainsci11050665 crossref_primary_10_3390_medsci9010010 crossref_primary_10_1038_s41582_020_00428_x crossref_primary_10_1007_s11571_020_09658_7 crossref_primary_10_1111_ejn_16138 crossref_primary_10_1016_j_clinph_2016_12_011 crossref_primary_10_3389_fnins_2019_00746 crossref_primary_10_1016_j_nicl_2018_101629 crossref_primary_10_1016_j_neuroscience_2017_02_053 crossref_primary_10_1016_j_neuroimage_2020_117653 crossref_primary_10_3389_fneur_2021_778951 crossref_primary_10_1016_j_cobeha_2025_101524 crossref_primary_10_1073_pnas_2026289118 crossref_primary_10_1097_SCS_0000000000005404 crossref_primary_10_1016_j_bja_2020_11_035 crossref_primary_10_1111_ajag_12417 crossref_primary_10_3390_brainsci10010042 crossref_primary_10_31083_j_jin2206142 crossref_primary_10_1097_WNP_0000000000000846 crossref_primary_10_1111_ejn_16149 crossref_primary_10_3389_fmed_2019_00317 crossref_primary_10_3390_jcm8030306 crossref_primary_10_7554_eLife_36173 crossref_primary_10_1186_s12883_018_1040_5 crossref_primary_10_3389_fneur_2018_00769 crossref_primary_10_1097_MD_0000000000015620 crossref_primary_10_1002_hbm_25405 crossref_primary_10_1136_bmjno_2023_000584 crossref_primary_10_1038_s42003_022_04109_x crossref_primary_10_1016_j_nicl_2019_102071 crossref_primary_10_21307_sjcapp_2018_011 crossref_primary_10_3390_brainsci11081107 crossref_primary_10_3390_diagnostics10050309 crossref_primary_10_1038_s41583_025_00934_1 crossref_primary_10_1016_j_neuroimage_2017_01_020 crossref_primary_10_3389_fnins_2019_00530 crossref_primary_10_1016_j_brainres_2024_149133 crossref_primary_10_3390_medicina59010078 crossref_primary_10_1093_nc_niw011 crossref_primary_10_1177_1545968319899914 crossref_primary_10_3389_fneur_2020_01027 crossref_primary_10_1093_brain_awx163 crossref_primary_10_1148_radiol_2017162161 crossref_primary_10_3389_fneur_2019_00248 crossref_primary_10_1002_hbm_23611 crossref_primary_10_1097_WCO_0000000000000873 crossref_primary_10_1016_j_concog_2018_06_004 crossref_primary_10_1002_hbm_24303 crossref_primary_10_3389_fnsys_2021_650528 crossref_primary_10_3390_brainsci12030355 crossref_primary_10_1186_s12883_020_01758_5 crossref_primary_10_3389_fnsys_2019_00008 |
| Cites_doi | 10.1016/j.tics.2005.10.010 10.1097/WCO.0b013e3282f1c720 10.1016/j.cortex.2013.11.005 10.1089/brain.2011.0019 10.1016/j.neuroimage.2008.12.008 10.1002/ana.24423 10.1073/pnas.071043098 10.1038/jcbfm.2010.86 10.1016/S1474-4422(12)70188-6 10.1146/annurev.med.60.060107.091250 10.1093/brain/awv169 10.1016/j.neuroscience.2005.10.029 10.1080/02699050802403557 10.1038/nrneurol.2013.279 10.1073/pnas.0504136102 10.1371/journal.pone.0046313 10.1186/1471-2377-10-35 10.1016/j.apmr.2004.02.033 10.1038/nn.2445 10.1016/j.tins.2009.11.002 10.1089/brain.2012.0117 10.1016/j.neuroimage.2011.07.044 10.1016/S0140-6736(05)73084-1 10.1016/j.neuroimage.2007.07.007 10.1016/j.neuroimage.2011.12.086 10.1016/S0140-6736(14)60042-8 10.1073/pnas.1418031112 10.1162/jocn.2010.21488 10.1212/WNL.0000000000001123 10.1038/nn.2303 10.1073/pnas.0704320104 10.1002/hbm.21079 10.2340/16501977-0940 10.1093/brain/awp313 10.1038/nature05758 10.1007/s00415-011-6303-7 10.1016/j.neuroimage.2013.08.048 10.1212/WNL.0b013e3182a43b78 10.1016/j.neuroimage.2014.10.044 10.1016/j.neuroimage.2007.04.042 10.1002/hbm.22753 10.1093/brain/124.7.1263 10.1523/JNEUROSCI.5626-10.2011 10.1523/JNEUROSCI.0415-15.2015 10.1016/j.neuroimage.2011.08.048 10.1097/ALN.0b013e318249d0a7 10.1073/pnas.98.2.676 10.1097/ALN.0b013e3181f697f5 10.1016/j.mri.2010.03.021 10.1002/(SICI)1097-0193(1997)5:4<317::AID-HBM19>3.0.CO;2-A 10.1002/hbm.20672 10.3174/ajnr.A2200 10.1089/brain.2012.0073 10.1002/hbm.21249 10.1212/WNL.58.3.349 10.1073/pnas.0135058100 10.1016/j.cortex.2014.12.001 10.1196/annals.1417.029 10.1016/j.neuroscience.2014.06.018 10.1136/jnnp.2004.045930 10.1002/hbm.20113 10.1093/brain/awp086 10.1089/brain.2012.0086 10.3389/fnhum.2013.00538 10.1016/j.neuroimage.2008.09.036 10.1016/S0140-6736(00)02271-6 10.1016/j.neuroimage.2005.02.018 10.1016/S1474-4422(04)00852-X |
| ContentType | Journal Article |
| Copyright | 2016 Elsevier Ltd Elsevier Ltd Copyright © 2016 Elsevier Ltd. All rights reserved. Copyright Elsevier Limited Jul 01, 2016 |
| Copyright_xml | – notice: 2016 Elsevier Ltd – notice: Elsevier Ltd – notice: Copyright © 2016 Elsevier Ltd. All rights reserved. – notice: Copyright Elsevier Limited Jul 01, 2016 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7RV 7TK 7X7 7XB 88E 88G 8AO 8C2 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH GNUQQ K9. KB0 M0S M1P M2M NAPCQ PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS PSYQQ Q9U 7X8 Q33 |
| DOI | 10.1016/S1474-4422(16)00111-3 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Nursing & Allied Health Database Neurosciences Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Psychology Database (Alumni) ProQuest Pharma Collection Lancet Titles ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials - QC ProQuest Central ProQuest One Community College ProQuest Central Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) ProQuest Health & Medical Collection Medical Database Psychology Database Nursing & Allied Health Premium ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic MEDLINE - Academic Université de Liège - Open Repository and Bibliography (ORBI) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Psychology ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials Lancet Titles ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Pharma Collection ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Psychology Journals (Alumni) Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Medical Library ProQuest Psychology Journals ProQuest One Academic UKI Edition ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | ProQuest One Psychology MEDLINE - Academic MEDLINE Neurosciences Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7RV name: Nursing & Allied Health Database url: https://search.proquest.com/nahs sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1474-4465 |
| EndPage | 842 |
| ExternalDocumentID | oai_orbi_ulg_ac_be_2268_204881 4091696811 27131917 10_1016_S1474_4422_16_00111_3 S1474442216001113 1_s2_0_S1474442216001113 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation | Belgian National Funds for Scientific Research (FNRS), European Commission, Natural Sciences and Engineering Research Council of Canada, James McDonnell Foundation, European Space Agency, Mind Science Foundation, French Speaking Community Concerted Research Action, Fondazione Europea di Ricerca Biomedica, University and University Hospital of Liège (Liège, Belgium), and University of Western Ontario (London, ON, Canada). |
