Vasoactive intestinal peptide promotes secretory differentiation and mitigates radiation-induced intestinal injury
Background Vasoactive intestinal peptide (VIP) is a neuronal peptide with prominent distribution along the enteric nervous system. While effects of VIP on intestinal motility, mucosal vasodilation, secretion, and mucosal immune cell function are well-studied, the direct impact of VIP on intestinal e...
Gespeichert in:
| Veröffentlicht in: | Stem cell research & therapy Jg. 15; H. 1; S. 348 - 14 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
London
BioMed Central
08.10.2024
BioMed Central Ltd BMC |
| Schlagworte: | |
| ISSN: | 1757-6512, 1757-6512 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Background
Vasoactive intestinal peptide (VIP) is a neuronal peptide with prominent distribution along the enteric nervous system. While effects of VIP on intestinal motility, mucosal vasodilation, secretion, and mucosal immune cell function are well-studied, the direct impact of VIP on intestinal epithelial cell turnover and differentiation remains less understood. Intestinal stem and progenitor cells are essential for the maintenance of intestinal homeostasis and regeneration, and their functions can be modulated by factors of the stem cell niche, including neuronal mediators. Here, we investigated the role of VIP in regulating intestinal epithelial homeostasis and regeneration following irradiation-induced injury.
Methods
Jejunal organoids were derived from male and female C57Bl6/J,
Lgr5
-EGFP-IRES-CreER
T2
or
Lgr5
-EGFP-IRES-CreER
T2
/
R26
R-LSL-TdTomato mice and treated with VIP prior to analysis. Injury conditions were induced by exposing organoids to 6 Gy of irradiation (IR). To investigate protective effects of VIP in vivo, mice received 12 Gy of abdominal IR followed by intraperitoneal injections of VIP.
Results
We observed that VIP promotes epithelial differentiation towards a secretory phenotype predominantly via the p38 MAPK pathway. Moreover, VIP prominently modulated epithelial proliferation as well as the number and proliferative activity of Lgr5-EGFP
+
progenitor cells under homeostatic conditions. In the context of acute irradiation injury in vitro, we observed that IR injury renders Lgr5-EGFP
+
progenitor cells more susceptible to VIP-induced modulations, which coincided with the strong promotion of epithelial regeneration by VIP. Finally, the observed effects translate into an in vivo model of abdominal irradiation, where VIP showed to prominently mitigate radiation-induced injury.
Conclusions
VIP prominently governs intestinal homeostasis by regulating epithelial progenitor cell proliferation and differentiation and promotes intestinal regeneration following acute irradiation injury. |
|---|---|
| AbstractList | Abstract Background Vasoactive intestinal peptide (VIP) is a neuronal peptide with prominent distribution along the enteric nervous system. While effects of VIP on intestinal motility, mucosal vasodilation, secretion, and mucosal immune cell function are well-studied, the direct impact of VIP on intestinal epithelial cell turnover and differentiation remains less understood. Intestinal stem and progenitor cells are essential for the maintenance of intestinal homeostasis and regeneration, and their functions can be modulated by factors of the stem cell niche, including neuronal mediators. Here, we investigated the role of VIP in regulating intestinal epithelial homeostasis and regeneration following irradiation-induced injury. Methods Jejunal organoids were derived from male and female C57Bl6/J, Lgr5-EGFP-IRES-CreERT2 or Lgr5-EGFP-IRES-CreERT2/R26R-LSL-TdTomato mice and treated with VIP prior to analysis. Injury conditions were induced by exposing organoids to 6 Gy of irradiation (IR). To investigate protective effects of VIP in vivo, mice received 12 Gy of abdominal IR followed by intraperitoneal injections of VIP. Results We observed that VIP promotes epithelial differentiation towards a secretory phenotype predominantly via the p38 MAPK pathway. Moreover, VIP prominently modulated epithelial proliferation as well as the number and proliferative activity of Lgr5-EGFP+ progenitor cells under homeostatic conditions. In the context of acute irradiation injury in vitro, we observed that IR injury renders Lgr5-EGFP+ progenitor cells more susceptible to VIP-induced modulations, which coincided with the strong promotion of epithelial regeneration by VIP. Finally, the observed effects translate into an in vivo model of abdominal irradiation, where VIP showed to prominently mitigate radiation-induced injury. Conclusions VIP prominently governs intestinal homeostasis by regulating epithelial progenitor cell proliferation and differentiation and promotes intestinal regeneration following acute irradiation injury. Background Vasoactive intestinal peptide (VIP) is a neuronal peptide with prominent distribution along the enteric nervous system. While effects of VIP on intestinal motility, mucosal vasodilation, secretion, and mucosal immune cell function are well-studied, the direct impact of VIP on intestinal epithelial cell turnover and differentiation remains less understood. Intestinal