Longitudinal perspective on the conundrum of central arterial stiffness, blood pressure, and aging

The age-associated increase in arterial stiffness has long been considered to parallel or to cause the age-associated increase in blood pressure (BP). Yet, the rates at which pulse wave velocity (PWV), a measure of arterial stiffness, and BP trajectories change over time within individuals who diffe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Jg. 64; H. 6; S. 1219
Hauptverfasser:	Scuteri, Angelo, Morrell, Christopher H, Orrù, Marco, Strait, James B, Tarasov, Kirill V, Ferreli, Liana Anna Pina, Loi, Francesco, Pilia, Maria Grazia, Delitala, Alessandro, Spurgeon, Harold, Najjar, Samer S, AlGhatrif, Majd, Lakatta, Edward G
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.12.2014
Schlagworte:	Adult Age Distribution Age Factors Aged Aged, 80 and over Aging Blood Pressure - physiology Disease Progression Female Follow-Up Studies Humans Hypertension - epidemiology Hypertension - physiopathology Incidence Italy - epidemiology Male Middle Aged Vascular Stiffness - physiology Young Adult Italy arteries blood pressure aging pulse wave analysis sex longitudinal studies
ISSN:	1524-4563, 1524-4563
Online-Zugang:	Weitere Angaben
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Abstract	The age-associated increase in arterial stiffness has long been considered to parallel or to cause the age-associated increase in blood pressure (BP). Yet, the rates at which pulse wave velocity (PWV), a measure of arterial stiffness, and BP trajectories change over time within individuals who differ by age and sex have not been assessed and compared. This study determined the evolution of BP and aortic PWV trajectories during a 9.4-year follow-up in >4000 community-dwelling men and women of 20 to 100 years of age at entry into the SardiNIA Study. Linear mixed effects model analyses revealed that PWV accelerates with time during the observation period, at about the same rate over the entire age range in both men and women. In men, the longitudinal rate at which BP changed over time, however, did not generally parallel that of PWV acceleration: at ages>40 years the rates of change in systolic BP (SBP) and pulse pressure (PP) increase plateaued and then declined so that SBP, itself, also declined at older ages, whereas PP plateaued. In women, SBP, diastolic BP, and mean BP increased at constant rates across all ages, producing an increasing rate of increase in PP. Therefore, increased aortic stiffness is implicated in the age-associated increase in SBP and PP. These findings indicate that PWV is not a surrogate for BP and that arterial properties other than arterial wall stiffness that vary by age and sex also modulate the BP trajectories during aging and lead to the dissociation of PWV, PP, and SBP trajectories in men.
AbstractList	The age-associated increase in arterial stiffness has long been considered to parallel or to cause the age-associated increase in blood pressure (BP). Yet, the rates at which pulse wave velocity (PWV), a measure of arterial stiffness, and BP trajectories change over time within individuals who differ by age and sex have not been assessed and compared. This study determined the evolution of BP and aortic PWV trajectories during a 9.4-year follow-up in >4000 community-dwelling men and women of 20 to 100 years of age at entry into the SardiNIA Study. Linear mixed effects model analyses revealed that PWV accelerates with time during the observation period, at about the same rate over the entire age range in both men and women. In men, the longitudinal rate at which BP changed over time, however, did not generally parallel that of PWV acceleration: at ages>40 years the rates of change in systolic BP (SBP) and pulse pressure (PP) increase plateaued and then declined so that SBP, itself, also declined at older ages, whereas PP plateaued. In women, SBP, diastolic BP, and mean BP increased at constant rates across all ages, producing an increasing rate of increase in PP. Therefore, increased aortic stiffness is implicated in the age-associated increase in SBP and