| GroupedDBID | --- --K --M -RU .1- .FO 0R~ 123 1B1 1P~ 1~5 29L 4.4 457 4G. 53G 5VS 7-5 71M 7RV 7X7 88E 8AO 8C2 8FI 8FJ AAEDT AAEDW AAIKJ AAKOC AALRI AAMRU AAQFI AAQQT AATTM AAXKI AAXLA AAXUO AAYWO ABBQC ABCQJ ABIVO ABJNI ABMAC ABMZM ABOCM ABTEW ABUWG ABWVN ACGFS ACIEU ACLOT ACPRK ACRLP ACRPL ACVFH ADBBV ADCNI ADMUD ADNMO AEIPS AEKER AENEX AEUPX AEVXI AFKRA AFPUW AFRHN AFTJW AFXIZ AGHFR AGWIK AHMBA AIGII AIIUN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANZVX APXCP AXJTR AZQEC BENPR BKEYQ BKOJK BNPGV BPHCQ BVXVI CCPQU CS3 DU5 DWQXO EBS EFJIC EFKBS EJD EO8 EO9 EP2 EP3 EX3 F5P FDB FEDTE FIRID FNPLU FYGXN FYUFA G-Q GBLVA GNUQQ HF~ HMCUK HVGLF HZ~ IHE J1W JCF KOM M1P M2M M41 MO0 N9A NAPCQ O-L O9- OP~ OZT P-8 P-9 P2P PC. PHGZM PHGZT PJZUB PPXIY PQQKQ PROAC PSQYO PSYQQ ROL RPZ SDG SEL SES SPCBC SSH SSN SSZ T5K TLN UHS UKHRP UV1 WOW XBR Z5R ~HD 3V. AACTN AFCTW AFKWA AJOXV ALIPV AMFUW RIG SDF AADPK ABLVK ABYKQ AJBFU ZA5 9DU AAYXX AFFHD CITATION CGR CUY CVF ECM EIF NPM 7TK 7XB 8FK K9. PKEHL PQEST PQUKI PRINS Q9U 7X8 PUEGO Q33 |
| ID | FETCH-LOGICAL-c645t-b1d740959e9b34eebbfcf94a2238131a88d912ea341614a1a4497bc75191a5cf3 |
| IEDL.DBID | BENPR |
| ISICitedReferencesCount | 185 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000377545800020&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1474-4422 1474-4465 |
| IngestDate | Sat Nov 29 01:27:48 EST 2025 Thu Nov 20 07:42:10 EST 2025 Sun Sep 28 08:56:48 EDT 2025 Sun Nov 30 05:33:47 EST 2025 Wed Feb 19 02:44:31 EST 2025 Tue Nov 18 21:56:31 EST 2025 Sat Nov 29 03:40:58 EST 2025 Fri Feb 23 02:28:57 EST 2024 Tue Feb 25 19:56:21 EST 2025 Tue Oct 14 19:33:14 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Language | English |
| License | Copyright © 2016 Elsevier Ltd. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c645t-b1d740959e9b34eebbfcf94a2238131a88d912ea341614a1a4497bc75191a5cf3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 scopus-id:2-s2.0-84964608657 |
| ORCID | 0000-0001-5991-1747 0000-0001-7164-8742 0000-0001-8021-3759 0000-0002-6919-3360 0000-0002-3096-3807 |
| PMID | 27131917 |
| PQID | 1797506344 |
| PQPubID | 26255 |
| PageCount | 13 |
| ParticipantIDs | liege_orbi_v2_oai_orbi_ulg_ac_be_2268_204881 proquest_miscellaneous_1808629918 proquest_miscellaneous_1797540644 proquest_journals_1797506344 pubmed_primary_27131917 crossref_primary_10_1016_S1474_4422_16_00111_3 crossref_citationtrail_10_1016_S1474_4422_16_00111_3 elsevier_sciencedirect_doi_10_1016_S1474_4422_16_00111_3 elsevier_clinicalkeyesjournals_1_s2_0_S1474442216001113 elsevier_clinicalkey_doi_10_1016_S1474_4422_16_00111_3 |
| PublicationCentury | 2000 |
| PublicationDate | 2016-07-01 |
| PublicationDateYYYYMMDD | 2016-07-01 |
| PublicationDate_xml | – month: 07 year: 2016 text: 2016-07-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England – name: London |
| PublicationTitle | Lancet neurology |
| PublicationTitleAlternate | Lancet Neurol |
| PublicationYear | 2016 |
| Publisher | Elsevier Ltd Elsevier Limited Elsevier |
| Publisher_xml | – name: Elsevier Ltd – name: Elsevier Limited – name: Elsevier |
| References | Laureys, Boly (bib6) 2012; 150 Dosenbach, Fair, Miezin (bib12) 2007; 104 Bernat (bib2) 2009; 60 Soddu, Vanhaudenhuyse, Bahri (bib38) 2012; 33 Vizuete, Pillay, Ropella, Hudetz (bib70) 2014; 275 Fransson (bib52) 2005; 26 Vanhaudenhuyse, Demertzi, Schabus (bib53) 2011; 23 Laureys, Faymonville, Moonen, Luxen, Maquet (bib65) 2000; 355 Barttfeld, Uhrig, Sitt, Sigman, Jarraya, Dehaene (bib51) 2015; 112 Passow, Specht, Adamsen (bib46) 2015; 36 Giacino, Fins, Laureys, Schiff (bib3) 2014; 10 Zeman (bib4) 2001; 124 Greicius, Krasnow, Reiss, Menon (bib34) 2003; 100 Thibaut, Bruno, Chatelle (bib20) 2012; 44 Kriegeskorte, Lindquist, Nichols, Poldrack, Vul (bib43) 2010; 30 Giacino, Kalmar, Whyte (bib22) 2004; 85 Lutkenhoff, Chiang, Tshibanda (bib60) 2015; 78 Laureys (bib5) 2005; 9 Raichle (bib42) 2011; 1 Murphy, Birn, Handwerker, Jones, Bandettini (bib29) 2009; 44 Stender, Gosseries, Bruno (bib39) 2014; 384 Monti, Rosenberg, Finoia, Kamau, Pickard, Owen (bib61) 2015; 84 Power, Mitra, Laumann, Snyder, Schlaggar, Petersen (bib36) 2014; 84 Kriegeskorte, Simmons, Bellgowan, Baker (bib44) 2009; 12 Wang, Hu, Gualtieri (bib24) 2006; 3 Arthuis, Valton, Regis (bib71) 2009; 132 Demertzi, Antonopoulos, Heine (bib47) 2015; 138 Guldenmund, Demertzi, Boveroux (bib56) 2013; 3 Shulman, Corbetta, Fiez (bib11) 1997; 5 Ashburner, Friston (bib41) 2009; 45 Riedl, Utz, Castrillon (bib45) 2015; 113 Keller, Hedden, Thompson, Anteraper, Gabrieli, Whitfield-Gabrieli (bib49) 2015; 64 He, Shulman, Snyder, Corbetta (bib63) 2007; 20 Gusnard, Akbudak, Shulman, Raichle (bib30) 2001; 98 Di Perri, Bastianello, Bartsch (bib27) 2013; 81 Raichle, MacLeod, Snyder, Powers, Gusnard, Shulman (bib9) 2001; 98 Power, Schlaggar, Petersen (bib37) 2015; 105 Crunelli, Hughes (bib58) 2010; 13 Fox, Snyder, Vincent, Corbetta, Van Essen, Raichle (bib10) 2005; 102 Vincent, Patel, Fox (bib48) 2007; 447 Bruno, Majerus, Boly (bib66) 2012; 259 Schnakers, Majerus, Giacino (bib21) 2008; 22 Ashburner (bib25) 2007; 38 Ashburner, Friston (bib40) 2005; 26 Coleman, Menon, Fryer, Pickard (bib68) 2005; 76 Vanhaudenhuyse, Noirhomme, Tshibanda (bib15) 2010; 133 Demertzi, Vanhaudenhuyse, Bredart, Heine, di Perri, Laureys (bib13) 2013; 7 Boly, Tshibanda, Vanhaudenhuyse (bib18) 2009; 30 Boveroux, Vanhaudenhuyse, Bruno (bib17) 2010; 113 Bruno, Vanhaudenhuyse, Schnakers (bib23) 2010; 10 Chai, Castanon, Ongur, Whitfield-Gabrieli (bib33) 2012; 59 Whitfield-Gabrieli, Nieto-Castanon (bib32) 2012; 2 Steriade (bib57) 2006; 137 Van Dijk, Sabuncu, Buckner (bib35) 2012; 59 Takahashi, Ishii, Miyamoto (bib26) 2010; 31 Wu, Zou, Hu (bib54) 2015; 35 Schiff (bib59) 2010; 33 Anderson, Druzgal, Lopez-Larson, Jeong, Desai, Yurgelun-Todd (bib64) 2011; 32 Hampson, Driesen, Roth, Gore, Constable (bib50) 2010; 28 Demertzi, Gomez, Crone (bib16) 2014; 52 Laureys, Owen, Schiff (bib1) 2004; 3 Peelle, Cusack, Henson (bib28) 2012; 60 Schiff (bib62) 2008; 1129 Leech, Kamourieh, Beckmann, Sharp (bib14) 2011; 31 Di, Biswal (bib19) 2012; 2 Blumenfeld (bib55) 2012; 11 Laureys, Faymonville, Luxen, Lamy, Franck, Maquet (bib67) 2000; 355 Lee, Lee, Muller, Noh, Mashour (bib69) 2012; 7 Giacino, Ashwal, Childs (bib7) 2002; 58 Sanders, Tononi, Laureys, Sleigh (bib8) 2012; 116 Behzadi, Restom, Liau, Liu (bib31) 2007; 37 Demertzi (10.1016/S1474-4422(16)00111-3_bib16) 2014; 52 Behzadi (10.1016/S1474-4422(16)00111-3_bib31) 2007; 37 Wang (10.1016/S1474-4422(16)00111-3_bib24) 2006; 3 Whitfield-Gabrieli (10.1016/S1474-4422(16)00111-3_bib32) 2012; 2 Power (10.1016/S1474-4422(16)00111-3_bib37) 2015; 105 Gusnard (10.1016/S1474-4422(16)00111-3_bib30) 2001; 98 Vincent (10.1016/S1474-4422(16)00111-3_bib48) 2007; 447 Laureys (10.1016/S1474-4422(16)00111-3_bib5) 2005; 9 Leech (10.1016/S1474-4422(16)00111-3_bib14) 2011; 31 Raichle (10.1016/S1474-4422(16)00111-3_bib9) 2001; 98 Boly (10.1016/S1474-4422(16)00111-3_bib18) 2009; 30 Bernat (10.1016/S1474-4422(16)00111-3_bib2) 2009; 60 Monti (10.1016/S1474-4422(16)00111-3_bib61) 2015; 84 Fransson (10.1016/S1474-4422(16)00111-3_bib52) 2005; 26 Laureys (10.1016/S1474-4422(16)00111-3_bib65) 2000; 355 Vanhaudenhuyse (10.1016/S1474-4422(16)00111-3_bib15) 2010; 133 Thibaut (10.1016/S1474-4422(16)00111-3_bib20) 2012; 44 Boveroux (10.1016/S1474-4422(16)00111-3_bib17) 2010; 113 Lutkenhoff (10.1016/S1474-4422(16)00111-3_bib60) 2015; 78 Ashburner (10.1016/S1474-4422(16)00111-3_bib40) 2005; 26 Bruno (10.1016/S1474-4422(16)00111-3_bib66) 2012; 259 Di (10.1016/S1474-4422(16)00111-3_bib19) 2012; 2 Peelle (10.1016/S1474-4422(16)00111-3_bib28) 2012; 60 Murphy (10.1016/S1474-4422(16)00111-3_bib29) 2009; 44 Riedl (10.1016/S1474-4422(16)00111-3_bib45) 2015; 113 Crunelli (10.1016/S1474-4422(16)00111-3_bib58) 2010; 13 Lee (10.1016/S1474-4422(16)00111-3_bib69) 2012; 7 Dosenbach (10.1016/S1474-4422(16)00111-3_bib12) 2007; 104 Giacino (10.1016/S1474-4422(16)00111-3_bib3) 2014; 10 Power (10.1016/S1474-4422(16)00111-3_bib36) 2014; 84 Hampson (10.1016/S1474-4422(16)00111-3_bib50) 2010; 28 Barttfeld (10.1016/S1474-4422(16)00111-3_bib51) 2015; 112 Bruno (10.1016/S1474-4422(16)00111-3_bib23) 2010; 10 Ashburner (10.1016/S1474-4422(16)00111-3_bib25) 2007; 38 Wu (10.1016/S1474-4422(16)00111-3_bib54) 2015; 35 Kriegeskorte (10.1016/S1474-4422(16)00111-3_bib44) 2009; 12 Schnakers (10.1016/S1474-4422(16)00111-3_bib21) 2008; 22 Laureys (10.1016/S1474-4422(16)00111-3_bib6) 2012; 150 Stender (10.1016/S1474-4422(16)00111-3_bib39) 2014; 384 Raichle (10.1016/S1474-4422(16)00111-3_bib42) 2011; 1 Guldenmund (10.1016/S1474-4422(16)00111-3_bib56) 2013; 3 Steriade (10.1016/S1474-4422(16)00111-3_bib57) 2006; 137 Anderson (10.1016/S1474-4422(16)00111-3_bib64) 2011; 32 Laureys (10.1016/S1474-4422(16)00111-3_bib1) 2004; 3 Van Dijk (10.1016/S1474-4422(16)00111-3_bib35) 2012; 59 Blumenfeld (10.1016/S1474-4422(16)00111-3_bib55) 2012; 11 Passow (10.1016/S1474-4422(16)00111-3_bib46) 2015; 36 Greicius (10.1016/S1474-4422(16)00111-3_bib34) 2003; 100 Demertzi (10.1016/S1474-4422(16)00111-3_bib47) 2015; 138 He (10.1016/S1474-4422(16)00111-3_bib63) 2007; 20 Schiff (10.1016/S1474-4422(16)00111-3_bib62) 2008; 1129 Fox (10.1016/S1474-4422(16)00111-3_bib10) 2005; 102 Kriegeskorte (10.1016/S1474-4422(16)00111-3_bib43) 2010; 30 Arthuis (10.1016/S1474-4422(16)00111-3_bib71) 2009; 132 Chai (10.1016/S1474-4422(16)00111-3_bib33) 2012; 59 Giacino (10.1016/S1474-4422(16)00111-3_bib22) 2004; 85 Schiff (10.1016/S1474-4422(16)00111-3_bib59) 2010; 33 Sanders (10.1016/S1474-4422(16)00111-3_bib8) 2012; 116 Giacino (10.1016/S1474-4422(16)00111-3_bib7) 2002; 58 Keller (10.1016/S1474-4422(16)00111-3_bib49) 2015; 64 Ashburner (10.1016/S1474-4422(16)00111-3_bib41) 2009; 45 Laureys (10.1016/S1474-4422(16)00111-3_bib67) 2000; 355 Zeman (10.1016/S1474-4422(16)00111-3_bib4) 2001; 124 Demertzi (10.1016/S1474-4422(16)00111-3_bib13) 2013; 7 Di Perri (10.1016/S1474-4422(16)00111-3_bib27) 2013; 81 Coleman (10.1016/S1474-4422(16)00111-3_bib68) 2005; 76 Vizuete (10.1016/S1474-4422(16)00111-3_bib70) 2014; 275 Vanhaudenhuyse (10.1016/S1474-4422(16)00111-3_bib53) 2011; 23 Takahashi (10.1016/S1474-4422(16)00111-3_bib26) 2010; 31 Soddu (10.1016/S1474-4422(16)00111-3_bib38) 2012; 33 Shulman (10.1016/S1474-4422(16)00111-3_bib11) 1997; 5 27131916 - Lancet Neurol. 2016 Jul;15(8):781-782 |
| References_xml | – volume: 102 start-page: 9673 year: 2005 end-page: 9678 ident: bib10 article-title: The human brain is intrinsically organized into dynamic, anticorrelated functional networks publication-title: Proc Natl Acad Sci USA – volume: 138 start-page: 2619 year: 2015 end-page: 2631 ident: bib47 article-title: Intrinsic functional connectivity differentiates minimally conscious from unresponsive patients publication-title: Brain – volume: 137 start-page: 1087 year: 2006 end-page: 1106 ident: bib57 article-title: Grouping of brain rhythms in corticothalamic systems publication-title: Neuroscience – volume: 3 start-page: 1715 year: 2006 end-page: 1722 ident: bib24 article-title: Systematic and distributed time-of-flight list mode PET reconstruction publication-title: IEEE Nucl Sci Symp Conf Rec (1997) – volume: 26 start-page: 839 year: 2005 end-page: 851 ident: bib40 article-title: Unified segmentation publication-title: Neuroimage – volume: 7 start-page: e46313 year: 2012 ident: bib69 article-title: Genuine and spurious phase synchronization strengths during consciousness and general anesthesia publication-title: PLoS One – volume: 133 start-page: 161 year: 2010 end-page: 171 ident: bib15 article-title: Default network connectivity reflects the level of consciousness in non-communicative brain-damaged patients publication-title: Brain – volume: 28 start-page: 1051 year: 2010 end-page: 1057 ident: bib50 article-title: Functional connectivity between task-positive and task-negative brain areas and its relation to working memory performance publication-title: Magn Reson Imaging – volume: 10 start-page: 35 year: 2010 ident: bib23 article-title: Visual fixation in the vegetative state: an observational case series PET study publication-title: BMC Neurol – volume: 59 start-page: 431 year: 2012 end-page: 438 ident: bib35 article-title: The influence of head motion on intrinsic functional connectivity MRI publication-title: Neuroimage – volume: 275 start-page: 340 year: 2014 end-page: 351 ident: bib70 article-title: Graded defragmentation of cortical neuronal firing during recovery of consciousness in rats publication-title: Neuroscience – volume: 64 start-page: 271 year: 2015 end-page: 280 ident: bib49 article-title: Resting-state anticorrelations between medial and lateral prefrontal cortex: association with working memory, aging, and individual differences publication-title: Cortex – volume: 22 start-page: 786 year: 2008 end-page: 792 ident: bib21 article-title: A French validation study of the Coma Recovery Scale-Revised (CRS-R) publication-title: Brain Inj – volume: 38 start-page: 95 year: 2007 end-page: 113 ident: bib25 article-title: A fast diffeomorphic image registration algorithm publication-title: Neuroimage – volume: 113 start-page: 1038 year: 2010 end-page: 1053 ident: bib17 article-title: Breakdown of within- and between-network resting state functional magnetic resonance imaging connectivity during propofol-induced loss of consciousness publication-title: Anesthesiology – volume: 20 start-page: 655 year: 2007 end-page: 660 ident: bib63 article-title: The role of impaired neuronal communication in neurological disorders publication-title: Curr Opin Neurol – volume: 44 start-page: 893 year: 2009 end-page: 905 ident: bib29 article-title: The impact of global signal regression on resting state correlations: are anti-correlated networks introduced? publication-title: Neuroimage – volume: 3 start-page: 273 year: 2013 