stem and progenitor cells are essential for the maintenance of intestinal homeostasis and regeneration, and their functions can be modulated by factors of the stem cell niche, including neuronal mediators. Here, we investigated the role of VIP in regulating intestinal epithelial homeostasis and regeneration following irradiation-induced injury. Methods Jejunal organoids were derived from male and female C57Bl6/J, Lgr5 -EGFP-IRES-CreER T2 or Lgr5 -EGFP-IRES-CreER T2 / R26 R-LSL-TdTomato mice and treated with VIP prior to analysis. Injury conditions were induced by exposing organoids to 6 Gy of irradiation (IR). To investigate protective effects of VIP in vivo, mice received 12 Gy of abdominal IR followed by intraperitoneal injections of VIP. Results We observed that VIP promotes epithelial differentiation towards a secretory phenotype predominantly via the p38 MAPK pathway. Moreover, VIP prominently modulated epithelial proliferation as well as the number and proliferative activity of Lgr5-EGFP + progenitor cells under homeostatic conditions. In the context of acute irradiation injury in vitro, we observed that IR injury renders Lgr5-EGFP + progenitor cells more susceptible to VIP-induced modulations, which coincided with the strong promotion of epithelial regeneration by VIP. Finally, the observed effects translate into an in vivo model of abdominal irradiation, where VIP showed to prominently mitigate radiation-induced injury. Conclusions VIP prominently governs intestinal homeostasis by regulating epithelial progenitor cell proliferation and differentiation and promotes intestinal regeneration following acute irradiation injury. Background Vasoactive intestinal peptide (VIP) is a neuronal peptide with prominent distribution along the enteric nervous system. While effects of VIP on intestinal motility, mucosal vasodilation, secretion, and mucosal immune cell function are well-studied, the direct impact of VIP on intestinal epithelial cell turnover and differentiation remains less understood. Intestinal stem and progenitor cells are essential for the maintenance of intestinal homeostasis and regeneration, and their functions can be modulated by factors of the stem cell niche, including neuronal mediators. Here, we investigated the role of VIP in regulating intestinal epithelial homeostasis and regeneration following irradiation-induced injury. Methods Jejunal organoids were derived from male and female C57Bl6/J, Lgr5-EGFP-IRES-CreER.sup.T2 or Lgr5-EGFP-IRES-CreER.sup.T2/R26R-LSL-TdTomato mice and treated with VIP prior to analysis. Injury conditions were induced by exposing organoids to 6 Gy of irradiation (IR). To investigate protective effects of VIP in vivo, mice received 12 Gy of abdominal IR followed by intraperitoneal injections of VIP. Results We observed that VIP promotes epithelial differentiation towards a secretory phenotype predominantly via the p38 MAPK pathway. Moreover, VIP prominently modulated epithelial proliferation as well as the number and proliferative activity of Lgr5-EGFP.sup.+ progenitor cells under homeostatic conditions. In the context of acute irradiation injury in vitro, we observed that IR injury renders Lgr5-EGFP.sup.+ progenitor cells more susceptible to VIP-induced modulations, which coincided with the strong promotion of epithelial regeneration by VIP. Finally, the observed effects translate into an in vivo model of abdominal irradiation, where VIP showed to prominently mitigate radiation-induced injury. Conclusions VIP prominently governs intestinal homeostasis by regulating epithelial progenitor cell proliferation and differentiation and promotes intestinal regeneration following acute irradiation injury. Keywords: VIP, Intestinal progenitor cells, Irradiation, Regeneration Vasoactive intestinal peptide (VIP) is a neuronal peptide with prominent distribution along the enteric nervous system. While effects of VIP on intestinal motility, mucosal vasodilation, secretion, and mucosal immune cell function are well-studied, the direct impact of VIP on intestinal epithelial cell turnover and differentiation remains less understood. Intestinal stem and progenitor cells are essential for the maintenance of intestinal homeostasis and regeneration, and their functions can be modulated by factors of the stem cell niche, including neuronal mediators. Here, we investigated the role of VIP in regulating intestinal epithelial homeostasis and regeneration following irradiation-induced injury.BACKGROUNDVasoactive intestinal peptide (VIP) is a neuronal peptide with prominent distribution along the enteric nervous system. While effects of VIP on intestinal motility, mucosal vasodilation, secretion, and mucosal immune cell function are well-studied, the direct impact of VIP on intestinal epithelial cell turnover and differentiation remains less understood. Intestinal stem and progenitor cells are essential for the maintenance of intestinal homeostasis and regeneration, and their functions can be modulated by factors of the stem cell niche, including neuronal mediators. Here, we investigated the role of VIP in regulating intestinal epithelial homeostasis and regeneration following