ESTRO ACROP: Technology for precision small animal radiotherapy research: Optimal use and challenges

Many radiotherapy research centers have recently installed novel research platforms enabling the investigation of the radiation response of tumors and normal tissues in small animal models, possibly in combination with other treatment modalities. Many more research institutes are expected to follow...

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Bibliographic Details
Published in:Radiotherapy and Oncology Vol. 126; no. 3; pp. 471 - 478
Main Authors: Verhaegen, Frank, Dubois, Ludwig, Gianolini, Stefano, Hill, Mark A., Karger, Christian P., Lauber, Kirsten, Prise, Kevin M., Sarrut, David, Thorwarth, Daniela, Vanhove, Christian, Vojnovic, Boris, Weersink, Robert, Wilkens, Jan J., Georg, Dietmar
Format: Journal Article
Language:English
Published: Ireland Elsevier B.V 01.03.2018
Elsevier BV
Elsevier
Subjects:
[INFO.INFO-IM] Computer Science [cs]/Medical Imaging
[PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph]
[SDV.CAN] Life Sciences [q-bio]/Cancer
Animals
BIOLUMINESCENCE TOMOGRAPHY
Cancer
Computer Science
CONFORMAL RADIOTHERAPY
DIFFUSE OPTICAL TOMOGRAPHY
Disease Models, Animal
DOSE CALCULATIONS
Hematology, Oncology, and Palliative Medicine
Image guided
IMAGE QUALITY
Irradiation
Life Sciences
Medical Imaging
Medical Physics
MICRO-CT
Neoplasms, Experimental
Neoplasms, Experimental - diagnostic imaging
Neoplasms, Experimental - radiotherapy
Physics
Precision
PRECLINICAL RESEARCH
RADIATION RESEARCH PLATFORM
Radiotherapy
Radiotherapy Planning, Computer-Assisted
Radiotherapy Planning, Computer-Assisted - instrumentation
Radiotherapy Planning, Computer-Assisted - methods
Radiotherapy, Image-Guided
Radiotherapy, Image-Guided - instrumentation
Radiotherapy, Image-Guided - methods
RELATIVE BIOLOGICAL EFFECTIVENESS
Small animal
Technology and Engineering
TISSUE SEGMENTATION
Irradiation
Small animal
Radiotherapy
Precision
Image guided
ISSN:0167-8140, 1879-0887, 1879-0887
Online Access:Get full text
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Summary:Many radiotherapy research centers have recently installed novel research platforms enabling the investigation of the radiation response of tumors and normal tissues in small animal models, possibly in combination with other treatment modalities. Many more research institutes are expected to follow in the coming years. These novel platforms are capable of mimicking human radiotherapy more closely than older technology. To facilitate the optimal use of these novel integrated precision irradiators and various small animal imaging devices, and to maximize the impact of the associated research, the ESTRO committee on coordinating guidelines ACROP (Advisory Committee in Radiation Oncology Practice) has commissioned a report to review the state of the art of the technology used in this new field of research, and to issue recommendations. This report discusses the combination of precision irradiation systems, small animal imaging (CT, MRI, PET, SPECT, bioluminescence) systems, image registration, treatment planning, and data processing. It also provides guidelines for reporting on studies.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Instructional Material/Guideline-1
ObjectType-Feature-3
content type line 23
ISSN:0167-8140
1879-0887
1879-0887
DOI:10.1016/j.radonc.2017.11.016