end-page: 285 ident: bib56 article-title: Thalamus, brainstem and salience network connectivity changes during propofol-induced sedation and unconsciousness publication-title: Brain Connect – volume: 10 start-page: 99 year: 2014 end-page: 114 ident: bib3 article-title: Disorders of consciousness after acquired brain injury: the state of the science publication-title: Nat Rev Neurol – volume: 59 start-page: 1420 year: 2012 end-page: 1428 ident: bib33 article-title: Anticorrelations in resting state networks without global signal regression publication-title: Neuroimage – volume: 78 start-page: 68 year: 2015 end-page: 76 ident: bib60 article-title: Thalamic and extrathalamic mechanisms of consciousness after severe brain injury publication-title: Ann Neurol – volume: 84 start-page: 320 year: 2014 end-page: 341 ident: bib36 article-title: Methods to detect, characterize, and remove motion artifact in resting state fMRI publication-title: NeuroImage – volume: 259 start-page: 1087 year: 2012 end-page: 1098 ident: bib66 article-title: Functional neuroanatomy underlying the clinical subcategorization of minimally conscious state patients publication-title: J Neurol – volume: 76 start-page: 432 year: 2005 end-page: 434 ident: bib68 article-title: Neurometabolic coupling in the vegetative and minimally conscious states: preliminary findings publication-title: J Neurol Neurosurg Psychiatry – volume: 58 start-page: 349 year: 2002 end-page: 353 ident: bib7 article-title: The minimally conscious state: definition and diagnostic criteria publication-title: Neurology – volume: 37 start-page: 90 year: 2007 end-page: 101 ident: bib31 article-title: A component based noise correction method (CompCor) for BOLD and perfusion based fMRI publication-title: Neuroimage – volume: 23 start-page: 570 year: 2011 end-page: 578 ident: bib53 article-title: Two distinct neuronal networks mediate the awareness of environment and of self publication-title: J Cogn Neurosci – volume: 35 start-page: 12932 year: 2015 end-page: 12946 ident: bib54 article-title: Intrinsic functional connectivity patterns predict consciousness level and recovery outcome in acquired brain injury publication-title: J Neurosci – volume: 105 start-page: 536 year: 2015 end-page: 551 ident: bib37 article-title: Recent progress and outstanding issues in motion correction in resting state fMRI publication-title: Neuroimage – volume: 30 start-page: 2393 year: 2009 end-page: 2400 ident: bib18 article-title: Functional connectivity in the default network during resting state is preserved in a vegetative but not in a brain dead patient publication-title: Hum Brain Mapp – volume: 12 start-page: 535 year: 2009 end-page: 540 ident: bib44 article-title: Circular analysis in systems neuroscience: the dangers of double dipping publication-title: Nat Neurosci – volume: 2 start-page: 275 year: 2012 end-page: 283 ident: bib19 article-title: Metabolic brain covariant networks as revealed by FDG-PET with reference to resting-state fMRI networks publication-title: Brain Connect – volume: 30 start-page: 1551 year: 2010 end-page: 1557 ident: bib43 article-title: Everything you never wanted to know about circular analysis, but were afraid to ask publication-title: J Cereb Blood Flow Metab – volume: 100 start-page: 253 year: 2003 end-page: 258 ident: bib34 article-title: Functional connectivity in the resting brain: a network analysis of the default mode hypothesis publication-title: Proc Natl Acad Sci USA – volume: 116 start-page: 946 year: 2012 end-page: 959 ident: bib8 article-title: Unresponsiveness not equal unconsciousness publication-title: Anesthesiology – volume: 98 start-page: 676 year: 2001 end-page: 682 ident: bib9 article-title: A default mode of brain function publication-title: Proc Natl Acad Sci USA – volume: 81 start-page: 1417 year: 2013 end-page: 1424 ident: bib27 article-title: Limbic hyperconnectivity in the vegetative state publication-title: Neurology – volume: 3 start-page: 537 year: 2004 end-page: 546 ident: bib1 article-title: Brain function in coma, vegetative state, and related disorders publication-title: Lancet Neurol – volume: 84 start-page: 167 year: 2015 end-page: 173 ident: bib61 article-title: Thalamo-frontal connectivity mediates top-down cognitive functions in disorders of consciousness publication-title: Neurology – volume: 85 start-page: 2020 year: 2004 end-page: 2029 ident: bib22 article-title: The JFK Coma Recovery Scale-Revised: measurement characteristics and diagnostic utility publication-title: Arch Phys Med Rehab – volume: 113 start-page: E1127 year: 2015 ident: bib45 article-title: Metabolic connectivity mapping reveals effective connectivity in the resting human brain publication-title: Proc Natl Acad Sci USA – volume: 33 start-page: 778 year: 2012 end-page: 796 ident: bib38 article-title: Identifying the default-mode component in spatial IC analyses of patients with disorders of consciousness publication-title: Hum Brain Mapp – volume: 31 start-page: 1873 year: 2010 end-page: 1878 ident: bib26 article-title: Measurement of gray and white matter atrophy in dementia with Lewy bodies using diffeomorphic anatomic registration through exponentiated lie algebra: a comparison with conventional voxel-based morphometry publication-title: AJNR Am J Neuroradiol – volume: 60 start-page: 1503 year: 2012 end-page: 1516 ident: bib28 article-title: Adjusting for global effects in voxel-based morphometry: gray matter decline in normal aging publication-title: Neuroimage – volume: 26 start-page: 15 year: 2005 end-page: 29 ident: bib52 article-title: Spontaneous low-frequency BOLD signal fluctuations: an fMRI investigation of the resting-state default mode of brain function hypothesis publication-title: Hum Brain Mapp – volume: 13 start-page: 9 year: 2010 end-page: 17 ident: bib58 article-title: The slow (<1 Hz) rhythm of non-REM sleep: a dialogue between three cardinal oscillators publication-title: Nat Neurosci – volume: 44 start-page: 487 year: 2012 end-page: 494 ident: bib20 article-title: Metabolic activity in external and internal awareness networks in severely brain-damaged patients publication-title: J Rehabil Med – volume: 355 start-page: 1790 year: 2000 end-page: 1791 ident: bib67 article-title: Restoration of thalamocortical connectivity after recovery from persistent vegetative state publication-title: Lancet – volume: 9 start-page: 556 year: 2005 end-page: 559 ident: bib5 article-title: The neural correlate of (un)awareness: lessons from the vegetative state publication-title: Trends Cogn Sci – volume: 98 start-page: 4259 year: 2001 end-page: 4264 ident: bib30 article-title: Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function publication-title: Proc Natl Acad Sci USA – volume: 355 start-page: 1825 year: 2000 end-page: 1826 ident: bib65 