irradiation-induced injury.Jejunal organoids were derived from male and female C57Bl6/J, Lgr5-EGFP-IRES-CreERT2 or Lgr5-EGFP-IRES-CreERT2/R26R-LSL-TdTomato mice and treated with VIP prior to analysis. Injury conditions were induced by exposing organoids to 6 Gy of irradiation (IR). To investigate protective effects of VIP in vivo, mice received 12 Gy of abdominal IR followed by intraperitoneal injections of VIP.METHODSJejunal organoids were derived from male and female C57Bl6/J, Lgr5-EGFP-IRES-CreERT2 or Lgr5-EGFP-IRES-CreERT2/R26R-LSL-TdTomato mice and treated with VIP prior to analysis. Injury conditions were induced by exposing organoids to 6 Gy of irradiation (IR). To investigate protective effects of VIP in vivo, mice received 12 Gy of abdominal IR followed by intraperitoneal injections of VIP.We observed that VIP promotes epithelial differentiation towards a secretory phenotype predominantly via the p38 MAPK pathway. Moreover, VIP prominently modulated epithelial proliferation as well as the number and proliferative activity of Lgr5-EGFP+ progenitor cells under homeostatic conditions. In the context of acute irradiation injury in vitro, we observed that IR injury renders Lgr5-EGFP+ progenitor cells more susceptible to VIP-induced modulations, which coincided with the strong promotion of epithelial regeneration by VIP. Finally, the observed effects translate into an in vivo model of abdominal irradiation, where VIP showed to prominently mitigate radiation-induced injury.RESULTSWe observed that VIP promotes epithelial differentiation towards a secretory phenotype predominantly via the p38 MAPK pathway. Moreover, VIP prominently modulated epithelial proliferation as well as the number and proliferative activity of Lgr5-EGFP+ progenitor cells under homeostatic conditions. In the context of acute irradiation injury in vitro, we observed that IR injury renders Lgr5-EGFP+ progenitor cells more susceptible to VIP-induced modulations, which coincided with the strong promotion of epithelial regeneration by VIP. Finally, the observed effects translate into an in vivo model of abdominal irradiation, where VIP showed to prominently mitigate radiation-induced injury.VIP prominently governs intestinal homeostasis by regulating epithelial progenitor cell proliferation and differentiation and promotes intestinal regeneration following acute irradiation injury.CONCLUSIONSVIP prominently governs intestinal homeostasis by regulating epithelial progenitor cell proliferation and differentiation and promotes intestinal regeneration following acute irradiation injury. Vasoactive intestinal peptide (VIP) is a neuronal peptide with prominent distribution along the enteric nervous system. While effects of VIP on intestinal motility, mucosal vasodilation, secretion, and mucosal immune cell function are well-studied, the direct impact of VIP on intestinal epithelial cell turnover and differentiation remains less understood. Intestinal stem and progenitor cells are essential for the maintenance of intestinal homeostasis and regeneration, and their functions can be modulated by factors of the stem cell niche, including neuronal mediators. Here, we investigated the role of VIP in regulating intestinal epithelial homeostasis and regeneration following irradiation-induced injury. Jejunal organoids were derived from male and female C57Bl6/J, Lgr5-EGFP-IRES-CreER.sup.T2 or Lgr5-EGFP-IRES-CreER.sup.T2/R26R-LSL-TdTomato mice and treated with VIP prior to analysis. Injury conditions were induced by exposing organoids to 6 Gy of irradiation (IR). To investigate protective effects of VIP in vivo, mice received 12 Gy of abdominal IR followed by intraperitoneal injections of VIP. We observed that VIP promotes epithelial differentiation towards a secretory phenotype predominantly via the p38 MAPK pathway. Moreover, VIP prominently modulated epithelial proliferation as well as the number and proliferative activity of Lgr5-EGFP.sup.+ progenitor cells under homeostatic conditions. In the context of acute irradiation injury in vitro, we observed that IR injury renders Lgr5-EGFP.sup.+ progenitor cells more susceptible to VIP-induced modulations, which coincided with the strong promotion of epithelial regeneration by VIP. Finally, the observed effects translate into an in vivo model of abdominal irradiation, where VIP showed to prominently mitigate radiation-induced injury. VIP prominently governs intestinal homeostasis by regulating epithelial progenitor cell proliferation and differentiation and promotes intestinal regeneration following acute irradiation injury. Vasoactive intestinal peptide (VIP) is a neuronal peptide with prominent distribution along the enteric nervous system. While effects of VIP on intestinal motility, mucosal vasodilation, secretion, and mucosal immune cell function are well-studied, the direct impact of VIP on intestinal epithelial cell turnover and differentiation remains less understood. Intestinal stem and progenitor cells are essential for the maintenance of intestinal homeostasis and regeneration, and their functions can be modulated by factors of the stem cell niche, including neuronal mediators. Here, we investigated the role