Umbilical cord mesenchymal stem cells for COVID‐19 acute respiratory distress syndrome: A double‐blind, phase 1/2a, randomized controlled trial

Acute respiratory distress syndrome (ARDS) in COVID‐19 is associated with high mortality. Mesenchymal stem cells are known to exert immunomodulatory and anti‐inflammatory effects and could yield beneficial effects in COVID‐19 ARDS. The objective of this study was to determine safety and explore effi...

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Bibliographic Details
Published in:	Stem cells translational medicine Vol. 10; no. 5; pp. 660 - 673
Main Authors:	Lanzoni, Giacomo, Linetsky, Elina, Correa, Diego, Messinger Cayetano, Shari, Alvarez, Roger A., Kouroupis, Dimitrios, Alvarez Gil, Ana, Poggioli, Raffaella, Ruiz, Phillip, Marttos, Antonio C., Hirani, Khemraj, Bell, Crystal A., Kusack, Halina, Rafkin, Lisa, Baidal, David, Pastewski, Andrew, Gawri, Kunal, Leñero, Clarissa, Mantero, Alejandro M. A., Metalonis, Sarah W., Wang, Xiaojing, Roque, Luis, Masters, Burlett, Kenyon, Norma S., Ginzburg, Enrique, Xu, Xiumin, Tan, Jianming, Caplan, Arnold I., Glassberg, Marilyn K., Alejandro, Rodolfo, Ricordi, Camillo
Format:	Journal Article
Language:	English
Published:	Hoboken, USA John Wiley & Sons, Inc 01.05.2021 Oxford University Press
Subjects:	Acute respiratory distress syndrome Adverse events Anti-Inflammatory Agents - therapeutic use Care and treatment cell transplantation cellular therapy Chemokines Clinical outcomes Clinical trials Coronaviruses COVID-19 COVID-19 - therapy Cytokine storm Cytokines Cytokines - blood Design Disease Double-Blind Method Double-blind studies Ethylenediaminetetraacetic acid Female Growth factors Hospitalization Human Clinical Humans Immunomodulation Inflammation Intravenous administration Laboratories Male Manufacturing Mesenchymal Stem Cell Transplantation - adverse effects Mesenchymal Stem Cell Transplantation - methods Mesenchymal Stem Cells Middle Aged Mortality Patients Plasma Respiratory distress syndrome respiratory tract SARS-CoV-2 - drug effects Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Stem cells transplantation Treatment Outcome Tumor necrosis factor-TNF Umbilical cord Umbilical Cord - cytology United Kingdom cell transplantation mesenchymal stem cells respiratory tract transplantation clinical trials cellular therapy umbilical cord
ISSN:	2157-6564, 2157-6580, 2157-6580
Online Access:	Get full text
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