article-title: PET scanning and neuronal loss in acute vegetative state publication-title: Lancet – volume: 104 start-page: 11073 year: 2007 end-page: 11078 ident: bib12 article-title: Distinct brain networks for adaptive and stable task control in humans publication-title: Proc Natl Acad Sci USA – volume: 1 start-page: 3 year: 2011 end-page: 12 ident: bib42 article-title: The restless brain publication-title: Brain Connect – volume: 150 start-page: 31 year: 2012 end-page: 35 ident: bib6 article-title: Unresponsive wakefulness syndrome publication-title: Arch Ital Biol – volume: 1129 start-page: 105 year: 2008 end-page: 118 ident: bib62 article-title: Central thalamic contributions to arousal regulation and neurological disorders of consciousness publication-title: Ann NY Acad Sci – volume: 7 start-page: 538 year: 2013 ident: bib13 article-title: Looking for the self in pathological unconsciousness publication-title: Front Hum Neurosci – volume: 447 start-page: 83 year: 2007 end-page: 86 ident: bib48 article-title: Intrinsic functional architecture in the anaesthetized monkey brain publication-title: Nature – volume: 112 start-page: 887 year: 2015 end-page: 892 ident: bib51 article-title: Signature of consciousness in the dynamics of resting-state brain activity publication-title: Proc Natl Acad Sci USA – volume: 132 start-page: 2091 year: 2009 end-page: 2101 ident: bib71 article-title: Impaired consciousness during temporal lobe seizures is related to increased long-distance cortical-subcortical synchronization publication-title: Brain – volume: 2 start-page: 125 year: 2012 end-page: 141 ident: bib32 article-title: Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks publication-title: Brain Connect – volume: 124 start-page: 1263 year: 2001 end-page: 1289 ident: bib4 article-title: Consciousness publication-title: Brain – volume: 5 start-page: 317 year: 1997 end-page: 322 ident: bib11 article-title: Searching for activations that generalize over tasks publication-title: Hum Brain Mapp – volume: 52 start-page: 35 year: 2014 end-page: 46 ident: bib16 article-title: Multiple fMRI system-level baseline connectivity is disrupted in patients with consciousness alterations publication-title: Cortex – volume: 11 start-page: 814 year: 2012 end-page: 826 ident: bib55 article-title: Impaired consciousness in epilepsy publication-title: Lancet Neurol – volume: 33 start-page: 1 year: 2010 end-page: 9 ident: bib59 article-title: Recovery of consciousness after brain injury: a mesocircuit hypothesis publication-title: Trends Neurosci – volume: 36 start-page: 2027 year: 2015 end-page: 2038 ident: bib46 article-title: Default-mode network functional connectivity is closely related to metabolic activity publication-title: Hum Brain Mapp – volume: 45 start-page: 333 year: 2009 end-page: 341 ident: bib41 article-title: Computing average shaped tissue probability templates publication-title: Neuroimage – volume: 32 start-page: 919 year: 2011 end-page: 934 ident: bib64 article-title: Network anticorrelations, global regression, and phase-shifted soft tissue correction publication-title: Hum Brain Mapp – volume: 60 start-page: 381 year: 2009 end-page: 392 ident: bib2 article-title: Chronic consciousness disorders publication-title: Ann Rev Med – volume: 384 start-page: 514 year: 2014 end-page: 522 ident: bib39 article-title: Diagnostic precision of PET imaging and functional MRI in disorders of consciousness: a clinical validation study publication-title: Lancet – volume: 31 start-page: 3217 year: 2011 end-page: 3224 ident: bib14 article-title: Fractionating the default mode network: distinct contributions of the ventral and dorsal posterior cingulate cortex to cognitive control publication-title: J Neurosci – volume: 9 start-page: 556 year: 2005 ident: 10.1016/S1474-4422(16)00111-3_bib5 article-title: The neural correlate of (un)awareness: lessons from the vegetative state publication-title: Trends Cogn Sci doi: 10.1016/j.tics.2005.10.010 – volume: 20 start-page: 655 year: 2007 ident: 10.1016/S1474-4422(16)00111-3_bib63 article-title: The role of impaired neuronal communication in neurological disorders publication-title: Curr Opin Neurol doi: 10.1097/WCO.0b013e3282f1c720 – volume: 52 start-page: 35 year: 2014 ident: 10.1016/S1474-4422(16)00111-3_bib16 article-title: Multiple fMRI system-level baseline connectivity is disrupted in patients with consciousness alterations publication-title: Cortex doi: 10.1016/j.cortex.2013.11.005 – volume: 1 start-page: 3 year: 2011 ident: 10.1016/S1474-4422(16)00111-3_bib42 article-title: The restless brain publication-title: Brain Connect doi: 10.1089/brain.2011.0019 – volume: 45 start-page: 333 year: 2009 ident: 10.1016/S1474-4422(16)00111-3_bib41 article-title: Computing average shaped tissue probability templates publication-title: Neuroimage doi: 10.1016/j.neuroimage.2008.12.008 – volume: 78 start-page: 68 year: 2015 ident: 10.1016/S1474-4422(16)00111-3_bib60 article-title: Thalamic and extrathalamic mechanisms of consciousness after severe brain injury publication-title: Ann Neurol doi: 10.1002/ana.24423 – volume: 98 start-page: 4259 year: 2001 ident: 10.1016/S1474-4422(16)00111-3_bib30 article-title: Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.071043098 – volume: 30 start-page: 1551 year: 2010 ident: 10.1016/S1474-4422(16)00111-3_bib43 article-title: Everything you never wanted to know about circular analysis, but were afraid to ask publication-title: J Cereb Blood Flow Metab doi: 10.1038/jcbfm.2010.86 – volume: 11 start-page: 814 year: 2012 ident: 10.1016/S1474-4422(16)00111-3_bib55 article-title: Impaired consciousness in epilepsy publication-title: Lancet Neurol doi: 10.1016/S1474-4422(12)70188-6 – volume: 60 start-page: 381 year: 2009 ident: 10.1016/S1474-4422(16)00111-3_bib2 article-title: Chronic consciousness disorders publication-title: Ann Rev Med doi: 10.1146/annurev.med.60.060107.091250 – volume: 138 start-page: 2619 year: 2015 ident: 10.1016/S1474-4422(16)00111-3_bib47 article-title: Intrinsic functional connectivity differentiates minimally conscious from unresponsive patients publication-title: Brain doi: 10.1093/brain/awv169 – volume: 137 start-page: 1087 year: 2006 ident: 10.1016/S1474-4422(16)00111-3_bib57 article-title: Grouping of brain rhythms in corticothalamic systems publication-title: Neuroscience doi: 10.1016/j.neuroscience.2005.10.029 – volume: 22 start-page: 786 year: 2008 ident: 10.1016/S1474-4422(16)00111-3_bib21 article-title: A French validation study of the Coma Recovery Scale-Revised (CRS-R) publication-title: Brain Inj doi: 10.1080/02699050802403557 – volume: 10 start-page: 99 year: 2014 ident: 10.1016/S1474-4422(16)00111-3_bib3 article-title: Disorders of consciousness after acquired brain injury: the state of the science publication-title: Nat