Impaired balance between neutrophil extracellular trap formation and degradation by DNases in COVID-19 disease

Background Thrombo-inflammation and neutrophil extracellular traps (NETs) are exacerbated in severe cases of COVID-19, potentially contributing to disease exacerbation. However, the mechanisms underpinning this dysregulation remain elusive. We hypothesised that lower DNase activity may be associated...

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Bibliographic Details
Published in:	Journal of translational medicine Vol. 22; no. 1; pp. 246 - 18
Main Authors:	Garcia, Geoffrey, Labrouche-Colomer, Sylvie, Duvignaud, Alexandre, Clequin, Etienne, Dussiau, Charles, Trégouët, David-Alexandre, Malvy, Denis, Prevel, Renaud, Zouine, Atika, Pellegrin, Isabelle, Goret, Julien, Mamani-Matsuda, Maria, Dewitte, Antoine, James, Chloe
Format:	Journal Article
Language:	English
Published:	London BioMed Central 07.03.2024 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Adaptive immunology Analysis Antigens Biomarkers Biomedical and Life Sciences Biomedicine Care and treatment Clinical deterioration COVID-19 Cytotoxicity Dendritic cells Deoxyribonuclease Emerging diseases Hospital patients Hospitalization Human health and pathology Immunology ImmunoVirology and ImmunoOncology Infectious diseases Inflammation Innate immunity Intensive care Leukocytes (neutrophilic) Life Sciences Lymphocytes Medicine/Public Health Neutrophils Pandemics Patients Physiology Proteins Ratios RNA sequencing Sepsis Testing France
ISSN:	1479-5876, 1479-5876
Online Access:	Get full text
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