of VIP in regulating intestinal epithelial homeostasis and regeneration following irradiation-induced injury. Jejunal organoids were derived from male and female C57Bl6/J, Lgr5-EGFP-IRES-CreER or Lgr5-EGFP-IRES-CreER /R26R-LSL-TdTomato mice and treated with VIP prior to analysis. Injury conditions were induced by exposing organoids to 6 Gy of irradiation (IR). To investigate protective effects of VIP in vivo, mice received 12 Gy of abdominal IR followed by intraperitoneal injections of VIP. We observed that VIP promotes epithelial differentiation towards a secretory phenotype predominantly via the p38 MAPK pathway. Moreover, VIP prominently modulated epithelial proliferation as well as the number and proliferative activity of Lgr5-EGFP progenitor cells under homeostatic conditions. In the context of acute irradiation injury in vitro, we observed that IR injury renders Lgr5-EGFP progenitor cells more susceptible to VIP-induced modulations, which coincided with the strong promotion of epithelial regeneration by VIP. Finally, the observed effects translate into an in vivo model of abdominal irradiation, where VIP showed to prominently mitigate radiation-induced injury. VIP prominently governs intestinal homeostasis by regulating epithelial progenitor cell proliferation and differentiation and promotes intestinal regeneration following acute irradiation injury. |
| ArticleNumber | 348 |
| Audience | Academic |
| Author | Ragab, Mohab Ermolova, Anastasia Giller, Maximilian Waldherr Ávila de Melo, Caroline Saur, Dieter Quante, Michael Steiger, Katja Schmid, Roland M. Wieland, Jessica Kohnke-Ertel, Birgit Maurer, H. Carlo Öllinger, Rupert Middelhoff, Moritz Demir, Ihsan Ekin Fischer, Julius Clemens Agibalova, Tatiana Heindl, Fabian Tschurtschenthaler, Markus Hempel, Anneke |
| Author_xml | – sequence: 1 givenname: Tatiana surname: Agibalova fullname: Agibalova, Tatiana organization: Department of Internal Medicine II, Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich – sequence: 2 givenname: Anneke surname: Hempel fullname: Hempel, Anneke organization: Department of Internal Medicine II, Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich – sequence: 3 givenname: H. Carlo surname: Maurer fullname: Maurer, H. Carlo organization: Department of Internal Medicine II, Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich – sequence: 4 givenname: Mohab surname: Ragab fullname: Ragab, Mohab organization: Department of Internal Medicine II, Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich – sequence: 5 givenname: Anastasia surname: Ermolova fullname: Ermolova, Anastasia organization: Department of Internal Medicine II, Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich – sequence: 6 givenname: Jessica surname: Wieland fullname: Wieland, Jessica organization: Department of Internal Medicine II, Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich – sequence: 7 givenname: Caroline surname: Waldherr Ávila de Melo fullname: Waldherr Ávila de Melo, Caroline organization: Department of Internal Medicine II, Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich – sequence: 8 givenname: Fabian surname: Heindl fullname: Heindl, Fabian organization: Department of Internal Medicine II, Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich – sequence: 9 givenname: Maximilian surname: Giller fullname: Giller, Maximilian organization: Department of Radiation Oncology, Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich – sequence: 10 givenname: Julius Clemens surname: Fischer fullname: Fischer, Julius Clemens organization: Department of Radiation Oncology, Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich – sequence: 11 givenname: Markus surname: Tschurtschenthaler fullname: Tschurtschenthaler, Markus organization: Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Chair of Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, Center for Translational Cancer Research (TranslaTUM), Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich – sequence: 12 givenname: Birgit surname: Kohnke-Ertel fullname: Kohnke-Ertel, Birgit organization: Department of Internal Medicine II, Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich – sequence: 13 givenname: Rupert surname: Öllinger fullname: Öllinger, Rupert organization: Institute of Molecular Oncology and Functional Genomics, Center for Translational Cancer Research (TranslaTUM), TUM School of Medicine and Health, Technical University of Munich – sequence: 14 givenname: Katja surname: Steiger fullname: Steiger, Katja organization: Institute of Pathology, TUM School of Medicine and Health, Technical University of Munich – sequence: 15 givenname: Ihsan Ekin surname: Demir fullname: Demir, Ihsan Ekin organization: Department of Surgery, Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, Else Kröner Clinician Scientist Professor for Translational Pancreatic Surgery – sequence: 16 givenname: Dieter surname: Saur fullname: Saur, Dieter organization: Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Chair of Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, Center for Translational Cancer Research (TranslaTUM), Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich – sequence: 17 givenname: Michael surname: Quante fullname: Quante, Michael organization: Department of Internal Medicine II, Faculty of Medicine, Freiburg University Medical Center, University of Freiburg – sequence: 18 givenname: Roland M. surname: Schmid fullname: Schmid, Roland M. organization: Department of Internal Medicine II, Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich – sequence: 19 givenname: Moritz orcidid: 0000-0001-8425-3985 surname: Middelhoff fullname: Middelhoff, Moritz email: moritz.middelhoff@mri.tum.de organization: Department of Internal Medicine II, Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39380035$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kktr3DAUhU1JadI0f6CLYiiUduHUsh4jr0IIfQwECn1thazHRIMtTSU5dPLre2eclHEpkReSr75zuL4-z4sjH7wpipeoPkeIs_cJ4YYvqrohVY1byqu7J8UJWtBFxShqjg7Ox8VZSusaFsZ1zciz4hi3mMMrPSniT5mCVNndmtL5bFJ2Xvblxmyy06bcxDAEqJbJqGhyiNtSO2tNND47mV3wpfS6HFx2K7njotRTvXJej8roQ1fn12PcviieWtknc3a_nxY_Pn74fvW5uv7yaXl1eV0pRmiuWoVx17QULZjijPK2NbhtJDEdxrIjFhFCa9vBsp2qsSRaa9o2xCrUaCoNPi2Wk68Oci020Q0ybkWQTuwLIa6EjNmp3gjQUE00p1QRsmhpaznhHLfIMm1Yw8DrYvLajN1gtILPj7Kfmc5vvLsRq3ArECKsAUdweHvvEMOvESYiBpeU6XvpTRiTwEDSumEMA_p6QlcSenPeBrBUO1xccoQYhWHsDM__Q8GjzeAUhMU6qM8E72YCYLL5nVdyTEksv32ds28O2Bsj-3yTQj_u_myag68OB_N3Ig8JA4BPgIohpWisUC7vEwLtul6gWuzyLKY8C8iz2OdZ3IG0-Uf64P6oCE-iBLBfmSjWYYyQvvSY6g8RWwk4 |
| CitedBy_id | crossref_primary_10_1016_j_fbio_2025_107032 crossref_primary_10_1016_j_toxicon_2025_108553 crossref_primary_10_1186_s12876_025_04024_5 crossref_primary_10_1007_s12017_025_08849_x crossref_primary_10_3389_fbioe_2025_1640682 crossref_primary_10_1002_mnfr_70057 |
| Cites_doi | 10.1126/sciadv.add8564 10.1053/j.gastro.2012.05.007 10.12688/f1000research.18039.1 10.1038/nature24489 10.1038/cddis.2017.226 10.1152/physrev.00018.2022 10.1038/s41467-024-47124-8 10.3390/pathogens3010073 10.1371/journal.pone.0016295 10.1210/en.2012-1069 10.1113/JP271931 10.1371/journal.pone.0204567 10.1007/s00726-011-1184-8 10.1016/j.cels.2015.12.004 10.1016/j.ecoenv.2023.115457 10.1038/s41467-019-13850-7 10.1046/j.1365-2982.2003.00409.x 10.1016/j.jpedsurg.2019.08.038 10.3389/fcimb.2020.00415 10.1016/j.gastha.2021.11.005 10.1186/s13059-014-0550-8 10.1073/pnas.0506580102 10.1016/j.jcmgh.2019.05.003 10.1101/060012 10.1371/journal.pone.0125225 10.1016/j.chom.2022.09.001 10.1038/nrm3721 10.1016/j.peptides.2007.05.006 10.1016/j.immuni.2020.02.016 10.1016/j.stem.2013.11.008 10.1152/ajpgi.00457.2001 10.14814/phy2.14363 10.1016/j.cell.2015.05.002 10.1152/ajpgi.00081.2017 10.1016/j.stem.2018.05.002 10.1016/j.bbamem.2020.183278 10.1038/ncb2581 10.1038/nature22313 10.1074/jbc.270.13.7420 10.1038/nature11965 10.1097/MPA.0b013e318214c783 10.1073/pnas.2106634118 10.1016/s0196-9781(99)00200-4 10.1126/science.1166202 10.1053/gast.2003.50141 10.1152/ajpgi.00142.2005 10.1016/j.jcmgh.2021.06.006 10.1038/s41586-020-2039-9 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2024 2024. The Author(s). COPYRIGHT 2024 BioMed Central Ltd. The Author(s) 2024 2024 |
| Copyright_xml | – notice: The Author(s) 2024 – notice: 2024. The Author(s). – notice: COPYRIGHT 2024 BioMed Central Ltd. – notice: The Author(s) 2024 2024 |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM ISR 7X8 5PM DOA |
| DOI | 10.1186/s13287-024-03958-z |
| DatabaseName | SpringerOpen Free (Free internet resource, activated by CARLI) CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Science MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1757-6512 |
| EndPage | 14 |
| ExternalDocumentID | oai_doaj_org_article_fc15d4d855c447959f8488391f6de626 PMC11462795 A811655895 39380035 10_1186_s13287_024_03958_z |
| Genre | Journal Article |
| GeographicLocations | United States |
| GeographicLocations_xml | – name: United States |
| GrantInformation_xml | – fundername: Deutsche Forschungsgemeinschaft grantid: 424415217 funderid: http://dx.doi.org/10.13039/501100001659 – fundername: Technische Universität München (1025) – fundername: CRC1371 grantid: 395357507 – fundername: Deutsche Forschungsgemeinschaft grantid: 424415217 |
| GroupedDBID | --- 0R~ 53G 5VS 7X7 88E 8FE 8FH 8FI 8FJ AAFWJ AAJSJ AASML ABDBF ABUWG ACGFS ACIHN ACJQM ACPRK ACUHS ADBBV ADUKV AEAQA AENEX AFKRA AFPKN AHBYD AHMBA AHYZX ALMA_UNASSIGNED_HOLDINGS AMKLP AMTXH AOIAM AOIJS BAPOH BAWUL BBNVY BCNDV BENPR BFQNJ BHPHI BMC BPHCQ BVXVI C6C CCPQU DIK E3Z EBD EBLON EBS EMOBN ESX F5P FYUFA GROUPED_DOAJ GX1 HCIFZ HMCUK HYE IAO IEA IHR IHW INH INR ISR ITC KQ8 LK8 M1P M7P M~E O5R O5S OK1 P2P PGMZT PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PUEGO RBZ ROL RPM RSV SBL SOJ SV3 TUS UKHRP AAYXX AFFHD CITATION -56 -5G -BR 3V. ACRMQ ADINQ ALIPV C24 CGR CUY CVF ECM EIF NPM 7X8 5PM |
| ID | FETCH-LOGICAL-c645t-9c33b295176c865899e392a4eb33ab4f14450fbbbbfbc03a4ddd5924fc12d5ae3 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 8 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001331326600003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1757-6512 |