Rev Neurol doi: 10.1038/nrneurol.2013.279 – volume: 102 start-page: 9673 year: 2005 ident: 10.1016/S1474-4422(16)00111-3_bib10 article-title: The human brain is intrinsically organized into dynamic, anticorrelated functional networks publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0504136102 – volume: 7 start-page: e46313 year: 2012 ident: 10.1016/S1474-4422(16)00111-3_bib69 article-title: Genuine and spurious phase synchronization strengths during consciousness and general anesthesia publication-title: PLoS One doi: 10.1371/journal.pone.0046313 – volume: 10 start-page: 35 year: 2010 ident: 10.1016/S1474-4422(16)00111-3_bib23 article-title: Visual fixation in the vegetative state: an observational case series PET study publication-title: BMC Neurol doi: 10.1186/1471-2377-10-35 – volume: 85 start-page: 2020 year: 2004 ident: 10.1016/S1474-4422(16)00111-3_bib22 article-title: The JFK Coma Recovery Scale-Revised: measurement characteristics and diagnostic utility publication-title: Arch Phys Med Rehab doi: 10.1016/j.apmr.2004.02.033 – volume: 13 start-page: 9 year: 2010 ident: 10.1016/S1474-4422(16)00111-3_bib58 article-title: The slow (<1 Hz) rhythm of non-REM sleep: a dialogue between three cardinal oscillators publication-title: Nat Neurosci doi: 10.1038/nn.2445 – volume: 33 start-page: 1 year: 2010 ident: 10.1016/S1474-4422(16)00111-3_bib59 article-title: Recovery of consciousness after brain injury: a mesocircuit hypothesis publication-title: Trends Neurosci doi: 10.1016/j.tins.2009.11.002 – volume: 3 start-page: 273 year: 2013 ident: 10.1016/S1474-4422(16)00111-3_bib56 article-title: Thalamus, brainstem and salience network connectivity changes during propofol-induced sedation and unconsciousness publication-title: Brain Connect doi: 10.1089/brain.2012.0117 – volume: 59 start-page: 431 year: 2012 ident: 10.1016/S1474-4422(16)00111-3_bib35 article-title: The influence of head motion on intrinsic functional connectivity MRI publication-title: Neuroimage doi: 10.1016/j.neuroimage.2011.07.044 – volume: 355 start-page: 1825 year: 2000 ident: 10.1016/S1474-4422(16)00111-3_bib65 article-title: PET scanning and neuronal loss in acute vegetative state publication-title: Lancet doi: 10.1016/S0140-6736(05)73084-1 – volume: 38 start-page: 95 year: 2007 ident: 10.1016/S1474-4422(16)00111-3_bib25 article-title: A fast diffeomorphic image registration algorithm publication-title: Neuroimage doi: 10.1016/j.neuroimage.2007.07.007 – volume: 60 start-page: 1503 year: 2012 ident: 10.1016/S1474-4422(16)00111-3_bib28 article-title: Adjusting for global effects in voxel-based morphometry: gray matter decline in normal aging publication-title: Neuroimage doi: 10.1016/j.neuroimage.2011.12.086 – volume: 384 start-page: 514 year: 2014 ident: 10.1016/S1474-4422(16)00111-3_bib39 article-title: Diagnostic precision of PET imaging and functional MRI in disorders of consciousness: a clinical validation study publication-title: Lancet doi: 10.1016/S0140-6736(14)60042-8 – volume: 112 start-page: 887 year: 2015 ident: 10.1016/S1474-4422(16)00111-3_bib51 article-title: Signature of consciousness in the dynamics of resting-state brain activity publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1418031112 – volume: 23 start-page: 570 year: 2011 ident: 10.1016/S1474-4422(16)00111-3_bib53 article-title: Two distinct neuronal networks mediate the awareness of environment and of self publication-title: J Cogn Neurosci doi: 10.1162/jocn.2010.21488 – volume: 84 start-page: 167 year: 2015 ident: 10.1016/S1474-4422(16)00111-3_bib61 article-title: Thalamo-frontal connectivity mediates top-down cognitive functions in disorders of consciousness publication-title: Neurology doi: 10.1212/WNL.0000000000001123 – volume: 12 start-page: 535 year: 2009 ident: 10.1016/S1474-4422(16)00111-3_bib44 article-title: Circular analysis in systems neuroscience: the dangers of double dipping publication-title: Nat Neurosci doi: 10.1038/nn.2303 – volume: 104 start-page: 11073 year: 2007 ident: 10.1016/S1474-4422(16)00111-3_bib12 article-title: Distinct brain networks for adaptive and stable task control in humans publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0704320104 – volume: 32 start-page: 919 year: 2011 ident: 10.1016/S1474-4422(16)00111-3_bib64 article-title: Network anticorrelations, global regression, and phase-shifted soft tissue correction publication-title: Hum Brain Mapp doi: 10.1002/hbm.21079 – volume: 44 start-page: 487 year: 2012 ident: 10.1016/S1474-4422(16)00111-3_bib20 article-title: Metabolic activity in external and internal awareness networks in severely brain-damaged patients publication-title: J Rehabil Med doi: 10.2340/16501977-0940 – volume: 133 start-page: 161 year: 2010 ident: 10.1016/S1474-4422(16)00111-3_bib15 article-title: Default network connectivity reflects the level of consciousness in non-communicative brain-damaged patients publication-title: Brain doi: 10.1093/brain/awp313 – volume: 3 start-page: 1715 year: 2006 ident: 10.1016/S1474-4422(16)00111-3_bib24 article-title: Systematic and distributed time-of-flight list mode PET reconstruction publication-title: IEEE Nucl Sci Symp Conf Rec (1997) – volume: 113 start-page: E1127 year: 2015 ident: 10.1016/S1474-4422(16)00111-3_bib45 article-title: Metabolic connectivity mapping reveals effective connectivity in the resting human brain publication-title: Proc Natl Acad Sci USA – volume: 447 start-page: 83 year: 2007 ident: 10.1016/S1474-4422(16)00111-3_bib48 article-title: Intrinsic functional architecture in the anaesthetized monkey brain publication-title: Nature doi: 10.1038/nature05758 – volume: 259 start-page: 1087 year: 2012 ident: 10.1016/S1474-4422(16)00111-3_bib66 article-title: Functional neuroanatomy underlying the clinical subcategorization of minimally conscious state patients publication-title: J Neurol doi: 10.1007/s00415-011-6303-7 – volume: 84 start-page: 320 year: 2014 ident: 10.1016/S1474-4422(16)00111-3_bib36 article-title: Methods to detect, characterize, and remove motion artifact in resting state fMRI publication-title: NeuroImage doi: 10.1016/j.neuroimage.2013.08.048 – volume: 81 start-page: 1417 year: 2013 ident: 10.1016/S1474-4422(16)00111-3_bib27 article-title: Limbic hyperconnectivity in the vegetative state publication-title: Neurology doi: 10.1212/WNL.0b013e3182a43b78 – volume: 105 start-page: 536 year: 2015 ident: 10.1016/S1474-4422(16)00111-3_bib37 article-title: Recent progress and outstanding issues in motion correction in resting state fMRI publication-title: Neuroimage doi: 10.1016/j.neuroimage.2014.10.044 – volume: 37 start-page: 90 year: 2007 ident: 10.1016/S1474-4422(16)00111-3_bib31 article-title: A component based noise correction method (CompCor) for BOLD and perfusion based fMRI publication-title: Neuroimage doi: 