PP. These findings indicate that PWV is not a surrogate for BP and that arterial properties other than arterial wall stiffness that vary by age and sex also modulate the BP trajectories during aging and lead to the dissociation of PWV, PP, and SBP trajectories in men.The age-associated increase in arterial stiffness has long been considered to parallel or to cause the age-associated increase in blood pressure (BP). Yet, the rates at which pulse wave velocity (PWV), a measure of arterial stiffness, and BP trajectories change over time within individuals who differ by age and sex have not been assessed and compared. This study determined the evolution of BP and aortic PWV trajectories during a 9.4-year follow-up in >4000 community-dwelling men and women of 20 to 100 years of age at entry into the SardiNIA Study. Linear mixed effects model analyses revealed that PWV accelerates with time during the observation period, at about the same rate over the entire age range in both men and women. In men, the longitudinal rate at which BP changed over time, however, did not generally parallel that of PWV acceleration: at ages>40 years the rates of change in systolic BP (SBP) and pulse pressure (PP) increase plateaued and then declined so that SBP, itself, also declined at older ages, whereas PP plateaued. In women, SBP, diastolic BP, and mean BP increased at constant rates across all ages, producing an increasing rate of increase in PP. Therefore, increased aortic stiffness is implicated in the age-associated increase in SBP and PP. These findings indicate that PWV is not a surrogate for BP and that arterial properties other than arterial wall stiffness that vary by age and sex also modulate the BP trajectories during aging and lead to the dissociation of PWV, PP, and SBP trajectories in men. The age-associated increase in arterial stiffness has long been considered to parallel or to cause the age-associated increase in blood pressure (BP). Yet, the rates at which pulse wave velocity (PWV), a measure of arterial stiffness, and BP trajectories change over time within individuals who differ by age and sex have not been assessed and compared. This study determined the evolution of BP and aortic PWV trajectories during a 9.4-year follow-up in >4000 community-dwelling men and women of 20 to 100 years of age at entry into the SardiNIA Study. Linear mixed effects model analyses revealed that PWV accelerates with time during the observation period, at about the same rate over the entire age range in both men and women. In men, the longitudinal rate at which BP changed over time, however, did not generally parallel that of PWV acceleration: at ages>40 years the rates of change in systolic BP (SBP) and pulse pressure (PP) increase plateaued and then declined so that SBP, itself, also declined at older ages, whereas PP plateaued. In women, SBP, diastolic BP, and mean BP increased at constant rates across all ages, producing an increasing rate of increase in PP. Therefore, increased aortic stiffness is implicated in the age-associated increase in SBP and PP. These findings indicate that PWV is not a surrogate for BP and that arterial properties other than arterial wall stiffness that vary by age and sex also modulate the BP trajectories during aging and lead to the dissociation of PWV, PP, and SBP trajectories in men.
Author	Scuteri, Angelo Pilia, Maria Grazia Delitala, Alessandro Lakatta, Edward G Spurgeon, Harold Orrù, Marco Morrell, Christopher H Najjar, Samer S AlGhatrif, Majd Tarasov, Kirill V Loi, Francesco Strait, James B Ferreli, Liana Anna Pina