| IngestDate | Fri Oct 03 12:52:22 EDT 2025 Tue Nov 04 02:05:58 EST 2025 Sun Nov 09 10:50:15 EST 2025 Tue Nov 11 10:54:53 EST 2025 Tue Nov 04 18:20:01 EST 2025 Thu Nov 13 16:08:58 EST 2025 Thu May 22 21:26:56 EDT 2025 Thu Jan 02 22:26:44 EST 2025 Tue Nov 18 21:30:03 EST 2025 Sat Nov 29 04:00:58 EST 2025 Sat Sep 06 07:28:23 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Irradiation Regeneration Intestinal progenitor cells VIP |
| Language | English |
| License | 2024. The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c645t-9c33b295176c865899e392a4eb33ab4f14450fbbbbfbc03a4ddd5924fc12d5ae3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0001-8425-3985 |
| OpenAccessLink | https://doaj.org/article/fc15d4d855c447959f8488391f6de626 |
| PMID | 39380035 |
| PQID | 3114502663 |
| PQPubID | 23479 |
| PageCount | 14 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_fc15d4d855c447959f8488391f6de626 pubmedcentral_primary_oai_pubmedcentral_nih_gov_11462795 proquest_miscellaneous_3114502663 gale_infotracmisc_A811655895 gale_infotracacademiconefile_A811655895 gale_incontextgauss_ISR_A811655895 gale_healthsolutions_A811655895 pubmed_primary_39380035 crossref_citationtrail_10_1186_s13287_024_03958_z crossref_primary_10_1186_s13287_024_03958_z springer_journals_10_1186_s13287_024_03958_z |
| PublicationCentury | 2000 |
| PublicationDate | 2024-10-08 |
| PublicationDateYYYYMMDD | 2024-10-08 |
| PublicationDate_xml | – month: 10 year: 2024 text: 2024-10-08 day: 08 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Stem cell research & therapy |
| PublicationTitleAbbrev | Stem Cell Res Ther |
| PublicationTitleAlternate | Stem Cell Res Ther |
| PublicationYear | 2024 |
| Publisher | BioMed Central BioMed Central Ltd BMC |
| Publisher_xml | – name: BioMed Central – name: BioMed Central Ltd – name: BMC |
| References | C Morral (3958_CR48) 2024 MI Love (3958_CR28) 2014 E Morel (3958_CR16) 2002 N Barker (3958_CR33) 2014 F Toumi (3958_CR9) 2003 J Talbot (3958_CR49) 2020 LA Schwerdtfeger (3958_CR13) 2020 A Liberzon (3958_CR31) 2015 P Sittipo (3958_CR36) 2020 A Diefenbach (3958_CR21) 2020 BS Sailaja (3958_CR1) 2016 A Subramanian (3958_CR29) 2005 AL Haber (3958_CR32) 2017 SW Koh (3958_CR45) 2000; 41 S Yu (3958_CR38) 2018 L Gonzalez-Mariscal (3958_CR40) 2020 J Raingeaud (3958_CR34) 1995 KS Sastry (3958_CR44) 2017 L Vornholz (3958_CR26) 2023 C Metcalfe (3958_CR35) 2014 SJ Buczacki (3958_CR43) 2013 AC Ericsson (3958_CR23) 2022 U Höckerfelt (3958_CR15) 2000 AK Maiti (3958_CR20) 2018 KT Walsh (3958_CR2) 2019 ER Gross (3958_CR3) 2012 B Yusta (3958_CR12) 2012 HB Yu (3958_CR22) 2021 KA Sharkey (3958_CR6) 2023 D Fabricius (3958_CR14) 2011 JH van Es (3958_CR42) 2012 P Cray (3958_CR37) 2021 V Lelievre (3958_CR11) 2007 C Abad (3958_CR19) 2003 D Jayawardena (3958_CR7) 2017 R Hokari (3958_CR10) 2005 O Lundgren (3958_CR4) 2011 3958_CR30 KS Yan (3958_CR39) 2017 C Lei (3958_CR24) 2022 DG Kirsch (3958_CR41) 2010 C Cui (3958_CR47) 2023 EZ Macosko (3958_CR27) 2015 X Wu (3958_CR18) 2015 M Iwasaki (3958_CR8) 2019; 8 M Delgado (3958_CR25) 2013 CA Rubio (3958_CR46) 2014 S Seo (3958_CR17) 2019 M Middelhoff (3958_CR5) 2020 |
| References_xml | – year: 2023 ident: 3958_CR26 publication-title: Sci Adv doi: 10.1126/sciadv.add8564 – year: 2012 ident: 3958_CR3 publication-title: Gastroenterology doi: 10.1053/j.gastro.2012.05.007 – volume: 8 start-page: 2629 year: 2019 ident: 3958_CR8 publication-title: F1000Research doi: 10.12688/f1000research.18039.1 – year: 2017 ident: 3958_CR32 publication-title: Nature doi: 10.1038/nature24489 – year: 2017 ident: 3958_CR44 publication-title: Cell Death Dis doi: 10.1038/cddis.2017.226 – year: 2023 ident: 3958_CR6 publication-title: Physiol Rev doi: 10.1152/physrev.00018.2022 – volume: 41 start-page: 4085 year: 2000 ident: 3958_CR45 publication-title: Invest Ophthalmol Vis Sci – year: 2024 ident: 3958_CR48 publication-title: Nat Commun doi: 10.1038/s41467-024-47124-8 – year: 2014 ident: 3958_CR46 publication-title: Pathogens doi: 10.3390/pathogens3010073 – year: 2011 ident: 3958_CR4 publication-title: PLoS ONE doi: 10.1371/journal.pone.0016295 – year: 2012 ident: 3958_CR12 publication-title: Endocrinology doi: 10.1210/en.2012-1069 – year: 2016 ident: 3958_CR1 publication-title: J Physiol doi: 10.1113/JP271931 – year: 2018 ident: 3958_CR20 publication-title: PLoS ONE doi: 10.1371/journal.pone.0204567 – year: 2013 ident: 3958_CR25 publication-title: Amino Acids doi: 10.1007/s00726-011-1184-8 – year: 2015 ident: 3958_CR31 publication-title: Cell Syst doi: 10.1016/j.cels.2015.12.004 – year: 2023 ident: 3958_CR47 publication-title: Ecotoxicol Environ Saf doi: 10.1016/j.ecoenv.2023.115457 – year: 2020 ident: 3958_CR5 publication-title: Nat Commun doi: 10.1038/s41467-019-13850-7 – year: 2003 ident: 3958_CR9 publication-title: Neurogastroenterol Motil doi: 10.1046/j.1365-2982.2003.00409.x – year: 2019 ident: 3958_CR17 publication-title: J Pediatr Surg doi: 10.1016/j.jpedsurg.2019.08.038 – year: 2020 ident: 3958_CR36 publication-title: Front Cell Infect Microbiol doi: 10.3389/fcimb.2020.00415 – year: 2022 ident: 3958_CR23 publication-title: Gastro Hep Adv doi: 10.1016/j.gastha.2021.11.005 – year: 2014 ident: 3958_CR28 publication-title: Genome Biol doi: 10.1186/s13059-014-0550-8 – year: 2005 ident: 3958_CR29 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0506580102 – year: 2019 ident: 3958_CR2 publication-title: Cell Mol