10.1016/j.neuroimage.2007.04.042 – volume: 36 start-page: 2027 year: 2015 ident: 10.1016/S1474-4422(16)00111-3_bib46 article-title: Default-mode network functional connectivity is closely related to metabolic activity publication-title: Hum Brain Mapp doi: 10.1002/hbm.22753 – volume: 124 start-page: 1263 year: 2001 ident: 10.1016/S1474-4422(16)00111-3_bib4 article-title: Consciousness publication-title: Brain doi: 10.1093/brain/124.7.1263 – volume: 31 start-page: 3217 year: 2011 ident: 10.1016/S1474-4422(16)00111-3_bib14 article-title: Fractionating the default mode network: distinct contributions of the ventral and dorsal posterior cingulate cortex to cognitive control publication-title: J Neurosci doi: 10.1523/JNEUROSCI.5626-10.2011 – volume: 35 start-page: 12932 year: 2015 ident: 10.1016/S1474-4422(16)00111-3_bib54 article-title: Intrinsic functional connectivity patterns predict consciousness level and recovery outcome in acquired brain injury publication-title: J Neurosci doi: 10.1523/JNEUROSCI.0415-15.2015 – volume: 59 start-page: 1420 year: 2012 ident: 10.1016/S1474-4422(16)00111-3_bib33 article-title: Anticorrelations in resting state networks without global signal regression publication-title: Neuroimage doi: 10.1016/j.neuroimage.2011.08.048 – volume: 116 start-page: 946 year: 2012 ident: 10.1016/S1474-4422(16)00111-3_bib8 article-title: Unresponsiveness not equal unconsciousness publication-title: Anesthesiology doi: 10.1097/ALN.0b013e318249d0a7 – volume: 98 start-page: 676 year: 2001 ident: 10.1016/S1474-4422(16)00111-3_bib9 article-title: A default mode of brain function publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.98.2.676 – volume: 113 start-page: 1038 year: 2010 ident: 10.1016/S1474-4422(16)00111-3_bib17 article-title: Breakdown of within- and between-network resting state functional magnetic resonance imaging connectivity during propofol-induced loss of consciousness publication-title: Anesthesiology doi: 10.1097/ALN.0b013e3181f697f5 – volume: 28 start-page: 1051 year: 2010 ident: 10.1016/S1474-4422(16)00111-3_bib50 article-title: Functional connectivity between task-positive and task-negative brain areas and its relation to working memory performance publication-title: Magn Reson Imaging doi: 10.1016/j.mri.2010.03.021 – volume: 5 start-page: 317 year: 1997 ident: 10.1016/S1474-4422(16)00111-3_bib11 article-title: Searching for activations that generalize over tasks publication-title: Hum Brain Mapp doi: 10.1002/(SICI)1097-0193(1997)5:4<317::AID-HBM19>3.0.CO;2-A – volume: 30 start-page: 2393 year: 2009 ident: 10.1016/S1474-4422(16)00111-3_bib18 article-title: Functional connectivity in the default network during resting state is preserved in a vegetative but not in a brain dead patient publication-title: Hum Brain Mapp doi: 10.1002/hbm.20672 – volume: 31 start-page: 1873 year: 2010 ident: 10.1016/S1474-4422(16)00111-3_bib26 article-title: Measurement of gray and white matter atrophy in dementia with Lewy bodies using diffeomorphic anatomic registration through exponentiated lie algebra: a comparison with conventional voxel-based morphometry publication-title: AJNR Am J Neuroradiol doi: 10.3174/ajnr.A2200 – volume: 2 start-page: 125 year: 2012 ident: 10.1016/S1474-4422(16)00111-3_bib32 article-title: Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks publication-title: Brain Connect doi: 10.1089/brain.2012.0073 – volume: 33 start-page: 778 year: 2012 ident: 10.1016/S1474-4422(16)00111-3_bib38 article-title: Identifying the default-mode component in spatial IC analyses of patients with disorders of consciousness publication-title: Hum Brain Mapp doi: 10.1002/hbm.21249 – volume: 58 start-page: 349 year: 2002 ident: 10.1016/S1474-4422(16)00111-3_bib7 article-title: The minimally conscious state: definition and diagnostic criteria publication-title: Neurology doi: 10.1212/WNL.58.3.349 – volume: 100 start-page: 253 year: 2003 ident: 10.1016/S1474-4422(16)00111-3_bib34 article-title: Functional connectivity in the resting brain: a network analysis of the default mode hypothesis publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0135058100 – volume: 64 start-page: 271 year: 2015 ident: 10.1016/S1474-4422(16)00111-3_bib49 article-title: Resting-state anticorrelations between medial and lateral prefrontal cortex: association with working memory, aging, and individual differences publication-title: Cortex doi: 10.1016/j.cortex.2014.12.001 – volume: 1129 start-page: 105 year: 2008 ident: 10.1016/S1474-4422(16)00111-3_bib62 article-title: Central thalamic contributions to arousal regulation and neurological disorders of consciousness publication-title: Ann NY Acad Sci doi: 10.1196/annals.1417.029 – volume: 275 start-page: 340 year: 2014 ident: 10.1016/S1474-4422(16)00111-3_bib70 article-title: Graded defragmentation of cortical neuronal firing during recovery of consciousness in rats publication-title: Neuroscience doi: 10.1016/j.neuroscience.2014.06.018 – volume: 76 start-page: 432 year: 2005 ident: 10.1016/S1474-4422(16)00111-3_bib68 article-title: Neurometabolic coupling in the vegetative and minimally conscious states: preliminary findings publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp.2004.045930 – volume: 26 start-page: 15 year: 2005 ident: 10.1016/S1474-4422(16)00111-3_bib52 article-title: Spontaneous low-frequency BOLD signal fluctuations: an fMRI investigation of the resting-state default mode of brain function hypothesis publication-title: Hum Brain Mapp doi: 10.1002/hbm.20113 – volume: 132 start-page: 2091 year: 2009 ident: 10.1016/S1474-4422(16)00111-3_bib71 article-title: Impaired consciousness during temporal lobe seizures is related to increased long-distance cortical-subcortical synchronization publication-title: Brain doi: 10.1093/brain/awp086 – volume: 150 start-page: 31 year: 2012 ident: 10.1016/S1474-4422(16)00111-3_bib6 article-title: Unresponsive wakefulness syndrome publication-title: Arch Ital Biol – volume: 2 start-page: 275 year: 2012 ident: 10.1016/S1474-4422(16)00111-3_bib19 article-title: Metabolic brain covariant networks as revealed by FDG-PET with reference to resting-state fMRI networks publication-title: Brain Connect doi: 10.1089/brain.2012.0086 – volume: 7 start-page: 538 year: 2013 ident: 10.1016/S1474-4422(16)00111-3_bib13 article-title: Looking for the self in pathological unconsciousness publication-title: Front Hum Neurosci doi: 10.3389/fnhum.2013.00538 – volume: 44 start-page: 893 year: 2009 ident: 10.1016/S1474-4422(16)00111-3_bib29 article-title: The impact of global signal regression on resting state correlations: are anti-correlated networks introduced? publication-title: Neuroimage doi: 10.1016/j.neuroimage.2008.09.036 – volume: 355 start-page: 1790 year: 2000 ident: 10.1016/S1474-4422(16)00111-3_bib67 article-title: Restoration of thalamocortical connectivity after recovery from persistent vegetative state publication-title: Lancet doi: 10.1016/S0140-6736(00)02271-6 – volume: 26 start-page: 839 year: 2005 ident: 10.1016/S1474-4422(16)00111-3_bib40 article-title: Unified segmentation publication-title: Neuroimage doi: 10.1016/j.neuroimage.2005.02.018 – volume: 3 start-page: 537 year: 2004 ident: 10.1016/S1474-4422(16)00111-3_bib1 article-title: Brain function in coma, vegetative state, and related disorders publication-title: Lancet Neurol doi: 10.1016/S1474-4422(04)00852-X – reference: 27131916 - Lancet Neurol. 2016 Jul;15(8):781-782 |