Author_xml	– sequence: 1 givenname: Angelo surname: Scuteri fullname: Scuteri, Angelo organization: From the Hospital San Raffaele Pisana-Istituto Ricovero e Cura a Carattere Sceintifico (IRCCS), Rome, Italy (A.S.); Laboratory of Cardiovascular Science, National Institute of Aging, Baltimore, MD (C.H.M., J.B.S., K.V.T., H.S., E.G.L.); Loyola University Maryland, Baltimore (C.H.M.); Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy (M.O., L.A.P.F., F.L., M.G.P., A.D.); Johns Hopkins School of Medicine, Baltimore, MD (M.A.); and MedStar Heart Institute, Washington, DC (S.S.N.) – sequence: 2 givenname: Christopher H surname: Morrell fullname: Morrell, Christopher H organization: From the Hospital San Raffaele Pisana-Istituto Ricovero e Cura a Carattere Sceintifico (IRCCS), Rome, Italy (A.S.); Laboratory of Cardiovascular Science, National Institute of Aging, Baltimore, MD (C.H.M., J.B.S., K.V.T., H.S., E.G.L.); Loyola University Maryland, Baltimore (C.H.M.); Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy (M.O., L.A.P.F., F.L., M.G.P., A.D.); Johns Hopkins School of Medicine, Baltimore, MD (M.A.); and MedStar Heart Institute, Washington, DC (S.S.N.) – sequence: 3 givenname: Marco surname: Orrù fullname: Orrù, Marco organization: From the Hospital San Raffaele Pisana-Istituto Ricovero e Cura a Carattere Sceintifico (IRCCS), Rome, Italy (A.S.); Laboratory of Cardiovascular Science, National Institute of Aging, Baltimore, MD (C.H.M., J.B.S., K.V.T., H.S., E.G.L.); Loyola University Maryland, Baltimore (C.H.M.); Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy (M.O., L.A.P.F., F.L., M.G.P., A.D.); Johns Hopkins School of Medicine, Baltimore, MD (M.A.); and MedStar Heart Institute, Washington, DC (S.S.N.) – sequence: 4 givenname: James B surname: Strait fullname: Strait, James B organization: From the Hospital San Raffaele Pisana-Istituto Ricovero e Cura a Carattere Sceintifico (IRCCS), Rome, Italy (A.S.); Laboratory of Cardiovascular Science, National Institute of Aging, Baltimore, MD (C.H.M., J.B.S., K.V.T., H.S., E.G.L.); Loyola University Maryland, Baltimore (C.H.M.); Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy (M.O., L.A.P.F., F.L., M.G.P., A.D.); Johns Hopkins School of Medicine, Baltimore, MD (M.A.); and MedStar Heart Institute, Washington, DC (S.S.N.) – sequence: 5 givenname: Kirill V surname: Tarasov fullname: Tarasov, Kirill V organization: From the Hospital San Raffaele Pisana-Istituto Ricovero e Cura a Carattere Sceintifico (IRCCS), Rome, Italy (A.S.); Laboratory of Cardiovascular Science, National Institute of Aging, Baltimore, MD (C.H.M., J.B.S., K.V.T., H.S., E.G.L.); Loyola University Maryland, Baltimore (C.H.M.); Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy (M.O., L.A.P.F., F.L., M.G.P., A.D.); Johns Hopkins School of Medicine, Baltimore, MD (M.A.); and MedStar Heart Institute, Washington, DC (S.S.N.) – sequence: 6 givenname: Liana Anna Pina surname: Ferreli fullname: Ferreli, Liana Anna Pina organization: From the Hospital San Raffaele Pisana-Istituto Ricovero e Cura a Carattere Sceintifico (IRCCS), Rome, Italy (A.S.); Laboratory of Cardiovascular Science, National Institute of Aging, Baltimore, MD (C.H.M., J.B.S., K.V.T., H.S., E.G.L.); Loyola University Maryland, Baltimore (C.H.M.); Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy (M.O., L.A.P.F., F.L., M.G.P., A.D.); Johns Hopkins School of Medicine, Baltimore, MD (M.A.); and MedStar Heart Institute, Washington, DC (S.S.N.) – sequence: 7 givenname: Francesco surname: Loi fullname: Loi, Francesco organization: From the Hospital San Raffaele Pisana-Istituto Ricovero e Cura a Carattere Sceintifico (IRCCS), Rome, Italy (A.S.); Laboratory of Cardiovascular Science, National Institute of Aging, Baltimore, MD (C.H.M., J.B.S., K.V.T., H.S., E.G.L.); Loyola University Maryland, Baltimore (C.H.M.); Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy (M.O., L.A.P.F., F.L., M.G.P., A.D.); Johns Hopkins School of Medicine, Baltimore, MD (M.A.); and MedStar Heart Institute, Washington, DC (S.S.N.) – sequence: 8 givenname: Maria Grazia surname: Pilia fullname: Pilia, Maria Grazia organization: From the Hospital San Raffaele Pisana-Istituto Ricovero e Cura a Carattere Sceintifico (IRCCS), Rome, Italy (A.S.); Laboratory of Cardiovascular Science, National Institute of Aging, Baltimore, MD (C.H.M., J.B.S., K.V.T., H.S., E.G.L.); Loyola University Maryland, Baltimore (C.H.M.); Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy (M.O., L.A.P.F., F.L., M.G.P., A.D.); Johns Hopkins School of Medicine, Baltimore, MD (M.A.); and MedStar Heart Institute, Washington, DC (S.S.N.) – sequence: 9 givenname: Alessandro