Gastroenterol Hepatol doi: 10.1016/j.jcmgh.2019.05.003 – ident: 3958_CR30 doi: 10.1101/060012 – year: 2015 ident: 3958_CR18 publication-title: PLoS ONE doi: 10.1371/journal.pone.0125225 – year: 2022 ident: 3958_CR24 publication-title: Cell Host Microbe doi: 10.1016/j.chom.2022.09.001 – year: 2014 ident: 3958_CR33 publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm3721 – year: 2007 ident: 3958_CR11 publication-title: Peptides doi: 10.1016/j.peptides.2007.05.006 – year: 2020 ident: 3958_CR21 publication-title: Immunity doi: 10.1016/j.immuni.2020.02.016 – year: 2014 ident: 3958_CR35 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2013.11.008 – year: 2002 ident: 3958_CR16 publication-title: Am J Physiol Gastrointest Liver Physiol doi: 10.1152/ajpgi.00457.2001 – year: 2020 ident: 3958_CR13 publication-title: Physiol Rep doi: 10.14814/phy2.14363 – year: 2015 ident: 3958_CR27 publication-title: Cell doi: 10.1016/j.cell.2015.05.002 – year: 2017 ident: 3958_CR7 publication-title: Am J Physiol Gastrointest Liver Physiol doi: 10.1152/ajpgi.00081.2017 – year: 2018 ident: 3958_CR38 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2018.05.002 – year: 2020 ident: 3958_CR40 publication-title: Biochim Biophys Acta Biomembr doi: 10.1016/j.bbamem.2020.183278 – year: 2012 ident: 3958_CR42 publication-title: Nat Cell Biol doi: 10.1038/ncb2581 – year: 2017 ident: 3958_CR39 publication-title: Nature doi: 10.1038/nature22313 – year: 1995 ident: 3958_CR34 publication-title: J Biol Chem doi: 10.1074/jbc.270.13.7420 – year: 2013 ident: 3958_CR43 publication-title: Nature doi: 10.1038/nature11965 – year: 2011 ident: 3958_CR14 publication-title: Pancreas doi: 10.1097/MPA.0b013e318214c783 – year: 2021 ident: 3958_CR22 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.2106634118 – year: 2000 ident: 3958_CR15 publication-title: Peptides doi: 10.1016/s0196-9781(99)00200-4 – year: 2010 ident: 3958_CR41 publication-title: Science doi: 10.1126/science.1166202 – year: 2003 ident: 3958_CR19 publication-title: Gastroenterology doi: 10.1053/gast.2003.50141 – year: 2005 ident: 3958_CR10 publication-title: Am J Physiol Gastrointest Liver Physiol doi: 10.1152/ajpgi.00142.2005 – year: 2021 ident: 3958_CR37 publication-title: Cell Mol Gastroenterol Hepatol doi: 10.1016/j.jcmgh.2021.06.006 – year: 2020 ident: 3958_CR49 publication-title: Nature doi: 10.1038/s41586-020-2039-9 |
| SSID | ssj0000330064 |
| Score | 2.4036846 |
| Snippet | Background
Vasoactive intestinal peptide (VIP) is a neuronal peptide with prominent distribution along the enteric nervous system. While effects of VIP on... Vasoactive intestinal peptide (VIP) is a neuronal peptide with prominent distribution along the enteric nervous system. While effects of VIP on intestinal... Background Vasoactive intestinal peptide (VIP) is a neuronal peptide with prominent distribution along the enteric nervous system. While effects of VIP on... Abstract Background Vasoactive intestinal peptide (VIP) is a neuronal peptide with prominent distribution along the enteric nervous system. While effects of... |
| SourceID | doaj pubmedcentral proquest gale pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 348 |
| SubjectTerms | Animals Biomedical and Life Sciences Biomedical Engineering and Bioengineering Blood vessels Cell Biology Cell Differentiation Dilatation Ethylenediaminetetraacetic acid Female Flumazenil Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Intestinal Mucosa - radiation effects Intestinal progenitor cells Irradiation Life Sciences Male Mice Mice, Inbred C57BL Organoids - metabolism Radiation Radiation Injuries - metabolism Radiation Injuries - pathology Regeneration Regenerative Medicine/Tissue Engineering Scientific equipment and supplies industry Stem Cells Stem Cells - drug effects Stem Cells - metabolism Stem Cells - radiation effects Vasoactive Intestinal Peptide - metabolism Vasoactive Intestinal Peptide - pharmacology Vasoactive intestinal peptides VIP |
| SummonAdditionalLinks | – databaseName: SpringerLINK Contemporary 1997-Present dbid: RSV link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELaggMSFNyVQICAkDmCRxHbiHAuiAglVqIVVb1biR9kKklW8i0R_PTPOQ01BlWCPziQbj-cZj78h5IVguQY3VNC6FJpyVye0hiHqwBCmFgFbQpeIxadif18eHZWfh0Nhfqx2H7ckg6UOai3zNx7yJlAI8Ck0YaWQ9PQyuQLuTqI6Hhwupi8rCaTo4GjHEzJ_vXXmhQJY_58m-YxPOl8veW7TNPiivZv_N4tb5MYQe8a7vbDcJpdsc4dc67tR_rpLukXl2yrYvxhRJED5kXyFdS_GxqtQuGd97DHSxL35eOyusu7XN64aE_9YBtQOoOsQ9gDHKeT9IEHm7FOXzQms5j3yde_9l3cf6NCSgeqcizUtNWN1BlFZkWsJwUtZWgiwKg4pOatq7iA9E4mr4edqnbCKG2MEpHhOp5kRlWX3yVbTNvYBiZkzuuQmL_CLCk9t6SQXBQhKkmelMzwi6bhESg945dg247sKeYvMVc9LBbxUgZfqNCKvpntWPVrHhdRvceUnSkTaDgNtd6wGxVXw5sJwI4XQnGNjdnhNCVFl6nJjIRuMyFOUG9UfW53shdqVCGwEHBIReR4oEG2jwXKe42rjvfp4eDAjejkQuRZmqavhdATwCgG6ZpQ7M0owB3p2-dkowAovYQ1dY9uNVwxSXwEpd84ist0L9DR1VjKJm8oRkTNRn_FmfqVZfgto5HisPSvwj1-PEq8GO-gvYP7DfyN_RK5nqDSh-nKHbK27jX1Mruqf66XvngQD8BvMMli0 priority: 102 providerName: Springer Nature |
| Title | Vasoactive intestinal peptide promotes secretory differentiation and mitigates radiation-induced intestinal injury |
| URI | https://link.springer.com/article/10.1186/s13287-024-03958-z https://www.ncbi.nlm.nih.gov/pubmed/39380035 https://www.proquest.com/docview/3114502663 https://pubmed.ncbi.nlm.nih.gov/PMC11462795 https://doaj.org/article/fc15d4d855c447959f8488391f6de626 |
