Clinical utility of circulating tumor DNA sequencing in advanced gastrointestinal cancer: SCRUM-Japan GI-SCREEN and GOZILA studies
Comprehensive genomic profiling enables genomic biomarker detection in advanced solid tumors. Here, to evaluate the utility of circulating tumor DNA (ctDNA) genotyping, we compare trial enrollment using ctDNA sequencing in 1,687 patients with advanced gastrointestinal (GI) cancer in SCRUM-Japan GOZI...
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| Vydané v: | Nature medicine Ročník 26; číslo 12; s. 1859 - 1864 |
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| Hlavní autori: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
New York
Nature Publishing Group US
01.12.2020
Nature Publishing Group |
| Predmet: | |
| ISSN: | 1078-8956, 1546-170X, 1546-170X |
| On-line prístup: | Získať plný text |
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| Abstract | Comprehensive genomic profiling enables genomic biomarker detection in advanced solid tumors. Here, to evaluate the utility of circulating tumor DNA (ctDNA) genotyping, we compare trial enrollment using ctDNA sequencing in 1,687 patients with advanced gastrointestinal (GI) cancer in SCRUM-Japan GOZILA (no. UMIN000016343), an observational ctDNA-based screening study, to enrollment using tumor tissue sequencing in the same centers and network (GI-SCREEN, 5,621 patients). ctDNA genotyping significantly shortened the screening duration (11 versus 33 days,
P
< 0.0001) and improved the trial enrollment rate (9.5 versus 4.1%,
P
< 0.0001) without compromising treatment efficacy compared to tissue genotyping. We also describe the clonal architecture of ctDNA profiles in ~2,000 patients with advanced GI cancer, which reinforces the relevance of many targetable oncogenic drivers and highlights multiple new drivers as candidates for clinical development. ctDNA genotyping has the potential to accelerate innovation in precision medicine and its delivery to individual patients.
An observational study on a large cohort of patients with gastrointestinal cancer demonstrates the utility of ctDNA analysis for accelerating the enrollment of patients in clinical trials with no accompanying deterioration in treatment efficacy. |
|---|---|
| AbstractList | Comprehensive genomic profiling enables genomic biomarker detection in advanced solid tumors. Here, to evaluate the utility of circulating tumor DNA (ctDNA) genotyping, we compare trial enrollment using ctDNA sequencing in 1,687 patients with advanced gastrointestinal (GI) cancer in SCRUM-Japan GOZILA (no. UMIN000016343), an observational ctDNA-based screening study, to enrollment using tumor tissue sequencing in the same centers and network (GI-SCREEN, 5,621 patients). ctDNA genotyping significantly shortened the screening duration (11 versus 33 days, P < 0.0001) and improved the trial enrollment rate (9.5 versus 4.1%, P < 0.0001) without compromising treatment efficacy compared to tissue genotyping. We also describe the clonal architecture of ctDNA profiles in ~2,000 patients with advanced GI cancer, which reinforces the relevance of many targetable oncogenic drivers and highlights multiple new drivers as candidates for clinical development. ctDNA genotyping has the potential to accelerate innovation in precision medicine and its delivery to individual patients. Comprehensive genomic profiling enables genomic biomarker detection in advanced solid tumors. Here, to evaluate the utility of circulating tumor DNA (ctDNA) genotyping, we compare trial enrollment using ctDNA sequencing in 1,687 patients with advanced gastrointestinal (GI) cancer in SCRUM-Japan GOZILA (no. UMIN000016343), an observational ctDNA-based screening study, to enrollment using tumor tissue sequencing in the same centers and network (GI-SCREEN, 5,621 patients). ctDNA genotyping significantly shortened the screening duration (11 versus 33 days, P < 0.0001) and improved the trial enrollment rate (9.5 versus 4.1%, P < 0.0001) without compromising treatment efficacy