surname: Delitala fullname: Delitala, Alessandro organization: From the Hospital San Raffaele Pisana-Istituto Ricovero e Cura a Carattere Sceintifico (IRCCS), Rome, Italy (A.S.); Laboratory of Cardiovascular Science, National Institute of Aging, Baltimore, MD (C.H.M., J.B.S., K.V.T., H.S., E.G.L.); Loyola University Maryland, Baltimore (C.H.M.); Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy (M.O., L.A.P.F., F.L., M.G.P., A.D.); Johns Hopkins School of Medicine, Baltimore, MD (M.A.); and MedStar Heart Institute, Washington, DC (S.S.N.) – sequence: 10 givenname: Harold surname: Spurgeon fullname: Spurgeon, Harold organization: From the Hospital San Raffaele Pisana-Istituto Ricovero e Cura a Carattere Sceintifico (IRCCS), Rome, Italy (A.S.); Laboratory of Cardiovascular Science, National Institute of Aging, Baltimore, MD (C.H.M., J.B.S., K.V.T., H.S., E.G.L.); Loyola University Maryland, Baltimore (C.H.M.); Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy (M.O., L.A.P.F., F.L., M.G.P., A.D.); Johns Hopkins School of Medicine, Baltimore, MD (M.A.); and MedStar Heart Institute, Washington, DC (S.S.N.) – sequence: 11 givenname: Samer S surname: Najjar fullname: Najjar, Samer S organization: From the Hospital San Raffaele Pisana-Istituto Ricovero e Cura a Carattere Sceintifico (IRCCS), Rome, Italy (A.S.); Laboratory of Cardiovascular Science, National Institute of Aging, Baltimore, MD (C.H.M., J.B.S., K.V.T., H.S., E.G.L.); Loyola University Maryland, Baltimore (C.H.M.); Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy (M.O., L.A.P.F., F.L., M.G.P., A.D.); Johns Hopkins School of Medicine, Baltimore, MD (M.A.); and MedStar Heart Institute, Washington, DC (S.S.N.) – sequence: 12 givenname: Majd surname: AlGhatrif fullname: AlGhatrif, Majd organization: From the Hospital San Raffaele Pisana-Istituto Ricovero e Cura a Carattere Sceintifico (IRCCS), Rome, Italy (A.S.); Laboratory of Cardiovascular Science, National Institute of Aging, Baltimore, MD (C.H.M., J.B.S., K.V.T., H.S., E.G.L.); Loyola University Maryland, Baltimore (C.H.M.); Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy (M.O., L.A.P.F., F.L., M.G.P., A.D.); Johns Hopkins School of Medicine, Baltimore, MD (M.A.); and MedStar Heart Institute, Washington, DC (S.S.N.) – sequence: 13 givenname: Edward G surname: Lakatta fullname: Lakatta, Edward G email: lakattae@grc.nia.nih.gov organization: From the Hospital San Raffaele Pisana-Istituto Ricovero e Cura a Carattere Sceintifico (IRCCS), Rome, Italy (A.S.); Laboratory of Cardiovascular Science, National Institute of Aging, Baltimore, MD (C.H.M., J.B.S., K.V.T., H.S., E.G.L.); Loyola University Maryland, Baltimore (C.H.M.); Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy (M.O., L.A.P.F., F.L., M.G.P., A.D.); Johns Hopkins School of Medicine, Baltimore, MD (M.A.); and MedStar Heart Institute, Washington, DC (S.S.N.). lakattae@grc.nia.nih.gov
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/25225210$$D View this record in MEDLINE/PubMed
BookMark	eNpNkN9LwzAQx4NM3A_9FyS--bDOJE2b7nGM6QZjE50PPpU0ucxKl9SkFfzvDajgcXDfOz7fg7sxGlhnAaEbSmaU5vRu_fq4ejqsds-b_W6xXsQhnxFOmThDI5oxnvAsTwf_9BCNQ3gnhHLOxQUasozFpGSEqq2zx7rrdW1lg1vwoQXV1Z-AncXdG2DlbG-170_YGazAdj5y0nfg6yhCVxtjIYQprhrnNG59bHoPUyytxvJY2-MlOjeyCXD1Wyfo5X51WK6T7f5hs1xsE5XzVCRZLoqKzZXKjVEiHjOvVGU0yWJonWaiEgUnigMlhZaFVJAzprg2kgshqWETdPuzt_Xuo4fQlac6KGgaacH1oaQ5y1KeRldEr3_RvjqBLltfn6T_Kv_-wr4BRr5q2w
CitedBy_id	crossref_primary_10_1080_03007995_2017_1330259 crossref_primary_10_1038_s41440_020_0404_6 crossref_primary_10_1373_clinchem_2018_287623 crossref_primary_10_1093_eurjpc_zwaf379 crossref_primary_10_1161_JAHA_119_013004 crossref_primary_10_1016_j_atherosclerosis_2017_10_031 crossref_primary_10_1038_s41440_023_01196_z crossref_primary_10_1016_j_ijcard_2018_03_117 crossref_primary_10_1097_HJH_0000000000001909 crossref_primary_10_1183_13993003_00837_2015 crossref_primary_10_1016_j_atherosclerosis_2016_10_032 crossref_primary_10_3389_fpubh_2022_877192 crossref_primary_10_1016_j_ijcard_2016_04_172 crossref_primary_10_1186_s12933_016_0472_8 crossref_primary_10_1038_s41598_018_20763_w