Inter-rater reliability of manual and automated region-of-interest delineation for PiB PET

A major challenge in positron emission tomography (PET) amyloid imaging studies of Alzheimer's disease (AD) is the reliable detection of early amyloid deposition in human brain. Manual region-of-interest (ROI) delineation on structural magnetic resonance (MR) images is generally the reference s...

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Bibliographic Details
Published in:	NeuroImage (Orlando, Fla.) Vol. 55; no. 3; pp. 933 - 941
Main Authors:	Rosario, Bedda L., Weissfeld, Lisa A., Laymon, Charles M., Mathis, Chester A., Klunk, William E., Berginc, Michael D., James, Jeffrey A., Hoge, Jessica A., Price, Julie C.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.04.2011 Elsevier Limited
Subjects:	Aged Aged, 80 and over Alzheimer Disease - cerebrospinal fluid Alzheimer Disease - diagnostic imaging Alzheimer's disease Amyloid - metabolism Aniline Compounds Atrophy Atrophy correction Automated Automated delineation Automation Brain - diagnostic imaging Confidence intervals Data Interpretation, Statistical Delineation Deposition Female Humans Image Processing, Computer-Assisted - methods Intra-class correlation coefficient Magnetic Resonance Imaging Male Manual delineation Medical imaging Methods Middle Aged Neurodegeneration Observer Variation Partial volume correction PET PiB Positron emission Positron-Emission Tomography - methods Positron-Emission Tomography - statistics & numerical data Radiopharmaceuticals Region-of-interest Reliability Reproducibility of Results Retention Sport utility vehicles SUV Thiazoles Tomography Atrophy correction Manual delineation Region-of-interest Automated delineation PiB Partial volume correction Intra-class correlation coefficient Reliability PET
ISSN:	1053-8119, 1095-9572, 1095-9572
Online Access:	Get full text
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