compared to tissue genotyping. We also describe the clonal architecture of ctDNA profiles in ~2,000 patients with advanced GI cancer, which reinforces the relevance of many targetable oncogenic drivers and highlights multiple new drivers as candidates for clinical development. ctDNA genotyping has the potential to accelerate innovation in precision medicine and its delivery to individual patients.Comprehensive genomic profiling enables genomic biomarker detection in advanced solid tumors. Here, to evaluate the utility of circulating tumor DNA (ctDNA) genotyping, we compare trial enrollment using ctDNA sequencing in 1,687 patients with advanced gastrointestinal (GI) cancer in SCRUM-Japan GOZILA (no. UMIN000016343), an observational ctDNA-based screening study, to enrollment using tumor tissue sequencing in the same centers and network (GI-SCREEN, 5,621 patients). ctDNA genotyping significantly shortened the screening duration (11 versus 33 days, P < 0.0001) and improved the trial enrollment rate (9.5 versus 4.1%, P < 0.0001) without compromising treatment efficacy compared to tissue genotyping. We also describe the clonal architecture of ctDNA profiles in ~2,000 patients with advanced GI cancer, which reinforces the relevance of many targetable oncogenic drivers and highlights multiple new drivers as candidates for clinical development. ctDNA genotyping has the potential to accelerate innovation in precision medicine and its delivery to individual patients. Comprehensive genomic profiling enables genomic biomarker detection in advanced solid tumors. Here, to evaluate the utility of circulating tumor DNA (ctDNA) genotyping, we compare trial enrollment using ctDNA sequencing in 1,687 patients with advanced gastrointestinal (GI) cancer in SCRUM-Japan GOZILA (no. UMIN000016343), an observational ctDNA-based screening study, to enrollment using tumor tissue sequencing in the same centers and network (GI-SCREEN, 5,621 patients). ctDNA genotyping significantly shortened the screening duration (11 versus 33 days, P < 0.0001) and improved the trial enrollment rate (9.5 versus 4.1%, P < 0.0001) without compromising treatment efficacy compared to tissue genotyping. We also describe the clonal architecture of ctDNA profiles in ~2,000 patients with advanced GI cancer, which reinforces the relevance of many targetable oncogenic drivers and highlights multiple new drivers as candidates for clinical development. ctDNA genotyping has the potential to accelerate innovation in precision medicine and its delivery to individual patients. An observational study on a large cohort of patients with gastrointestinal cancer demonstrates the utility of ctDNA analysis for accelerating the enrollment of patients in clinical trials with no accompanying deterioration in treatment efficacy. Comprehensive genomic profiling enables genomic biomarker detection in advanced solid tumors. Here, to evaluate the utility of circulating tumor DNA (ctDNA) genotyping, we compare trial enrollment using ctDNA sequencing in 1,687 patients with advanced gastrointestinal (GI) cancer in SCRUM-Japan GOZILA (no. UMIN000016343), an observational ctDNA-based screening study, to enrollment using tumor tissue sequencing in the same centers and network (GI-SCREEN, 5,621 patients). ctDNA genotyping significantly shortened the screening duration (11 versus 33 days, P < 0.0001) and improved the trial enrollment rate (9.5 versus 4.1%, P < 0.0001) without compromising treatment efficacy compared to tissue genotyping. We also describe the clonal architecture of ctDNA profiles in ~2,000 patients with advanced GI cancer, which reinforces the relevance of many targetable oncogenic drivers and highlights multiple new drivers as candidates for clinical development. ctDNA genotyping has the potential to accelerate innovation in precision medicine and its delivery to individual patients. An observational study on a large cohort of patients with gastrointestinal cancer demonstrates the utility of ctDNA analysis for accelerating the enrollment of patients in clinical trials with no accompanying deterioration in treatment efficacy. |