crossref_primary_10_1161_JAHA_119_015396 crossref_primary_10_1016_j_jad_2015_11_019 crossref_primary_10_1161_HYPERTENSIONAHA_120_16740 crossref_primary_10_1161_HYPERTENSIONAHA_118_11987 crossref_primary_10_1007_s11845_017_1617_9 crossref_primary_10_1161_ATVBAHA_124_322001 crossref_primary_10_1016_j_exger_2017_05_016 crossref_primary_10_1016_j_mcna_2016_08_006 crossref_primary_10_1016_j_ejrad_2023_110794 crossref_primary_10_1038_jhh_2015_62 crossref_primary_10_1007_s11906_017_0788_0 crossref_primary_10_1080_10641963_2018_1545853 crossref_primary_10_1007_s13410_020_00901_9 crossref_primary_10_1177_1747493020971905 crossref_primary_10_1016_j_ijcard_2020_03_081 crossref_primary_10_1093_ajh_hpy145 crossref_primary_10_1038_s41591_019_0643_8 crossref_primary_10_1177_2048004016661679 crossref_primary_10_1007_s40292_019_00301_z crossref_primary_10_1161_HYPERTENSIONAHA_124_23717 crossref_primary_10_1007_s40519_025_01714_7 crossref_primary_10_1007_s40520_019_01260_0 crossref_primary_10_1016_j_maturitas_2016_07_003 crossref_primary_10_1007_s11906_015_0569_6 crossref_primary_10_1016_j_bbadis_2015_11_013 crossref_primary_10_1088_1361_6560_aa591d crossref_primary_10_1161_JAHA_120_017804 crossref_primary_10_1159_000495634 crossref_primary_10_1161_HYPERTENSIONAHA_115_07079 crossref_primary_10_3389_fragi_2025_1625070 crossref_primary_10_1097_HJH_0000000000003378 crossref_primary_10_1038_s41598_019_45703_0 crossref_primary_10_1016_j_ijcard_2018_07_106 crossref_primary_10_1159_000381098 crossref_primary_10_1007_s40520_017_0787_7 crossref_primary_10_1186_s13195_017_0262_x crossref_primary_10_1016_j_jamda_2019_11_014 crossref_primary_10_1111_jch_13623 crossref_primary_10_1016_j_jacadv_2023_100423 crossref_primary_10_1002_ajhb_23449 crossref_primary_10_2337_dc21_1921 crossref_primary_10_1016_j_exger_2016_06_003 crossref_primary_10_1161_HYPERTENSIONAHA_121_17579 crossref_primary_10_1161_STROKEAHA_116_016321 crossref_primary_10_1016_j_neuron_2024_09_017 crossref_primary_10_1097_HJH_0000000000001144 crossref_primary_10_1111_jgs_14271 crossref_primary_10_1093_eurjpc_zwad028 crossref_primary_10_1097_HJH_0000000000001824 crossref_primary_10_1007_s11906_014_0523_z crossref_primary_10_1111_jch_13614 crossref_primary_10_1038_s41440_018_0047_z crossref_primary_10_1016_j_jacc_2019_12_041 crossref_primary_10_1161_HYPERTENSIONAHA_118_11143 crossref_primary_10_1249_JES_0000000000000223 crossref_primary_10_1177_20480040231225384 crossref_primary_10_1111_eci_12493 crossref_primary_10_3389_fcvm_2023_1092525 crossref_primary_10_1093_ajh_hpz008 crossref_primary_10_1161_JAHA_119_014547 crossref_primary_10_1161_HYPERTENSIONAHA_120_16149 crossref_primary_10_1007_s44200_025_00078_8 crossref_primary_10_1007_s10484_024_09641_6 crossref_primary_10_2991_artres_k_191124_001 crossref_primary_10_1016_j_cyto_2018_08_027 crossref_primary_10_1113_JP283581 crossref_primary_10_1097_HJH_0000000000003283 crossref_primary_10_1161_HYPERTENSIONAHA_121_17558 crossref_primary_10_1161_CIRCRESAHA_118_311378 crossref_primary_10_1161_JAHA_122_027329 crossref_primary_10_1177_0271678X241302172 crossref_primary_10_23736_S0022_4707_20_10814_4 crossref_primary_10_1097_HJH_0000000000002899 crossref_primary_10_1016_j_hipert_2015_08_001 crossref_primary_10_1016_j_mad_2018_03_012 crossref_primary_10_2478_sjecr_2019_0069 crossref_primary_10_1007_s11357_020_00321_x crossref_primary_10_1007_s11357_022_00699_w crossref_primary_10_1371_journal_pone_0157493 crossref_primary_10_1038_s41440_024_01831_3 crossref_primary_10_1007_s40520_017_0815_7 crossref_primary_10_2337_dc16_1773 crossref_primary_10_1111_jch_14361 crossref_primary_10_2217_nmt_15_17 crossref_primary_10_1016_j_ijcard_2019_08_011 crossref_primary_10_1097_HJH_0000000000002002 crossref_primary_10_1371_journal_pone_0139211 crossref_primary_10_1097_HJH_0000000000003217 crossref_primary_10_1161_HYPERTENSIONAHA_119_13973 crossref_primary_10_1093_ajh_hpv180 crossref_primary_10_1161_HYPERTENSIONAHA_122_19693 crossref_primary_10_3390_ijms24086910 crossref_primary_10_1177_2047487320915342 crossref_primary_10_1007_s11906_017_0724_3
ContentType	Journal Article
Copyright	2014 American Heart Association, Inc.