| Volume | 15 |
| WOSCitedRecordID | wos001331326600003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVADU databaseName: BioMed Central Open Access Free customDbUrl: eissn: 1757-6512 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000330064 issn: 1757-6512 databaseCode: RBZ dateStart: 20100101 isFulltext: true titleUrlDefault: https://www.biomedcentral.com/search/ providerName: BioMedCentral – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1757-6512 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000330064 issn: 1757-6512 databaseCode: DOA dateStart: 20100101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1757-6512 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000330064 issn: 1757-6512 databaseCode: M~E dateStart: 20100101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1757-6512 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000330064 issn: 1757-6512 databaseCode: M7P dateStart: 20150101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1757-6512 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000330064 issn: 1757-6512 databaseCode: 7X7 dateStart: 20150101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1757-6512 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000330064 issn: 1757-6512 databaseCode: BENPR dateStart: 20150101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Publicly Available Content Database customDbUrl: eissn: 1757-6512 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000330064 issn: 1757-6512 databaseCode: PIMPY dateStart: 20150101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVAVX databaseName: SpringerLINK Contemporary 1997-Present customDbUrl: eissn: 1757-6512 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000330064 issn: 1757-6512 databaseCode: RSV dateStart: 20100301 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9MwELdggMQL4nMERgkIiQewlsR24jxuaBOToIo6qMqTlfgDiiCtmhaJ_fXcOUnVDGm80IdKta-pfB--u_r8O0JeCZZqcEMZrXKhKXdVRCsYog42wtgiYIvvEjH9kI3HcjbLi51WX1gT1sIDt4w7dDoWhhsphOYcG2M7CTrH8tilxkI0jrsvRD07yZTfgyFNB2fb35KR6WEDaRfYE7gkGrFcSHox8EQesP_vbXnHL12umbx0cOr90eldcqcLJMOjdgH3yDVb3ye32taSvx-Q1bRsFqXfzEKEhABLRvIlFrEYGy59FZ5twgbDRjxoD_tWKetWWGFZm_Dn3ENwAN0KMQxwnEISD-pgdp86r7-DaB6Sz6cnn969p11_BapTLtY014xVCYRYWaolRCJ5biFaKjnk16ysuINcS0SugperdMRKbowRkK-BSBIjSssekb16UdvHJGTO6JybNMO_R3hsUUoiA6lHaZI7wwMS97xWugMfxx4YP5RPQmSqWvkokI_y8lEXAXmz_c6yhd64kvoYRbilRNhsPwDKpDplUv9SpoA8RwVQ7R3UrfGrI4koRcAhEZCXngKhM2qszflabppGnZ1PBkSvOyK3gFXqsrvqALxCtK0B5cGAEmxbD6Zf9JqocAoL4mq72DSKQR4rIH9OWUD2W83cLp3lTOIJcUDkQGcHvBnO1PNvHloc76gnGf7w2169VbepNVcw_8n_YP5TcjtB8_QFlgdkb73a2Gfkpv61njerEbmezTL_LkfkxvHJuJiMvM2PsFy3gLHi7GPxBT5Nzqd_ANs6WgI |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Zb9QwELaggOCF-wgUGhASDxCRje3EeSyIqhXLCrVl1Tcr8dFuBckq3kWiv54Z51BTUCXIoz05PB7PEY-_IeQ1p6kCM5RFZc5VxGwZRyU0RRYU4cQgYIuvEjGfZrOZODrKv3aHwlyf7d5vSXpN7Ze1SN87iJtgQYBNiWKacxGdXSXXGFgsTOTbP5gPf1ZiCNHB0PYnZP5668gKebD-P1XyOZt0MV_ywqapt0U7d_5vFHfJ7c73DLdbYblHrpjqPrnRVqP89YA088LVhdd_IaJIwOJH8iXmvWgTLn3innGhQ08T9-bDvrrKqp3fsKh0-GPhUTuArkHYA2yPIO4HCdLnn7qoTmE2H5JvO58OP-5GXUmGSKWMr6JcUVom4JVlqRLgvOS5AQerYBCS06JkFsIzHtsSLluqmBZMa80hxLNqkmheGPqIbFR1ZZ6QkFqtcqbTDP-osInJrWA8A0GJ0yS3mgVk0k-RVB1eOZbN-C593CJS2fJSAi-l56U8C8jb4Z5li9ZxKfUHnPmBEpG2fUPdHMtu4Ur4cq6ZFpwrxrAwO3ymAK9yYlNtIBoMyBbKjWyPrQ76Qm4LBDYCDvGAvPIUiLZRYTrPcbF2Tu4d7I-I3nREtoZRqqI7HQG8QoCuEeXmiBLUgRp1v-wFWGIX5tBVpl47SSH05RBypzQgj1uBHoZOcypwUzkgYiTqI96Me6rFiUcjx2PtSYYvftdLvOz0oLuE-U__jXyL3Nw9_DKV073Z52fkVoILyGdibpKNVbM2z8l19XO1cM0Lrwx-A_SBW5g |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Zb9QwELagHOKF-wgUGhASDyVqEtuJ81iOFRXVqqKw6puV-ChBkKySLBL99cw4yWpTUCXEPjqTbDwezxHPfEPIS04TBWYoDYqMq4DZIgwKGAosKMLIIGCL6xKxOEznc3Fykh1tVPG7bPfxSLKvaUCUpqrbW2rbb3GR7LUQQ8HmAPsShDTjIji7TK4wbBqE8frxYv2VJYRwHYzuWC3z11snFskB9_-pnjfs0_ncyXMHqM4uzW79_4xuk5uDT-rv90J0h1wy1V1yre9S-eseaRZ5W-dOL_qILgFKAcmXmA-jjb90CX2m9Vv0QPHM3h-7rnT9uvt5pf0fpUPzALoG4RBwPCgrDZKlN59aVt9gle-TL7P3n99-CIZWDYFKGO-CTFFaxOCtpYkS4NRkmQHHK2cQqtO8YBbCNh7aAn62UCHNmdaaQ-hnVRRrnhv6gGxVdWUeEZ9arTKmkxS_tLDIZFYwnoIAhUmcWc08Eo3LJdWAY47tNL5LF8-IRPa8lMBL6Xgpzzyyu75n2aN4XEj9BqVgTYkI3G6gbk7lsKElvDnXTAvOFWPYsB1eU4C3GdlEG4gSPbKDMiT7cta1HpH7AgGPgEPcIy8cBaJwVJjmc5qv2lYeHH-aEL0aiGwNs1T5UDUBvELgrgnl9oQS1ISaXH4-CrPES5hbV5l61UoKITGHUDyhHnnYC_d66jSjAg-bPSImYj_hzfRKVX51KOVY7h6n-MevR-mXg35sL2D-438j3yHXj97N5OHB_OMTciPG_eMSNLfJVteszFNyVf3syrZ55vTCb7u5ZHw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Vasoactive+intestinal+peptide+promotes+secretory+differentiation+and+mitigates+radiation-induced+intestinal+injury&rft.jtitle=Stem+cell+research+%26+therapy&rft.au=Agibalova%2C+Tatiana&rft.au=Hempel%2C+Anneke&rft.au=Maurer%2C+H.+Carlo&rft.au=Ragab%2C+Mohab&rft.date=2024-10-08&rft.pub=BioMed+Central+Ltd&rft.issn=1757-6512&rft.eissn=1757-6512&rft.volume=15&rft.issue=1&rft_id=info:doi/10.1186%2Fs13287-024-03958-z&rft.externalDBID=ISR&rft.externalDocID=A811655895 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1757-6512&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1757-6512&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1757-6512&client=summon |