| Audience | Academic |
| Author | Tsuji, Akihito Yamashita, Riu Nakamura, Yoshiaki Oki, Eiji Morizane, Chigusa Yamanaka, Takeharu Esaki, Taito Kato, Takeshi Furuse, Junji Yamaguchi, Kensei Yasui, Hisateru Goto, Masahiro Sakamoto, Yasutoshi Miki, Izumi Kawamoto, Yasuyuki Tsuchihara, Katsuya Okamoto, Wataru Ohtsu, Atsushi Taniguchi, Hiroya Nakajima, Takako Kawakami, Hisato Odegaard, Justin I. Ueno, Makoto Denda, Tadamichi Nishida, Naohiro Komatsu, Yoshito Hata, Masayuki Ikeda, Masafumi Yamamoto, Yoshiyuki Nishina, Tomohiro Yamazaki, Kentaro Bando, Hideaki Kagawa, Yoshinori Ohtsubo, Koushiro Ichiki, Hiroko Takahashi, Naoki Yoshino, Takayuki Kato, Ken Matsuhashi, Nobuhisa |
| Author_xml | – sequence: 1 givenname: Yoshiaki surname: Nakamura fullname: Nakamura, Yoshiaki organization: Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Translational Research Support Section, National Cancer Center Hospital East – sequence: 2 givenname: Hiroya orcidid: 0000-0003-1407-6682 surname: Taniguchi fullname: Taniguchi, Hiroya organization: Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Translational Research Support Section, National Cancer Center Hospital East – sequence: 3 givenname: Masafumi orcidid: 0000-0002-4050-2086 surname: Ikeda fullname: Ikeda, Masafumi organization: Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East – sequence: 4 givenname: Hideaki orcidid: 0000-0001-5041-2765 surname: Bando fullname: Bando, Hideaki organization: Department of Clinical Oncology, Aichi Cancer Center Hospital – sequence: 5 givenname: Ken orcidid: 0000-0002-1733-5072 surname: Kato fullname: Kato, Ken organization: Department of Gastrointestinal Oncology, National Cancer Center Hospital, Biobank Translational Research Support Section, National Cancer Center Hospital – sequence: 6 givenname: Chigusa surname: Morizane fullname: Morizane, Chigusa organization: Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital – sequence: 7 givenname: Taito surname: Esaki fullname: Esaki, Taito organization: Department of Gastrointestinal and Medical Oncology, National Hospital Organization Kyushu Cancer Center – sequence: 8 givenname: Yoshito surname: Komatsu fullname: Komatsu, Yoshito organization: Department of Cancer Center, Hokkaido University Hospital – sequence: 9 givenname: Yasuyuki surname: Kawamoto fullname: Kawamoto, Yasuyuki organization: Department of Cancer Center, Hokkaido University Hospital – sequence: 10 givenname: Naoki surname: Takahashi fullname: Takahashi, Naoki organization: Department of Gastroenterology, Saitama Cancer Center – sequence: 11 givenname: Makoto orcidid: 0000-0003-4480-0029 surname: Ueno fullname: Ueno, Makoto organization: Department of Gastroenterology, Hepatobiliary and Pancreatic Medical Oncology Division, Kanagawa Cancer Center – sequence: 12 givenname: Yoshinori surname: Kagawa fullname: Kagawa, Yoshinori organization: Department of Colorectal Surgery, Kansai Rosai Hospital – sequence: 13 givenname: Tomohiro surname: Nishina fullname: Nishina, Tomohiro organization: Department of Gastrointestinal Medical Oncology, National Hospital Organization Shikoku Cancer Center – sequence: 14 givenname: Takeshi surname: Kato fullname: Kato, Takeshi organization: Department of Surgery, National Hospital Organization Osaka National Hospital – sequence: 15 givenname: Yoshiyuki surname: Yamamoto fullname: Yamamoto, Yoshiyuki organization: Department of Gastroenterology and Hepatology, University of Tsukuba Hospital – sequence: 16 givenname: Junji surname: Furuse fullname: Furuse, Junji organization: Department of Medical Oncology, Kyorin University Hospital – sequence: 17 givenname: Tadamichi surname: Denda fullname: Denda, Tadamichi organization: Division of Gastroenterology, Chiba Cancer Center – sequence: 18 givenname: Hisato orcidid: 0000-0002-3280-4850 surname: Kawakami fullname: Kawakami, Hisato organization: Department of Medical Oncology, Kindai University Hospital – sequence: 19 givenname: Eiji orcidid: 0000-0002-9763-9366 surname: Oki fullname: Oki, Eiji organization: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University – sequence: 20 givenname: Takako surname: Nakajima fullname: Nakajima, Takako organization: Department of Medical Oncology, St. Marianna University School of Medicine – sequence: 21 givenname: Naohiro surname: Nishida fullname: Nishida, Naohiro organization: Department of Frontier Science for Cancer and Chemotherapy, Graduate School of Medicine, Osaka University – sequence: 22 givenname: Kensei surname: Yamaguchi fullname: Yamaguchi, Kensei organization: Department of Gastroenterological Chemotherapy, Cancer Institute Hospital of Japanese Foundation for Cancer Research – sequence: 23 givenname: Hisateru surname: Yasui fullname: Yasui, Hisateru organization: Department of Medical Oncology, Kobe City Medical Center General Hospital – sequence: 24 givenname: Masahiro orcidid: 0000-0003-4279-8682 surname: Goto fullname: Goto, Masahiro organization: Cancer Chemotherapy Center, Osaka Medical College Hospital – sequence: 25 givenname: Nobuhisa surname: Matsuhashi fullname: Matsuhashi, Nobuhisa organization: Department of Surgical Oncology, Graduate School of Medicine, Gifu University – sequence: 26 givenname: Koushiro surname: Ohtsubo fullname: Ohtsubo, Koushiro organization: Division of Medical Oncology, Cancer Research Institute, Kanazawa University – sequence: 27 givenname: Kentaro surname: Yamazaki fullname: Yamazaki, Kentaro organization: Division of Gastrointestinal Oncology, Shizuoka Cancer Center – sequence: 28 givenname: Akihito orcidid: 0000-0003-4034-1945 surname: Tsuji fullname: Tsuji, Akihito organization: Department of Clinical Oncology, Kagawa University Hospital – sequence: 29 givenname: Wataru surname: Okamoto fullname: Okamoto, Wataru organization: Translational Research Support Section, National Cancer Center Hospital East, Cancer Treatment Center, Hiroshima University Hospital – sequence: 30 givenname: Katsuya surname: Tsuchihara fullname: Tsuchihara, Katsuya organization: Translational Research Support Section, National Cancer Center Hospital East, Division of Translational Informatics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center – sequence: 31 givenname: Takeharu surname: Yamanaka fullname: Yamanaka, Takeharu organization: Division of Biostatistics, National Cancer Center Hospital East – sequence: 32 givenname: Izumi surname: Miki fullname: Miki, Izumi organization: Translational Research Support Section, National Cancer Center Hospital East – sequence: 33 givenname: Yasutoshi surname: Sakamoto fullname: Sakamoto, Yasutoshi organization: Translational Research Support Section, National Cancer Center Hospital East – sequence: 34 givenname: Hiroko surname: Ichiki fullname: Ichiki, Hiroko organization: Translational Research Support Section, National Cancer Center Hospital East – sequence: 35 givenname: Masayuki surname: Hata fullname: Hata, Masayuki organization: Translational Research Support Section, National Cancer Center Hospital East – sequence: 36 givenname: Riu surname: Yamashita fullname: Yamashita, Riu organization: Division of Translational Informatics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center – sequence: 37 givenname: Atsushi surname: Ohtsu fullname: Ohtsu, Atsushi organization: Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East – sequence: 38 givenname: Justin I. surname: Odegaard fullname: Odegaard, Justin I. organization: Guardant Health – sequence: 39 givenname: Takayuki orcidid: 0000-0002-0489-4756 surname: Yoshino fullname: Yoshino, Takayuki email: tyoshino@east.ncc.go.jp organization: Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33020649$$D View this record in MEDLINE/PubMed |
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| Title | Clinical utility of circulating tumor DNA sequencing in advanced gastrointestinal cancer: SCRUM-Japan GI-SCREEN and GOZILA studies |
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