Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation

Barrier integrity is central to the maintenance of healthy immunological homeostasis. Impaired skin barrier function is linked with enhanced allergen sensitization and the development of diseases such as atopic dermatitis (AD), which can precede the development of other allergic disorders, for examp...

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Bibliographic Details
Published in:Mucosal immunology Vol. 15; no. 5; pp. 908 - 926
Main Authors: Trompette, Aurélien, Pernot, Julie, Perdijk, Olaf, Alqahtani, Rayed Ali A, Domingo, Jaime Santo, Camacho-Muñoz, Dolores, Wong, Nicholas C, Kendall, Alexandra C, Wiederkehr, Andreas, Nicod, Laurent P, Nicolaou, Anna, von Garnier, Christophe, Ubags, Niki D J, Marsland, Benjamin J
Format: Journal Article
Language:English
Published: United States Elsevier Limited 01.08.2022
Subjects:
Allergens
Asthma
Atopic dermatitis
Child
Dermatitis
Dermatitis, Atopic
Diet
Dietary Fiber
Disease
Eczema
Epidemiology
Fatty acids
Fatty Acids, Volatile
Food allergies
Food Hypersensitivity
Gene expression
Homeostasis
Humans
Hypotheses
Immunology
Inflammation
Keratinocytes
Lifestyles
Lipids
Metabolism
Metabolites
Mitochondria
Skin
Skin diseases
Westernization
ISSN:1933-0219, 1935-3456, 1935-3456
Online Access:Get full text
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Summary:Barrier integrity is central to the maintenance of healthy immunological homeostasis. Impaired skin barrier function is linked with enhanced allergen sensitization and the development of diseases such as atopic dermatitis (AD), which can precede the development of other allergic disorders, for example, food allergies and asthma. Epidemiological evidence indicates that children suffering from allergies have lower levels of dietary fibre-derived short-chain fatty acids (SCFA). Using an experimental model of AD-like skin inflammation, we report that a fermentable fibre-rich diet alleviates systemic allergen sensitization and disease severity. The gut-skin axis underpins this phenomenon through SCFA production, particularly butyrate, which strengthens skin barrier function by altering mitochondrial metabolism of epidermal keratinocytes and the production of key structural components. Our results demonstrate that dietary fibre and SCFA improve epidermal barrier integrity, ultimately limiting early allergen sensitization and disease development.The Graphical Abstract was designed using Servier Medical Art images ( https://smart.servier.com ).
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ISSN:1933-0219
1935-3456
1935-3456
DOI:10.1038/s41385-022-00524-9