Polymorphic variants at NDUFC2, encoding a mitochondrial complex I subunit, associate with cardiac hypertrophy in human hypertension

Background A dysfunction of NADH dehydrogenase, the mitochondrial Complex I (CI), associated with the development of left ventricular hypertrophy (LVH) in previous experimental studies. A deficiency of Ndufc2 (subunit of CI) impairs CI activity causing severe mitochondrial dysfunction. The T allele...

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Bibliographic Details
Published in:	Molecular medicine (Cambridge, Mass.) Vol. 29; no. 1; pp. 107 - 13
Main Authors:	Gallo, Giovanna, Forte, Maurizio, Cotugno, Maria, Marchitti, Simona, Stanzione, Rosita, Tocci, Giuliano, Bianchi, Franca, Palmerio, Silvia, Scioli, Mariarosaria, Frati, Giacomo, Sciarretta, Sebastiano, Barbato, Emanuele, Volpe, Massimo, Rubattu, Speranza
Format:	Journal Article
Language:	English
Published:	London BioMed Central 09.08.2023 Springer Nature B.V BMC
Subjects:	Adult Aged Animals Biomedical and Life Sciences Biomedicine Cardiac hypertrophy Cardiology Cardiomegaly - genetics Cardiomyocytes Cardiovascular disease Diuretics Electron Transport Complex I - genetics Genotype Heart Humans Hypertension Hypertension - complications Hypertension - genetics Hypertrophy, Left Ventricular - complications Hypertrophy, Left Ventricular - genetics Male Middle Aged Mitochondrial complex I Mitochondrial dysfunction Molecular Medicine NDUFC2 Oxidative stress Rats Research Article Signal Transduction SIRT3 Stroke United States > US Italy Hypertension Cardiac hypertrophy Mitochondrial complex I Mitochondrial dysfunction SIRT3 NDUFC2
ISSN:	1528-3658, 1076-1551, 1528-3658
Online Access:	Get full text
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