| SSID | ssj0021481 |
| Score | 2.5815086 |
| Snippet | Between pathologically impaired consciousness and normal consciousness exists a scarcely researched transition zone, referred to as emergence from minimally... Summary Background Between pathologically impaired consciousness and normal consciousness exists a scarcely researched transition zone, referred to as... BACKGROUNDBetween pathologically impaired consciousness and normal consciousness exists a scarcely researched transition zone, referred to as emergence from... Background Between pathologically impaired consciousness and normal consciousness exists a scarcely researched transition zone, referred to as emergence from... |
| SourceID | liege proquest pubmed crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 830 |
| SubjectTerms | Adolescent Adult Aged Brain damage Brain death Brain Mapping Case-Control Studies Child Cohort Studies Consciousness Consciousness - physiology Female Fluorodeoxyglucose F18 - metabolism Human health sciences Humans Magnetic Resonance Imaging Male Medical imaging MEDLINE - statistics & numerical data Metabolism Middle Aged Neural Networks (Computer) Neurologie Neurology Oxygen - blood Patients Persistent Vegetative State - diagnostic imaging Persistent Vegetative State - physiopathology Positron-Emission Tomography Sciences de la santé humaine State court decisions Studies Traumatic brain injury Young Adult |
| Title | Neural correlates of consciousness in patients who have emerged from a minimally conscious state: a cross-sectional multimodal imaging study |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S1474442216001113 https://www.clinicalkey.es/playcontent/1-s2.0-S1474442216001113 https://dx.doi.org/10.1016/S1474-4422(16)00111-3 https://www.ncbi.nlm.nih.gov/pubmed/27131917 https://www.proquest.com/docview/1797506344 https://www.proquest.com/docview/1797540644 https://www.proquest.com/docview/1808629918 https://orbi.uliege.be/handle/2268/204881 |
| Volume | 15 |
| WOSCitedRecordID | wos000377545800020&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1474-4465 dateEnd: 20251007 omitProxy: false ssIdentifier: ssj0021481 issn: 1474-4465 databaseCode: 7X7 dateStart: 20020501 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1474-4465 dateEnd: 20251007 omitProxy: false ssIdentifier: ssj0021481 issn: 1474-4465 databaseCode: 7RV dateStart: 20020501 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1474-4465 dateEnd: 20251007 omitProxy: false ssIdentifier: ssj0021481 issn: 1474-4465 databaseCode: BENPR dateStart: 20020501 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Psychology Database customDbUrl: eissn: 1474-4465 dateEnd: 20251007 omitProxy: false ssIdentifier: ssj0021481 issn: 1474-4465 databaseCode: M2M dateStart: 20020501 isFulltext: true titleUrlDefault: https://www.proquest.com/psychology providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELdYixAvfH8UxmQkHkDCrHbc2OEFAdrES6tpfGhvluM4rFKWjKYt4n_gj-bOcdMXtiHxEiWNf6oTX-5-Z5_vCHmRZFa4UpVMCeeY9ClndswLpjkvRA6EW47LUGxCzWb65CQ7ihNubQyr3OjEoKiLxuEc-T4IDhi3NJHy3fkPhlWjcHU1ltDYIUPMVCYHZPjhYHZ03LtcQPaDyyWVZFIKsd3Ds_-5__ElT1-Fmussucg6DStcwr6YhQZrdHj7f5_jDrkVeSh93wnOXXLN1_fIjWlcab9PfmPWDmjgsHpHhYSUNiVc1WAym1WLCpLOaxrTsrb052lDT-3aUx_2cxYU961QSzF1yZmtql9bLA2bmN7CzfASWBuiwbA3IbrxrCngFEBYPomG9LcPyNfDgy8fP7FYuYG5VE6WLOeFkjjD6LM8kd7neenKTFqBBCHhVusi48LbBN0rabmVMlO5U0AnuZ24MnlIBnVT-8eEimzidCl8OS7G0hdJrlwCFC-zaS58lqkRkZsRMy6mNcfqGpXp49dwoA0OtOFdDB83yYi86WHnXV6PqwDpRhzMZtMqqFkDlucqoPob0LdRWbSGm1aYcYdGME8DFJC6R0Y-1PGcf_nT10FiTbPI52YtDGYRD-er6ruxzuTeAPHWBvM2az4iuxthNdtu9ZI6Is_726B9cEnJ1h4EpmsDnPDSNhrdZvBD9Ig86j6a_pULBeKQcfXk8g48JTeBqKZdmPQuGSwXK_-MXHfr5bxd7JEddfwNjycqHPVeVANwNRXTPzC3XaQ |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwELZKi4AL78dCASOBBBKmseONEySEEFC1artCUFBvxnEculKalM3uVv0P_BZ-IzPOYy-05dIDt2Tj2VjOPL6x50HI0zAxwuYqZ0pYy6SLODMBz1jMeSZSANwyyH2zCTUaxXt7yacl8rvLhcGwyk4nekWdVRb3yNeAccC4RaGUbw9_MuwahaerXQuNhi223PERuGz1m80P8H2fCbH-cff9Bmu7CjAbyeGUpTxTEne_XJKG0rk0zW2eSCPQeIXcxHGWcOFMiNBfGm6kTFRqFUAdboY2D-F_L5AV0OMcQ8jU52-9gweuhXfwpJJMSiEWGUNrX_ofn_Pohe_wzsKTbOFKgQfmJ2Neb_vWr_1vq3adXG1RNn3XiMUNsuTKm-TSThtHcIv8wpokMMBib5IC4TatcrgrARBUsxrVPx2XtC06W9Oj_Yrum7mjzmerZhSzcqihWJjlwBTF8YKW-hSt1_DQLzqrfawbzsbHbh5UGVwCETaHor64723y9VzW4g5ZLqvS3SNUJEMb58LlQRZIl4WpsiEA2MREqXBJogZEdhyibVu0HXuHFLqPzkPG0shYmjcRilyHA_KqJztsqpacRRB17Ke7lFwwIhrs6lmE6m-Erm5VYa25roUOGmok5pEnBcq4p2zRXoPi_uWlL72E6GqSjvVcaKyR7q9nxQ9trE6dBrci1liVOuYDstoJh15Mq5eMAXnSPwbdigdmpnTAMM0YQLynjolxUwC8rHhA7jZC2i-5UMAOCVf3T5_AY3J5Y3dnW29vjrYekCsAyaMmIHyVLE8nM_eQXLTz6biePPLqhpLv5y2pfwAjUbS7 |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFLbGhiZeuF8KA4wEEkgLrR03jpEQQoyKabSaBEh7M47jsEpZMpq20_4Dv4hfxznOpS9s42UPvKVNvtZyzvH5jn0uhDwPleE2k1kgubWBcBELzIClQcxYyhMg3GKQ-WYTcjKJDw7U_hr53ebCYFhluyb6hTotLe6R90FwwLhFoRD9rAmL2N8ZvTv-GWAHKTxpbdtp1CKy505PwH2r3u7uwLt-wfno49cPn4Kmw0BgIzGcBwlLpcCdMKeSUDiXJJnNlDAcDVnITByninFnQnQDhGFGCCUTK4H2MDO0WQi_e4VsSDEcYveEMR93zh64Gd7ZE1IEQnC-yh7qf-m-fMmiV77bexCeZRc3cjw8P5v_ejs4uvE_z-BNcr1h3_R9rS63yJorbpPNcRNfcIf8wlol8IDFniU50nBaZvCpAKJQLio0C3Ra0KYYbUVPDkt6aJaOOp_FmlLM1qGGYsGWI5Pnpyss9albb-CmfwFB5WPgcDQ-pvOoTOESQNg0ivqiv3fJt0uZi3tkvSgL94BQroY2zrjLBulAuDRMpA2B2CoTJdwpJXtEtNKibVPMHXuK5LqL2kMh0yhkmtWRi0yHPfK6gx3X1UwuAkStKOo2VReMiwZ7exFQ_g3oqmaJrDTTFdeDGo1gFnkoIOMO2bDAmt39y59ue23R5SyZ6iXXWDvdXy_yH9pYnTgN7kassVp1zHpkq1UUvRpWpyU98qy7DWsuHqSZwoHA1M8AEz73mRg3C8D7invkfq2w3ZRzCeKgmHx4_gCekk1QUP15d7L3iFwDph7VceJbZH0-W7jH5KpdzqfV7IlfeSj5ftmK-gdn171S |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Neural+correlates+of+consciousness+in+patients+who+have+emerged+from+a+minimally+conscious+state%3A+a+cross-sectional+multimodal+imaging+study&rft.jtitle=Lancet+neurology&rft.au=Di+Perri%2C+Carol&rft.au=Bahri%2C+Mohamed+Ali&rft.au=Amico%2C+Enrico&rft.au=Thibaut%2C+Aurore&rft.date=2016-07-01&rft.pub=Elsevier+Ltd&rft.issn=1474-4422&rft.eissn=1474-4465&rft.volume=15&rft.issue=8&rft.spage=830&rft.epage=842&rft_id=info:doi/10.1016%2FS1474-4422%2816%2900111-3&rft.externalDocID=S1474442216001113 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1474-4422&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1474-4422&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1474-4422&client=summon |