Copyright_xml	– notice: 2014 American Heart Association, Inc.
DBID	CGR CUY CVF ECM EIF NPM 7X8
DOI	10.1161/HYPERTENSIONAHA.114.04127
DatabaseName	Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	no_fulltext_linktorsrc
Discipline	Medicine
EISSN	1524-4563
ExternalDocumentID	25225210
Genre	Multicenter Study Research Support, N.I.H., Intramural Journal Article Research Support, N.I.H., Extramural
GeographicLocations	Italy
GeographicLocations_xml	– name: Italy
GrantInformation_xml	– fundername: NIA NIH HHS grantid: N01-AG-1-2109 – fundername: Intramural NIH HHS grantid: Z01 AG000856
GroupedDBID	--- .-D .3C .55 .GJ .XZ .Z2 01R 0R~ 18M 1J1 2WC 3O- 40H 4Q1 4Q2 4Q3 53G 5GY 5RE 5VS 71W 77Y 7O~ AAAAV AAAXR AAFWJ AAGIX AAHPQ AAIQE AAJCS AAMOA AAMTA AAQKA AARTV AASCR AASOK AAXQO AAYEP ABASU ABBUW ABDIG ABJNI ABOCM ABPXF ABQRW ABVCZ ABXVJ ABXYN ABZAD ABZZY ACCJW ACDDN ACEWG ACGFO ACGFS ACILI ACLDA ACWDW ACWRI ACXJB ACXNZ ACZKN ADBBV ADFPA ADGGA ADGHP ADHPY ADNKB AE3 AE6 AEBDS AEETU AENEX AFBFQ AFDTB AFEXH AFFNX AFNMH AFUWQ AGINI AHMBA AHOMT AHQNM AHQVU AHRYX AHVBC AIJEX AINUH AJCLO AJIOK AJNWD AJNYG AJZMW AKCTQ AKULP ALKUP ALMA_UNASSIGNED_HOLDINGS ALMTX AMJPA AMKUR AMNEI AOHHW AOQMC BAWUL BCGUY BOYCO BQLVK BS7 C1A C45 CGR CS3 CUY CVF DIK DIWNM DUNZO E.X E3Z EBS ECM EEVPB EIF EJD ERAAH EX3 F2K F2L F2M F2N F5P FCALG FL- FW0 GNXGY GQDEL GX1 H0~ H13 HLJTE HZ~ IKREB IKYAY IN~ IPNFZ JF9 JG8 JK3 JK8 K-A K-F K8S KD2 KMI KQ8 L-C L7B N4W N9A NPM N~7 N~B N~M O9- OAG OAH OB3 OCUKA ODA ODMTH OGROG OHYEH OK1 OL1 OLG OLH OLU OLV OLY OLZ OPUJH ORVUJ OUVQU OVD OVDNE OVIDH OVLEI OWBYB OWU OWV OWW OWX OWY OWZ OXXIT OZ- P-K P2P PQQKQ R58 RAH RIG RLZ S4R S4S T8P TEORI TR2 TSPGW V2I VVN W3M W8F WH7 WOQ WOW X3V X3W X7M XXN XYM YFH YHZ YOC YYM YYP ZFV ZGI ZZMQN 7X8 ADKSD
ID	FETCH-LOGICAL-c6437-5678b29cc6ffc71279bcbfd05555dd357b7840c4e108da8ace622c4dfa477a1f2
IEDL.DBID	7X8
ISICitedReferencesCount	138
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000345129900019&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1524-4563
IngestDate	Wed Oct 01 14:58:48 EDT 2025 Mon Jul 21 06:02:55 EDT 2025
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	6
Keywords	arteries blood pressure aging pulse wave analysis sex longitudinal studies
Language	English
License	2014 American Heart Association, Inc.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c6437-5678b29cc6ffc71279bcbfd05555dd357b7840c4e108da8ace622c4dfa477a1f2
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
OpenAccessLink	https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.114.04127
PMID	25225210
PQID	1625343622
PQPubID	23479
ParticipantIDs	proquest_miscellaneous_1625343622 pubmed_primary_25225210
PublicationCentury	2000
PublicationDate	2014-December
PublicationDateYYYYMMDD	2014-12-01
PublicationDate_xml	– month: 12 year: 2014 text: 2014-December
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States
PublicationTitle	Hypertension (Dallas, Tex. 1979)
PublicationTitleAlternate	Hypertension
PublicationYear	2014
SSID	ssj0014447
Score	2.5109816
Snippet	The age-associated increase in arterial stiffness has long been considered to parallel or to cause the age-associated increase in blood pressure (BP). Yet, the...
SourceID	proquest pubmed
SourceType	Aggregation Database Index Database
StartPage	1219
SubjectTerms	Adult Age Distribution Age Factors Aged Aged, 80 and over Aging Blood Pressure - physiology Disease Progression Female Follow-Up Studies Humans Hypertension - epidemiology Hypertension - physiopathology Incidence Italy - epidemiology Male Middle Aged Vascular Stiffness - physiology Young Adult
Title	Longitudinal perspective on the conundrum of central arterial stiffness, blood pressure, and aging
URI	https://www.ncbi.nlm.nih.gov/pubmed/25225210 https://www.proquest.com/docview/1625343622
Volume	64
WOSCitedRecordID	wos000345129900019&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText
inHoldings	1
isFullTextHit
isPrint
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8NAEF7Uinjx_agvtuCxa_PYzSYnKdLSgw09KNRT2Cd4MKmt8fc7u0npSRC8JKdAMvnyzbc7k_kQurc0CWLNMqKVYMTNmSQp45ZEVhjIpypLZODNJniep_N5Nms33FZtW-WaEz1R60q5PfJBCEI9pkC30ePikzjXKFddbS00tlEnBinjUM3nmyoCpd5gDFIUJSAU4j3U8ySRhIPJ22wEgjF3jDWcDN3I3Ac3eor_rjR9xhkf_vdej9BBqzXxsAHHMdoy5Qnam7bV9FMknyvnVlRr54yFF5vfLnFVYhCGGNbKdamX9QeuLG7bOLFvAgXUYiAHax1T9rFvf8e-p7Zemj4Wpcbe_ugMvY5HL08T0nouEOVKeIRB8pJRplRireIQj0wqabUbC8a0jhmXHJaEipowSLVIhTLwlIpqKyjnIrTROdopq9JcImyDTCaKSZoGhsJJxCKLZUSVZiHgRnVRbx29AjDtChWiNFW9Kjbx66KL5hUUi2b4RhGBYATJEVz94eprtA_6hjbdJzeoY-GLNrdoV31_va-Wdx4scMxn0x9K5MpE
linkProvider	ProQuest
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Longitudinal+perspective+on+the+conundrum+of+central+arterial+stiffness%2C+blood+pressure%2C+and+aging&rft.jtitle=Hypertension+%28Dallas%2C+Tex.+1979%29&rft.au=Scuteri%2C+Angelo&rft.au=Morrell%2C+Christopher+H&rft.au=Orr%C3%B9%2C+Marco&rft.au=Strait%2C+James+B&rft.date=2014-12-01&rft.issn=1524-4563&rft.eissn=1524-4563&rft.volume=64&rft.issue=6&rft.spage=1219&rft_id=info:doi/10.1161%2FHYPERTENSIONAHA.114.04127&rft.externalDBID=NO_FULL_TEXT
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1524-4563&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1524-4563&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1524-4563&client=summon